Potassium sparing diuretics

&
Antidiuretics

Dr.Rathnakar U.P.
MD.DIH.PGDHM

www.scribd.com
 Spironolactone
Amiloride & Triamterene MR + Aldosterone
Synth of aldosterone
induced proteins
Na Na
Na Channel Na K ATPase
w Nucleus
K

K
DT/CT
Potassium sparing
diuretics
Potassium sparing diuretics- ADEs
Potassium sparing diuretics-Uses
Potassium sparing diuretics-Spironolactone
MOA
Potassium sparing diuretics-Spironolactone
ADEs
Potassium sparing diuretics-Spironolactone
CIs
Potassium sparing diuretics-Spironolactone
uses
Potassium sparing diuretics-Spironolactone
Combinations
 CHLOROTHIAZI
MANNITOL DE

METOLAZONE
ACETAZOLAMID
E
Thiazide
Glycerol
SPIRONOLACTON
E
FURESEMIDE
Amiloride
Diuretics-Summary
ADH [Vasopressin]
Post pitutary
Acts on V1 & V2 receptors
Kidney: [V2 receptors]
 Increases permeability-CD & Water absorption
Blood vessels: [V1 receptors] Vasoconstriction
Uterus-Contraction
CNS: Neurotransmittor
 Vasopressin

Vasopressin- Vasopressin- Uses

Not absorbed orally- 1. V2 action-Diabetes
i.v or nasal insipidus[Pitutary]
Lypressin, Terlipressin & 2. V1 action-bleeding esophageal
Desmopressin-Analogues varices

Other drugs for DI

1.Thiazide diuretic!
2.Indomethacin
3.Chlorpropamide
Desmopressin [Analogue of Vasopressin]
Neurogenic Diabetes insipidus
Nephrogenic Diabetes insipidus
Diuretic Site of MOA ADEs Uses
action
CA[I] PT Inhibition of CA Acidosis Glaucoma,
[Acetazolamide] Decreased Mountain
availability of H+ sickness
ions Epilepsy
Osmotic PT Osmotic Dangerous in Raised ICT
[Mannitol] Loop of H Prevent reabsorption CCF Glaucoma
of water

Loop Thick Na+K+2Cl- Hypokalemia, Edema

[Frusemide] AscLH transporter Deafness, Ac.Pulm edema
Hypocalcemia

Thiazide DT Na+Cl- Symporter Hypokalemia Edema

[Hydrochlorothi Hyperurecemia HTN
azide] Hypercalcemia

K Sparing Hyperkalemia With other

Amiloride & DT diuretics to
Triamterene Block Na channels prevent K loss
Spironolactone Bind-MR receptors Gynaecomastia