IF ONLY MY CHILD COULD TALK!

Dr. Julie Logan D.C., MAPS

True Health Medical Center
Naperville, Illinois
True Health Medical Center
Disclaimer

• Information is for educational purposes only

• Not to be taken as specific medical advice
• All medical decisions regarding your child’s
health issues should be discussed with your
health care provider
A Child With Autism…

•“Doesn't speak or has delayed speech, or loses previous

ability to say words or sentences
•Can't start a conversation or keep one going, or only starts
one to make requests or label items
•Speaks with an abnormal tone or rhythm and may use a
singsong voice or robot-like speech
•Repeats words or phrases verbatim, but doesn't understand
how to use them
•Doesn't appear to understand simple questions or directions”
Speech Makes Us Human
Neuro-Inflammation:

• Causes:

• Treatments:

• Tried and True Therapies for Resolving

Apraxia and Restoring Verbal
Communication:
The Many Physiologic Stresses Our Kids Face
• Oxidative Stress
• Mitochondrial Dysfunction
• Impaired Detoxification
– Methylation Defects
– Sulfation Defects
– Cysteine Deficiency
– Glutathione Deficiency (GSH)
• Gastrointestinal Dysfunction
– Dysbiosis
– Malabsorption /Maldigestion
– Inflammation
– Intestinal Permeability
• Immune System Dysregulation/Inflammation
– Proinflammatory Cytokines
– Microglial Activation
– Th1/ Th2 skewing
– Increased Autoimmune Markers
• Neurological Dysregulation
– Abnormal EEG
– Neurotransmitter imbalances

All can lead to Neuroinflammation

Causes of Neuroinflammation
• Toxic metabolites​
• Autoimmunity​
• Allergens​
• Aging​
• Microbes/Infections​
• Viruses​
• Traumatic brain injury​
• Spinal cord injury​
• Air pollution​
• Passive smoke​
• Mycotoxins​
Neuroinflammation leads to the
familiar symptoms…
• Behaviors
– Attention/Focus
– Hyperactivity
– OCD
– Stimming (verbal, visual, motor…)
– Mood Dysregulation
• Social Delay
• Motor Skills
• Processing Problems (auditory, visual, tactile
smell)
• Speech and Language Delays
Neuroinflammation

• Neuroinflammation is widely regarded as a

chronic process.
• Acute inflammation usually follows injury to the
central nervous system immediately, and is
characterized by inflammatory molecules,
endothelial cell activation, platelet deposition,
and tissue edema.
• Chronic inflammation is the sustained
activation of glial cells and recruitment of other
immune cells into the brain.
The Unresolved Inflammatory
Response
aka Chronic Inflammation
• The Innate immune response is activated
• Mast Cells Degranulate-histamines and
prostaglandins
• Microglial cells are activated
• Glutamate is released
• Excess Excitation ensues, interferes with brain
tasking
• Leading to
– Dysautonomia
– Mitochondrial dysfunction
– Oxidative stress

Nicolas G. Bazan, ... Ludmila Belayev, in Basic Neurochemistry

2012
Immune Dysregulation
• Th1 and Th2 skewing
• Abnormal cell-mediated immunity (Molloy, 2006)
• Abnormal T-cell subsets, decreased NK cells (Zimmerman, 1998; Gupta, 1996)
• Pro-inflammatory cytokines,TNF alpha, IL-6 (Jyonuchi, 2001; Maes, 2001)
• Mercury, Lead, and Aluminum cause Th1/Th2 skewed immune system
• Pro-inflammatory Cytokines in the Brain- MCP-1, TGF beta-1,
• Purkinje cell loss (Vargas, Pardo, Laurence, 2005)
• Microglial Activation, Innate immune system activation, Microvasculitis (Vargas,
Pardo 2005)
• Abnormal EEG, Seizure activity
• Increased Autoimmunity
• Autoantibodies to neural antigens (Connolly, 1999)
• Mylein basic protein and Neuronal Axonal Filament Protein Antibodies (Gupta,
1996 /Singh, 1997)
•
Neuroinflammation
Orchestration-Microglial Cells
• Innate immune cells of the CNS
• Microglia are key cells in overall brain maintenance—
they are constantly scavenging the CNS for plaques,
damaged or unnecessary neurons and synapses, and
infectious agents. Since these processes must be
efficient to prevent potentially fatal damage, microglia
are extremely sensitive to even small pathological
changes in the CNS.
• –
Curr Med Chem. 2007;14(11):1189-97.

