Agents Classified by the IARC Monographs, Volumes 1102

CAS No
026148-68-5
000083-32-9
025732-74-5
000075-07-0
000075-07-0
000060-35-5
000103-90-2
059277-89-3
000494-38-2
008018-07-3
000107-02-8
000079-06-1
000079-10-7
000107-13-1
000050-76-0
023214-92-8
003688-53-7
001402-68-2
006795-23-9
002757-90-6
000116-06-3
000309-00-2
000107-05-1
000057-06-7
002835-39-4

Agent
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)
Acenaphthene
Acepyrene (3,4-dihydrocyclopenta[cd]pyrene)
Acetaldehyde
Acetaldehyde associated with consumption of alcoholic
beverages
Acetamide
Acetaminophen (see Paracetamol)
Aciclovir
Acid mists, strong inorganic
Acridine orange
Acriflavinium chloride
Acrolein
Acrylamide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Acrylic acid
Acrylic fibres
Acrylonitrile
Acrylonitrile-butadiene-styrene copolymers
Actinomycin D
Adriamycin
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
AF-2 [2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide]
Aflatoxins
Aflatoxin M1
Agaritine
Alcoholic beverages
Aldicarb
Aldrin
Allyl chloride
Allyl isothiocyanate
Allyl isovalerate
Alpha particles (see Radionuclides)
Aluminium production

000915-67-3
004657-93-6
000117-79-3
000060-09-3
000097-56-3
000150-13-0

Amaranth
5-Aminoacenaphthene
2-Aminoanthraquinone
para-Aminoazobenzene
ortho-Aminoazotoluene
para-Aminobenzoic acid

000092-67-1 4-Aminobiphenyl
000081-49-2
000082-28-0
000712-68-5
000099-57-0

1-Amino-2,4-dibromoanthraquinone
1-Amino-2-methylanthraquinone
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
2-Amino-4-nitrophenol

Group
2B
3
3
2B
1
2B
3
1
3
3
3

Volume
40, Sup 7
92
92
36, Sup 7, 71
100E
7, Sup 7, 71
76
54, 100F
16, Sup 7
13, Sup 7
63

Year
1987
2010
2010
1999
in prep
1999
2000
in prep
1987
1987
1995

2A

60

1994

3
3
2B
3
3

19, Sup 7, 71
19, Sup 7
71
19, Sup 7
10, Sup 7

1999
1987
1999
1987
1987

2A

10, Sup 7

1987

2B
1
2B
3
1
3
3
3
3
3

31, Sup 7
56, 82, 100F
56
31, Sup 7
44, 96, 100E
53
5, Sup 7
36, Sup 7, 71
73
36, Sup 7, 71

1
3
3
3
2B
2B
3
1
2B
3
2B
3

34, Sup 7,
100F
8, Sup 7
16, Sup 7
27, Sup 7
8, Sup 7
8, Sup 7
16, Sup 7
1, Sup 7, 99,
100F
101
27, Sup 7
7, Sup 7
57

1987
in prep
1993
1987
in prep
1991
1987
1999
1999
1999
in prep
1987
1987
1987
1987
1987
1987
in prep
in prep
1987
1987
1993

CAS No
000121-88-0
000119-34-6
000121-66-4
002432-99-7
000061-82-5
000069-53-4
051264-14-3

000523-50-2
000062-53-3
000090-04-0
000104-94-9
000191-26-4
000120-12-7
000118-92-3
000084-65-1
001309-64-4
001345-04-6
000052-46-0
024938-64-5
000140-57-8

000313-67-7
000313-67-7

Agent
2-Amino-5-nitrophenol
4-Amino-2-nitrophenol
2-Amino-5-nitrothiazole
11-Aminoundecanoic acid
Amitrole
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
Ampicillin
Amsacrine
Androgenic (anabolic) steroids
Anaesthetics, volatile
Angelicin plus ultraviolet A radiation
Aniline
ortho-Anisidine
para-Anisidine
Anthanthrene
Anthracene
Anthranilic acid
Anthraquinone
Antimony trioxide
Antimony trisulfide
Apholate
para-Aramid fibrils
Aramite
Areca nut
Aristolochic acid
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
Aristolochic acid, plants containing

007440-38-2 Arsenic and inorganic arsenic compounds

064436-13-1

Arsenobetaine and other organic arsenic compounds that

are not metabolized in humans
Art glass, glass containers and pressed ware
(manufacture of)

001332-21-4
013768-00-8 Asbestos (all forms, including actinolite, amosite,
012172-73-5 anthophyllite, chrysotile, crocidolite, tremolite)
017068-78-9 (NB: Mineral substances (e.g. talc or vermiculite) that
012001-29-5 contain asbestos should also be regarded as
012001-28-4 carcinogenic to humans.)
014567-73-8
Atrazine
001912-24-9 (NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
012174-11-7 Attapulgite (see Palygorskite)
000492-80-8 Auramine
Auramine production
012192-57-3 Aurothioglucose

Group
3
3
3
3
3

Volume
57
16, Sup 7
31, Sup 7
39, Sup 7

Year
1993
1987
1987
1987

79

2001

3
2B
2A
3
3
3
2B
3
3
3
3
2B
2B
3
3
3
2B
1

50
76
Sup 7
11, Sup 7
40, Sup 7
27, Sup 7
73
27, Sup 7
92
92
16, Sup 7
101
47
47
9, Sup 7
68
5, Sup 7
85, 100E

1990
2000
1987
1987
1987
1987
1999
1987
2010
2010
1987
in prep
1989
1989
1987
1997
1987
in prep

82, 100A

2011

82, 100A
23, Sup 7,
100C

2011

1
3
2A

100C
58

14, Sup 7,
100C

73

2B
1
3

1, Sup 7, 99,
100F
Sup 7, 99,
100F
13, Sup 7

in prep
in prep
1993

in prep

1999

in prep
in prep
1987

CAS No

Agent
Azacitidine
000320-67-2 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000115-02-6 Azaserine
000446-86-6 Azathioprine
000151-56-4
001072-52-2
000800-24-8
000103-33-3
000202-94-8
000202-33-5
000211-91-6
000225-11-6
000225-51-4
000056-55-3

Aziridine
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
2-(1-Aziridinyl)ethanol
Aziridyl benzoquinone
Azobenzene
11H-Benz[bc]aceanthrylene
Benz[j]aceanthrylene
(NB: Overall evaluation upgraded to Group 2B with
supporting mechanistic and other relevant data)
Benz[l]aceanthrylene
Benz[a]acridine
Benz[c]acridine
Benz[a]anthracene

Group
50

1990

2B

10, Sup 7
26, Sup 7,
100A

1987

9, Sup 7, 71

1999

9, Sup 7
9, Sup 7
8, Sup 7
92

1987
1987
1987
2010

2B

92

2010

3
3
3
2B

92
32, Sup 7
32, Sup 7
92
29, Sup 7.
100F
29, Sup 7,
99, 100F

2010
1987
1987
2010

1
2B
3
3
3
3

000092-87-5 Benzidine

000214-17-5
000196-78-1
000203-33-8
000205-99-2
000203-12-3
000205-82-3
000207-08-9
000238-84-6
000243-17-4
000205-12-9
000271-89-6
000191-24-2
000195-19-7
000119-61-9
000050-32-8
000192-97-2
000105-11-3
000094-36-0
000140-11-4
001694-09-3
007440-41-7

Year

2A

000071-43-2 Benzene

Benzidine, dyes metabolized to

(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
Benzo[b]chrysene
Benzo[g]chrysene
Benzo[a]fluoranthene
Benzo[b]fluoranthene
Benzo[ghi]fluoranthene
Benzo[j]fluoranthene
Benzo[k]fluoranthene
Benzo[a]fluorene
Benzo[b]fluorene
Benzo[c]fluorene
Benzofuran
Benzo[ghi]perylene
Benzo[c]phenanthrene
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
Benzophenone
Benzo[a]pyrene
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
Benzo[e]pyrene
para-Benzoquinone dioxime
Benzoyl peroxide
Benzyl acetate
Benzyl violet 4B
Beryllium and beryllium compounds

Volume

99, 100F

2011

in prep
in prep
in prep

3
3
3
2B
3
2B
2B
3
3
3
2B
3

92
92
92
92
92
92
92
92
92
92
63
92

2010
2010
2010
2010
2010
2010
2010
2010
2010
2010
1995
2010

2B

92

2010

2B

101

in prep

92, 100F

in prep

92
29, Sup 7, 71
36, Sup 7, 71
40, Sup 7, 71
16, Sup 7
58, 100C

2010
1999
1999
1999
1987
in prep

1
3
3
3
3
2B
1

CAS No

002168-68-5
003296-90-0
000111-44-4
000494-03-1
000154-93-8
013483-18-6
056894-91-8
000542-88-1
000107-30-2
000108-60-1
002386-90-5
000117-81-7
001675-54-3
008052-42-4
008052-42-4
011056-06-7
000129-17-9

003844-45-9
005589-96-8
083463-62-1
000075-27-4
000074-96-4
000075-25-2
000055-98-1
000106-99-0
000055-98-1
000111-76-2
057018-52-7
000141-32-2
025013-16-5
000128-37-0
000085-68-7
003068-88-0
000096-48-0
007440-43-9
000331-39-5
000058-08-2

