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Tissues - collections of similar cells and the substances surrounding them Tissue classification based on structure of cells, composition of noncellular extracellular matrix, and cell function Major types of adult tissues Epithelial Connective Muscle Nervous Histology: Microscopic Study of Tissues Biopsy: removal of tissues for diagnostic purposes Autopsy: examination of organs of a dead body to determine cause of death
Embryonic Tissue
3 major germ layers that form the embryonic disc (source of stem cells) Endoderm Inner layer Forms lining of digestive tract and derivatives Mesoderm Middle layer Forms tissues as such muscle, bone, blood vessels Ectoderm Outer layer Forms skin and neuroectoderm
I. Epithelial Tissue
Cellularity - Consists almost entirely of cells Covers body surfaces, lines hollow organs, and forms glands
Outside surface of the body Lining of digestive, respiratory and urogenital systems Heart and blood vessels Linings of many body cavities
Polarity - Has apical, basal, and lateral surfaces Rests on a basement membrane Specialized cell contacts bind adjacent cells together Avascular - no blood vessels Regenerative -Replaces lost cells by cell division
Functions of Epithelia
Protecting underlying structures; e.g., epithelium lining the mouth Acting as barriers; e.g., skin Permitting the passage of substances; e.g., cells lining air sacs in lungs and nephrons in kidney Secreting substances; e.g., pancreatic cells Absorbing substances; e.g., lining of stomach and small intestine
Figure 4.1
Classification of Epithelium
Number of layers of cells
Simple- one layer of cells. Each extends from basement membrane to the free surface Stratified- more than one layer. Pseudostratified- tissue appears to be stratified, but all cells contact basement membrane so it is in fact simple
Shape of cells
Squamous- flat, scale-like Cuboidal- about equal in height and width Columnar- taller than wide
Classifications of Epithelia
Figure 4.3a
Figure 4.3b
Figure 4.3c
Figure 4.3d
Stratified Epithelia
Contain two or more layers of cells Regenerate from below Major role is protection Are named according to the shape of cells at apical layer
Figure 4.3e
Transitional Epithelium
Figure 4.3h
Epithelium: Glandular
A gland is one or more cells that makes and secretes an aqueous fluid Two types of glands formed by infolding of epithelium:
Endocrine: no contact with exterior of body; ductless; produce hormones (pituitary, thyroid, adrenals, pancreas) Exocrine: open to exterior of body via ducts (sweat, oil)
Exocrine glands classified either by structure or by the method of secretion Classified by structure
Unicellular: goblet cells Multicellular: sweat, oil, pituitary, adrenal
Connexon proteins are transmembrane proteins. Present in electrically excitable tissues (heart, smooth muscle)
Basal lamina and reticular layers of the underlying connective tissue deep to it form the basement membrane
Connective Tissue
Most diverse and abundant tissue Main classes
Connective tissue proper Cartilage Bone tissue Blood
Characteristics
Mesenchyme as their common tissue of origin (mesenchyme derived from mesoderm) Varying degrees of vascularity Nonliving extracellular matrix, consisting of ground substance and fibers Cells are not as abundant nor as tightly packed together as in epithelium
Figure 4.5
Protein fibers
Collagen fibers. Composed of the protein collagen. Strong, flexible, inelastic; great tensile strength (i.e. resist stretch). Perfect for tendons, ligaments Elastic fibers. Contain molecules of protein elastin that resemble coiled springs. Returns to its original shape after stretching or compression. Perfect for lungs, large blood vessels Reticular fibers. Formed from fine collagenous fibers; form branching networks (stroma). Fill spaces between tissues and organs.
Ground Substance
Interstitial (tissue) fluid within which are one or more of the molecules listed below: Hyaluronic acid: a polysaccharide. Very slippery; serves as a good lubricant for joints. Common in most connective tissues. Proteoglycans: protein and polysaccharide complex. Polysaccharides called glyocosaminoglycans (chondroitin sulfate, keratin sulfate). Protein part attaches to hyaluronic acid. Able to trap large amounts of water. Adhesive molecules: hold proteoglycan aggregates together. Chondronectin in cartilage, osteonectin in bone, fibronectin in fibrous connective tissue. Functions as a molecular sieve through which nutrients diffuse between blood capillaries and cells
Figure 4.12b
Adipose Tissue
Figure 4.12c
Figure 4.12d
Figure 4.12e
Figure 4.12f
Bundles and sheets of collagenous and elastic fibers oriented in multiple directions In walls of elastic arteries (aorta), lungs, vocal ligaments Strong, yet elastic; allows for recoil of tissue after being stretched
Hyaline Cartilage
Figure 4.12g
Elastic Cartilage
Figure 4.12h
Fibrocartilage
Figure 4.12i
Bone Tissue
Figure 4.12j
Blood Tissue
Figure 4.12k
Muscle Tissue
Characteristics Cells are referred to as fibers Contracts or shortens with force when stimulated Moves entire body and pumps blood Types Skeletal:attached to bones Cardiac: muscle of the heart. Smooth: muscle associated with tubular structures and with the skin. Nonstriated and involuntary.
Figure 4.14a
Figure 4.14b
Figure 4.14c
Nervous Tissue
Figure 4.15
Elastic fibers fragment, bind to calcium ions, and become less elastic
Arterial walls and elastic ligaments become less elastic
Rate of blood cell synthesis declines in the elderly Injuries dont heal as readily