Microglial activation and its implications in the brain

diseases.
Dheen ST1, Kaur C, Ling EA

• The inflammatory response is mediated by the activated

microglia, the resident immune cells of the CNS, which
normally respond to neuronal damage and remove the
damaged cells by phagocytosis.

• Activation of microglia is a hallmark of brain

pathology. The chronic activation of microglia may in
turn cause neuronal damage through the release of
potentially cytotoxic molecules such as proinflammatory
cytokines, reactive oxygen intermediates, proteinases and
complement protein
Mast Cell Activation and Mutation
• Triggers:
T-cell interactions
Abnl microbiome
• Infections: Lyme,
H. pylori, EBV, …
• Ehlers-Danlos
• Allergens
• Mold
Various triggers cause Mast Cells to degranulate
And release a variety of inflammatory compounds
Mast Cells cause Microglial Activation (PANS Flare)
Brain Excitotoxicity

• Microglia release proinflammatory

mediators, that cause
• Glutamate release from neurons,
• Glutamate binds to the NMDA receptor,
• Allowing Calcium to flow into cells rapidly
• Excess Calcium excites the cells and
causes damage to neurons
The principle excitatory receptor, the N-Methyl-D-Aspartate (NMDA) receptor,
and its associated calcium (Ca2+) permeable ion channel are activated by
glutamate.
Stimulators of the Excitotoxic
Cascade
• Immune response to infections (quinolinic
acid)
• Calcium intake (sometimes)
• Food based excitotoxins-glutamates,
MSG, amines, aspartate, nutrasweet,
sometimes glutamine, caffeine, dyes,
sulfites, proprionates, sometimes phenols
Oxidative Stress and
Mitochondrial Dysfunction

• The inner membrane of the mitochondria ​contains a large amount

of free radical scavengers including:​
– glutathione​
– vitamin C
– vitamin E
– Anti-oxidant enzymes such as SOD-(superoxide dismutase)
• Some children with autism have lower levels of reduced glutathione
and SOD, which could lead to mitochondrial damage and
dysfunction.​
• Impairments in mitochondrial function lead to further oxidative
stress and continued lower glutathione levels.​
Oxidative Stress and the Brain

Neurons are highly vulnerable to oxidative

stress and are the first cells to be affected
• Brain has high energy needs-consumes
20% of body’s oxygen
• Has high ATP requirement (mitochondria)
• Neurons don’t make their own glutathione
• Limited antioxidant capacity
Evidence linking oxidative stress, mitochondrial
dysfunction, and inflammation in the brain of
individuals with autism.
Rossignol DA1, Frye RE2
• “The brain regions found to contain
these physiological abnormalities in
individuals with ASD are involved in
speech and auditory processing, social
behavior, memory, and sensory and motor
coordination.”
• Front Physiol. 2014 Apr 22;5:150. doi: 10.3389/fphys.2014.00150.
eCollection 2014.
Dysautonomia

• Loss of balance between Sympathetic and

Parasympathetic branches of the ANS
• Increased release of norepinephrine,
epinephrine, cortisol, excitatory
neurotransmitters
• Chronic stress response
• Loss of proper Vagal nerve function
 Possible Signs and Symptoms of
Vagus Nerve Dysfunction/Dysautonomia
in ASD

