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 disease of the heart muscle in which the heart loses its ability to pump
blood effectively
 the heart muscle becomes enlarged or abnormally thick or rigid.
 In rare cases, the muscle tissue in the heart is replaced with scar tissue.
 As cardiomyopathy progresses  the heart becomes weaker and less able
to pump blood through the body  to heart failure, arrhythmias, systemic
and pulmonary edema and, more rarely, endocarditis.

The 3 main types of cardiomyopathy are:

u Dilated cardiomyopathy

u Hypertrophic cardiomyopathy

u Restrictive cardiomyopathy
Dilated Cardiomyopathy
u most common form of cardiomyopathy
u generally occurs in adults aged 20 to 60 years

u more common in men

 the heart muscle begins to dilate or stretch and become thinner

 Ventricular chamber size

over time, the heart becomes weaker  heart failure
 symptoms of heart failure: fatigue, edema, and SOB
 can also lead to heart valve problems (regurgitation), arrhythmias, and blood
clots in the heart (poor blood flow), emboli formation
 a common reason for needing a heart transplant.
Hypertrophic Cardiomyopathy
 occurs when the heart muscle thickens abnormally (left ventricle)
 1.) obstructive type - the septum thickens and bulges into the left
ventricle blocks the flow of blood into the aorta  the ventricle must
work much harder to pump blood past the blockage and out to the
- symptoms can include chest pain, dizziness, shortness of breath,
or fainting.
- can also affect the mitral valve, causing blood to leak backward
through the valve.
2.) non-obstructive type - the entire ventricle may become thicker
(symmetric ventricular hypertrophy) or it may happen only at the bottom of
the heart (apical hypertrophy). The right ventricle also may be affected.
Hypertrophic Cardiomyopathy

 Left ventricular hypertrophy (thick ventricular wall)  
ventricular chamber size  hold less blood  CO
  pressure in the ventricles and lungs
 changes in the cardiac muscles  interfere with the heart's
electrical signals, leading to arrhythmias  sudden cardiac arrest
u inherited because of a gene mutation

u develop over time because of high blood pressure or aging often,

the cause is unknown.

Restrictive Cardiomyopathy
u tends to mostly affect older adults
u the ventricles become stiff and rigid due to replacement of the normal heart muscle

with abnormal tissue, such as scar tissue.

u As a result, the ventricles cannot relax normally and expand to fill with blood, which

causes the atria to become enlarged.

u Eventually, blood flow in the heart is reduced, and complications such as heart failure

or arrhythmias occur.
u radiation treatments, infections, or scarring after surgery

u Hemochromatosis - a condition in which too much iron is deposited into tissues,

including heart tissue

u Amyloidosis, a disease in which abnormal proteins are deposited into heart tissue

u Sarcoidosis, a disease in which inflammation produces tiny lumps of cells in various

organs in the body, including the heart

Types and Causes:
u Ischemic cardiomyopathy - caused by CAD & MI , w/c leave scars in the heart
u Idiopathic cardiomyopathy - the cause is unknown.
u Hypertensive cardiomyopathy - seen in people who have high BP for a long time,
particularly when it has gone untreated for years.
u Infectious cardiomyopathy - HIV, viral myocarditis
u Alcoholic cardiomyopathy - usually begins about 10 years after sustained, heavy
alcohol consumption.
u Toxic cardiomyopathy – due to cocaine, amphetamines, and some chemotherapy
drugs (doxorubicin, daunorubicin)
u Peripartum cardiomyopathy: This type appears in women during the last
trimester of pregnancy or after childbirth.
u Radiotherapy (cobalt)
u diabetes and thyroid disease
Major Risk Factors
uHaving a family history of cardiomyopathy, heart failure, or sudden
cardiac death
uHaving a disease or condition that can lead to cardiomyopathy, such

u Coronary artery disease

u A previous heart attack

u Myocarditis

uDiseases that can damage the heart (for example, hemochromatosis,

sarcoidosis, or amyloidosis)
uLong-term alcoholism

uLong-term high blood pressure

uDiabetes and other metabolic diseases

Signs and Symptoms

u some have no symptoms in the early stages of the disease

u as cardiomyopathy progresses and the heart weakens, signs and

symptoms of heart failure usually appear.

These signs and symptoms include:


uShortness of breath after exercise or even at rest

uSwelling of the abdomen, legs, ankles, and feet

uOther signs and symptoms: dizziness, lightheadedness, fainting during

exercise, abnormal heart rhythms, murmurs

The main goals of treating cardiomyopathy are to:
u Manage any conditions that cause or contribute to the cardiomyopathy

u Control symptoms so that the person can live as normally as possible

u Stop the disease from getting worse

u Reduce complications and the chance of sudden cardiac death

u Diuretics, which remove excess fluid and sodium from the body.

u Angiotensin-converting enzyme (ACE) inhibitors, which lower blood pressure and

reduce stress on the heart.

u Beta-blockers, which slow the heart rate by reducing the speed of the heart's

u Calcium channel blockers, which slow a rapid heartbeat by reducing the force

and rate of heart contractions, decrease BP

u Digoxin - increases the force of heart contractions and slows
the heartbeat.
u Anticoagulants, which prevent blood clots from forming.

Anticoagulants are often used in the treatment of dilated

u Antiarrhythmia medicines, which keep the heart beating in a

normal rhythm.
u Antibiotics, which are used before dental or surgical procedures.

Antibiotics help to prevent endocarditis, an infection of the heart

walls, valves, and vessels.
u Corticosteroids, which reduce inflammation.
u Septal myectomy
- also called septal myomectomy
- is open-heart surgery for hypertrophic obstructive
- generally used in younger patients and when medicines aren't
working well.
u Procedure:

1. a surgeon removes part of the thickened septum that is bulging into

the left ventricle  this widens the pathway in the ventricle that
leads to the aortic valve and improves blood flow through the heart
and out to the body
2. If necessary, the mitral valve can be repaired or replaced at the
same time. This surgery is often successful, and the person can return
to a normal life with no symptoms.
u Surgically implanted devices.
- Surgeons can place several different types of devices in the heart to
help it beat more effectively.
1. A left ventricular assist device (LVAD)
- helps the heart pump blood to the body
- LVAD can be used as a long-term therapy or as a short-term
treatment for people who are waiting for a heart transplant.
2. An implantable cardioverter defibrillator (ICD)
- is used in people who are at risk of life-threatening arrhythmia or
sudden cardiac death.
- This small device is implanted in the chest and connected to the heart
with wires. If the ICD senses a dangerous change in heart rhythm, it
will send an electric shock to the heart to restore a normal heartbeat.
u Heart Transplant
Assist Device
Lifestyle Changes
uThe doctor may recommend lifestyle changes to manage a condition
that is causing the cardiomyopathy. These changes may help reduce
symptoms. Lifestyle changes may include:
uQuitting smoking

uLosing excess weight

uEating a low-salt diet

uGetting moderate exercise, such as walking, and avoiding strenuous

uAvoiding the use of alcohol and illegal drugs

uGetting enough sleep and rest

uReducing stress

uTreating underlying conditions, such as diabetes and high blood

Heart Transplant
uan operation in which the diseased heart in a person is replaced with a
healthy heart from a deceased donor.
u 90% of heart transplants are performed on patients with end-stage

heart failure --- condition has become so severe that all

treatments, other than heart transplant, have failed.

Survival rates:
u 88 % of patients survive the first year after transplant

u 72 % survive for 5 years

u 50 % survive for 10 yrs.

u 16 % survive 20 years.