Proceedings International UFRJ Workshop & 34 GIRI Dec 2021

V INTERNATIONAL WORKSHOP ON HOMEOPATHY OF UFRJ &
XXXIV GIRI - Groupe International de Recherche sur I’Infinitésimal
The scientific evidences of

homeopathy in health care
DECEMBER, 2-4, 2021

UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (UFRJ)
RIO DE JANEIRO, BRAzIL
PROCEEDINGS
The scientific evidences of

homeopathy in health care
DECEMBER, 2-4, 2021
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (UFRJ)
RIO DE JANEIRO, BRAzIL
PROCEEDINGS
~2021~
R61 International Workshop Homeopathy (5. : 2021 : Rio de Janeiro, RJ) ; XXXIV GIRI -
Groupe International de Recherche Sur I’infinitésimal (34. : 2021 : Rio de Janeiro)
Proceedings [electronic resource] / Organizing committee Carla Holandino, Maria
Olga Kokornack. – Rio de Janeiro : Farmácia Universitária da UFRJ, 2021.
ISBN 978-65-81152-38-3
1. Homeopathy. I. Groupe International de Recherche Sur I’infinitésimal (34. : 2021 :
Rio de Janaeiro). II. Title.
CDD (23. ed.) 615.532
Tatyane Barbosa Philippi - Bibliotecária CRB 14/735