• Poor self regulation/tantrums

• Irritable when misses meals
• Difficult transitioning to new environment
– Light, sound, temperature sensitivities
• Need for deep pressure to help regulate
• Head banging, self injury
• Food refusal
• Licking behavior (salt seeking)
• Constipation/Dysmotility/Bloating/Small Intestinal Bacterial
Overgrowth
True Health Medical Center
Cell Membrane Repair/Apraxia
Therapies
• Cell Membrane Repair-fats, cholesterol, fat-
soluble vitamins and antioxidants, phospholipids
• Methylation support
• Folate sources and BH4
• Address Dysautonomia
• Decrease excitotoxicity
• Choline enhancing agents, cholinergics
• Mitochondrial support
The Need for Cell membrane
Repair-Neuroinflammation is Cell
Membrane Damage
Cell Membrane Repair Consists
of: Building Blocks
• Healthy fats,-PUFA-Omega 3’s, saturated
fats, plant oils
• Cholesterol
• Fat soluble vitamins
• Fat soluble antioxidants
• Nutrients to support myelination
• Substances to calm cellular excitotoxicity
• Substances to improve cellular
detoxification
 Fats/Lipids are good for your brain!
• Fats, are an integral part of all cell membranes, and are
vulnerable to destruction through oxidation by free radicals
and neurotxoxins, like mercury.
• Fatty acid oxidation in the brain leads to poor cell to cell
communication, microglial activation, glutamate excitotoxicity,
methylation/sulfation deficits, glutathione depletion,
mitochondrial dysfunction and chronic inflammation! !!!
• Fat Soluble Vitamins and Antioxidants are uniquely suited to
pass thru the blood brain barrier and alleviate oxidative stress
in the lipid(fat) portion of the brain.
– 70% of the Brain is made up of fat.
– 25% of our Cholesterol resides in the brain.
– The mylein sheath is predominantly fat.
Cell Membranes are Mostly Fat
•Phospholipids
•Choline
•Serine
•Inositol
•Ethanolamine

•Cholesterol
•Glycolipids
Cholesterol
• Cholesterol is abundant in the tissue
of the brain and nervous system.
• Myelin, which covers nerve axons to help conduct the electrical
impulses that make movement, sensation, thinking, learning,
and remembering possible, is over one fifth cholesterol by
weight.
• Cholesterol was found to be the most important factor
in the formation of synapses, the basis of our learning
and memory.
• Cholesterol is a precursor to steroid hormones and vitamin D.
• The human body uses cholesterol to synthesize bile acids,
which are important for the digestion of fats.
Cholesterol and Myelin

Myelin contains an especially high level of

cholesterol and insulates and protects the
axon of the neuron.
Myelin increases the speed by which impulses
travel along the neuron.
 Low Cholesterol

• Early death
• Suicide
• Personality disorders
• Mood disorders
• Penal confinement in men
• Aggressive and violent behavior
• Sensory issues
• Language issues
(Martinez-Carpio, 2009)
Cholesterol helps with ASD,
hyperactivity, irritability, growth, sleep
and interactions
Fat Soluble Vitamins

• Vitamins A, D, E, K
• Antioxidant, anti-inflammatory effect
• Strongly immunomodulating
• Viruses and Pertussis disconnect retinoid
receptors in the eyes.
• Natural vitamin A may reconnect the retinoid
receptors critical for vision, sensory perception,
language processing and attention.
• Fat soluble vitamins often deficient in ASD due
to gut issues and malabsorption
 Phospholipids-Phosphatidyl choline

• Integral part of cell membranes –membrane fluidity

• Membrane fluidity is important for proper signaling and flow of
information and nutrients in and out of cells.
• Requires a large percentage of the available methyl groups to
make phospholipids. Undermethylated state will
compromise the synthesis of this critical lipid
 Phosphatidyl Serine
• Supports the function of many vital enzymes.
• Acts as an antioxidant, and quells inflammation in the
brain.
• Helps with stress induced damage in the brain.
• Specifically breaks down cortisol and decreases cortisol-
mediated damage to the structures of the brain responsible
for learning and memory

