Human Metabolism Bilirubin-diglucuron 2. Main Map Glycosaminoglyc Per Hellung Larsen & Jens Dilling Lundgren & Lars Helleberg & Mogens Sandbjerg Hansen = 7 © Munksgaard 1987 UDP-Glucuronate — 13 Purine joe SR ade SATE S'ADP!" S'AMP<—5'IMP fae sre pace >) 184 “ATP Of MO arte Norse -GTP 2d05ADP yp age, Gu NORRIE STP” S'GOP™S GMP 6 XMP cone 8 DNA CTP ower ae 5-P-Ribosyl+1 -ai -TTp 2'de5’GDP 2p FPG Glycerol =< Ke ATP NADH a tis =| HsCoa Sos a = "7 a meee ysophosphatidate}-#Phosphatid Betaine ; ees Acetate Acety/-CoA , Choline 7 P Choline CDP-Choli 3~CHa | cre PP-ePLipoproteins ceride are Phosphoglycerides Apoproteins Phosphatidyl—inositol Speen: Fide ») Diphosphatidyl-glycerol Sphingomyelin Phosphatidyl-choline Gangliosides | A (Lecithin) Yeon Additional SY Phosphatidyl-ethanolamine {ier fdjesarine lm Cerebrosides . Phosphatidyl-serine ceride te OMP (inositol Sal uoe \ ome bin Pathway oe Ethenolamine Glucose or cr Serine galactose ate i> CDP-Diacylglycerol °” a ‘e-diaveenee“ " N—Acylsphingosine B HSCOA in | Acyl-Can Sphinaosineau “* 140 AIP Prrinian oyto ar ree CDP amas | RR GTP S'UTP _S'UDP S'UMP=—>—5'Orolidylate RNA cre ae Zz f is “si eA Orotate = or oom 2'eS'UDP oa Me N vad THEA 2'deS'TDP 2 det TMP Coan (de)Nucleotide ‘HzO 137 9 ? TH Phenylalanine (de) (de) (de) Ge) nama AdenosineGuanosine Cytidine Thymidine wox—Phenylpyruvate Ls = Heo Phenjladtateh co ie 4 int iis Melanin- (de) (de) Phenylacetate iene BL __-_-Uridine____| > er no Fmt nate oes athe me By iy Be ye! Fao Guanine Uracil = Thymine staniaine: #20 3 A~—Dihvdroxyml — ome Pp cl i Cs Soy ‘Ge Cs a= P- Giycerate-t'*° i Xylulose-5 -P 55 | Solace wo ‘ mG 2-P-Glycerate\ > P-C hydro- ,, Carbamoyl- i 3 20 : otae 7 aspartate ayo — ? Glycerate: Phosphoenolpyruvate Aspartate ig AM 2 i, mop Ht Carbamoyl-P==<— C02 Pyruvate <= C wap o — > HP ator air me oe ~<—+Tyrosine ——+ Thyroxine sort | Lactate Hydroxyett as tHe yor PyidoxaP cor . (eon N DHPAAHO Cytosel ip | Cofactor: Biotin em 182 -+—+-Dopa p-Hydroxyphenylpyruvate eae 4 Oxaloacetate 2 7 foo . Hombaettate 122 Dopamine 8 NADH Os 4-| Maleyl- Malate "ce" Citrate He acetoacetate a a sy = Norepinephrine ee ‘Aconina ‘H2O I~ ____» Fumarate _/ Woradrenaiine)Ethanolamine 7 P-Ethanolamine cOz air Pyridoxal-P H-Pyruvate > P-Serine ~ CDP-Ethar CIP PP~2P Pyridoxal-P _ ies Y -OH-| Pate serine <= — yore joacrylate “© ee ead Threonine COz 2 ai Aminoacetone +s ry Cysteine ~-+++ Methionine 8 _ > e Alanine de FADH2 s40 Lipoamideved) SCOAtATP. Transport as citrate ie Reaured at the FEA-synihesis, Acetyl-CoA ~ “Kwek & Se. 2 Canines Lipoamidetox) wi 4 — tpoamide XC akddinde ra > CDP-Serin CIP PP~aP Acyl-CoA ' He Buturyl-ACP ---- 3° A naora Crotonyl-ACP Cytosol — gay | D-3-Hydroxybuty: FRA-synthesis NADPH Acetoacetyl-ACP- s4gf-COmacr ‘Only during the first cycle Acetyl-ACP Malonvi-ACPolamine COztHSCoA Serine e 10 . 12 Palmitoyl-CoA 7 Linolate . . Fatty acids------— . ———— Eicosanoids (FFA) Linolenate ie (Essential unsaturated fatty acids) 8 anna Acyl-AMP The names of a RCA cytosa the metabolites refer AMP ot scene, joe Acyl-CoA — Gaupat ode ie. first cycle of events i we ' ' > Neate eenoncria ' yI-ACP! a | Enoyl-CoA : 1 He FFA~catabolism } ! i (p-ouidation! SSS ad 402) | Hydroxyacyl-CoA ' It sor [SNADH ' ; Ketnaryl—CoA.ta ee a Dihydrothymine phenyiglycol- “8° yanthine { aldehyde yy = Stl 3» ‘| a-Amino acids Keto acids Arginine~ 2 < 47) 8879. ny aaCHa evewevsay FADH? Oitrie acid cycle 4 ‘HO Epinephrine 179 , ToA-cyole } (Adronaine) Acetoacetate Succinate ,,, Isocitrate scan