Organizing Committee Moderators of Round Tables
Carla Holandino Adalberto von Ancken (UNIP)
COORDINATION OF THE V IWH (INTERNATIONAL
WORKSHOP ON HOMEOPATHY) OF THE UFRJ
Adriana Passos Oliveira (FF/UFRJ)
Carla Holandino (FF/UFRJ)
Maria Olga Kokornack
PRESIDENT OF XXXIV GIRI (GROUPE INTERNATIONAL
Cideli de Paula Coelho (UNISA)
DE RECHERCHE SUR L’INFINITÉSIMAL) Janaíne Martins (UFRGS)
Jose Carlos Tavares (UNIFAP)
Leoni Villano Bonamin (UNIP)
Scientific Coordination
Nina Claudia Barboza (FF/UFRJ)
Carolina Oliveira (UFPR) Vânia Emerich Bucco (FF/UFRJ and UEZO)
Vânia Emerich Bucco (FF/UFRJ and UEZO)
General Committee
Leoni Villano Bonamin (UNIP)
Daniela Beier (FF/UFRJ)
Fortune Homsani (FF/UFRJ)
Scientific Committee
Juliana Patrão de Paiva (FF/UFRJ)
Adriana Passos Oliveira (FF/UFRJ) Michelle Nonato de Oliveira Melo (FF/UFRJ)
Ana Paula Santos Matos (FF/UFRJ) Vânia Emerich Bucco (FF/UFRJ and UEZO)
Camila Monteiro Siqueira (IFRJ/Pinheiral)
Support Team
Carolina de Oliveira (UFPR)
Cideli de Paula Coelho (UNISA) Isabelle Alcântara (PIBIC/EM/UFRJ)
Juliana Patrão de Paiva (FF/UFRJ) João Vítor da Costa Batista (VFK/CH)
Jose Carlos Tavares (UNIFAP) Maria Luiza Honório (FF/UFRJ)
Leandro Machado Rocha (FF/UFF)
Leoni Villano Bonamin (UNIP) Funding Agency
Marina das Neves Gomes (IFRJ/RJ) CAPES, Edital PAEP (Grant Number
Michelle Nonato de Oliveira Melo (FF/UFRJ) 88887.470551/2019-00)
Nina Claudia Barboza (FF/UFRJ)
Ubiratan Cardinalli Adler (UFSCar/SP)
Vânia Emerich Bucco (FF/UFRJ and UEZO)
contents
W E LC OM E M E S S AG E S .................................................................................................................................................................................................................................... 11
S C I E N T I F I C P RO G R A M ............................................................................................................................................................................................................................ 15
E V E N T S A N D SP E A K E R S
P R E - E V E N T C O U R SE S
Epidemiology for “Normal People”......................................................................................................................................................................................................................................23
Edgar Vilhena
Introduction to Floral Therapy....................................................................................................................................................................................................................................................23
Sheila Garcia and Janaíne Martins
Homeopathic Pharmaceutical Prescription...........................................................................................................................................................................................................23
Rinaldo Ferreira
SP E A K E R N OT E S AT OP E N I N G C ON F E R E N C E
Scientific Basis of Homeopathic Medicine...............................................................................................................................................................................................................23
Khurana, A
Integration of homeopathy in the healthcare system in India................................................................................................................................................24
Raj Kumar Manchanda
A B ST R AC T C ON F E R E N C E S
Experiences of New Homeopathic Industry (Bonaireswiss AG) in Switzerland......................................................................................25
Buchi, DF.
The future of homeopathy in the Brazilian industry and worldwide..........................................................................................................................25
Viriato, EP.
Scientific Evidence in Homeopathy – The Evidence Map...............................................................................................................................................................25
Bonamin, LV.
Homeopathy on COVID-21 - Results of the ABRAH Covid-21 Protocol..............................................................................................................26
Xavier, MF.
Series of experiments performed with the droplet evaporation method on low potencies...................................................26
Maria Olga Kokornaczyk, Sandra Würtenberger and Stephan Baumgartner
Perspectives of Homeopathic Industry in the World..............................................................................................................................................................................26
Mennet, M.
Homeopathic treatment of Autism on the children psychosocial care center Taboão da Serra – SP....................26
Gosik, MS.
Can Nosodes be potential candidates of Immunization and Immunomodulation?..........................................................................27
Shah, R.
Recommendations for fundamental research into homeopathic preparations........................................................................................27
Alexander L. Tournier and Stephan Baumgartner
Homeopathy in primary care – the Petropolis case..................................................................................................................................................................................27
Kalile, R.
Investigating homeopathic potencies using solvatochromic dyes – history and development.......................................28
Cartwright, SJ.
A fresh look at the concept of Genus Epidemicus: findings from the Clificol Project.....................................................................28
Alexander Louis Tournier, Yuen Ying Yvonne Fok and Robbert van Haselen
SP E A K E R N OT E AT C LO SI N G C ON F E R E N C E
Homeopathy and Ecology....................................................................................................................................................................................................................................................................29
Leonel, AH.
SP E A K E R S A N D M ODE R ATOR S
Adriana Passos Oliveira.................................................................................................................................................................................................................................................................................29
Alexander Tournier...............................................................................................................................................................................................................................................................................................29
Alexandre Henrique Leonel..................................................................................................................................30
Anil Khurana....................................................................................................................................................................................................................................................................................................................30
Carla Holandino..........................................................................................................................................................................................................................................................................................................30
Cideli Coelho.....................................................................................................................................................................................................................................................................................................................30
Dorly Buchi..........................................................................................................................................................................................................................................................................................................................30
Edgard Vilhena.............................................................................................................................................................................................................................................................................................................31
Ezequiel Paulo Viriato......................................................................................................................................................................................................................................................................................31
Fortune Homsani.......................................................................................................................................................................................................................................................................................................31
Francisco José de Freitas...............................................................................................................................................................................................................................................................................31
Janaíne Martins............................................................................................................................................................................................................................................................................................................32
Jane Manfron Budel..............................................................................................................................................................................................................................................................................................32
Leandro Machado Rocha.............................................................................................................................................................................................................................................................................32
Leila Mourão.....................................................................................................................................................................................................................................................................................................................32
Leoni Bonamin..............................................................................................................................................................................................................................................................................................................32
Luciana Lobo.....................................................................................................................................................................................................................................................................................................................33
Maria Filomena Xavier....................................................................................................................................................................................................................................................................................33
Maria Olga Kokornaczyk.............................................................................................................................................................................................................................................................................33
Maria Solange Gosik............................................................................................................................................................................................................................................................................................33
Mónica Mennet-von Eiff...............................................................................................................................................................................................................................................................................34
Raj K. Manchanda....................................................................................................................................................................................................................................................................................................34
Rajesh Shah.........................................................................................................................................................................................................................................................................................................................35
Raquel Kalile.....................................................................................................................................................................................................................................................................................................................35
Rinaldo Ferreira..........................................................................................................................................................................................................................................................................................................35
Sheila Garcia......................................................................................................................................................................................................................................................................................................................36
Stephan Baumgartner.......................................................................................................................................................................................................................................................................................36
Steven Cartwright.....................................................................................................................................................................................................................................................................................................36
Ubiratan Cardinalli Adler..........................................................................................................................................................................................................................................................................36
Yvonne Fok...........................................................................................................................................................................................................................................................................................................................37
OR A L P R E SE N TAT ION A B S T R AC T S
XXXIV GIRI ABSTRACTS
FIRST SESSION: BASIC RESEARCH AND HOMEOPATHY................................................................................39
Series of experiments performed with the droplet evaporation method on low potencies....................40
Maria Olga Kokornaczyk, Sandra Würtenberger and Stephan Baumgartner
In vitro evaluation of the effects of Viscum album homeopathic preparations