Agent
Group
Volume
Beta particles (see Radionuclides)
Betel quid with tobacco
1
85, 100E
Betel quid without tobacco
1
85, 100E
Biomass fuel (primarily wood), indoor emissions from
2A
95
household combustion of
Bis(1-aziridinyl)morpholinophosphine sulfide
3
9, Sup 7
2,2-Bis(bromomethyl)propane-1,3-diol
2B
77
Bis(2-chloroethyl)ether
3
9, Sup 7, 71
N,N-Bis(2-chloroethyl)-2-naphthylamine (see
Chlornaphazine)
Bischloroethyl nitrosourea (BCNU)
2A
26, Sup 7
1,2-Bis(chloromethoxy)ethane
3
15; Sup 7, 71
1,4-Bis(chloromethoxymethyl)benzene
3
15; Sup 7, 71
Bis(chloromethyl)ether; chloromethyl methyl ether
4, Sup 7,
1
(technical-grade)
100F
Bis(2-chloro-1-methylethyl)ether
3
41, Sup 7, 71
Bis(2,3-epoxycyclopentyl)ether
3
47, 71
Bis(2-ethylhexyl) phthalate (see Di(2-ethylhexyl)
phthalate)
Bisphenol A diglycidyl ether (Araldite )
3
47, 71
Bisulfites
3
54
Bitumens, extracts of steam-refined and air-refined
2B
35, Sup 7
Bitumens, steam-refined, cracking-residue and air-refined
3
35, Sup 7
Bleomycins
(NB: Overall evaluation upgraded to Group 2B with
2B
26, Sup 7
supporting evidence from other relevant data)
Blue VRS
3
16, Sup 7
Boot and shoe manufacture and repair (see Leather dust,
25, Sup 7
Benzene)
Bracken fern
2B
40, Sup 7
Brilliant Blue FCF, disodium salt
3
16, Sup 7
Bromochloroacetic acid
2B
101
Bromochloroacetonitrile
3
52, 71
Bromodichloromethane
2B
52, 71
Bromoethane
3
52, 71
Bromoform
3
52, 71
4, Sup 7,
Busulfan
1
100A
1,3-Butadiene
1
97, 100F
1,4-Butanediol dimethanesulfonate (see Busulfan)
2-Butoxyethanol
3
88
1-tert-Butoxypropan-2-ol
3
88
n-Butyl acrylate
3
39, Sup 7, 71
Butylated hydroxyanisole (BHA)
2B
40, Sup 7
Butylated hydroxytoluene (BHT)
3
40, Sup 7
Butyl benzyl phthalate
3
73
beta-Butyrolactone
2B
11, Sup 7, 71
gamma-Butyrolactone
3
11, Sup 7, 71
Cadmium and cadmium compounds
1
58, 100C
Caffeic acid
2B
56
Caffeine
3
51
Calcium carbide production
3
92

Year
in prep
in prep
2010
1987
2000
1999

1987
1999
1999
in prep
1999
1999

1999
1992
1987
1987
1987
1987
1987
1987
1987
in prep
1999
1999
1999
1999
2011
in prep
2006
2006
1999
1987
1987
1999
1999
1999
in prep
1993
1991
2010

CAS No
Agent
000056-25-7 Cantharidin
000105-60-2 Caprolactam
Captafol
002425-06-1 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000133-06-2 Captan
000063-25-2 Carbaryl
000086-74-8 Carbazole
020073-24-9 3-Carbethoxypsoralen
001333-86-4 Carbon black
Carbon electrode manufacture
000056-23-5 Carbon tetrachloride
003567-69-9 Carmoisine
Carpentry and joinery
053973-98-1 Carrageenan, degraded (Poligeenan)
009000-07-1 Carrageenan, native
000120-80-9 Catechol
Chimney sweeping (see Soot)
000075-87-6 Chloral
000302-17-0 Chloral hydrate

Group
Volume
3
10, Sup 7
4
39, Sup 7, 71
2A

53

1991

3
3
3
3
2B
2A
2B
3
2B
2B
3
2B

30, Sup 7
12, Sup 7
32, Sup 7, 71
40, Sup 7
65, 93
92
20, Sup 7, 71
8, Sup 7
25, Sup 7
31, Sup 7
31, Sup 7
15, Sup 7, 71
92
63
84
26, Sup 7,
100A
84

1987
1987
1999
1987
2010
2010
1999
1987
1987
1987
1987
1999
2010
1995
2004

2A

50

1990

2B
2B
3
2B
3

79
20, Sup 7
30, Sup 7
48
52

2001
1987
1987
1990
1991

2B

48

1990

2A

29, Sup 7, 71

1999

3
3

000305-03-3 Chlorambucil

010599-90-3 Chloramine
Chloramphenicol
000056-75-7 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000057-74-9 Chlordane
000143-50-0 Chlordecone (Kepone)
006164-98-3 Chlordimeform
000115-28-6 Chlorendic acid
Chlorinated drinking-water
Chlorinated paraffins of average carbon chain length C12
and average degree of chlorination approximately 60%
000098-87-3
alpha-Chlorinated toluenes (benzal chloride,
000098-07-7
benzotrichloride, benzyl chloride) and benzoyl chloride
000100-44-7
(combined exposures)
000098-88-4

000494-03-1 Chlornaphazine
000107-14-2
000106-47-8
000510-15-6
000124-48-1
077439-76-0
000075-45-6
000075-00-3

Chloroacetonitrile
para-Chloroaniline
Chlorobenzilate
Chlorodibromomethane
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
Chlorodifluoromethane
Chloroethane
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)
013010-47-4 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
013909-09-6
(Methyl-CCNU) (see Semustine)
000593-70-4 Chlorofluoromethane

Year
1987
1999

2011
2004

3
2B
3
3
2B
3
3

4, Sup 7,
100A
52, 71
57
30, Sup 7
52, 71
84
41, Sup 7, 71
52, 71

1999
1993
1987
1999
2004
1999
1999

2A

26, Sup 7

1987

41, Sup 7, 71

1999

2011

CAS No
Agent
000067-66-3 Chloroform
Chloromethyl methyl ether (see Bis(chloromethyl)ether;
000107-30-2
chloromethyl methyl ether)
000513-37-1 1-Chloro-2-methylpropene
000563-47-3 3-Chloro-2-methylpropene
000088-73-3
000121-73-3 Chloronitrobenzenes
000100-00-5
Chlorophenols (see Polychlorophenols)
Chlorophenoxy herbicides
005131-60-2 4-Chloro-meta-phenylenediamine
000095-83-0 4-Chloro-ortho-phenylenediamine
000126-99-8 Chloroprene
000101-21-3 Chloropropham
000054-05-7 Chloroquine
001897-45-6 Chlorothalonil
000095-69-2 4-Chloro-ortho-toluidine
000095-79-4 5-Chloro-ortho-toluidine
000075-88-7 2-Chloro-1,1,1-trifluoroethane
Chlorozotocin
054749-90-5 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000057-88-5 Cholesterol
007440-47-3 Chromium, metallic
016065-83-1 Chromium (III) compounds
018540-29-9 Chromium (VI) compounds
000218-01-9 Chrysene
000532-82-1 Chrysoidine
006373-74-6 CI Acid Orange 3
000523-44-4 CI Acid Orange 20
006459-94-5 CI Acid Red 114
000569-61-9 CI Basic Red 9
001937-37-7 CI Direct Black 38 (see Benzidine, dyes metabolized to)
002602-46-2 CI Direct Blue 6 (see Benzidine, dyes metabolized to)
002429-74-5 CI Direct Blue 15
016071-86-6 CI Direct Brown 95 (see Benzidine, dyes metabolized to)
001936-15-8 CI Orange G
002425-85-6 CI Pigment Red 3
059865-13-3 Ciclosporin (see Cyclosporine)
051481-61-9 Cimetidine
000087-29-6 Cinnamyl anthranilate
Cisplatin
015663-27-1 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000518-75-2 Citrinin
006358-53-8 Citrus Red No. 2
000637-07-0 Clofibrate
000050-41-9 Clomiphene citrate
Clonorchis sinensis (infection with)
Coal, indoor emissions from household combustion of
Coal dust
Coal gasification

Group
Volume
2B
73

Year
1999

2B
3

63
63

1995
1995

65

1996

2B
3
2B
2B
3
3
2B
2A
3
3

41, Sup 7
27, Sup 7
27, Sup 7
71
12, Sup 7
13, Sup 7
73
77, 99
77, 99
41, Sup 7, 71

1987
1987
1987
1999
1987
1987
1999
2010
2010
1999

2A

50

1990

3
3
3
1
2B
3
3
3
2B
2B

31, Sup 7
49
49
49, 100C
92
8, Sup 7
57
8, Sup 7
57
57, 99

2B

57

1993

3
3

8, Sup 7
57

1987
1993

3
3

50
77

1990
2000

2A

26, Sup 7

1987

3
2B
3
3
1
1
3
1

40, Sup 7
8, Sup 7
66
21, Sup 7
61, 100B
95, 100E
68
92, 100F

1987
1987
1996
1987
2011
in prep
1997
in prep

1987
1990
1990
in prep
2010
1987
1993
1987
1993
2010

CAS No
Agent
008007-45-2 Coal tars (see Coal-tar distillation)
008007-45-2 Coal-tar distillation
065996-93-2 Coal-tar pitch
007440-48-4
007440-48-4
012070-12-1
007440-48-4
010026-24-1
068603-42-9

010380-28-6
000191-07-1
000091-64-5
008001-58-9
000102-50-1
000120-71-8
004170-30-3
008002-05-9
000098-82-8
014901-08-7
000139-05-9
012663-46-6
000108-94-1
000202-98-2
027208-37-3
007099-43-6
000050-18-0
006055-19-2
059865-13-3
079217-60-0
004342-03-4
005160-02-1
000117-10-2
000080-08-0
020830-81-3
000050-29-3
001163-19-5
052918-63-5
000083-63-6
000613-35-4
002303-16-4
000615-05-4