• Ulmann L. Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats. Prostaglandins Leukot
Essent Fatty Acids. 2001 Mar;64(3):189-95.
• Lomnitski L. Distinct alterations in phospholipid metabolism in brains of apolipoprotein E-deficient mice. J Neurosci Res. 1999 Nov
15;58(4):586-92.
• Suzuki S. Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats. J
Nutr. 2001 Nov;131(11):2951-6.
• Castilho JC. Phosphatidylserine: an antidepressive or a cognitive enhancer? Prog Neuropsychopharmacol Biol Psychiatry. 2004
Jul;28(4):731-8.
• Pepeu G. Nootropic drugs and brain cholinergic mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13 SupplS77-S88.
• Schreiber S. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci.
2000;37(4):302-7.
Antioxidants
• Vitamin E
• Vitamin A, vitamin K
• Vitamin C
• Selenium, Zinc
• Reduced Glutathione (r-GSH)
• Alpha-Lipoic acid, CoQ10, NADH, and GSH
act as a team
• Carnitine, Phosphatidyl Choline, PS
• Bioflavonoids (catechins) and Carotenoids
• Superfruits (noni, goji, acai, mangosteen…)
True Health Medical Center
Cell Membrane Repair/Apraxia
Therapies
• Cell Membrane Repair-fats, cholesterol, fat-soluble
vitamins and antioxidants, phospholipids
• Methylation support
• Folate sources
• Address Dysautonomia
• Decrease excitotoxicity
• AcetylCholine enhancing agents, cholinergics
• Mitochondrial support
Proven Track Record Therapies
to Help with Speech!
.
Methylcobalamin Injections-Dr.
James Neubrander
• “In my practice, 94% of children have been found to
respond to Methyl-B12 therapy.
• Executive function is improved in 90% of children –
things like awareness, cognition, appropriateness, eye
contact when called, and “just being more like a normal
kid.” Speech and language is improved in 80% of
children – all phases including spontaneous language,
more complex sentences, increased vocabulary, etc.
Socialization and emotion is improved in 70% of the
children – initiation and interactive play”
• https://tacanow.org/family-resources/methyl-b12-a-treatment-for-asd-with-methylation-issues/
Methylcobalamin: mechanism of
Action
• Because oxidative stress is present in the majority of children on the
spectrum, there arises the continual need for the methionine-
homocysteine-glutathione biochemical pathway to recycle enough
homocysteine back to methionine to drive methylation reactions
• In the brain this accounts for focus, attention, synchronization
of brain waves, speech, language, socialization, emotion)
• Also to shunt enough homocysteine onward to become
glutathione to satisfy the body’s transsulfuration needs
(quenching free radicals, decreasing inflammation, removing toxic
chemicals and heavy metals from the body).

• Methyl-B12: Doing It Right! Methylcobalamin Update USAAA Semi-annual Conference

Denver, Colorado August 2007
Methylation, Folate, BH4 Cycles
Methylcobalamin Administration

• 75 mcg per kg every 3 days is starting

protocol-this can be modified as needed
• Given subcutaneously by the parents or to
self
• Almost painless
• Filled by a compounding pharmacy such
as Pure Compounding Pharmacy in
Naperville, IL
Synapsin Nasal Spray

• Neuroprotective
• Decreases excitotoxicity
• Decreases oxidative stress induced
inflammation
• Improves neuroinflammation outcomes
• Blend of nicotinamide riboside, panax
ginseng extract, and MB12
• * JooSS etal.Prevention ofinflammationͲmediatedneurotoxicitybyRg3anditsrolein
microglialactivation.BiolPharmBull.2008Jul;31(7):1392Ͳ6. * BaoHY,
ZhangJ,YeoSJ,etal.Memoryenhancingandneuroprotectiveeffectsofselected
ginsenosides.ArchPharmRes.2005Mar;28(3):335Ͳ42.
 Methylcobalamin-High Statistical Success in
Supporting Language Development
• Effectiveness of Methylcobalamin and Folinic Acid
Treatment on Adaptive Behavior in Children with Autistic
Disorder Is Related to Glutathione Redox Status
Richard E. Frye, 1 ,* Stepan Melnyk, 1 George Fuchs, 1 Tyra Reid, 1 Stefanie
Jernigan, 1 Oleksandra Pavliv, 1 Amanda Hubanks, 1 David W. Gaylor, 2 Laura
Walters, 1 and S. Jill James 1
Leucovorin: Rx Folinic Acid