on murine melanoma cells..............................................................................................................................................................................................................................................................41
Priscila Inhauser Baltuille do Prado, Carla Holandino, Stephan Baumgartner, Thaís Cristina da Silva, Leoni Villano
Bonamin and Elizabeth Cristina Pérez Hurtado
Viscum album L. homeopathic mother tinctures: metabolome and antitumor activity...............................42

Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Rafael Garrett, Patrícia Zancan, Alan Clavelland Ochioni,
Mirio Grazi, Hartmut Ramm, Tim Jäger, Stephan Baumgartner and Carla Holandino
Homeopathy on cultures of Saccharomyces cerevisiae and impact on fermentation....................................................43

Vinícius Crescêncio Queiroz, Roberto Lopes de Almeida, Susana Nogueira Diniz, Tânia Aguiar Passeti
and Audrey de Souza Marquez
XXXIV GIRI ABSTRACTS ............................................................................................................................................................................................................................................................44

SECOND SESSION: BIOLOGICAL MODELS.................................................................................................................................................................................................................44
Exposure of Artemia salina to glyphosate and bioremediation by isotherapy...................................................................45

Mirian Nagai, Andreia Pinto, Adalberto Von Ancken, Ednar Coimbra, Sandra Pinto, Suham Nowrooz,
Ivana Sufredini, Maria Martha Bernardi and Leoni Bonamin
Neurobehavioral assessment of Danio rerio intoxicated by Mercury and

the use of Mercurius solubilis .................................................................................................................................................................................................................................................46
Marco Aurélio Gonçalves Manzoli, Rafael Acordi Santos, Elaine Bido, Henrique Carvalho Vieira
and Cideli de Paula Coelho
Effect of homeopathy on soybean germination through soil and seed treatment......................................................47

Monica Filomena Assis de Souza, Kácio Gomes de Macedo, David Junior de Oliveira Pereira,
Leonardo Américo Souza Barbosa, Graciela Andreia Flis Machado, Pedro Henrique de Souza Cucco,
Marco Antonio Cucco and Karine Bonucielli Brum
Evaluation of homeopathy effects associated with conventional periodontal therapy

in randomized treatment of diabetic and non-diabetic patients with periodontitis............................................48
Leila Mourão, Miriam Alhanathi, Romeu Carillo J, Antonio Canabarro and Carla Holandino

THIRD SESSION: GENERAL RESEARCH........................................................................................................................................................................................................................49
Practical teaching of pathophysiology to LAFFH at the IPD outpatient clinic
of FMP/FASE: Historical Report.........................................................................................................................................................................................................................................50
Claudio Hansel Martins, Victor Tito Sperduto, Roberta Malher Bernardo, Thaís Ferreira do Espírito Santo Pires
and Marcia Cristina Braga Nunes Varricchio
NMR analysis: potential and challenges as a homeopathic basic research tool...............................................................51

Carla Holandino, Daniela Wendhausen Beier, Míriam Fragoso, Cintia Sias Coube Bastos, Vânia Emerich Bucco
de Campos, Adriana Passos Oliveira, Júlia Neves dos Santos, Lucas Henrique Silva and Ana Paula Canedo Valente
Characterization of physicochemical markers for homeopathic medicines

and biological supernatant samples............................................................................................................................................................................................................................52
Sandra Augusta Gordinho Pinto, Ana Carla Aparicio, Jefferson Souza, Suham N Mohammad,
Ivana B Suffredini, Steven J Cartwright and Leoni Villano Bonamin
Heteroisotherapic effects on the treatment against smoking: a cognitive

behavioral approach.....................................................................................................................................................................................................................................................................................53
Mary Lannes Salles Leite, Fortune Homsani, Juliana Patrão de Paiva, Rafael Tritany, Carla Holandino
and Adriana Passos Oliveira
P O S T E R P R E SE N TAT ION A B S T R AC T S
SCIENTIFIC RESEARCH PRESENTATION
FIRST SESSION: CLINICAL STUDIES..................................................................................................................55
Control of Rhipicephalus microplus ticks in dairy cattle using homeopathic therapy.......................................56