Group
1
1

Volume
35, Sup 7
92, 100F
35, Sup 7,
100F

Year
1987
in prep
in prep

Cobalt and cobalt compounds

(NB: Evaluated as a group)

2B

52

1991

Cobalt metal with tungsten carbide

2A

86

2006

Cobalt metal without tungsten carbide

Cobalt sulfate and other soluble cobalt(II) salts
Coconut oil diethanolamine condensate
Coffee (urinary bladder)
(NB: There is some evidence of an inverse relationship
between coffee drinking and cancer of the large bowel;
coffee drinking could not be classified as to its
carcinogenicity to other organs)
Coke production
Continuous glass filament (see Glass filament)
Copper 8-hydroxyquinoline
Coronene
Coumarin
Creosotes
meta-Cresidine
para-Cresidine
Crotonaldehyde
Crude oil
Cumene
Cycasin
Cyclamates (sodium cyclamate)
Cyclochlorotine
Cyclohexanone
4H-Cyclopenta[def]chrysene
Cyclopenta[cd]pyrene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
5,6-Cyclopenteno-1,2-benzanthracene

2B
2B
2B

86
86
101

2006
2006
in prep

2B

51

1991

92, 100F

in prep

3
3
3
2A
3
2B
3
3
2B
2B
3
3
3
3

15, Sup 7
32, Sup 7
77
92
27, Sup 7
27, Sup 7
63
45
101
10, Sup 7
73
10, Sup 7
47, 71
92

1987
1987
2000
2010
1987
1987
1995
1989
in prep
1987
1999
1987
1999
2010

2A

92

2010

92
26, Sup 7,
100A

2010

2011

Cyclophosphamide

Cyclosporine

50, 100A

2011

2B
3
2B
3
2B
2B
3
3
3
2B
3
2B

26, Sup 7
57
50
24, Sup 7
10, Sup 7
53
48, 71
53
8, Sup 7
16, Sup 7
30, Sup 7
79

1987
1993
1990
1987
1987
1991
1999
1991
1987
1987
1987
2001

Dacarbazine
D & C Red No. 9
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)
Dapsone
Daunomycin
DDT (4,4'-Dichlorodiphenyltrichloroethane)
Decabromodiphenyl oxide
Deltamethrin
Diacetylaminoazotoluene
N,N'-Diacetylbenzidine
Diallate
2,4-Diaminoanisole

CAS No
000101-80-4
000099-56-9
005307-14-2
000095-80-7
000095-70-5
000439-14-5
000334-88-3
000226-36-8
000224-42-0
000215-58-7
000053-70-3
000224-41-9
000194-59-2
000262-12-4
005385-75-1
000207-83-0
000192-47-2
000192-65-4
000189-64-0
000189-55-9
000191-30-0
000192-51-8
000631-64-1
003252-43-5
000096-12-8
000096-13-9
000079-43-6
003018-12-0
007572-29-4
000541-73-1
000095-50-1
000106-46-7
000091-94-1
000110-57-6
028434-86-8
000107-06-2
000075-09-2
000609-20-1
000078-87-5
000096-23-1
000542-75-6
000062-73-7
000115-32-2
069655-05-6
000060-57-1
001464-53-5

Agent
4,4'-Diaminodiphenyl ether
1,2-Diamino-4-nitrobenzene
1,4-Diamino-2-nitrobenzene
2,4-Diaminotoluene
2,5-Diaminotoluene
Diazepam
Diazomethane
Dibenz[a,h]acridine
Dibenz[a,j]acridine
Dibenz[a,c]anthracene
Dibenz[a,h]anthracene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Dibenz[a,j]anthracene
7H-Dibenzo[c,g]carbazole
Dibenzo-para-dioxin
Dibenzo[a,e]fluoranthene
13H-Dibenzo[a,g]fluorene
Dibenzo[h,rst]pentaphene
Dibenzo[a,e]pyrene
Dibenzo[a,h]pyrene
Dibenzo[a,i]pyrene
Dibenzo[a,l]pyrene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Dibenzo[e,l]pyrene
Dibromoacetic acid
Dibromoacetonitrile
1,2-Dibromo-3-chloropropane
2,3-Dibromopropan-1-ol
Dichloroacetic acid
Dichloroacetonitrile
Dichloroacetylene
meta-Dichlorobenzene
ortho-Dichlorobenzene
para-Dichlorobenzene
3,3'-Dichlorobenzidine
trans-1,4-Dichlorobutene
3,3'-Dichloro-4,4'-diaminodiphenyl ether
1,2-Dichloroethane
Dichloromethane (Methylene chloride)
2,6-Dichloro-para-phenylenediamine
1,2-Dichloropropane
1,3-Dichloro-2-propanol
1,3-Dichloropropene (technical-grade)
Dichlorvos
Dicofol
Didanosine
Dieldrin
1,2:3,4-Diepoxybutane (see Monographs on 1,3Butadiene)
Diesel engine exhaust (see Engine exhaust, diesel)

Group
2B
3
3
2B
3
3
3
2B
2B
3

Volume
29, Sup 7
16, Sup 7
57
16, Sup 7
16, Sup 7
66
7, Sup 7
32, Sup 7
32, Sup 7
92

Year
1987
1987
1993
1987
1987
1996
1987
1987
1987
2010

2A

92

2010

3
2B
3
3
3
3
3
2B
2B

92
32, Sup 7
69
92
92
92
92
92
92

2010
1987
1997
2010
2010
2010
2010
2010
2010

2A

92

2010

3
2B
2B
2B
2B
2B
3
3
3
3
2B
2B
3
2B
2B
2B
3
3
2B
2B
2B
3
3
3

92
101
52, 71, 101
20, Sup 7, 71
77
84
52, 71
39, Sup 7, 71
73
73
73
29, Sup 7
15, Sup 7, 71
16, Sup 7
20, Sup 7, 71
71
39, Sup 7
41, Sup 7, 71
101
41, Sup 7, 71
53
30, Sup 7
76
5, Sup 7
11, Sup 7

2010
in prep
in prep
1999
2000
2004
1999
1999
1999
1999
1999
1987
1999
1987
1999
1999
1987
1999
in prep
1999
1991
1987
2000
1987
1987

CAS No

000111-42-2
000103-23-1
000117-81-7
001615-80-1

Agent
Diesel fuels, distillate (light)
Diesel fuel, marine
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
Diethanolamine
Di(2-ethylhexyl) adipate
Di(2-ethylhexyl)phthalate
1,2-Diethylhydrazine

000056-53-1 Diethylstilbestrol
000064-67-5
000105-55-5
000101-90-6
000641-48-5
000094-58-6
000794-93-4
002973-10-6
000828-00-2
000119-90-4
000091-93-0
000060-11-7
000140-56-7
025962-77-0
022975-76-4
004063-41-6
000087-62-7
000121-69-7
000075-60-5
000119-93-7
000079-44-7
000068-12-2
000057-14-7
000540-73-8
000868-85-9
022349-59-3
000077-78-1
105735-71-5
022506-53-2
075321-20-9
042397-64-8
042397-65-9
000101-25-7
000121-14-2

Diethyl sulfate
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N,N'-Diethylthiourea
Diglycidyl resorcinol ether
Dihydroaceanthrylene
Dihydrosafrole
Dihydroxymethylfuratrizine (see also Panfuran S)
Diisopropyl sulfate
Dimethoxane
3,3'-Dimethoxybenzidine (ortho-Dianisidine)
3,3'-Dimethoxybenzidine-4,4'-diisocyanate
para-Dimethylaminoazobenzene
para-Dimethylaminoazobenzenediazo sodium sulfonate
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2furyl)-vinyl]-1,3,4-oxadiazole
4,4'-Dimethylangelicin plus ultraviolet A radiation
4,5'-Dimethylangelicin plus ultraviolet A radiation
2,6-Dimethylaniline (2,6-Xylidine)
N,N-Dimethylaniline
Dimethylarsenic acid
3,3'-Dimethylbenzidine (ortho-Tolidine)
Dimethylcarbamoyl chloride
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Dimethylformamide
1,1-Dimethylhydrazine
1,2-Dimethylhydrazine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Dimethyl hydrogen phosphite
1,4-Dimethylphenanthrene
Dimethyl sulfate
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
3,7-Dinitrofluoranthene
3,9-Dinitrofluoranthene
1,3-Dinitropyrene
1,6-Dinitropyrene
1,8-Dinitropyrene
Dinitrosopentamethylenetetramine
2,4-Dinitrotoluene

Group
Volume
3
45
2B

45

2B
3
2B
2B

77, 101
77
77, 101
4, Sup 7, 71
21, Sup 7,
100A

Year
1989
1989
2000
2000
in prep
1999
2011

2A

54, 71

1999

3
2B
3
2B
3
2B
3
2B
3
2B
3

79
36, Sup 7, 71
92
10, Sup 7
24, Sup 7
54, 71
15, Sup 7
4, Sup 7
39, Sup 7
8, Sup 7
8, Sup 7

2001
1999
2010
1987
1987
1999
1987
1987
1987
1987
1987

2B

7, Sup 7

1987

3
3
2B
3
2B
2B

Sup 7
Sup 7
57
57
100C
1, Sup 7

1987
1987
1993
1993
in prep
1987

2A

12, Sup 7, 71

1999

3
2B

47, 71
4, Sup 7, 71

1999
1999

2A

4, Sup 7, 71

1999

48, 71
92

1999
2010

2A

4, Sup 7, 71

1999

2B
2B
3
2B
2B
3
2B

65
65
46
46
46
11, Sup 7
65

1996
1996
1989
1989
1989
1987
1996

3
3

CAS No
000606-20-2
000618-85-9
000123-91-1
000492-17-1
002475-45-8
002832-40-8
000097-77-8
001143-38-0
040762-15-0
000562-10-7
082413-20-5
000150-69-6

