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Mycoses
Dr. R. Tan
Subcutaneous Mycoses
these are chronic, localized infections of the skin and
subcutaneous tissue following the traumatic
implantation of the etiologic agent
The causative fungi are all soil saprophytes (grow in
soil or in decaying vegetation) of regional
epidemiology whose ability to adapt to the tissue
environment and elicit disease is variable
Should be introduced into subcutaneous tissue in
order to produce disease
Lesions spread slowly from the implantation area
Pathology is frequently the result of the interaction
between host and pathogen, with contributions both
from fungal invasiveness and from host
responses
the pathogens of subcutaneous mycoses have only a
few common characteristics and belong to very
different taxonomic groups
Mode of Transmission :
Direct subcutaneous inoculation via:
Traumatic implantation
rose thorn
stepping on a stick
intravenous catheter
contaminated dressings
Disease Causative Incidenc
Organism e
Sporothricosis Sporothrix schenckii Rare
olony morphology:
Cream-colored to black, moist,
wrinkled, leathery or velvety
colonies with narrow white
border develop within 3 – 5 days
icroscopic morphology:
lymphatics become
thickened, cordlike
fatal
The natural course of the lung lesion is gradual
progression to death
Osteoarticular sporotrichosis
Most patients also have cutaneous lesions and
Treatment:
In most Cases: self – limited infection
Potassium Iodide
4-6 ml three time a day for 2-4 months
orally
has therapeutic benefits in the cutaneous
manifestations
Extracutaneous forms of sporotrichosis may need a
combination of antifungal treatment with
Amphotericin B or itraconazole together with surgical
debridement
Control:
Prevention of trauma in the following occupations:
- gardeners
- miners
-
Chromoblastomycosis
Chromomycosis/Chromoblastomycosis is caused by
traumatic implantation of any of the several
dematiaceous fungus specie into the subcutaneous
tissue
dematiaceous fungus
fungi that produce varying degree of melanin-like
pigments
These pigments are found in the conidia and/or
plant debris
Feet
Mycotic Mycetoma
Granules ( white, yellow, red or black) are extruded in
pus
the granules contain septate, variously shaped hyphae
observed:
1) flask-shaped phialides that bear
rounded conidia
2) simple or branched conidiophores
bearing pyriform conidia (3-5 um) with
truncated bases
Exophiala jeanselmei
colony morphology: surface is brownish
black, or greenish black and skin-like; it
then becomes covered with short velvety,
grayish hyphae
Microscopic morphology:
young culture consist of many yeast-like
budding cells
septate hyphae form with numerous
conidiogenous cells (annellides) that
are slender, tubular, sometimes
branched, and characteristically tapered
to a narrow, elongated tip
Microscopic morphology:
large brown to black, spherical
cleistothecia are formed
mostly submerged in the agar and
Graphium eumorphum
the Graphium type of asexual
tissue - for histological examination
Direct Microscopy:
Serosanguinous fluid containing the granules should be
infections
Control:
RHINOSPORIDIOSIS
A chronic infection characterized by the development
of polypoid masses of the nasal mucosa
Etiologic agent: Rhinosporidium seeberi
Produce large spherules in lesions and in epithelial
Sulfa drugs
The
End
Thank You!