2010 ageLOC Science

year in review

16 Total Patents
2 Awards Received 4 Published Scientific Articles

AGELOC SCIENCE IS A GLOBAL PHENOMENON

9 Oral Presentations 14 Scientific Posters

Nu Skin, with ageLOC science, stands apart from the competition because our approach is based upon 30 years of breakthrough anti-aging research. Our research continues to gain recognition and is validated through presentations at global scientific conferences.Joe Chang, Ph.D.

Helsinki, Finland Berlin, Germany Santa Barbara, CA USA Brussels, Belgium New York, NY USA Barcelona, Spain Les Diablerets, Switzerland Tokyo, Japan

Anaheim, CA USA

Atlanta, GA USA

Bangkok, Thailand Singapore, China Buenos Aires, Argentina

ageLOC Science 2010 Timeline

Conducted First pre-clinical study on ageLOC Completed First heatmap validating ageLOC nutritional science

Presented Nutritional Research at Oxygen Club of California 2010 World Congress Awarded DSM Nutraceutical Research Award Presented at New York Society of Cosmetic Chemists Meeting

JANUARY
Appointed Dr. Stuart Kim to Nu Skin Anti-Aging Scientific Advisory Board

FEBRUARY
Initiated Full-scale clinical trial on ageLOC Vitality

MARCH

Presented arNOX Research at Oxygen Club of California 2010 World Congress

Presented

Presented 4 Studies at Experimental Biology 10

Submitted Provisional Patent on ageLOC Vitality Presented Research at International Coenzyme Q Association Meeting

Presented at CoLONGY Conference Presented Research at 40th Annual European Society for Dermatological Research

APRIL
Two additional patent submissions, one in 2010 and another in 2011, confirm the credibility of ageLOC science and our commitment to developing and protecting our IP as we pioneer this new area of anti-aging science. We are taking anti-aging products to the next level and are ensuring exclusivity for our distributors.Steve Wood, Ph.D.,
Director of Global Research, Pharmanex

MAY

JUNE
"With research in the anti-aging industry rapidly evolving, we were honored to present at CoLONGY 2010the First International Congress on Controversies in Longevity, Health, and Aging. This conference was devoted to topics on aging, and it was an exciting opportunity for us to present our research supporting ageLOC science.Jamie Barger,
Ph.D., LifeGen Technologies

Published

Article in Cosmetics and Toiletries

Presented Research at Society for Investigative Dermatology Presented Research at Biology of Aging Gordon Research Conference

Published Article in Journal of Cosmetic Science Published Article in Journal of Cosmetic Dermatology Sponsored University of Tokyo Science Symposium

JULY

AUGUST

SEPTEMBER

The SID is committed to fostering publication of innovative, cutting edge science from prominent researchers in skin biology and encouraging scientific collaborations among researchers worldwide. The findings presented at this meeting were new genetic research that was peer reviewed and accepted for publication.Helen Knaggs, Ph.D., Vice President, Nu Skin Global
Research and Development

Presented arNOX Research at International Federation of Societies of Cosmetic Chemists

Presented Youth Gene Cluster Research at International Federation of Societies of Cosmetic Chemists

SEPTEMBER

continued

OCTOBER
Launched First ageLOC Nutrition Product ageLOC Vitality

Presented at University of Tokyo Science Symposium

2 Presentations at First World Congress on Targeting Mitochondria Presented at In-Cosmetics Asia Conference Presented at Asian Cosmetic Chemistry Society
In-Cosmetics is a prestigious global organization and is touted as the leading exhibition for personal care ingredients. Being chosen as a speaker at the anti-aging session is an honor and signifies global recognition for Nu Skin as a leader in anti-aging science in the personal care industry.
Helen Knaggs, Ph.D., Vice President, Nu Skin Global Research and Development

NOVEMBER

DECEMBER
Published Article in Anti-Aging Medical News Presented at Society of Cosmetic Chemists Annual Meeting

Awarded Young Scientist of the Year by Society of Cosmetic Chemists

ageLOC Science Publications and Presentations

FULL LIST
Patent Submission
May 2010 Provisional Patent on Vitality # 01336-36004, ORAL FORMULATIONS FOR COUNTERACTING EFFECTS OF AGING. Submitted May 24, 2010. Barger, J.L., Mastaloudis, A., Prolla, T. A., Weindruch, R., and Wood, S.M.

