Escolar Documentos
Profissional Documentos
Cultura Documentos
• Active transport
•Specific or non-specific
Major superfamilies in
prokaryotes
•MF (major facilitator, >1000)
http://opm.phar.umich.edu/?images=all
Antibiotic resistance: what is it?
• One of the world's most pressing public health
problems.
http://www.public.asu.edu/~shaydel/personnel.html
Importance of efflux pumps in
bacterial resistance
FINDINGS
• not evolved in response to
antibiotics
• Fluoroquinolone-resistant strains
Importance of efflux pumps in
bacterial resistance
•MICs of antibiotics seen
increased
•Unregulated overexpression is
disadvantageous
Discussion and conclusion
•Increasing evidence about role
of efflux pumps in antibiotic
resistance