Brazilan Journal of Pharmaceutical Sciences vol. 42 supe 02, 2013 58 cPF099 INFLUENCE OF DIRTARY SOY INTAKE ON THYROID FUNCTION FERNANDA SILVA GRACIANI Une, BAURU, SP, BRASIL. Introduction and objective: Tho thyroid gland produces, mong other, the hormones 35, “tricadothyronine (T3) andthyroxine (14), which are essetsal for normal growth and development and play an important role in energy metabolism. Among the changes inthis uland, hypothyroidism is the most common and is associated witha deficiency of T3 and TS. The treatment is Performed by the daily intake ofthese hormones disabled. Soy hes heen lately widely promoted ssa food hat helps Aight cancer, hypertension, menopause, osteaporosis and others. However, studies have shown that consumption can interfere with thyroid activity. Therefor, the aim ofthis work is to gather the lares information about the infcnee and relationship of power derived from soybeans and functioning of the thyroid sland. Materials and methods: This study was based on survey data from articles searched PubMed and Seience Direct. Ht was stipulated a restriction with respect to years of publication of the articles surveyed less than 10) years. Results and conclusion: Sties in animals and humans have showen the infence of consumption of soy products anda decrease in serum T3 and T4. An important study demonstrated the presence of goiter and high levels of thyroid-stimulating hormone (TSH) in healthy paiens who consumed 30 widay for a month of soybean dervatives, andthe withdrawal of feeding reversed ‘his sate. Many studies show that soy isoflavones, especially genistein is responsible for inactivating the thyreoid peroxidase (TPO), promoting a decrease inthe levels of thyroid harmones. This eview brings the canchision, that it should stil have many efforts for deepening levels and mechanisms of action responsibo fr this effect. However, despite the benefits of soy isoflavones, ‘wo already have data that clearly show the relationship between soy products and tne possible development of hypothyroidism clinical andsub-clinieal. Again, we emphasize the great value of the knowledge onthe subjeet of health professionals, particularly doctors and promoters of Pharmaceutical Care cero INFLUENCE OF SYRINGE FILTERS ON ROBUSTNESS OF HPLC METHODS FRANCINY APARECIDA ALVES", ANDREIA RIBEIRO DE MENDONCA; PEDRO GONCALVES OLIVEIRA School of Pharmacy, Anhersbi Morumbi University, SAO PAULO, SP, BRASIL. Introduction and objective: The validation of analytical methods isthe process that establishes, tha the performance of the method meets the requirements forthe inlended analytical applications. Typical performance parameters used of method validation tudes include specificity, precision, accuracy linearity, range and robustness. Althongh robustness of analytical procedures is generally noticed least of al, itis one of most important validation parameters. In connection with HPCL technique, some of recommended ‘variables tobe evaluated are column type; tempersture; pH; fow rate; buffer concentration; additive concentration; mobile phase composition; gradient slope; initial and final phase composition; injection volume and sample preparation. This work aimed to study the influence of syringe filters on robustness of HPLC methods in order to propose its consideration during waldation studies. Materials and methods: A standard solution of diacerein 0.1 mgiiL was used, filtered before vial; column Hypersil ODS 5 lum, 446 x 250) mm; mabile phase eompounded by methanol/water acetic acid (65/35/1); wave langth 254 nm, fax 2 mLimin.; ‘temperature 40°C. four replicates of 20 pL were injected for each different filter material (nyion; PVDP; cellulose). Resuls and conclusion: Nylon filters presented worst performance and suggested incompati lity between it and diacerei. In this ‘case, the replicates from same vial resulted in peak areas ranged from 160024 to 2995434 (211 0898 « 646935.6/C Celfalose and PDP membrane were cansidered the best option. This presented peak arcas ranged from 5099252 to 5052500 (6075876333058, 66(CV=0,65%). Iris important to include the syringe filters asa variable tobe considered during the assessment of robustness of HPLC method, [ts relevant to consider tae material of the membrane and is respective sour.Brazilian Journal of Pharmaceutical Sciences vol. 48, suppl. 