• Dr. Richard Frye MD, PhD & his group recently published the results of a
Folinic Acid improved
multi-year study that demonstrated that
speech and language and other symptoms in children
with autism.
• Cerebral folate deficiency (CFD) was discovered a little over 10 years
ago. As more and more cases were described with this disorder, it was clear
that many cases had symptoms consistent with autism.
• This disorder (CFD) was caused, in some cases, by Folate Receptor
Alpha Autoantibodies (FRAAs) which were blocking the
transportation of folate into the brain.
• Benefit greatest in kids who have brain autoimmunity with antibodies that
block the vitamin’s transport into brain cells – https://www.nofone.org/dr-
frye-q-and-a-folinic
 Folate receptor autoimmunity and cerebral
folate deficiency in low-functioning autism
with neurological deficits Neuropediatrics 2007 Quadros, Ramaeker

• Twenty-five patients with early-onset low-functioning autism with or

without neurological deficits, were evaluated.
• In spite of normal serum folate, CSF 5MTHF was low in 23 of 25
patients. The reduced CSF folate in 19 of these 23 patients could be
explained by serum FR autoantibodies blocking the folate binding
site of the membrane-attached FR on the choroid epithelial cells.
• Oral folinic acid supplements led to normal CSF 5MTHF and
partial or complete clinical recovery after 12 months.
• Serum FR autoimmunity appears to represent an important factor in
the pathogenesis of reduced folate transport to the nervous system
among children with early-onset low-functioning autism associated
with or without neurological deficits.
Forms of Folic Acid
• Folate/Folic Acid
– Least active form
– Needs to be converted to DHF and THF
• Folinic (5-formyl THF)
– Non-methylated active form
– Dose for Cerebral Folate Deficiency .5-2mg/kg/day in 3 divided
doses
– Rx called Leucovorin
– Can be compounded to avoid excipients (lactose)
– Available OTC
• Methylfolate (5-methyl THF)
– Methylated form
– Most active form
– Rx called Deplin, Cerefolin (also contains NAC)
– Available OTC
Motor Connect-Neuromuscular
Coordination of Speech

• Motor-Connect was developed to provide key nutrients involved in neuronal

health. The four nutrients in this formula work together to help with
neuronal connectivity, energy production, cell membrane integrity,
and overall neuronal health. Specifically targeting the cerebellar role
Speech and the Cerebellum
• The Cerebellum coordinates movement patterns

• Specifically, the cerebellum plays an important role in speech

articulation, prosody (i.e. characteristics of speech style including
rhythm, speed, emphasis, and pitch), and planning and processing
of speech and language
• The cerebellum is important for all types of eye movements and for
ensuring fixation stability
• (FYI) visual input is incredibly important for normal brain
development
• The neural basis of ataxic dysarthria.Spencer KA, Slocomb DL
• Cerebellum. 2007; 6(1):58-65.
Benfotiamine inhbits iNOS, COX-2, HSP 70, TNF-
alpha, and IL-6 in microglia (and improves
cerebellar function)
Biotin has immunomodulatory and anti-
inflammatory effects
independent of biotin dependent carboxylases
True Health Medical Center
Cell Membrane Repair/Apraxia Protocol
• Cell Membrane Repair-fats, cholesterol, fat-soluble
vitamins and antioxidants, phospholipids
• Methylation support
• Folate sources
• Decrease Excitotoxicity
• Address Dysautonomia
• Choline enhancing agents, cholinergics
• Mitochondrial support
• Low pressure HBOT
Address Excitotoxicity

