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Bambang Rahadi
Cardiac Function
• Size of a fist
• Beats : 100.000 times/day
• Pumsp 7500L of blood/day
• Requires Oxygenated blood
( provided through coronary
arteries)
Faktor-faktor utama suplai dan demand
oksigen miokard
Suplai Oksigen Miokard Kebutuhan Oksigen
Miokard
Rhee JW, Sabatine MS, Lilly LS: Ischemic heart disease. In Lilly LS. Pathophysiology of heart disease, 5 th ed.
Philadelphia, Lippincott Williams & Wilkins, Wolters Kluwer, 2011, pp 137.
Supply and demand coronary reperfussion
missmatch due to CAD
ANGINA SYMPTOM
Mechanism of Cell death in MI
The Cause of ACS
ENDOTHELIUM
• Triggered by :
– High cholesterol
– High BPSmoking
– Immune Injury
– Obesity
– Diabetes
Evolution of Atherosclerosis Plaque
Different Stage of Atherosclerosis Development
Vulnerable Plaque
Mechanisms of coronary thrombus formation
Consequences of Coronary Thrombosis
Atherosclerosis –Atherothrombosis A Generalized
And Progressive Disease
Atherothrombosis
Unstable
angina ACS
NSTEMI
Atherosclerosis Thrombosis STEMI
CV death
Stable angina
Adapted from Libby P. Circulation. 2001;104:365-372
Plaque Rupture with thrombosis
Jalur Trombosis
Terima Kasih