http://informahealthcare.com/doi/abs/10.

1081/CEH-120003202

Daily Exercise Reduces Measures of Heart Rate and Blood Pressure Variability in
Hypertensive Rats

Read More: http://informahealthcare.com/doi/abs/10.1081/CEH-120003202

2002, Vol. 24, No. 3 , Pages 221-234

S. E. DiCarlo1, H. L. Collins1, D. W. Rodenbaugh1, M. R. Smitha2, R. D. Berger2 and V. K. Yeragani3

1
Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48201, U.S.A.
2
Department of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, U.S.A.
3
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine,
Detroit, MI, 48201, U.S.A.

This study was designed to test the hypothesis that daily spontaneous running (DSR) reduces measures of
heart rate and blood pressure variability in spontaneously hypertensive rats (SHR). After 8 weeks of DSR or
sedentary control, rats were chronically instrumented with arterial catheters. Daily exercise reduced most
measures of heart rate (HR) and blood pressure variability. Specifically DSR decreased heart rate, Low
Frequency Power (LF: 0.19–0.61 Hz), and Low Frequency/High Frequency (HF: 1.2–2.5 Hz) ratio of HR.
Furthermore, Total Power (TP), LF power, and LF/HF ratio of systolic blood pressure were reduced by daily
spontaneous running. Finally, TP, LF and HF powers and LF/HF ratios of diastolic blood pressure were
reduced by daily spontaneous running. These data demonstrate that daily exercise reduces sympathetic
activity and possibly increases cardiac reserve in hypertensive animals.

Keywords

Exercise training, Power spectral analysis, Hypertension

“Este estudo foi desenhado para testar a hipótese de que a execução espontânea diário (DSR) reduz
medidas da freqüência cardíaca e variabilidade da pressão arterial em ratos espontaneamente hipertensos
(SHR). Após 8 semanas de DSR ou sedentário controle, os ratos foram instrumentados com cateter arterial.
O exercício diário reduziu a maioria das medidas da freqüência cardíaca (FC) e variabilidade da pressão
arterial. Especificamente DSR diminuição do ritmo cardíaco, baixa freqüência (LF: 0.19-0.61Hz), e baixa
freqüência / alta freqüência (HF: 1.2-2.5Hz) proporção de RH. Além disso, a Total Power (TP), o poder LF e
LF / HF de pressão arterial sistólica foram reduzidos através da execução espontânea diária. Finalmente,
TP, LF e HF poderes e as razões BF / AF da pressão arterial diastólica foram reduzidos pela execução
espontânea diária. Estes dados demonstram que o exercício diário reduz a atividade simpática e,
possivelmente, aumenta a função cardíaca em animais hipertensos.”