02, 2013 as cPris3 PREVALENCE OF ENTEROPARASITOSIS IN UNDERPRIVILEGED COMMUNITY IN BELENZINHO REGION, SAO PAULO, SP VITOR EDUARDO ANTUNES BINATTI’; AURINDA MARIA DOS REIZ; ANDREIA BARTACHINI GOMES. Schoo! of Pharmacy, Anhembi Moruinbi University, SAO PAULO, SP, BRASIL. Introduction and objective: Although intestinal parasites are among the most frequently encountered human pathogens, and the parasitological diseases are considered a secious public health problem in Brazil litte attention has been given to this theme. The aim of this stady was to determine the prevalence of intestinal parasites cn children in a poor community in the region of ‘Belenzinho, Sao Paulo SP, Brazil in the period from May to June 2010. Materials and methods: Medical records of 77 children between 12 months and 16 years old containing results of parasitological ‘exams performed by Ritchio method were analyzed. Results and conclusion: The results of purastological diagnosis tests showed that 31.25% of children previously evaluated showed infection by Giardia lambiia, 8.19% by Endolimax nana; 15.63% by Trichurstrichiura, 9.28% by Ascaris lumbricoides, 3.13%oby Entamoebahistobytica, 6.25% by association of Endolimax: nana and Giardia lamblia, Additionally, 3. (3% was found of positivity for multiple infections caused by Ascaris lumbricoides and lodamoebsa sp and by scarfs lumbricoides and Endollmax hana. Among the found parasites the higher frequency was of protoroa, Thus, the rests reinforce the important role of health professionals as health educators in order to work out way’ of prevention through educational activities such as lectures, informative or audience with simple and straightforward language, which ensures the presence of the pharmacist inthe community through pharmaceutieal assistince programs given by family assistance programs offered by the Government. cPrIsd PREVALENCE OF INTOXICATIONS IN PATIENTS ATTENDED AT EMERGENCY IN LENCOIS PAULISTAAMONG. 2007-2041 FERNANDA SILVA GRACIANT. Uni, BAURU, SP, BRASIL, Introduction and objective: Intoxication is the demonstration, by signs and symptoms ofthe harmful effects produced in a living ‘organism as a result oftheir interaction with exogenous chermical. This is currently a scrious problem of publi health throughout ‘the world, which seems to be related to the availability of products for consumption and are generally easier to access. Among the substances related to poisoning are cleaning products, ayricultural products, plants, industrial chemicals and food products, which may vary by region studied, The objective of this study was to present data on the prevalence of exogenous intoxications ‘to emergency core in the city of Lensois Paulista ‘Materials and methods: Analysis was performed on records of patients seen inthe emergency deparment ofthe city of Lencois Paulisig-SP-Brazil, inthe period 2007-2011, with parameter of age, sex of patients, the place where exposure to toxie agents, fagents and the route of toxic poisoning ‘Results and conclusion: Women had a higher incidence of poisoning eases 69% of eases (116 patients), where the main causative agents were medications, suel as antidepressants, ani-inflammutory, anti-hypertensive drugs and hypnotics. Among the 169 eases recorded in this period, 85% occurred within their homes. Children totaled 77% of cases. All samples came from areas of low socioeconomic status, which may give indication ofa relationship between the prevalence of intoxication and level of education. Data presented in this study show the importance of providing even nowadays, ineans of information to dhe population about the potential of poisoning, especially prescription drugs and their proper preparation, tus preserving livesBrazilian Joumal of Pharmaceutical Sciences CRF-SP_ BOARD Pedro Eduardo Menegasso int Dra Raquel Rizzi General Secretary: Dra. Priscila Nogueira Camacho Dejuste Financial Director: Dr. Marces Machado Ferreira EXECUTIVE COMMITTEE, Dr. Fabio Rit ro da Siva (Coordinator) Dt. Antonio Gerald Ribeiro cos Santos J. Dr. Geraldo Aléio de Olvera Dr. Jas Vaniton de Almeida Dr. Marcos Machado Ferreira SCIENTIFIC COMMITEE i. Mario Hirata (Presider of honor) Dra. Patricia de Carvalho Mastroianni (Coordinator Dra. Akimi Mor! Honda Dr Alberto Keel Kurebayashi Dr Antonio Gales Pizzolito Dr Antonio Tavora de Albuquerque Siva Dr Anselmo Gomes de Olveira Dra, Cistiane Fina Guard Dra. Elviede Marianne Bacchi Dra. Hellen Dea Barros Maluly Dra, Margarete Atom Kishi Dra, Masa Fernanda Carvalho Dra, Nice Cardoso Barbosa Dra, Priscila Noguera Camacho Dejuste Dr. Tarcisio José Palhano Dr. Humberto Gomes Ferraz Dr Leonardo Régis Leva Persia Dra, Luciane Maria Ribeiro Noto Dra. Marna lai Dr. Marlus Cheri Dra, Nona Sivara Romano Lieber Dr Roberto Paris Fho Dra, Resério D, Crespo Hirata Dra Tais Bauab ra. Terezinha de Jesus Andreoli Pinto