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Stroke
Stroke is a syndrome characterized by the
acute onset of a neurologic deficit that persists for at least 24 hours, reflects focal involvement of the CNS, and is the result of a disturbance of the cerebral circulation.
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Stroke
Ischemia
Lack of O2 energy failure depolarization
glutamate release influx Na+/Ca2+ cellular swelling + mitochondrial injury + enzyme activation Necrotic and programmed cell death.
Hemorrhage
Intracerebral, Subarachnoidal, Subdural /
epidural.
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Risk Factors
Modified Unmodified
Dyslipidemia Age Smoking Habits Genetic factors. Caffeine Hyperuricemia Hyperglicemia hypertension
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Hemorrhage
Hypertensive
Non hypertensive
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Autoregulation
Rise of perfusion pressure
Pressuredependent activation of smooth muscles
vasoconstrict ion
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Autoregulation
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Chronic Hypertension
Chronic hypertens ion
Structural changes of walls of the arteries
SH
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Rupture of microaneurysm
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Predilection Sites
Long, narrow penetrating arteries
Caudate and putaminal branches of the MCA Branches of the basilar artery pons Thalamic branches of PCA Branches of the superior cerebellar arteries
nuclei dentata
Cerebellum substantia alba
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Clinical Findings
Sudden onset Clinical worsening due to edema Rupture to ventricles Improvemen t once deficit stabilizes
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Lobar Hemorrhage
Symptoms and signs varies according to the
location :
Pontine hemorrhage
Coma within minutes! Rupture to the fourth ventricle Pinpoint pupils Death in 48 hours
hyperthermia
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Treatments
Cerebellar decompression Cerebral decompression Antihypertensiv e agents? Discontinuing of anticoagulant and antithrombotic CI to surgery medications
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Treatments
Thorough history. (onset, duration, loss of
consciousness, visual disturbances, risk factors, related symptoms, headache, seizure, nausea, vomiting, etc)
Gas Analysis
Treatments
Oxygenization Iv fluid balance Decrease of consciousness breathing
normovolemic state
Treatments
Other therapies related to sign and symptoms
Treatments of the risk factors (anti hypertensive
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Differential Diagnoses
Space Occupying Lesion (SOL) Hypoglycemia Hyperosmotic Hyperosmolar State Diabetic Ketoacidosis
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Case Report
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Identity
Mr. ED 59 years old Male Rawa Lumbu, Bekasi, West Java. Date of Admission : March 14th 2012
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History
Admitted to the ER decrease of
consciousness approximately 3 hours before admission sudden onset was not on any kind of activities followed by weakness on the right side of the body and inability to speak properly. Routine consumption of daily medicines : none. (-), loss of consciousness (-), visual disturbances (-).
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The patient never felt these kind of symptoms No known history of hypertension, and
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Clinical findings
GCS : E3V4M6 BP HR RR T
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Neurological Findings
Cranial N. VII : Flattened right SNL Cranial N. XII : right deviation of the tongue 0000 5555 Motoric : 0000 5555 Sensoric
: symmetric : (+)
Physiologic reflexes
Treatments
Oxygenization Isotonic fluid Watch on ICP rise Anti hypertensive agents with observations :
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Thank You
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