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infections
Coxsackieviruses
Coxsackieviruses are part of the
enterovirus family of viruses (which also includes polioviruses and hepatitis A virus) that live in the human digestive tract. They can spread from person to person, usually on unwashed hands and surfaces contaminated by feces, where they can live for several days.
Coxsackievirus
Coxsackievirus (sometimes written as two
words, Coxsackie's virus) belongs to a group of viruses called enteroviruses. Coxsackievirus infections occur most often during summer and fall Coxsackievirus infections occur most often in young children
Groups
Coxsackievirus are divided into group A and
group B viruses based on early observations of their Pathogenicty in mice. Group A Coxsackievirus were noted to cause a flaccid paralysis, which was caused by generalized myositis, while group B Coxsackievirus were noted to cause a spastic paralysis due to focal muscle injury and degeneration of neuronal tissue. At least 23 serotypes (1-22, 24) of group A and 6 serotypes (1-6) of group B are recognized
Several Serotypes
At least 23 serotypes
(1-22, 24) of group A and 6 serotypes (1-6) of group B are recognized
Diseases Caused by
Coxsackievirus
Herpangina
coxsackie A virus Hand-foot-and-mouth disease Coxsackievirus A16 and enterovirus 71 Pleurodynia coxsackie B virus Myocardial and pericardial infections coxsackie B virus. (B3) Viral meningitis Coxsackievirus or echovirus
Coxsackievirus syndrome
Hand, foot, and mouth
disease, a type of Coxsackievirus syndrome, causes painful red blisters in the throat and on the tongue, gums, hard palate, inside of the cheeks, and the palms of hands and soles of the feet.
Herpangina,
Herpangina, an
infection of the throat which causes redringed blisters and ulcers on the tonsils and soft palate, the fleshy back portion of the roof of the mouth.
Coxsackie B3 - Myocarditis
Coxsackie B3 has been
found to be one of the main causes of certain debilitating or lifethreatening diseases, such as viral myocarditis. In about 20% of the cases, there can be progressive disease or recurrence of symptoms; the heart damage can be extensive, causing arrhythmias, weakened left ventricular functions
Difficult to Diagnose ?
Many infections are caused by Coxsackie
viruses, most of which are never diagnosed precisely. Coxsackie type A usually is associated with surface rashes (exanthemas) while type B typically causes internal symptoms (pleurodynia, myocarditis) but both can also cause paralytic disease or mild respiratory tract infection. The latter can be caused by several Coxsackie virus types and by Echoviruses and the symptoms are much like a rhinovirus infection
Is Coxsackie Contagious?
VERY contagious Passed on by:
Unwashed hands Surfaced contaminated by feces Sneezes or coughs
Newer treatments ?
Specific antiviral therapy
such as Pleconaril shows promise in the treatment of meningitis and other life threatening infections due to enteroviruses. However, the safety or efficacy of this drug to be considered with more tails
Prevention
Coxsackie virus is
transmitted by contamination with feces, which means you can catch the virus by touching your mouth or eating without thoroughly washing your hands. Good hand wash reduces the spread of infection in society
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