000072-20-8

015086-94-9
000106-89-8

000106-88-7
000141-37-7
002443-39-2

Agent
2,6-Dinitrotoluene
3,5-Dinitrotoluene
1,4-Dioxane
2,4'-Diphenyldiamine
Disperse Blue 1
Disperse Yellow 3
Disulfiram
Dithranol
Doxefazepam
Doxylamine succinate
Droloxifene
Dry cleaning (occupational exposures in)
Dulcin
Dyes metabolized to benzidine (see Benzidine, dyes
metabolized to)
Electric fields, extremely low-frequency
Electric fields, static
Endrin
Engine exhaust, diesel
Engine exhaust, gasoline
Eosin
Epichlorohydrin
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
1,2-Epoxybutane
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6methylcyclo-hexanecarboxylate
cis-9,10-Epoxystearic acid
Epstein-Barr virus

Group
2B
3
2B
3
2B
3
3
3
3
3
3
2B
3

Volume
65
65
11, Sup 7, 71
16, Sup 7
48
48
12, Sup 7
13; Sup 7
66
79
66
63
12, Sup 7

Year
1996
1996
1999
1987
1990
1990
1987
1987
1996
2001
1996
1995
1987

80
80
5, Sup 7
46
46
15, Sup 7

2002
2002
1987
1989
1989
1987

11, Sup 7, 71

1999

47, 71

1999

11, Sup 7, 71

1999

3
1

1999
2011

3
3
3
2A
2B
3
2A

2B

066733-21-9 Erionite

029975-16-4 Estazolam
Estrogen therapy, postmenopausal
Estrogen-progestogen menopausal therapy (combined)
Estrogen-progestogen oral contraceptives (combined)
(NB: There is also convincing evidence in humans that
these agents confer a protective effect against cancer in
the endometrium and ovary)
000064-17-5 Ethanol in alcoholic beverages
000536-33-4 Ethionamide
000140-88-5 Ethyl acrylate
000100-41-4 Ethylbenzene
000051-79-6 Ethyl carbamate (Urethane)
000074-85-1 Ethylene
Ethylene dibromide
000106-93-4 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Ethylene oxide
000075-21-8 (NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)

3
1
1

11, Sup 7, 71
70, 100B
42, Sup 7,
100C
66
72, 100A
72, 91, 100A

72, 91, 100A

2011

1
3
2B
2B
2A
3

96, 100E
13, Sup 7
39, Sup 7, 71
77
7, Sup 7, 96
60

in prep
1987
1999
2000
2010
1994

2A

15, Sup 7, 71

1999

97, 100F

in prep
1996
2011
2011

in prep

CAS No
Agent
000420-12-2 Ethylene sulfide
Ethylenethiourea
000096-45-7 (NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
000103-11-7 2-Ethylhexyl acrylate
000062-50-0 Ethyl methanesulfonate
N-Ethyl-N-nitrosourea
000759-73-9 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
005456-28-0 Ethyl selenac
020941-65-5 Ethyl tellurac
Etoposide
033419-42-0 (NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
033419-42-0
015663-27-1 Etoposide in combination with cisplatin and bleomycin
011056-06-7
000097-53-0 Eugenol
000314-13-6 Evans blue
002353-45-9 Fast Green FCF
051630-58-1 Fenvalerate
014484-64-1 Ferbam
001309-37-1 Ferric oxide
Firefighter (occupational exposure as a)
Fission products, including strontium-90
Flat-glass and specialty glass (manufacture of)
002164-17-2 Fluometuron
000206-44-0 Fluoranthene
000086-73-7 Fluorene
Fluorescent lighting
016984-48-8 Fluorides (inorganic, used in drinking-water)
000051-21-8 5-Fluorouracil
Foreign bodies (see Surgical implants and other foreign
bodies)
000050-00-0 Formaldehyde
003570-75-0 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
Frying, emissions from high-temperature
Fuel oils, distillate (light)
Fuel oils, residual (heavy)
116355-83-0 Fumonisin B1
000110-00-9 Furan
000067-45-8 Furazolidone
000098-01-1 Furfural
Furniture and cabinet making (see Wood dust)
000054-31-9 Furosemide (Frusemide)
Fusarium graminearum, F. culmorum, and F.
crookwellense, toxins derived from (zearalenone,
deoxynivalenol, nivalenol, and fusarenone X)
Fusarium moniliforme, toxins derived from (fumonisin B1,
116355-83-0
fumonisin B2, and fusarin C)
Fusarium sporotrichioides, toxins derived from (T-2 toxin)

Group
Volume
3
11, Sup 7
3

Year
1987

79

2001

3
2B

60
7, Sup 7

1994
1987

2A

17, Sup 7

1987

3
3

12, Sup 7
12, Sup 7

1987
1987

76, 100A

2011

76, 100A

2011

3
3
3
3
3
3
2B
1
3
3
3
3
3
3
3

36, Sup 7
8, Sup 7
16, Sup 7
53
12, Sup 7
1, Sup 7
98
100D
58
30, Sup 7
92
92
55
27, Sup 7
26, Sup 7

1987
1987
1987
1991
1987
1987
2010
in prep
1993
1987
2010
2010
1992
1987
1987

1
2B
2A
3
2B
2B
2B
3
3
3

88, 100F
7, Sup 7
95
45
45
82
63
31, Sup 7
63
25, Sup 7
50

in prep
1987
2010
1989
1989
2002
1995
1987
1995
1987
1990

56

1993

2B

56

1993

56

1993

CAS No
001303-00-0

025812-30-0
067730-11-4
067730-10-3
000765-34-4
000556-52-5
005431-33-4
007460-84-6
000126-07-8
004680-78-8
016568-02-8
001317-60-8

Agent
Gallium arsenide (see Arsenic and inorganic arsenic
compounds)
Gamma-Radiation (see X- and Gamma-Radiation)
Gasoline
(NB: Overall evaluation upgraded to Group 2B with
supporting evidence from other relevant data)
Gasoline engine exhaust (see Engine exhaust, gasoline)
Gemfibrozil
Glass filament, continuous
Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'd]imidazole)
Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)
Glycidaldehyde
Glycidol
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Glycidyl oleate
Glycidyl stearate
Griseofulvin
Guinea Green B
Gyromitrin
Haematite
Haematite mining (underground)

002784-94-3
033229-34-4
002871-01-4
059820-43-8

000076-44-8
000118-74-1
000087-68-3
000067-72-1
000070-30-4
000142-83-6
000680-31-9

Hair colouring products (personal use of)

Hairdresser or barber (occupational exposure as a)
HC Blue No. 1
HC Blue No. 2
HC Red No. 3
HC Yellow No. 4
Helicobacter pylori (infection with)
Hepatitis B virus (chronic infection with)
Hepatitis C virus (chronic infection with)
Hepatitis D virus
Heptachlor
Hexachlorobenzene
Hexachlorobutadiene
Hexachlorocyclohexanes
Hexachloroethane
Hexachlorophene
2,4-Hexadienal
Hexamethylphosphoramide
High-temperature frying (see Frying)
Hot mate (see Mate, hot)
Household combustion of biomass fuel (see Biomass
fuel, indoor emissions from household combustion of)
Household combustion of coal (see Coal, indoor
emissions from household combustion)
Human herpesvirus type 4 (see Epstein-Barr virus)
Human herpesvirus type 8 (see Kaposi sarcoma
herpesvirus)
Human immunodeficiency virus type 1 (infection with)

Group

Volume
86, 100C

2B

Year
in prep

45

1989

66
43, 81

1996
2002

2B

40, Sup 7

1987

2B
2B

40, Sup 7
11, Sup 7, 71

1987
1999

2A

77

2000

3
3
2B
3
3
3

11, Sup 7
11, Sup 7
79
16, Sup 7
31, Sup 7
1, Sup 7
1, Sup 7,
100D
57, 99
57, 99
57
57
57
57
61, 100B
59, 100B
59, 100B
59
79
79
73
20, Sup 7
73
20, Sup 7
101
15, Sup 7, 71

1987
1987
2001
1987
1987
1987

3
3

1
3
2A
2B
3
3
3
1
1
1
3
2B
2B
3
2B
2B
3
2B
2B

67, 100B

in prep
2010
2010
1993
1993
1993
1993
2011
2011
2011
1994
2001
2001
1999
1987
1999
1987
in prep
1999

2011

CAS No

023255-93-8
000086-54-4
000302-01-2
007647-01-0
000058-93-5
007722-84-1
000123-31-9
000129-43-1
001689-82-3
000148-24-3
026782-43-4
000127-07-1
000193-39-5
022398-80-7

010043-66-0

076180-96-6

Agent
Human immunodeficiency virus type 2 (infection with)
Human papillomavirus genus beta (except types 5 and 8)
and genus gamma
Human papillomavirus types 5 and 8 (in patients with
epidermodysplasia verruciformis)
Human papillomavirus types 6 and 11
Human papillomavirus types 16, 18, 31, 33, 35, 39, 45,
51, 52, 56, 58, 59
(NB: The HPV types that have been classified as
carcinogenic to humans can differ by an order of
magnitude in risk for cervical cancer)
Human papillomavirus types 26, 53, 66, 67, 70, 73, 82
Human papillomavirus types 30, 34, 69, 85, 97
(NB: Classified by phylogenetic analogy to the HPV
genus alpha types classified in Group 1)
Human papillomavirus type 68
Human T-cell lymphotropic virus type I
Human T-cell lymphotropic virus type II
Hycanthone mesylate
Hydralazine
Hydrazine
Hydrochloric acid
Hydrochlorothiazide
Hydrogen peroxide
Hydroquinone
1-Hydroxyanthraquinone
4-Hydroxyazobenzene
8-Hydroxyquinoline
Hydroxysenkirkine
Hydroxyurea
Hypochlorite salts
Indeno[1,2,3-cd]pyrene
Indium phosphide
(NB: Overall evaluation upgraded to Group 2A)
Insulation glass wool
Involuntary smoking (see Tobacco smoke, second-hand)
Iodine-131 (see Radioiodines)
Ionizing radiation (all types)
IQ (2-Amino-3-methylimidazo[4,5-f]quinoline)
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Iron and steel founding (occupational exposure during)