-Namenda and Amantadine (RX)-oppose the

NMDA receptor and glutamate mediated
cascade
-L theanine, melatonin, GABA, glycine
-Magnesium-blocks the calcium channel
-Lithium orotate-inhibits NMDA receptor
-Vinpocetine and benfotiamine
-AVOID excitotoxins in foods!!!!!
Natural Agents to
Decrease Microglial Activation
• Resveratol- neuroprotective
• Pycnogenol- antioxidant
• Vinpocetine-Ca regulation
• Gastrodia elata- brain injury neuroprotective
• Pipera kadsura (Japanese pepper)- PGE2
inhibitor
• (Reishi Mushroom)-immune modulatory
• (Horny Goat Weed)- improves blood flow
• PQQ (pyrroloquinoline quinone)- PGE2 and
COX-2 inhibitor
 Address Dysautonomia
Down-regulate Sympathetic (high NE, Epi)
• Adaptogenic Herbs- Adrenal glandular support.
• Beta Blockers- Propranolol
• Alpha 2 adenoreceptor agonists- Clonidine, Guanfacine
• NMDA receptor antagonists- Memantine, Amantadine
• Upregulate inhibitory neurotransmitters- GABA, L-theanine, Taurine,
Glycine
• Chiropractic adjustments
• Benfotiamine/Biotin (Motor-Connect)

Up-regulate Parasympathetic
• Acetylcholine (phosphatidylcholine, phosphatidylserine)
• Acetylcholinesterase Inhibitors (galantamine, huperizine A,
piracetam)
• Vagus Nerve Stimulation-TENS unit or Chiropractic adjustments

Address Gut Issues- especially SIBO

Down-regulate the Sympathetic
Physiologic Response
• Propranolol- beta adrenergic receptor
antagonist
• Blocks the effects of excitatory
neurotransmitters
epinephrine/norepinephrine
• Studied for anxiety, aggression, excitation
• Grade A for research for this use
Propranolol for treating emotional, behavioral,
autonomic dysregulation in children and
adolescents with autism spectrum disorders. Sagar-
Ouriaghli I1, Lievesley K1,2, Santosh PJ1,3,2 .
• Propranolol led to significant improvements in cognitive
performance - verbal problem solving, social skills,
mouth fixation, and conversation reciprocity; and improvement
in semantic networks and functional connectivity.

• Improvements in EBAD-emotional, behavioral and

autonomic dysregulation, anxiety, aggressive, self-
injurious and hypersexual behaviours.
 Effect of Propranolol on Verbal Problem
Solving in Autism Spectrum
• Some studies suggest drugs decreasing noradrenergic activity are
beneficial in ASD.
• In individuals without neurodevelopmental diagnoses, propranolol is
beneficial only for difficult network flexibility-dependent problems.
• However, in populations with altered noradrenergic
regulation, propranolol also benefits performance for simple
problems. Due to decreased flexibility of access to networks in ASD,
we wished to examine the effect of propranolol on NF in ASD.
• ASD subjects benefited from propranolol on simple anagrams,
whereas control subjects were impaired by propranolol.

•Neurocase: The Neural Basis of Cognition 2008

Beversdorf
Adaptogens
plant compounds that have a normalizing impact
on the HPA axis under times of stress, help with
blood sugar regulation, anxiety, immune
modulation
•Panax Ginseng- lowers cortisol
•Siberian Ginseng
•Holy Basil- anticonvulsant properties
•Licorice/Glycyrrhizin- increases cortisol
•Rhodiola rosea
•Ashwaganda- blood sugar regulation
•Bacopa
•Gotu Kola
•Moringa oleifera- anti-inflammatory
•Schisandra

