UNIVERSIDADE FEDERAL DE UBERLNDIA

INSTITUTO DE CINCIAS BIOMDICAS

REA DE CINCIAS FISIOLGICAS

CURSO DE BIOMEDICINA
ESTUDO DIRIGIDO DE FARMACOLOGIA
Distribuio, Metabolismo e Eliminao de Frmacos
Prof. Dr. Hudson Armando Nunes Canabrava

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Nome por Extenso bem Legvel

Uberlndia, ______ de _______________ de 20____

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Assinatura do(a) Aluno(a)

NOTA: _____(_________________________)

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Visto do(a) Professor(a)

Vista dada em: _____/_____/20______

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Assinatura do(a) Aluno(a) na vista da Prova

Pedido de Reviso em: _____/_____/20______

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Observaes do(a) Professor(a):

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Visto do(a) Professor(a)

1 - Defina o Metabolismo de Primeira Passagem e explique como esse fenmeno pode interfere na farmacocintica
das drogas administradas pela via oral (citando exemplos).
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2- Um acadmico do curso de Biomedicina iniciou estgio de iniciao cientfica no laboratrio de Farmacologia e foi
incumbido de calcular o volume de distribuio aparente de um princpio ativo, extrado de uma planta do Cerrado, o
qual apresenta potencial teraputico. O volume de distribuio calculado para o princpio foi de 68 L /Kg. O aluno,
apesar de bem orientado com relao os procedimentos experimentais a serem seguidos e com relao aos clculo a
serem realizados, espantou-se com o valor, j que ouvira em suas aulas de Fisiologia que o volume de gua em um
homem de 70 kg de aproximadamente 40 L. Assim, intrigado, pensou inclusive em repetir os experimentos, j que
julgou ter cometido algum erro gritante. Seu orientador estava participando de um congresso, de forma que ele no
tinha com quem dividir sua aflio. Contudo, na hora do almoo ele lhe encontra e comenta o ocorrido. Voc diria a
ele que de fato um grande erro foi cometido? Por qu?
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3- Embora o paracetamol seja um analgsico-antipirtico muito seguro em doses teraputicas, na dosagem excessiva
pode ocorrer hepatotoxicidade aguda grave. Descreva o mecanismo desse fenmeno, incluindo uma possvel
interao com etanol.
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4- SC e AP, de 19 e 20 anos, respectivamente, engravidaram mesmo utilizando contraceptivos orais que contem etinilestradiol, um
estrognio sinttico que metabolizado pela CYP3A4. Poucas semanas antes de descobrirem a gravidez, SC estava utilizando
rifampicina para o tratamento da tuberculose e AP um antibitico de amplo espectro, ampicilina, para o tratamento de uma
infeco das vias areas superiores. Estudos realizados em animais de laboratrio indicam que a ampicilina diminuiu a populao
de bactrias da flora intestinal durante o perodo de tratamento, mas a rifampicina o faz apenas inicialmente, de forma que nesse
caso a ao sobre a flora pode ser desconsiderada. Baseado nos dados acima e em conhecimentos de farmacocintica, avente
explicaes para a gravidez no planejada de SC e de AP.
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5- A figura abaixo mostra a excreo urinria do fenobarbital (pka 7,3), um cido fraco, em diferentes condies de pH
urinrio.

pH 8,0

E x c r e o U r in r ia
C u m u la tiv a d o F e n o b a r b ita l (% )

35
30
25

pH 7,0

20
15

pH 6,0

10
5
0
0

25

50

75

100

Tempo (horas)
Explique as diferenas observadas utilizando o pH 7,0 como referncia.
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