009004-66-4
009004-51-7
001338-16-5
015503-86-3
000054-85-3
003778-73-2
000078-79-5
000067-63-0

Iron-dextran complex
Iron-dextrin complex
Iron sorbitol-citric acid complex
Isatidine
Isonicotinic acid hydrazide (Isoniazid)
Isophosphamide
Isoprene
Isopropyl alcohol
Isopropyl alcohol manufacture using strong acids

Group
Volume
2B
67
3

Year
1996

90, 100B

2011

100B

2011

90, 100B

2011

64, 90, 100B

2011

2B

100B

2011

2B

100B

2011

2A
1
3
3
3
2B
3
3
3
3
2B
3
3
3
3
3
2B

100B
67, 100B
67
13, Sup 7
24, Sup 7
4, Sup 7, 71
54
50
36, Sup 7, 71
15, Sup 7, 71
82
8, Sup 7
13, Sup 7
10, Sup 7
76
52
92

2011
2011
1996
1987
1987
1999
1992
1990
1999
1999
2002
1987
1987
1987
2000
1991
2010

2A

86

2006

43, 81

2002

100D

in prep

2B

2A

1
2B
3
3
3
3
3
2B
3
1

56
34, Sup 7,
100F
2, Sup 7
2, Sup 7
2, Sup 7
10, Sup 7
4, Sup 7
26, Sup 7
60, 71
15, Sup 7, 71
Sup 7, 100F

1993
in prep
1987
1987
1987
1987
1987
1987
1999
1999
in prep

CAS No
000120-58-1
006870-67-3
000520-18-3
000501-30-4
000303-34-4
000105-74-8
007439-92-1

005141-20-8
005989-27-5

021884-44-6
000632-99-5

000121-75-5
000123-33-1
000542-78-9
012427-38-2
000551-74-6

068006-83-7
013045-94-8
000071-58-9
077094-11-2
077500-04-0
000108-78-1
000148-82-3
000050-44-2
007439-97-6
000531-76-0

Agent
Group
Volume
Isopropyl oils
3
15, Sup 7, 71
Isosafrole
3
10, Sup 7
Jacobine
3
10, Sup 7
Jet fuel
3
45
Kaempferol
3
31, Sup 7
Kaposi sarcoma herpesvirus
1
70, 100B
Kojic acid
3
79
Lasiocarpine
2B
10, Sup 7
Lauroyl peroxide
3
36, Sup 7, 71
Lead
2B
23, Sup 7
Lead compounds, inorganic
2A
87
Lead compounds, organic
(NB: Organic lead compounds are metabolized at least
in part, to ionic lead both in humans and animals. To the
3
23, Sup 7, 87
extent that ionic lead, generated from organic lead, is
present in the body, it will be expected to exert the
toxicities associated with inorganic lead.)
Leather dust
1
100C
Leather goods manufacture
3
25, Sup 7
Leather tanning and processing
3
25, Sup 7
Light Green SF
3
16, Sup 7
d-Limonene
(NB: Overall evaluation downgraded to Group 3 with
3
73
supporting evidence from other relevant data)
Lumber and sawmill industries (including logging)
3
25, Sup 7
Luteoskyrin
3
10, Sup 7
Madder root (Rubia tinctorum)
3
82
Magenta
2B
57, 99, 100F
Magenta production
1
57, 99, 100F
Magnetic fields, extremely low-frequency
2B
80
Magnetic fields, static
3
80
Malathion
3
30, Sup 7
Maleic hydrazide
3
4, Sup 7
Malonaldehyde
3
36, Sup 7, 71
Maneb
3
12, Sup 7
Mannomustine dihydrochloride
3
9, Sup 7
Mate
3
51
Mate, hot
2A
51
MeA-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)
2B
40, Sup 7
Medphalan
3
9, Sup 7
Medroxyprogesterone acetate
2B
21, Sup 7
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline)
2B
56
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)
2B
56
Melamine
(NB: Overall evaluation downgraded to Group 3 with
3
73
supporting evidence from other relevant data)
9, Sup 7,
Melphalan
1
100A
6-Mercaptopurine
3
26, Sup 7
Mercury and inorganic mercury compounds
3
58
Merphalan
2B
9, Sup 7
Metabisulfites
3
54

Year
1999
1987
1987
1989
1987
2011
2001
1987
1999
1987
2006

2006

in prep
1987
1987
1987
1999
1987
1987
2002
in prep
in prep
2002
2002
1987
1987
1999
1987
1987
1991
1991
1987
1987
1987
1993
1993
1999
2011
1987
1993
1987
1992

CAS No
Agent
000060-56-0 Methimazole
000059-05-2 Methotrexate
000072-43-5 Methoxychlor
Methoxsalen (8-methoxypsoralen) plus ultraviolet A
000298-81-7
radiation
5-Methoxypsoralen
000484-20-8 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000096-33-3 Methyl acrylate
073459-03-7 5-Methylangelicin plus ultraviolet A radiation
000124-58-3 Methylarsonic acid
000075-55-8 2-Methylaziridine (Propyleneimine)
000592-62-1 Methylazoxymethanol acetate
000074-83-9 Methyl bromide
001634-04-4 Methyl tert-butyl ether
000598-55-0 Methyl carbamate
000074-87-3 Methyl chloride
003351-28-8 1-Methylchrysene
003351-32-4 2-Methylchrysene
003351-31-3 3-Methylchrysene
003351-30-2 4-Methylchrysene
003697-24-3 5-Methylchrysene
001705-85-7 6-Methylchrysene
000099-80-9 N-Methyl-N,4-dinitrosoaniline
4,4'-Methylenebis(2-chloroaniline) (MOCA)
000101-14-4 (NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
000838-88-0 4,4'-Methylene bis(2-methylaniline)
000101-77-9 4,4'-Methylenedianiline
000101-68-8 4,4'-Methylenediphenyl diisocyanate
000093-15-2 Methyleugenol
033543-31-6 2-Methylfluoranthene
001706-01-0 3-Methylfluoranthene
000078-98-8 Methylglyoxal
000693-98-1 2-Methylimidazole
000822-36-6 4-Methylimidazole
000074-88-4 Methyl iodide
000108-10-1 Methyl isobutyl ketone
Methylmercury compounds
(NB: Evaluated as a group)
000080-62-6 Methyl methacrylate
Methyl methanesulfonate
000066-27-3 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000129-15-7 2-Methyl-1-nitroanthraquinone (uncertain purity)
N-Methyl-N-nitro-N-nitrosoguanidine (MNNG)
000070-25-7 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Methyl-N-nitrosourea
000684-93-5 (NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
000615-53-2 N-Methyl-N-nitrosourethane

Group
Volume
3
79
3
26, Sup 7
3
20, Sup 7
24, Sup 7,
1
100A

Year
2001
1987
1987
2011

2A

40, Sup 7

1987

3
3
2B
2B
2B
3
3
3
3
3
3
3
3
2B
3
3

39, Sup 7, 71
Sup 7
100C
9, Sup 7, 71
10, Sup 7
41, Sup 7, 71
73
12, Sup 7
41, Sup 7, 71
92
92
92
92
92
92
1, Sup 7

1999
1987
in prep
1999
1987
1999
1999
1987
1999
2010
2010
2010
2010
2010
2010
1987

57, 99, 100F

in prep

2B
2B
3
2B
3
3
3
2B
2B
3
2B

4, Sup 7
39, Sup 7
19, Sup 7, 71
101
92
92
51
101
101
41, Sup 7, 71
101

1987
1987
1999
in prep
2010
2010
1991
in prep
in prep
1999
in prep

2B

58

1993

60

1994

2A

7, Sup 7, 71

1999

2B

27, Sup 7

1987

2A

4, Sup 7

1987

2A

17, Sup 7

1987

2B

4, Sup 7

1987

CAS No
090456-67-0
000298-00-0
000832-69-9
085878-63-3
000493-52-7
000144-34-3
000056-04-2
000443-48-1

Agent
N-Methylolacrylamide
Methyl parathion
1-Methylphenanthrene
7-Methylpyrido[3,4-c]psoralen
Methyl red
Methyl selenac
Methylthiouracil
Metronidazole
Michlers base [4,4-methylenebis(N,N-dimethyl)000101-61-1
benzenamine]
000090-94-8 Michlers ketone [4,4-Bis(dimethylamino)benzophenone]
101043-37-2 Microcystin-LR
Microcystis extracts
Mineral oils, highly-refined
Mineral oils, untreated or mildly treated
002385-85-5 Mirex
000050-07-7 Mitomycin C
065271-80-9 Mitoxantrone
Modacrylic fibres
000096-24-2 3-Monochloro-1,2-propanediol
000315-22-0 Monocrotaline
000150-68-5 Monuron
MOPP and other combined chemotherapy including
alkylating agents
000110-91-8 Morpholine
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]-2003795-88-8
oxazolidinone
000083-66-9 Musk ambrette
000081-15-2 Musk xylene
000505-60-2 Mustard gas (see Sulfur mustard)
000055-98-1 Myleran (see Busulfan)
003771-19-5 Nafenopin
000091-20-3 Naphthalene
002243-62-1 1,5-Naphthalenediamine
003173-72-6 1,5-Naphthalene diisocyanate
111189-32-3 Naphtho[1,2-b]fluoranthene
000203-20-3 Naphtho[2,1-a]fluoranthene
000193-09-9 Naphtho[2,3-e]pyrene
000134-32-7 1-Naphthylamine

