Escolar Documentos
Profissional Documentos
Cultura Documentos
cidos
Nucleicos
Mendeliana
DNA (identidade)
Dogma Central (DNA - RNA - Protena)
Regulao da expresso gnica
DNA recombinante
Totalidade da informao gentica
Previso do desenvolvimento
Watson, JD (1993). Gene 135: 309-315
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
Redescoberto em 1900
Felipe R. da Silva
descoberta da nuclena
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
princpio transformante
Griffith, F. (1928) Significance of pneumococcal
types. J. Hygiene 27:113-159.
Lisa
(S)
Avery, O.T., MacLeod, C.M. & McCarty, M.
(1944). Studies on the chemical nature of the
substance inducing transformation of
Pneumococcal types. J. Exp. Med. 79, 137-159
Biologia Computacional MO640A
Felipe R. da Silva
Nucleotdeo
Os Acares
Felipe R. da Silva
Pentose
Ribose e Desoxirribose
Monmero
Felipe R. da Silva
Felipe R. da Silva
Bases Nitrogenadas
Bases Nitrogenadas
Pirimidinas
Purinas
Felipe R. da Silva
Nucleosdeos
Base Nitrogenada
Felipe R. da Silva
Nucleotdeos
Adenina
Felipe R. da Silva
Felipe R. da Silva
Nucleotdeos e
Desoxirribonucleotdeos
Ribose
Desoxirribose
Biologia Computacional MO640A
Felipe R. da Silva
Contedo de bases
Felipe R. da Silva
Concluses de Chargaff
em diferentes espcies
Adenina
Timina
Guanina
Citosina
Timo de bezerro
1,7
1,6
1,2
1,0
Figado de vaca
1,6
1,5
1,3
1,0
Levedura
1,8
1,9
1,0
1,0
Bacilo da tuberculose
1,1
1,0
2,6
2,4
Felipe R. da Silva
Felipe R. da Silva
1920 - 1958
degraus
1916 - 2004
Felipe R. da Silva
A famosa imagem 51
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
Sulco
Menor
Sulco
Maior
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
Felipe R. da Silva
dogma central
DNA
protena
RNA
animao
Felipe R. da Silva
Felipe R. da Silva
Replicao DNA
descoberta do mRNA
Felipe R. da Silva
Felipe R. da Silva
Dogma central
Dogma central
DNA
DNA
RNA
RNA
prote
protena
prote
protena
Felipe R. da Silva
Dogma central
Felipe R. da Silva
Felipe R. da Silva
Dogma central
Felipe R. da Silva
10
Cdigo Gentico
Felipe R. da Silva
Nobel 1978
pela descoberta das enzimas de
restrio e sua aplicao nos
problemas de gentica molecular
Nobel 1980
pelos estudos da bioqumica de
cidos nucleicos, especialmente de
DNA recombinante
Felipe R. da Silva
Felipe R. da Silva
11
PCR
Nobel de Qumica 1993
pela inveno da PCR
Mullis, K.B (1983). The unusual origin of the polymerase chain reaction. Sci Am, 4: 56-65.
Nobel 1980
pelas contribuies na determinao de seqncias
Biologia Computacional
Felipe R. da Silva de cidos nucleicos
Saiki R, K.; Scharf S; Faloona F; Mullis K. B; Horn G. T; Erlich H. A.; Arnheim N. (1985).
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis
for diagnosis of sickle cell anemia. Science, 230(4732):1350-4.
Biologia Computacional MO640A
MO640A
Felipe R. da Silva
Estrutura de um gene
tgaggaacggtgcctggaaaagggcaagaatatccggcatgggcatgagtagcttgaaactgctgaagtatgtcctgtgttt
cttcaacttgccttttggatctgtgtctgctgcattttgggctttgggatctacctgctgatccacaacacttcggagtgct
cttccataacctcccctccctcacgctgggcaatgtgtttgtcatcggggctctattatcatggtagttgccttcctgggct
gcatgggctctagcaaggaaaacagtgtctgcttatgtcgttcttcatcctgctgctgattatcctccttgctgaggtgacc
tggccatcctgctctttgtatatgaacagaagctgaatgagtatgtggctaagggtctgacgacagcatccaccgttaccac
tcagacgttagcaccaaggcagcgtgggactccatccgtcatttctgcagtgttgtggtataaatggcacgagtgattggac
cagtggcccaccagatcttgcccctcagatcgaaaagtggagggttgctatgcgaaagcaagactgtggtttcttccaattt
cctgagtatcggaatcatcaccatctgtgtatgtgtgattgaggtgttgggatgtcctttgcactgaccctgaactgccaga
ttgacaaaaccagccagaccatagggcatgatctgcagtagttctgtggtgaagagacttgtttcatctccggaagtgcaaa
accattatagcatgaagccctacatgatcactgcaggatgatcctcctcccatcctttcccttttaggtccctgtcttatac
aaccagagaagtgggtgttggccaggcacatcccatctcagcagcaagacaatctttcactcactgacggcagcagccatgt
ctctcaaagtggtgaagtaatatctgagcatcttttagacaagagaggcaaagacaaactggatttaatggcccaaatcaaa
gggtgaacccaggatatgaatttttgcatcttcccattgtcgaattagtctccgcctctaaataatgcccagtcttctcccc
aaagtcaagcaagagactagttgaagggagtctggggccaggctcactggaccattgtcacaaccctctgtttctctttgac
taagtgcctggctacaggaattacacagttctctttctccaaagggcaagatctcatttcaatttcttattagagggcctta
ttgatgtgttctaagtctttccagaaaaaaactatccagtgattatatcctgatttcaaccagtcacttagctgataatcac
agtaagaagacttctggtatatctctctatcagataagattttgttaatgtactattttactcttcaataaataaaacattt
attatctcaaaatagccccggatatctgtgttaccagccttgtctcggccacctcaaggaaatcactaaatttagccgaaag
gactgaggaacggtgcctggaaaagggcaagaatatccggcatgggcatgagtagcttgaaactgctgaagtatgtcctgtt
tttcttcaacttgccttttggaaataaagctgctgcattttgggctttgggatctacct
Introns
Exons
Science, 252:1651-1656.
Felipe R. da Silva
Felipe R. da Silva
12
Splicing
III
II
ntrons
Transcrio
I
RNA primrio
(Temporrio)
III
II
Splicing
mRNA
(Maduro)
Felipe R. da Silva
Alguns conceitos
DNA
3-UTR
OH
O-Me
O-Me
Protena
I
II
Exons
Felipe R. da Silva
III
Traduo
Modificao
Ps-Traducional
Biologia Computacional MO640A
Unicamp, 1 Sem. 2010
Estrutura de um promotor
Fita Codificante
a que tem a mesma seqncia que o mRNA
Intron x Exon
UTR
poliA
Felipe R. da Silva
Felipe R. da Silva
13