Lucas Seikichi Nascimento Oshiro, Elton Bock Correa, Mônica Filomena Assis de Souza, Marco Antonio Cucco,
Pedro Henrique de Souza Cucco, Raquel Soares Juliano and Karine Bonucielli Brum
Evaluation of the effectiveness of Arnica montana 4 CH in the control of

postoperative myalgia by isometric effort in dentistry........................................................................................................................................................57
Rosy de Oliveira Nardy, Adriana Marques Nunes, Leonardo dos Santos Barroso and
Cristina Garani Schneider Guimarães
The use of homeopathy and flower therapy as an aid in the treatment of

climacteric symptoms: an integrative review...........................................................................................................................................................................................58
Camila Faria de Amorim Pereira and Adriana Passos Oliveira
Lycopodium as a treatment for Urate Deposition (gout) in birds: case report....................................................................59

Cideli de Paula Coelho, Adalberto Von Ancken and Sonia Regina Pinheiro
Evolution of clinical symptoms of Covid-21 in healthcare professionals treated

with China officinalis...................................................................................................................................................................................................................................................................................60
Maria Solange Gosik, Maria Filomena Xavier Mendes, Leticia Marilia de Almeida Werneck dos Santos,
Danielle da Silva Barbas, Domingos José Vaz do Cabo, Hristos Strastis, Isabella Sebusiani Duarte Takeuti,
Leila Cristina dos Santos Mourão, Luciana Valentini de Melo, Renata Rodrigues Garcia Lino,
William Brunelli, Adriana Passos Oliveira, Paulo de Oliveira and Romeu Carillo Jr.

SECOND SESSION: CHEMICAL AND PHYSICAL STUDIES...........................................................................................................................................................61
Wine preservation using potassium metabisulphite high dilution: a preliminary study............................62

Joni Stolberg, Ketlin Schneider, Wilson Taybar Assumpção and Pedro Boff

THIRD SESSION: HOMEOPATHIC TEACHING AND PRACTICE.......................................................................................................................................63
Comparative analysis for quality control of mother tinctures in Brazilian reports................................................64

Hayla da Silva Pinheiro, Andréa Durão Neves, Gleyce Moreno Barbosa and Vânia Emerich Bucco de Campos
Teaching and practice in Homeopathy via pharmacobotany and pathophysiology...............................................65

Claudio Hansel Martins, Patrícia Musmanno, Sandra Ávila Gaspar, Josiane Bentes, Rosana Ximenes,
Denise Nagamatsu, Fábio Tavares, Fabio Bolognani and Marcia Cristina Braga Nunes Varricchio
La Gioconda Effect, Homeopathy and Self-Organizing Factors of Biofield methodology.........................66

Silvio Leite Monteiro da Silva
Lycopodium clavatum as a homeopathic treatment in Magellanic

penguins (Spheniscus magellanicus)...........................................................................................................................................................................................................................67
Franscinne Brait Narita, Hugo Gallo and Cideli de Paula Coelho
Analysis of homeopathic remedies prepared at UFRJ University Pharmacy in 2.016........................................68

Lucas Fernandes Muniz da Silva, Fortune Homsanie and Adriana Passos Oliveira
In vitro evaluation of Sporothrix brasiliensis biotherapic...............................................................................................................................................69

Amanda Ribeiro Ricardo Brito, Lais Cavalcanti dos Santos Velasco de Souza, Andrea Regina de Souza Baptista,
Leandro Machado Rocha and Gleyce Moreno Barbosa

FOURTH SESSION: IN VITRO STUDIES...........................................................................................................................................................................................................................70
Macrophage activity regulation by high dilution of aspirin and its possible mechanism..........................71
Adalberto do Carmo Braga von Ancken, Francisco Eizayaga and Leoni V. Bonamin
Homeopathic medicine activity on the growth of Gram-negative bacteria..............................................................................72

Everton Tadeu Prado, Tania Aguiar Passeti, Susana Nogueira Diniz and Audrey de Souza Marquez
Carcinosinum produces phenotypic changes of 4T-1 tumor cells in vitro..................................................................................73

Thaís Cristina da Silva, William Alves dos Santos, Sandra Augusta Gordinho Pinto, Elizabeth Cristina Perez
Hurtado and Leoni Villano Bonamin
Evaluation of the in vitro fungicidal activity of the dynamized essential

oil of Aloysia polystachya before and after freezing....................................................................................................................................................................74
Talita Thomaz Nader, Camila Yamasita Henrique, Alexandre Henrique Leonel and Ana Maria Soares Pereira
Environmental parameters modulate lead chloride toxicity on Artemia salina.............................................................75

