Escolar Documentos
Profissional Documentos
Cultura Documentos
Oral Mucosa
Frenal Tag
Lingual Tonsil, Foliate Papillitis
Geographic Tongue
Orofacial Granulomatosis
Crohn’s Disease
Sarcoidosis
Pyostomatitis Vegetans
Wegener’s Granulomatosis
Progressive Systemic Sclerosis
Verruciform Xanthoma
Oral Submucous Fibrosis
Amyloidosis
Oral Pigmentation
Age Changes
*Frenal Tag
* Not in textbook
Lingual Tonsil, Foliate Papillitis
• Inflammation or reactive
hyperplasia of this tissue causes
enlargement known as foliate
papillitis.
• Histopathologic features:
- acanthosis at edges.
- dense neutrophil infiltration of
epithelium )microabscesses) &
lamina propria, with underlying
chronic inflammation.
Orofacial Granulomatosis
• A clinical term used to describe common
clinicopathological manifestations of a
variety of disorders.
• Histopathologically: non-caseating
chronic granulomatous inflammation with
or without giant cells, and edema of
tissue.
• Possible causes:
8. Crohn’s disease
9. Sarcoidosis
10.Infective granulomas
11.Foreign bodies
12.Melkersson-Rosenthal syndrome
13.Allergies
14.Idiopathic.
Crohn’s Disease
• A chronic granulomatous disease
involving any part of GIT, most
commonly terminal ileum.
• Oral manifestations:
2. Diffuse swellings of lips & cheeks
)orofacial granulomatosis).
3. Edematous hyperplastic
buccolabial mucosa with fissuring
)cobblestone appearance).
4. Edematous hyperplastic
enlargements of buccolabial
mucosa involving sulci, with
polypoid tag-like lesions or deep
folds.
5. Aphthous or linear fissure-like
ulcers.
6. Atrophic glossitis due to vitamin
B12 malabsorption.
Sarcoidosis
• Young adults.
Histopqathologic Features:
Laboratory Findings:
• Histopathologic Features:
• Regarded as a premalignant
condition often associated with
epithelial atrophy and dysplasia.
Amyloidosis
• AL type: fragments of
immunoglobulin light chains in
primary )idiopathic) amyloidosis
and amyloidosis associated with
multiple myeloma.
- Macroglossia.
• Diagnosis is confirmed by
biopsy )Congo red stain).
• Acquired causes:
- associated with systemic disease:
Addison’s disease, pulmonary disease,
HIV infection.
- associated with hyperkeratosis, chronic
inflammation, and lichen planus.
- smoker’s melanosis.*
• Acquired causes:
- drug-induced.
- idiopathic oral melanotic macule )oral
freckle).
- lentigo simplex.
• Sublingual varices.
• Foliate papillitis.