Aula Prtica 1 - Captulo 2

1. Obtenha no R os resultados apresentados na Tabela 2.2 e na Figura 2.3

utilizando os comandos a seguir.
require(survival)
tempos<- c(1,2,3,3,3,5,5,16,16,16,16,16,16,16,16,1,1,1,1,4,5,7,8,10,10,12,16,16
,16)
cens<-c(0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,1,1,0,0,0,0,0)
grupos<-c(rep(1,15),rep(2,14))
ekm<- survfit(Surv(tempos,cens)~grupos)
summary(ekm)
plot(ekm, lty=c(2,1), xlab="Tempo (semanas)",ylab="S(t) estimada")
legend(1,0.3,lty=c(2,1),c("Controle","Esteride"),lwd=1, bty="n")
## note o que ocorre se for introduzido o comando mark.time = F
plot(ekm, lty=c(2,1), mark.time= F, xlab="Tempo (semanas)",ylab="S(t) estimada"
)
legend(1,0.3,lty=c(2,1),c("Controle","Esteride"),lwd=1, bty="n")
2. Descubra mais informaes sobre os I.C de S(t) usando o help do R, isto :
> help(survfit)
Obs: leia o que diz em conf.type e rode os comandos a seguir notando as diferenas
nos resultados obtidos
ekm<- survfit(Surv(tempos,cens)~grupos, conf.type="plain")
summary(ekm)
ekm<- survfit(Surv(tempos,cens)~grupos, conf.type="log-log")
summary(ekm)
3. Obtenha os resultados da Tabela 2.3 utilizando os comandos
tempos<- c(1,2,3,3,3,5,5,16,16,16,16,16,16,16,16,1,1,1,1,4,5,7,8,10,10,12,16,16
,16)
cens<-c(0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,1,1,0,0,0,0,0)
grupos<-c(rep(1,15),rep(2,14))
ss<-survfit(coxph(Surv(tempos[grupos==2],cens[grupos==2])~1,method = "breslow")
)
summary(ss)
racum<- -log(ss$surv)
racum
4. Obtenha os resultados apresentados na Tabela 2.5 e Figura 2.5
require(survival)
tempos<- c(3,4,5.7,6.5,6.5,8.4,10,10,12,15)
cens<- c(1,0,0,1,1,0,1,0,1,1)
ekm<- survfit(Surv(tempos,cens))
summary(ekm)
plot(ekm,conf.int=T, xlab="Tempo (em meses)", ylab="S(t) estimada", bty="n")
Obs: faa uso tambm das opes: conf.type="plain" e "log-log"
ekm<- survfit(Surv(tempos,cens), conf.type="plain")
summary(ekm)

plot(ekm,conf.int=T, xlab="Tempo (em meses)", ylab="S(t) estimada", bty="n")

ekm<- survfit(Surv(tempos,cens), conf.type="log-log")
summary(ekm)
plot(ekm,conf.int=T, xlab="Tempo (em meses)", ylab="S(t) estimada", bty="n")
5. Obtenha o tempo mdio usando os comandos abaixo
t<- tempos[cens==1]
tj<-c(0,as.numeric(levels(as.factor(t))))
surv<-c(1,as.numeric(levels(as.factor(ekm$surv))))
surv<-sort(surv, decreasing=T)
k<-length(tj)-1
prod<-matrix(0,k,1)
for(j in 1:k){
prod[j]<-(tj[j+1]-tj[j])*surv[j]
}
tm<-sum(prod)
tm
6. Compare por meio do teste log-rank as curvas apresentadas na Figura 2.3
require(survival)
tempos<- c(1,2,3,3,3,5,5,16,16,16,16,16,16,16,16,1,1,1,1,4,5,7,8,10,10,12,16,16
,16)
cens<-c(0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,1,1,1,0,0,0,0,0)
grupos<-c(rep(1,15),rep(2,14))
ekm<- survfit(Surv(tempos,cens)~grupos)
summary(ekm)
plot(ekm, lty=c(2,1), xlab="Tempo (semanas)",ylab="S(t) estimada")
legend(1,0.3,lty=c(2,1),c("Controle","Esteride"),lwd=1, bty="n")
survdiff(Surv(tempos,cens)~grupos,rho=0)
7. Construa e rode os comandos para os exerccios 2, 3 e 4 do Captulo 2.