Group
3
3
3
3
3
3
2B
2B

Volume
60
30, Sup 7
92
40, Sup 7
8, Sup 7
12, Sup 7
79
13, Sup 7

Year
1994
1987
2010
1987
1987
1987
2001
1987

2B

27, Sup 7, 99

2010

2B
2B
3
3

99
94
94
33, Sup 7
33, Sup 7,
100F
20, Sup 7
10, Sup 7
76
19, Sup 7
101
10, Sup 7
53

2010
2010
2010
1987

1
2B
2B
2B
3
2B
2B
3

in prep
1987
1987
2000
1987
in prep
1987
1991

Sup 7, 100A

2011

47, 71

1999

7, Sup 7

1987

65
65

1996
1996

1987
2002
1987
1999
2010
2010
2010
1987

2B
3
3

2B
2B
3
3
3
3
3
3

000091-59-8 2-Naphthylamine

000086-88-4 1-Naphthylthiourea (ANTU)

000139-94-6 Nithiazide
Neutron radiation
(NB: Overall evaluation upgraded to Group 1 with
supporting evidence from other relevant data)
007440-02-0 Nickel, metallic and alloys
Nickel compounds
Nickel refining (see Nickel compounds)
000061-57-4 Niridazole

3
3

24, Sup 7
82
27, Sup 7
19, Sup 7, 71
92
92
92
4, Sup 7
4, Sup 7, 99,
100F
30, Sup 7
31, Sup 7

75, 100D

in prep

2B
1

49
49, 100C
11
13, Sup 7

1990
in prep
1976
1987

2B

in prep
1987
1987

CAS No

000139-13-9
000602-87-9
000099-59-2
000091-23-6
000602-60-8
000098-95-3
020268-51-3
063041-90-7
000092-93-3
007496-02-8
001836-75-5
000892-21-7
000607-57-8
000059-87-0
000067-20-9
000555-84-0
000531-82-8
000051-75-2
000126-85-2
000075-52-5
000086-57-7
000581-89-5
020589-63-3
000079-46-9
005522-43-0
000789-07-1
057835-92-4
037620-20-5
071267-22-6
000924-16-3
001116-54-7
000055-18-5

000062-75-9
000086-30-6
000156-10-5
000621-64-7
029291-35-8
055557-01-2
055557-02-3
030310-80-6
085502-23-4
060153-49-3
010595-95-6
004549-40-0
000059-89-2

Agent
Nitrate or nitrite (ingested) under conditions that result in
endogenous nitrosation
Nitrilotriacetic acid and its salts
(NB: Evaluated as a group)
5-Nitroacenaphthene
5-Nitro-ortho-anisidine
2-Nitroanisole
9-Nitroanthracene
Nitrobenzene
7-Nitrobenz[a]anthracene
6-Nitrobenzo[a]pyrene
4-Nitrobiphenyl
6-Nitrochrysene
Nitrofen (technical-grade)
3-Nitrofluoranthene
2-Nitrofluorene
Nitrofural (Nitrofurazone)
Nitrofurantoin
1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
Nitrogen mustard
Nitrogen mustard N-oxide
Nitromethane
1-Nitronaphthalene
2-Nitronaphthalene
3-Nitroperylene
2-Nitropropane
1-Nitropyrene
2-Nitropyrene
4-Nitropyrene
N'-Nitrosoanabasine (NAB)
N'-Nitrosoanatabine (NAT)
N-Nitrosodi-n-butylamine
N-Nitrosodiethanolamine
N-Nitrosodiethylamine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Nitrosodimethylamine
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
N-Nitrosodiphenylamine
para-Nitrosodiphenylamine
N-Nitrosodi-n-propylamine
N-Nitrosofolic acid
N-Nitrosoguvacine
N-Nitrosoguvacoline
N-Nitrosohydroxyproline
3-(N-Nitrosomethylamino)propionaldehyde
3-(N-Nitrosomethylamino)propionitrile
N-Nitrosomethylethylamine
N-Nitrosomethylvinylamine
N-Nitrosomorpholine

Group

Volume

Year

2A

94

2010

2B

73

1999

2B
3
2B
3
2B
3
3
3
2B
2B
3
2B
3
3
2B
2B
2A
2B
2B
3
3
3
2B
2B
3
2B
3
3
2B
2B

16, Sup 7
27, Sup 7
65
33, Sup 7
65
46
46
4, Sup 7
46
30, Sup 7
33, Sup 7
46
50
50
7, Sup 7
7, Sup 7
9, Sup 7
9, Sup 7
77
46
46
46
29, Sup 7, 71
46
46
46
37, Sup 7, 89
37, Sup 7, 89
17, Sup 7
17, Sup 7, 77

1987
1987
1996
1987
1996
1989
1989
1987
1989
1987
1987
1989
1990
1990
1987
1987
1987
1987
2000
1989
1989
1989
1999
1989
1989
1989
2007
2007
1987
2000

2A

17, Sup 7

1987

2A

17, Sup 7

1987

3
3
2B
3
3
3
3
3
2B
2B
2B
2B

27, Sup 7
27, Sup 7
17, Sup 7
17, Sup 7
85
85
17, Sup 7
85
85
17, Sup 7
17, Sup 7
17, Sup 7

1987
1987
1987
1987
2004
2004
1987
2004
2004
1987
1987
1987

CAS No
016543-55-8
064091-91-4
000100-75-4
007519-36-0
000930-55-2
013256-22-9
000088-72-2
000099-08-1
000099-99-0
000099-55-8
000804-36-4
118399-22-7

025038-54-4
000303-47-9
022966-79-6
002646-17-5

000523-44-4
001936-15-8
000604-75-1
000129-20-4

012174-11-7
012174-11-7
000794-93-4
000103-90-2
010048-32-5
000056-38-2
000149-29-1
000090-65-3
057465-28-8

057117-31-4
000076-01-7
000087-86-5
052645-53-1
000198-55-0

Agent
N'-Nitrosonornicotine (NNN) and 4-(NNitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
N-Nitrosopiperidine
N-Nitrosoproline
N-Nitrosopyrrolidine
N-Nitrososarcosine
2-Nitrotoluene
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)

Group

Volume

Year

89, 100E

in prep

2B
3
2B
2B

17, Sup 7
17, Sup 7
17, Sup 7
17, Sup 7

1987
1987
1987
1987

2A

101

in prep

Nitrotoluenes

65

1996

5-Nitro-ortho-toluidine
Nitrovin
Nodularins
Non-arsenical insecticides (occupational exposures in
spraying and application of)
Nylon 6
Ochratoxin A
Oestradiol mustard
Oestrogen (see Estrogen)
Oil Orange SS
Opisthorchis felineus (infection with)
Opisthorchis viverrini (infection with)
Oral contraceptives, combined estrogen-progestogen
(see Estrogen-progestogen oral contraceptives)
Orange I (see CI Acid Orange 20)
Orange G (see CI Orange G)
Oxazepam
Oxyphenbutazone
Painter (occupational exposure as a)
Paint manufacture (occupational exposure in)
Palygorskite (Attapulgite) (long fibres, > 5 micrometres)
Palygorskite (Attapulgite)(short fibres, < 5 micrometres)
Panfuran S (containing dihydroxymethylfuratrizine)
Paracetamol (Acetaminophen)
Parasorbic acid
Parathion
Patulin
Paving and roofing with coal-tar pitch (see Coal-tar pitch)
Penicillic acid
3,4,5,3,4-Pentachlorobiphenyl (PCB-126)
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
2,3,4,7,8-Pentachlorodibenzofuran
(NB: Overall evaluation upgraded to Group 1 based on
mechanistic and other relevant data)
Pentachloroethane
Pentachlorophenol (see Polychlorophenols)
Permethrin
Perylene

3
3
3

48
31, Sup 7
94

1990
1987
2010

2A

53

1991

3
2B
3

19, Sup 7
56
9, Sup 7

1987
1993
1987

2B
3
1

8, Sup 7
61
61, 100B

1987
1994
2011

2B
3
1
3
2B
3
2B
3
3
3
3
3

66
13, Sup 7
47, 98, 100F
47
68
68
24, Sup 7
73
10, Sup 7
30, Sup 7
40, Sup 7
92
10, Sup 7