Awards
Angela Mastaloudis, Senior Scientist, Received the DSM Nutraceutical Research Award
Remona Gopaul, Associate Senior Scientist, Named Young Scientist of the Year by the Society of Cosmetic Chemists

Journal Articles
July 2010 Reducing skin stress response with willow bark-derived salicin, Cosmetics and Toiletries (July, 2010): 32-36. Gopaul, R., Knaggs, H., and Langerveld, A.
September 2010 Impact of Scientific Innovations on the Personal Care Industry, Journal of Cosmetic Science, 9(3) 2010; 260-263. Knaggs, H. An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging, Journal of Cosmetic Dermatology, 9(3) 2010; 196-201. Gopaul, R., Gibson, M., Knaggs, H., Holley, K.C., and Lephard, J.

December 2010 Nutritional and genetic strategies for longevity. Anti-Aging Medical News. Winter 2010:36-40. Bartlett, M.

FULL LIST
Oral Presentations
March 2010 Resveratrol mimics caloric restriction and retards aging in the heart. Oxidents and antioxidants in biology, Oxygen Club of California World Congress, March 17-20, 2010, Santa Barbara, CA. Prolla, T. Aging and Genesthe Link with Skin. New York Society of Cosmetic Chemists Meeting, Helen Knaggs. June 2010 Transcriptional biomarkers of age and their modulation by dietary intervention. CoLONGY, The 1st International Congress on Controversies in Longevity, Health and Aging. Barcelona, Spain, June 24-27, 2010. Barger, J., Wood, S.M., Weindruch, R., and Prolla, T. August 2010 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Conference, Les Diblerets, Switzerland, August 21-27, 2010. Wood, S.M., Barger, J., Prolla, T. A., Weindruch, R., Mastaloudis, A., and Ferguson, S. September 2010 Mitochondria and Aging. Japan Symposium. Mechanisms of Ageing and Development 2010;13:449-450;480-486. Prolla, T. November 2010 A nutritional strategy to oppose the genetic expression of aging and loss of vitality. 1st World Congress on Targeting Mitochondria, Strategies, Innovation and Clinical Applications, Berlin, Germany, November 18-19, 2010. Wood, S. M., Ferguson, S. B., Barger, J. L., Prolla, T. A., Weindruch, R., and Bartlett, M. Targeting age-related gene expression improves mental and physical vitality. 1st World Congress on Targeting Mitochondria, Strategies, Innovation and Clinical Applications, Berlin, Germany, November 18-19, 2010. Ferguson, S. B., Tan, N., Dong, Y., Lu, J., Fisk, N.A., Wood, S.M., Zhu, J., and Bartlett, M. Genes and Aging: Links to Skin, In-Cosmetics Asia; Bangkok, Thailand, Helen Knaggs. Why Do People Look Younger for Their Age, Asian Cosmetic Chemistry Society; Singapore, China, Helen Knaggs.

December 2010 A Review of Current Genomic Techniques Used in Gene Expression Profiling of the Skin, Society of Cosmetic Chemists Annual Meeting; New York, New York, Remona Gopaul.