STAT (craton: 209K op Catecholamines 160 TPP, Uipoamide, 0 i ti Cofactor: Cobatanin= Succinyl-CoA "Se" 2 Oxalosuccinate Methyl-malonyl- vt 82 a y 119, (8 “CoA cosnan”~ g—Ketoglutardte~ co: HSCOA nat 73, ; NADH or Glutan gine 2 B-Amino— 77 | aor (GluNH GlutAMPHPP-2P butyrate Heo nn GhNHZ+ATP a) Fyridosa-P me Aspartate «—> Oxaloacetate A ahuttag ie ee /ATP4+NADPH x Pyridoxat-P Glutamate semialdehyde=2— 23 auptep=2P Argininosuccinate 0 Glycine A’-Pyrrolin—5 -carboxylate 2 Fumarate Hemoglobin NADPH Myoglobin 8508 4 esas 7 Mie Aialaataetes Dralinger Used ating So all cycles Malonyl-CoA Melatonin % 5—Hydroxy- tryptamine ea C02 Estra A iaiaig a | tryptophan ye Histamine IS) I 4 Tryptophan———\—__ 425-Dihycr coe iysi ivalnenstiicBod cholecalcife! a ysine cetoacetyl-Co, — Histidine / : Kidney \_ as Phenylalanine~Tyrosine-_\———» acca Ketogenic amino acids Drnithine-<— Arginine | ytine*™ li 25 sas Coe? che a-Ketoisocaproate Cofactors: Beil tie S FOHNAOH 0 Isovaleryl-CoA _ QO iecen Fea” Aoyl-CoA "i P 450 diol «Testosterone Estrone Aldosterone Testes Ovary Adrenal cis + a ca | a Androstendione Corticosterone oxy- P 480 ol 17-Hydroxy- * *° Cortison «—— Cortisol <— progesterone *— Progesterone . Cay Adtenal Cn fase Ca Uterus and * ‘corpus luteum “Htanye setae Pregnenolone slecalciferol I si iver 200,22- ea Dihydroxy- Cholecal- 7 -Dehydro- cholesterol ciferol cholesterol { en (Vit Dab Squalene ~~.» CholesterolSee (Mm. FAD FADH? Amines General reectons a o (Cys-taurine, his~histamine, dopa-dopatine, for anino acios m hydroxy-trpserotonn, lutamate~GABA) Creatine. Orn: G Acylglycine Cyclic AMP aed a Cre HSCoA. (cAMP) HO a 7 a Guanidinoacetat HSCoA ? ai = ATP S'AMP —-HSCoA ycine oe NADEH id P 450 axifications 467 pp=2p Fer re 4 NADP* FAD sp ° edn ai ee 00r Biliverdi ATP. are a PH = NADt TPP FMN crescye Bilirubin apo ° Me ATP ATP AP aed SOF... Niacin Thiamine Riboflavin Panthothenate aee+a-Ketogiutarate Oeaus ding snbesi 164 Her proline is incorpore coxsuccnate he peptide chain Npeptces P-Creatine Heme 64 Agee Protoporphyrin 18 Hydroxyproline Methionine home 2002 s 4 Smnbesis : ‘oproporphyrinogen 1 Coproporphyrinogen | | _stethyimalonyl-CoA pape Cytochromes — reptiaes | $27 ~<+—+— Valine — Catalase «2 Uroporphyrinogen D-Methylmalonyl-CoA Peroxidase Nt 165 Tetrapyrrole EE: 1) Hone citaboase 3 Hi tonne Isoleucine —- Threonine Porphobilinogen sete 2H HSCoA ws en $“Aminolevulinate ee -diglucuronide Propionyl-CoA iomonige. HSCaA, y-Ketobutyr @ pigments co: / ye NADH. T 5 6FADHe p-Methylcrotonyl-CoA bP §-Adenosyl-2, S-Adenosyl— ATP#GOe\ Gofactor: = > methionine ... s« homocysteine es (~CHs) (SAM) _ eg = i oe B-Methyl-glutaconyl _ am ‘Adenosine af collagen ied into Homocysteine Serine Pyridoxal-P- @ Kuo ‘ Cystathionine sucen Cystine 2 a 2 (ayearP) NADPH 63 - Homoserine C stein Ze Glutathione =—— 2 Glutath y 2(6-Giu+ ATP) fox) 2HO HO: 02 Ged) Qxidative phospherylation : Mitochondria ATP ATP. NADH+H*\, ” FMI sy oi cyt brady Er oat 2)\ Cyt ay al NAD* FMNHeACoQio *Scyt bi)A Cyt cht3) Accyt oft2)Acyt al 2m 2 Ht aC3 Car cis Cle cio Gs : : Trihydroxy- G BoHydroxy-B- aor Nappi M a4 — |sopentenyl- coprostanoate - methyl-glutary!= ——~ evalonate s—» rophosphate CoA 105 HSCoA. ae COz Py 7 = Cholate 4 Acetoacetate + NADH 109 "ATP -H rca Ne oe utyrate Choly-CoA Cysteine ione ‘Ketone bodes a Mitochondria, mainly in the liver COr Glycine Taurine H ATP. HSCoA HSCoA +2) Cyt att3)N¥ Cutt) \/ 1/2 02 +3) 7 Cyt aa(t 2)“ Cult+)“ 0 aw H20 Glycocholate Taurocholate| Bie saitsia felt Jovosielins. 8 a