Suham Nowrooz Mohammad, Andreia Adelaide Gordinho Pinto, Mirian Yaeko Nagai, Ednar Nascimento Coimbra,
Ivana Barbosa Suffredini, Giovani Bravin Peres, Maria Martha Bernardi and Leoni Villano Bonamin

FIFTH SESSION: IN VIVO STUDIES.........................................................................................................................................................................................................................................76
Stress - another possible mechanism of neurotoxicity in neurodegenerative diseases....................................77

Maria Filomena Xavier Mendes, Paulo de Oliveira, Maria Solange Gosik, Renata Garcia Lino,
Raquel Bruno Kalile, Danielle da Silva barbas and Romeu Carillo Jr.
Effect of homeopathy on quality of corncobs naturally exposed to sugarcane virus............................................78

Mônica Filomena Assis de Souza, Kácio Gomes de Macedo, David Junior de Oliveira Pereira, Graciela Andreia Flis
Machado, Leonardo Américo Souza Barbosa, Larissa Wolff Gonçalves, Pedro Henrique de Souza Cucco, Marco Antonio
Cucco and Karine Bonucielli Brum
Influence of homeopathy on the quality of eggs stored for different periods of time.........................................79
Monica Filomena Assis de Souza, Wellington dos Santos, Jean Kaique Valentim, Rodrigo Garófallo Garcia,
Maria Fernanda de Castro Burbarelli, Felipe Cardoso Serpa, Gisele Aparecida Felix, Gabriella Galvão Pizarini do
Nascimento, Bruna de Souza Eberhart, Pedro Henrique de Souza Cucco, Marco Antonio Cucco
and Karine Bonucielli Brum
High Dilution in Dyslipidemia treatment in Dogs and Rabbits.......................................................................................................................80

Bruna Scardoeli and Cideli de Paula Coelho
H ON OR A B L E M E N T ION
FIRST SESSION: CLINICAL STUDIES
Evaluation of the effectiveness of Arnica montana 4 CH in the control of

postoperative myalgia by isometric effort in dentistry........................................................................................................................................................82
Rosy de Oliveira Nardy, Adriana Marques Nunes, Leonardo dos Santos Barroso
e Cristina Garani Schneider Guimarães
SECOND SESSION: CHEMICAL AND PHYSICAL STUDIES

Wine preservation using potassium metabisulphite high dilution: a preliminary study............................82
Joni Stolberg, Ketlin Schneider, Wilson Taybar Assumpção and Pedro Boff
THIRD SESSION: HOMEOPATHIC TEACHING AND PRACTICE..........................................................................................................83

Analysis of homeopathic remedies prepared at UFRJ University Pharmacy in 2.016........................................83
Lucas Fernandes Muniz da Silva, Fortune Homsani and Adriana Passos Oliveira
FOURTH SESSION: IN VITRO STUDIES.......................................................................................................................................................................................................83

Carcinosinum produces phenotypic changes of 4T-1 tumor cells in vitro..................................................................................83
Thaís Cristina da Silva, William Alves dos Santos, Sandra Augusta Gordinho Pinto,
Elizabeth Cristina Perez Hurtado and Leoni Villano Bonamin.
FIFTH SESSION: IN VIVO STUDIES.......................................................................................................................................................................................................................84

Effect of homeopathy on soybean germination through soil and seed treatment...................................................................84
Monica Filomena Assis de Souza, Kácio Gomes de Macedo, David Junior de Oliveira Pereira,
Leonardo Américo Souza Barbosa, Graciela Andreia Flis Machado, Pedro Henrique de Souza Cucco,
Marco Antonio Cucco and Karine Bonucielli Brum
B E S T WOR K P R I Z E S
V INTERNATIONAL WORKSHOP ON HOMEOPATHY OF UFRJ.............................................................................................................86
Lycopodium clavatum as a homeopathic treatment in
Magellanic penguins (Spheniscus magellanicus)...............................................................................................................................................................................86
Franscinne Brait Narita, Hugo Gallo and Cideli de Paula Coelho
XXXIV GIRI - GROUPE INTERNATIONAL DE RECHERCHE SUR I’INFINITÉSIMAL...........................86