FULL LIST
Posters
March 2010 Antioxidation and lifespan-extension activities of CordyMax in oxidative stress and aging models #A177. Oxidants and Antioxidants in Biology, Oxygen Club of California World Congress, March 17-20, 2010, Santa Barbara, CA. Zhu, J., Zhang, Y., Yang, J., Tan, N., Zhao, C., and Mastaloudis, A. (presenter; received DSM Research Award)
Age-Related Oxidase (arNOX) Implicated in Aging-Related Oxidative Damage to Skin Proteins,Oxygen Club of California, 2010 World Congress, Santa Barbara, California. Morr, D. M., Morr, D. J., Meadows, C., Draelos, Z., and Kern, D. G. April 2010 CordyMax extends the lifespan in an aging model: a preliminary report, Abstract #A310. Experimental Biology 10, April 24-28, 2010 Anaheim, CA. Tan, N., Zhang, Y., Yang, J., Zhao, C., and Zhu, J. S. Improvement of exercise metabolism and carotenoid antioxidant scores with CordyMax and LifePak in young Chinese elite athletes, Abstract #D356. Experimental Biology 10, April 24-28, 2010 Anaheim, CA. Duan, L., Zhao, L., Liang, C., Lu, L., Gao, L., Li, G., and Zhu, J.S. Maturational alteration of differential expressions of GC:AT-biased genotypes of Cordyceps sinensis fungi and Paecilomyces hepiali in Cordyceps sinensis, Abstract #B210. Experimental Biology 10, April 24-28, 2010 Anaheim, CA. Zhu, J. S., Gao, L., Yao, Y., and Zhou, Y. Antioxidation activities of CordyMax in an oxidative stress model: a mechanism of its anti-aging properties, Abstract #311. Experimental Biology 10, April 24-28, 2010 Anaheim, CA. Yang, J., Tan, N., Zhao, C., Zhang, Y., and Zhu, J. S. May 2010 Appearance in Japanese Women Correlates with AgeRelated NADH Oxidase Levels and Blood Markers of Lipid Oxidation, Society for Investigative Dermatology; J. Invest Dermatol 130. S. 6 (2010). Morr, D. J., Morr, D. M., Kern, D. G., and Wood, S. M. Regulating the Expression of Genes Associated with the Synthesis and Maintenance of Dermal Hyaluronan and Barrier Lipids Via Topical Treatment of SalicinAn In Vitro Analysis, Society for Investigative Dermatology; J. Invest Dermatol 130. S. 84 (2010). Gopaul, R. and Knaggs, H. Salicin Regulates the Expression of Functional Youth Gene Clusters to Reflect a More Youthful Skin Profile, International Federation of Societies of Cosmetic Chemists Annual Meeting, Buenos Aires, Argentina. Gopaul, R., Langerveld, A., Knaggs, H., and Lephart, J. Inhibition by Coenzyme Q10 of Age Related Oxidase (arNOX) Caused Oxidative Damage in Skin Proteins, International Coenzyme Q Association Meeting, Brussels, Belgium. Morr, D. M., Morr, D. J., Meadows, C., Draelos, Z., and Kern, D. G. June 2010 Appearance in Japanese Women Correlates with the Presence of Inosotides and Lysolipids, Both Significant Inhibitors of Age-Related NADH Oxidase Levels, 40th Annual European Society for Dermatological Research, June 2010. Morr, D. J., Morr, D. M., Kern, D. G., Wood, S. M., Toyoda, H., and Knaggs, H. August 2010 Transcriptional Biomakers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Conference, Les Diblerets, Switzerland, August 21-27, 2010. Wood, S.M., Barger, J., Prolla, T. A., Weindruch, R., Mastaloudis, A., and Ferguson, S. September 2010 Anti-Aging Effects of Superoxide Reduction in Skin by the Application of Specific Inhibitors of Age-Related NADH Oxidase (arNOX), International Federation of Societies of Cosmetic Chemists, Buenos Aires, Argentina. Kern, D. G., Meadows, C., Fuller, B. B., Knaggs, H., Morr, D. M., and Morr, D. J. Salicin Reduces the Expression of Genes Associated with Skin InflammationAn In Vitro Analysis, Society for Investigative Dermatology; J. Invest Dermatol 130. S. 85 (2010). Gopaul, R. and Knaggs, H.

summary
Nu Skin scientists and our scientific partners have just concluded a breakthrough year, building our body of knowledge in anti-aging research at an accelerating rate with more than 20 presentations at 11 prestigious conferences and symposia around the world. We believe Nu Skins ongoing research, combined with our research partnerships, including LifeGen Technologies, will deepen the companys understanding of gene expression and its impact on reversing the effects of aging even later in life. With our exclusive focus on identifying, targeting, and resetting Youth Gene Clusters, we believe ageLOC science is the answer to anti-aging. Its a scientific breakthrough that goes beyond the signs to target the ultimate sources of aging. For more information about ageLOC science, please visit ageloc.com.