1996
1987
in prep
1989
1997
1997
1987
1999
1987
1987
1987
2010
1987

100F

in prep

100F

in prep

41, Sup 7, 71
53, 71
53
92

3
3

1999
1999
1991
2010

CAS No
Agent
060102-37-6 Petasitenine
Petroleum refining (occupational exposures in)
Petroleum solvents
Pickled vegetables (traditional in Asia)
Phenacetin
000062-44-2 (NB: Overall evaluation upgraded to Group 1 with
supporting evidence from other relevant data)
Phenacetin, analgesic mixtures containing
000085-01-8 Phenanthrene
000136-40-3 Phenazopyridine hydrochloride
000156-51-4 Phenelzine sulfate
000103-03-7 Phenicarbazide
000050-06-6 Phenobarbital
000108-95-2 Phenol
000077-09-8 Phenolphthalein
000063-92-3 Phenoxybenzamine hydrochloride
000050-33-9 Phenylbutazone
000108-45-2 meta-Phenylenediamine
000106-50-3 para-Phenylenediamine
000122-60-1 Phenyl glycidyl ether
000135-88-6 N-Phenyl-2-naphthylamine
000090-43-7 ortho-Phenylphenol
000057-41-0 Phenytoin
105650-23-5 PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)
014596-37-3 Phosphorus-32, as phosphate
000213-46-7 Picene
001918-02-1 Picloram
000051-03-6 Piperonyl butoxide
007440-07-5 Plutonium
053973-98-1 Poligeenan (see Carrageenan, degraded)
009003-01-4 Polyacrylic acid
059536-65-1 Polybrominated biphenyls
001336-36-3 Polychlorinated biphenyls
Polychlorinated dibenzo-para-dioxins (other than 2,3,7,8tetrachlorodibenzo-para-dioxin)
Polychlorinated dibenzofurans
Polychlorophenols and their sodium salts (mixed
exposures)
009010-98-4 Polychloroprene
009002-88-4 Polyethylene
009016-87-9 Polymethylene polyphenyl isocyanate
009011-14-7 Polymethyl methacrylate
009003-07-0 Polypropylene
009003-53-6 Polystyrene
009002-84-0 Polytetrafluoroethylene
009009-54-5 Polyurethane foams
009003-20-7 Polyvinyl acetate
009002-89-5 Polyvinyl alcohol
009002-86-2 Polyvinyl chloride
009003-39-8 Polyvinyl pyrrolidone
003564-09-8 Ponceau 3R
003761-53-3 Ponceau MX

Group
3
2A
3
2B

Volume
31, Sup 7
45
47
56

Year
1987
1989
1989
1993

24, Sup 7,
100A

2011

1
3
2B
3
3
2B
3
2B
2B
3
3
3
2B
3
3
2B
2B
1
3
3
3
1

Sup 7, 100A
92
24, Sup 7
24, Sup 7
12, Sup 7
79
47, 71
76
24, Sup 7
13, Sup 7
16, Sup 7
16, Sup 7
47, 71
16, Sup 7
73
66
56
78, 100D
92
53
30, Sup 7
78, 100D

2011
2010
1987
1987
1987
2001
1999
2000
1987
1987
1987
1987
1999
1987
1999
1996
1993
in prep
2010
1991
1987
in prep

3
2B
2A

19, Sup 7
41, Sup 7
18, Sup 7

1987
1987
1987

69

1997

69

1997

2B

53, 71

1999

3
3
3
3
3
3
3
3
3
3
3
3
2B
2B

19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7
19, Sup 7, 71
8, Sup 7
8, Sup 7

1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987
1987

CAS No
004548-53-2
023746-34-1
007758-01-2
002955-38-6
029069-24-7
000053-03-2

000366-70-1

000051-02-5
001120-71-4
000122-42-9
000057-57-8
000627-12-3
000115-07-1
000075-56-9
000051-52-5
087625-62-5
000129-00-0
000110-86-1
085878-62-2
000058-14-0
000117-39-5
000106-51-4
000082-68-8

013233-32-4
013982-63-3
015262-20-1
010043-92-2
000050-55-5
000108-46-3
000480-54-6
1

Agent
Group
Volume
Ponceau SX
3
8, Sup 7
Potassium bis(2-hydroxyethyl)dithiocarbamate
3
12, Sup 7
Potassium bromate
2B
73
Prazepam
3
66
Prednimustine
3
50
Prednisone
3
26, Sup 7
Printing inks
3
65
Printing processes (occupational exposures in)
2B
65
Procarbazine hydrochloride
(NB: Overall evaluation upgraded to Group 2A with
2A
26, Sup 7
supporting evidence from other relevant data)
Proflavine salts
3
24, Sup 7
Progestins
2B
Sup 7
Progestogen-only contraceptives
2B
72
Pronetalol hydrochloride
3
13, Sup 7
1,3-Propane sultone
2B
4, Sup 7, 71
Propham
3
12, Sup 7
beta-Propiolactone
2B
4, Sup 7, 71
n-Propyl carbamate
3
12, Sup 7
Propylene
3
60
Propylene oxide
2B
60
Propylthiouracil
2B
79
Ptaquiloside
3
40, Sup 7
Pulp and paper manufacture
3
25, Sup 7
Pyrene
3
92
Pyridine
3
77
Pyrido[3,4-c]psoralen
3
40, Sup 7
Pyrimethamine
3
13, Sup 7
Quercetin
3
73
para-Quinone
3
15, Sup 7, 71
Quintozene (Pentachloronitrobenzene)
3
5, Sup 7
Radiofrequency electromagnetic fields1
2B
102
Radioiodines, including iodine-131
1
78, 100D
Radionuclides, alpha-particle-emitting, internally
deposited
1
78, 100D
(NB: Specific radionuclides for which there is sufficient
evidence in humans are also listed individually as
Group 1 agents)
Radionuclides, beta-particle-emitting, internally deposited
(NB: Specific radionuclides for which there is sufficient
1
78, 100D
evidence in humans are also listed individually as
Group 1 agents)
Radium-224 and its decay products
1
78, 100D
Radium-226 and its decay products
1
78, 100D
Radium-228 and its decay products
1
78, 100D
Radon-222 and its decay products
1
43, 78, 100D
Refractory ceramic fibres
2B
43, 81
Reserpine
3
24, Sup 7
Resorcinol
3
15, Sup 7, 71
Retrorsine
3
10, Sup 7

Includes radiofrequency electromagnetic fields from wireless phones

Year
1987
1987
1999
1996
1990
1987
1996
1996
1987
1987
1987
1999
1987
1999
1987
1999
1987
1994
1994
2001
1987
1987
2010
2000
1987
1987
1999
1999
1987
in prep
in prep

in prep

in prep
in prep
in prep
in prep
in prep
2002
1987
1999
1987

CAS No
000081-88-9
000989-38-8
023246-96-0
013292-46-1
026308-28-1

Agent
Rhodamine B
Rhodamine 6G
Riddelliine
Rifampicin
Ripazepam
Rubber manufacturing industry

023537-16-8 Rugulosin
Rock (stone) wool
008047-67-4 Saccharated iron oxide
Saccharin and its salts
000081-07-2 (NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
000094-59-7 Safrole
Salted fish, Chinese-style
000085-83-6 Scarlet Red
Schistosoma haematobium (infection with)
Schistosoma japonicum (infection with)
Schistosoma mansoni (infection with)
007782-49-2 Selenium and selenium compounds
000563-41-7 Semicarbazide hydrochloride
Semustine [1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1013909-09-6
nitrosourea, Methyl-CCNU]
000480-81-9 Seneciphylline
002318-18-5 Senkirkine
015501-74-3 Sepiolite
068308-34-9 Shale oils
000138-59-0
007631-86-9
014808-60-7
000122-34-9
007758-19-2
000148-18-5
000132-27-4

000052-01-7
010048-13-2
018883-66-4
007664-93-9
010098-97-2
000100-42-5
009003-54-7
009003-55-8

Shiftwork that involves circadian disruption

Shikimic acid
Silica, amorphous
Silica dust, crystalline, in the form of quartz or cristobalite
Simazine
Slag wool
Sodium chlorite
Sodium diethyldithiocarbamate
Sodium ortho-phenylphenate
Solar radiation
Soot (as found in occupational exposure of chimney
sweeps)
Special-purpose fibres such as E-glass and '475' glass
fibres
Spironolactone
Sterigmatocystin
Streptozotocin
Stress (see Volume 100)
Strong-inorganic-acid mists containing sulfuric acid (see
Acid mists)
Strontium-90 (see Fission products)
Styrene
Styrene-acrylonitrile copolymers
Styrene-butadiene copolymers

Group
3
3
2B
3
3

3
3
3

Volume
16, Sup 7
16, Sup 7
10, Sup 7, 82
24, Sup 7
66
28, Sup 7,
100F
40, Sup 7
43, 81
2, Sup 7

73

2B
1
3
1
2B
3
3
3

10, Sup 7
56, 100E
8, Sup 7
61, 100B
61
61
9, Sup 7
12, Sup 7

Year
1987
1987
2002
1987
1996
in prep
1987
2002
1987
1999
1987
in prep
1987
2011
1994
1994
1987
1987

Sup 7, 100A

2011

3
3
3

10, Sup 7
31, Sup 7
68
35, Sup 7,
100F
98
40, Sup 7
68
68, 100C
73
43, 81
52
12, Sup 7
73
55, 100D
35, Sup 7,
100F

1987
1987
1997

1
2A
3
3
1
3
3
3
3
2B
1
1

in prep
2010
1987
1997
in prep
1999
2002
1991
1987
1999
in prep
in prep

2B

81

2002

3
2B
2B

79
10, Sup 7
17, Sup 7

2001
1987
1987

2B
3
3

60, 82
19, Sup .7
19, Sup 7

2002
1987
1987

CAS No
000096-09-3
000108-30-5
000842-07-9
003118-97-6
000085-86-9
006416-57-5
006368-72-5
000127-69-5
000095-06-7
000057-68-1
000723-46-6
007446-09-5

Agent
Styrene-7,8-oxide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Succinic anhydride
Sudan I
Sudan II
Sudan III
Sudan Brown RR
Sudan Red 7B
Sulfafurazole (Sulfisoxazole)
Sulfallate
Sulfamethazine
(NB: Overall evaluation downgraded to Group 3 with
supporting evidence from other relevant data)
Sulfamethoxazole
Sulfites
Sulfur dioxide

000505-60-2 Sulfur mustard

002783-94-0

022571-95-5
014807-96-6
014807-96-6
014807-96-6
010540-29-1
001401-55-4
000846-50-4