•Adrenal Cortex Extract

True Health Medical Center
Cell Membrane Repair/Apraxia Protocol
• Cell Membrane Repair-fats, cholesterol, fat-soluble
vitamins and antioxidants, phospholipids
• Methylation support
• Folate sources and BH4
• Decrease Excitotoxicity
• Address Dysautonomia
• Choline enhancing agents, cholinergics
• Mitochondrial support
• Low pressure HBOT
ACETYLCHOLINE
• Known as the learning neurotransmitter,
acetylcholine improves mental function
including memory storage and recall, attention
control, social interaction, language abilities,
reasoning, logic and creative thoughts.
• It regulates digestion and mood
• Acts in both the brain and the peripheral
nervous system. Increasing it can increase
plasticity, cognition , brain performance
Galantamine-nootropic
Ghaleiha A. et al. (2013) Galantamine efficacy and tolerability as an augmentative therapy in autistic children: A randomized, double-blind, placebo-controlled trial. Journal of
Psychopharmacology. 28(7), Read Abstract (New Window)

• In addition to blocking Ach-Esterase, galantamine has a second benefit,

unique to it over all other inhibitors which can have decreased efficacy over
time.
• Galantamine can also mimic the effects of Acetylcholine by acting
directly on and modulating nicotinic receptors. This interaction allows it
to maintain it’s effectiveness long term.
• You can find it available both as an over the counter supplement —derived
from plant sources (snowdrop and daffodil) and as a prescription — a
chemical synthesized to match the molecular structure of the natural
source.
 A Prospective, Open-Label Trial of
Galantamine in Autistic Disorder
Dr. Rob Nicolson, Beth Craven-Thuss, and Judy Smith.
Journal of Child and Adolescent Psychopharmacology.
October 2006, 16(5): 621-629.

• Thirteen children with autism (mean age, 8.8 ± 3.5 years)

participated in a 12-week, open-label trial of galantamine
• Results: Patients showed a significant reduction in parent-rated
irritability and social withdrawal on the ABC
• Significant improvements in emotional lability and inattention
on the Conners’ Parent Rating Scale—Revised
• Clinician ratings showed reductions in the anger subscale
• Eight of 13 participants were rated as responders on the basis of
their improvement scores on the Clinical Global Impressions scale
• Overall, galantamine was well-tolerated, with no significant
adverse effects apart from headaches in one patient
Other Cholinergics/Nootropics

• L-theanine
• Caffeine
• Piracetam
• Bacopa
• Panax ginseng
• Rhodiola
• Gingko biloba
• GetSmart formula
Reduce Oxidative Stress

• Detox metals
• Detox molds, chemicals , pesticides
• Increase glutathione levels-Transdermal,
oral, nebulizer, IV
• Antioxidants-see earlier slide
• Nrf-2 pathway inducers-regulate cell
protective responses
• Balancing pH
Support Mitochondrial Function
• Vitamin B1, B2, B3, B5, and Biotin
• Antioxidants
– Glutathione
– Alpha Lipoic Acid- careful
– Coenzyme Q10
– Vitamin E
– Vitamin K

• L-Carnitine, creatine
• Magnesium
When Looking for More- Non
Responders
• Removal of toxic metals
• Antiviral therapy
• Chronic infections
• Mold exposure
• Vision Therapy-does your child need this?
• HBOT
Hyperbaric Oxygen Reduces
Neuroinflammation
 Hyperbaric treatment for children with autism:
a multicenter randomized, double blind, controlled
trial
BMC Pediatr. 2009 Mar 13;9(1):21.
Rossignol DA, Rossignol LW, Smith S, Schneider C, Logerquist S, Usman A,
Neubrander J, Madren EM, Hintz G, Grushkin B, Mumper EA.

CONCLUSIONS: Children with autism who received hyperbaric

treatment at 1.3 atm and 24% oxygen for 40 hourly
sessions had significant improvements in overall
functioning, receptive language, social interaction, eye
contact, and sensory/cognitive awareness compared to
children who received slightly pressurized room air.
PMID: 19284641
Don’t Give Up!
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