Escolar Documentos
Profissional Documentos
Cultura Documentos
- Adrenergic receptor antagonists Non-selective - blockers Phenoxybenzamine, phentolamine Selective 1- blockers Doxazosin, prazosin, terazosin Tamsulosin-Selective 1A-blocker -Adrenergic receptor antagonists Non-selective -blockers Nadalol, pindolol, propranolol, timolol Selective 1-blockers Acebutolol, atenolol, esmolol, metoprolol - and -Adrenergic receptor antagonists Carvedilol, labetalol
Sympatholytics
Drugs that reduce sympathetic activity Adrenergic receptor antagonists Ganglion blocking agents Sympathetic neuronal blocking agents Therapeutic effects of adrenergic receptor antagonists are primarily due blockade of 1 and 1receptors Adverse effects due to blockade of 2 and 2 receptors
Selective 1- blockers
Doxazosin, prazosin, terazosin, silodosin, tamsulosin, alfuzosin, trimazosin Orally administered Relax smooth muscles in bladder neck and prostate obstruction to urine flow Relax vascular muscles, vasodilation and BP Rx of BPH, hypertension A/E Hypotension, dizziness, oedema
Doxazosin - Hypertension and benign prostatic hyperplasia (BPH) Silodosin - Benign prostatic hyperplasia Prazosin - Hypertension Alfuzosin - Benign prostatic hyperplasia Terazosin - Hypertension and BPH Tamsulosin - Selective 1A-blockerBenign prostatic hyperplasia
Tamsulosin
relatively selective for 1a-adrenergic receptors, which are (mainly present in the prostate). Hence, it may have a more selective action in BPH with minimal effects on blood pressure
Silodosin
high affinity and selectivity for 1A adrenergic receptors which ensures that it works quickly and effectively to relieve the symptoms of BPH. low affinity for 1B receptors (in the blood vessels) hence low incidence of orthostatic and vasodilatory side effects.