Sunlamps and sunbeds (see Ultraviolet-emitting tanning

devices)
Sunset Yellow FCF
Surgical implants and other foreign bodies:
- Polymeric implants prepared as thin smooth film (with
the exception of poly(glycolic acid))
- Metallic implants prepared as thin smooth films
- Implanted foreign bodies of metallic cobalt, metallic
nickel and an alloy powder containing 66-67% nickel,
13-16% chromium and 7% iron
Surgical implants and other foreign bodies:
- Organic polymeric materials (as a group)
- Orthopaedic implants of complex composition
- Cardiac pacemakers
- Silicone breast implants
- Implanted foreign bodies of metallic chromium or
titanium and of cobalt-based, chromium-based and
titanium-based alloys, stainless steel and depleted
uranium
- Dental materials
- Ceramic implants
Symphytine
Talc containing asbestiform fibres (see Asbestos)
Talc not containing asbestos or asbestiform fibres
Talc-based body powder (perineal use of)
Tamoxifen
(NB: There is also conclusive evidence that tamoxifen
reduces the risk of contralateral breast cancer in breast
cancer patients)
Tannic acid and tannins
Tea
Temazepam

Group

Volume

Year

2A

60

1994

3
3
3
3
3
3
3
2B

15, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
8, Sup 7
24, Sup 7
30, Sup 7

1987
1987
1987
1987
1987
1987
1987
1987

79

2001

3
3
3

79
54
54
9, Sup 7,
100F

2001
1992
1992

in prep

8, Sup 7

1987

2B

74

1999

74

1999

31, Sup 7
42, Sup 7
42, Sup 7, 93
93

1987
1987
2010
2010

66, 100A

2011

3
3
3

10, Sup 7
51
66

1987
1991
1996

3
2B

CAS No
029767-20-2
008001-50-1
015721-02-5
001746-01-6
000630-20-6
000079-34-5
000127-18-4
022248-79-9
000116-14-3
000509-14-8
000083-67-0
000058-55-9
000062-55-5
000139-65-1
000052-24-4
000141-90-2
000062-56-6
000137-26-8
007440-29-1
013463-67-7

000108-88-3
026471-62-5
000095-53-4
089778-26-7
008001-35-2

Agent
Teniposide
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Terpene polychlorinates (Strobane)
2,2',5,5'-Tetrachlorobenzidine
2,3,7,8-Tetrachlorodibenzo-para-dioxin
1,1,1,2-Tetrachloroethane
1,1,2,2-Tetrachloroethane
Tetrachloroethylene (Perchloroethylene)
Tetrachlorvinphos
Tetrafluoroethylene
Tetrakis(hydroxymethyl)phosphonium salts
Tetranitromethane
Textile manufacturing industry (work in)
Theobromine
Theophylline
Thioacetamide
4,4'-Thiodianiline
Thiotepa
Thiouracil
Thiourea
Thiram
Thorium-232 and its decay products
Titanium dioxide
Tobacco, smokeless
Tobacco smoke, second-hand
Tobacco smoking
Toluene
Toluene diisocyanates
ortho-Toluidine
Toremifene
Toxaphene (Polychlorinated camphenes)
Toxins derived from certain Fusarium species (see
Fusarium)

000299-75-2 Treosulfan
000052-68-6
000817-09-4
000076-03-9
000545-06-2
000071-55-6
000079-00-5
000079-01-6
000096-18-4
000102-71-6
001954-28-5
001582-09-8
090370-29-9
000137-17-7
000088-05-1
003902-71-4
000118-96-7

Trichlorfon
Trichlormethine (Trimustine hydrochloride)
Trichloroacetic acid
Trichloroacetonitrile
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichloroethylene
1,2,3-Trichloropropane
Triethanolamine
Triethylene glycol diglycidyl ether
Trifluralin
4,4',6-Trimethylangelicin plus ultraviolet A radiation
2,4,5-Trimethylaniline
2,4,6-Trimethylaniline
4,5',8-Trimethylpsoralen
2,4,6-Trinitrotoluene

Group

Volume

2A

76

3
3
1
3
3
2A
3
2B
3
2B
2B
3
3
2B
2B
1
2B
3
3
1
2B
1
1
1
3
2B
1
3
2B

5, Sup 7
27, Sup 7
69, 100F
41, Sup 7, 71
20, Sup 7, 71
63
30, Sup 7
19, Sup 7, 71
48, 71
65
48
51
51
7, Sup 7
27, Sup 7
50, 100A
79
79
53
78, 100D
47, 93
89, 100E
83, 100E
83, 100E
47, 71
39, Sup 7, 71
77, 99, 100F
66
79

1
3
2B
3
3
3
3
2A
2A
3
3
3
3
3
3
3
3

26, Sup 7,
100A
30, Sup 7
50
84
52, 71
20, Sup 7, 71
52, 71
63
63
77
11, Sup 7, 71
53
Sup 7
27, Sup 7
27, Sup 7
40, Sup 7
65

Year
2000
1987
1987
in prep
1999
1999
1995
1987
1999
1999
1996
1990
1991
1991
1987
1987
2011
2001
2001
1991
in prep
2010
in prep
in prep
in prep
1999
1999
in prep
1996
2001

2011
1987
1990
2004
1999
1999
1999
1995
1995
2000
1999
1991
1987
1987
1987
1987
1996

CAS No
000217-59-4
000068-76-8
000545-55-1
000051-18-3
000115-96-8
038571-73-2
000126-72-7
000057-39-6
062450-06-0
062450-07-1
000072-57-1
012070-12-1
007440-48-4

000066-75-1
001314-62-1
000128-66-5
000143-67-9
002068-78-2
000108-05-4

000593-60-2

000075-01-4
009003-22-9
000100-40-3
000106-87-6

000075-02-5

000075-35-4
009011-06-7
000075-38-7
000088-12-0
025013-15-4
012001-79-5

013983-17-0

Agent
Triphenylene
Tris(aziridinyl)-para-benzoquinone (Triaziquone)
Tris(1-aziridinyl)phosphine oxide
2,4,6-Tris(1-aziridinyl)-s-triazine
Tris(2-chloroethyl) phosphate
1,2,3-Tris(chloromethoxy)propane
Tris(2,3-dibromopropyl) phosphate
(NB: Overall evaluation upgraded to Group 2A with
supporting evidence from other relevant data)
Tris(2-methyl-1-aziridinyl)phosphine oxide
Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole)
Trp-P-2 (3-Amino-1-methyl-5H-pyrido[4,3-b]indole)
Trypan blue
Tungsten carbide with cobalt metal (see Cobalt metal
with tungsten carbide)
Ultraviolet radiation (wavelengths 100-400 nm,
encompassing UVA, UVB, and UVC)
Ultraviolet-emitting tanning devices
Uracil mustard
Urethane (see Ethyl carbamate)
Vanadium pentoxide
Vat Yellow 4
Vinblastine sulfate
Vincristine sulfate
Vinyl acetate
Vinyl bromide
(NB: (1) Overall evaluation upgraded to Group 2A
based on mechanistic and other relevant data;
(2) For practical purposes, vinyl bromide should be
considered to act similarly to the human carcinogen
vinyl chloride.)
Vinyl chloride
Vinyl chloride-vinyl acetate copolymers
4-Vinylcyclohexene
4-Vinylcyclohexene diepoxide
Vinyl fluoride
(NB: (1) Overall evaluation upgraded to Group 2A
based on mechanistic and other relevant data;
(2) For practical purposes, vinyl fluoride should be
considered to act similarly to the human carcinogen
vinyl chloride.)
Vinylidene chloride
Vinylidene chloride-vinyl chloride copolymers
Vinylidene fluoride
N-Vinyl-2-pyrrolidone
Vinyl toluene
Vitamin K substances
Welding fumes
(NB: Volume 100D concluded that there is sufficient
evidence for ocular melanoma in welders)
Wollastonite
Wood dust

Group
3
3
3
3
3
3

Volume
92
9, Sup 7
9, Sup 7
9, Sup 7
48, 71
15, Sup 7, 71

Year
2010
1987
1987
1987
1999
1999

2A

20, Sup 7, 71

1999

3
2B
2B
2B

9, Sup 7
31, Sup 7
31, Sup 7
8, Sup 7

1987
1987
1987
1987

100D

in prep

1
2B

100D
9, Sup 7

in prep
1987

2B
3
3
3
2B

86
48
26, Sup 7
26, Sup 7
63

2006
1990
1987
1987
1995

2A

39, Sup 7,
71, 97

2008

1
3
2B
2B

97, 100F
19, Sup 7
60
60

in prep
1987
1994
1994

2A

63, 97

2008

39, Sup 7, 71
19, Sup 7
39, Sup 7, 71
19, Sup 7, 71
60
76

1999
1987
1999
1999
1994
2000

49

1990

3
3
3
3
3
3
2B
3
1

68
62, 100C

1997
in prep

CAS No

001330-20-7
000095-68-1
000095-78-3
000085-84-7
000131-79-3
007481-89-2
000315-18-4
001318-02-1
030516-87-1
012122-67-7
000137-30-4

Agent
Wood smoke (see Biomass fuel, indoor emissions from
household combustion)
X- and Gamma-Radiation
Xylenes
2,4-Xylidine
2,5-Xylidine
Yellow AB
Yellow OB
Zalcitabine
Zectran
Zeolites other than erionite (clinoptilolite,
phillipsite,mordenite, non-fibrous Japanese zeolite,
synthetic zeolites)
Zidovudine (AZT)
Zineb
Ziram

Last update: 17 June 2011

Group

1
3
3
3
3
3
2B
3
3
2B
3
3

Volume

75, 100D
47, 71
16, Sup 7
16, Sup 7
8, Sup 7
8, Sup 7
76
12, Sup 7

Year

in prep
1999
1987
1987
1987
1987
2000
1987

68

1997

76
12, Sup 7
53

2000
1987
1991