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EVEROLIMUS EVERTOR 10MG

- ANTICANCER DRUGS |
BIOCON | MHP

MILLION HEALTH PHARMACEUTICALS


DESCRIPTION

• Evertor 10mg tablet consist of an active ingredient


known as Everolimus which is intrude with growth of
cancer cell and process is slows down.Evertor 10mg
tablet is not a curable medication, which is helps to
slow their spreading in to the body.
EVERTOR PRESCRIBING INFORMATION

• Primarily Evertor 10mg tablet indicated for the


treatment kidney carcinoma Breast carcinoma
Brain carcinoma Everolimus is also indicated in
various advanced stage cancer in stomach,
intestines or pancreas.
EVERTOR MECHANISM

• Everolimus is an inhibitor of mTOR, joins at high


compatibility to FK506 binding protein 12, via
producing drug complex that inhibits the
productive of mTOR. This inhibition reduce the
activity of effectors downstream, which may leads
to stoppage of cell progression from G1 into S
phase, Finally causes cell growth arrest and
apoptosis
KIDNEY CARCINOMA
ADME PROCESS

• ABSORPTION
The maximium plasma concentration time of Everolimus reaches within 1 to
2 hours.

• DISTRIBUTION
Albumin human plasma protein bound of 74%.

• METABOLISM
In hepatic Everolimus metabolism is occurred, which is a substrate of
CYP3A4. The metabolites of Everolimus in 3 process; Three
monohydroxylated metabolite, Two hydrolytic rings opened products,
Phosphatidylcholine conjugate of Everolimus.

• ELIMINATION
half life period of Everolimus is 30 hours The elimination primarily via 5% in
urine; the parent compound has been detected in urine or feces.
PRODUCT
DETAILS:

Brand : Evertor
Ingredients : Everolimus
Strength : 10mg
Manufactured : Biocon
Package : 10 Tablets in
a strip
DOSAGE REGIMEN

• In breast cancer, renal cell cancer, pancreatic


cancer, Neuro endocrine cancer: The prescribed
dosage is 10mg should be taken as a single dose. In
Brain or intracranial cancer: The prescribed dosage
of Evertoras 10mg a single dose. is 4.5mg/m2 given
orally In pediatric: The pediatric dosage of Evertor
as a single dose in brain or intracranial tumor is
4.5mg/m2 should be given orally.
OVER DOSAGE

• The over dosage of Everolimus is limited, If over


dosage occurs patient must be provide with
supportive measures. And monitor evidence of
toxicity in Everolimus over dosage

WHEN TO TAKE THE DRUG EVERTOR


• Evertor 10mg tablets should be given with or without
food.
EVERTOR CAUSED SIDE EFFECTS

• Hypersensitivity reactions Lymphomas & other


malignancy Serious infections Kidney graft
thrombosis Hepatic artery thrombosis Nephrotoxicity
Hyperlipemia Angioedema Interstitial lung disease
Thrombocytopenia Male infertility Proteinuria New
commencement of diabetes
SAFETY PRECAUTIONS

• LYMPHOMAS
• Developed hazard of skin cancers, patient may protect
from UV light
• SERIOUS INFECTIONS
• Patients getting Evertor 10mg have severe risk of
achieve various infections related to bacteria, virus, and
fungi
HEPATIC ARTERY THROMBOSIS
• Evertor 10ng tablet therapy should not be
recommended in In liver transplant patients,
• EMBRYO FETAL TOXICITY
• using Evertor 10mg in pregnancy condition Causes fetal
damage
NEPHROTOXICITY

• While using Evertor 10mg tablet in renal impaired


patients Renal function should be monitored
frequently; drug use with caution
• INTERSTITIAL LUNG DISEASE
• In Evertor 10mg therapy interstitial lung disease
occur Blood glucose level should be monitored
DRUG INTERACTION

• Evertor 10mg tablet interaction with strong inhibitor


of CYP3A4, or P-gp, cause reducing the efflux of
Everolimus and high plasma concentration of
Everolimus. Interaction of Evertor with strong
CYP3A4 inducers, will increasing the disclosure of
Everolimus. Combination ofEvertor with cyclosporine
will increasing the AUC level of Everolimus
frequently.
PREGNANCY & LACTATION

• Pregnancy category of Everolimus C In patients


Evertor is used only after knowing the benefits to the
mother exceed the risk to fetus. Breast feeding
should not be suggested
CONTRAINDICATION

• If patients are contraindicated to the components


present in the Evertor 10mg tablet. Some
anaphylactic reaction occurs.
MISSED DOSE

• If the dose is missed, consult with healthcare


practitioner and follow the instructions given by
them. Thereby missed dose should be avoid and
follow the regular dosing schedule.
CONTACT US:

• MOBILE NO: +91-9940472902


• E-MAIL: millionhealthpharmaceuticals@gmail.com
• WEBSITE
URL: https://millionpharma.com/evertor.php