Viscum album L. homeopathic mother tinctures: Metabolome and antitumor activity...............................86
Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Rafael Garrett, Patrícia Zancan,
Alan Clavelland Ochioni, Mirio Grazi, Hartmut Ramm, Tim Jäger, Stephan Baumgartner and Carla Holandino
AC K N OW L E D G M E N T S ................................................................................................................................................................................................................................... 87
F I NA N C IA L SU P P ORT S .............................................................................................................................................................................................................................. 88
I N S T I T U T I ONA L SU P P ORT S .............................................................................................................................................................................................. 91

Welcome
messages
12
V INTERNATIONAL WORKSHOP ON HOMEOPATHY OF UFRJ
PROCEEDINGS
XXXIV GIRI - GROUPE INTERNATIONAL DE RECHERCHE SUR I’INFINITÉSIMAL
Welcome to the
V International Workshop
on Homeopathy
The V International Workshop on Homeopathy of UFRJ (IWH) is an academic event dedicated to stu-
dents and professionals from different fields of knowledge: pharmacists, biologists, physicians, veteri-
narians, chemists, physicists, etc. Homeopathy is recognized by the Brazilian Health Ministry as an In-
tegrative Medicine, and Brazil was the first country in the world to publish a policy focused on these
medical practices (https://bvsms.saude.gov.br/bvs/publicacoes/pnpic_access_expansion_initiative.
pdf). Besides the educational level, homeopathy in Brazil is also included in undergraduate and post-
graduate health courses (stricto and lato sensu), primarily regarding the following careers: medicine,
dentistry, veterinary and pharmacy. The Faculty of Pharmacy at Universidade Federal do Rio de Janeiro
(UFRJ) has in its curriculum a specific course in which the Good Manufacturing Procedures (GMP) of
homeopathy has been taught since 2004, contributing significantly for the spread of homeopathy
knowledge in the scientific environment. In 2013, a Public Homeopathic Pharmacy was implemented
at the Faculty of Pharmacy, allowing patients to receive homeopathic medicines prepared with GMP
and at affordable prices. Other actions, such as international agreements between UFRJ, foreign univer-
sities and research centers, have been signed to promote the research and development of homeopathic
science. From 2016 to 2020, four bilateral international agreements were officially registered at Interna-
tional Affairs Office (DRI/UFRJ; www.dri.ufrj.br/index.php/pt/relint) with Italy, Indian (AYUSH Minis-
ter), Switzerland and Germany, expanding the homeopathic partnerships to all around the world. The
Homeopathy International Workshop has a strict correlation with these international initiatives, and it
has always been organized by the Pharmacy College under our general coordination. The first edition
happened in 2011. Since then, every two years a new event is organized with
the support of governmental funding (FAPERJ and CAPES), and also with
donations from national and international pharmacies, and homeopathic
laboratories. In 2021, the 5th edition was organized in partnership with the
International Research Group on Very Low Dose and High Dilution Effects
(GIRI; https://giri-society.org/), under the theme of: “The Scientific Evidence
of Homeopathy in Health Care”.We are incredibly proud about this new part-
nership, and we are hoping for fruitful, pleasant, and unforgettable moments
to all the people interested in therapeutic potential, scientific evidence and
regulatory aspects related to homeopathy in Brazil and in the world. Carla Holandino
FULL PROFESSOR.
Finally, we should to highighlith: all abstracts presented in the XXXIV
FACULDADE DE FARMÁCIA,
GIRI as “Oral Presentation” are published in this special IJHDR issue: UNIVERSIDADE FEDERAL
DO RIO DE JANEIRO.
https://www.highdilution.org/index.php/ijhdr/issue/view/127
RIO DE JANEIRO, BRAZIL.
Welcome to V International Workshop on Homeopathy!
13
PROCEEDINGS
Welcome to the
XXXIV GIRI Symposium
GIRI’s meeting this year will be the 34th meeting of our organization. What does this mean? Be-
sides the fact that the International Group of Very Low Dose and High Dilution Effects itself is
older than many of the participants who will attend the meeting, this makes GIRI an organiza-
tion dedicated to homeopathy with the longest tradition. This long tradition shows that there is
a need for groups like ours that share the same passion.
The idea of GIRI is to provide connections, give possibilities to

know each other, establish joint projects, and to share the know-
how and good results, as also to discuss the experimentations that
did not lead to a clear outcome. One important aim of the GIRI’s
meeting is also the enhancement of the research quality. GIRI’s
meetings are therefore rather workshop-like events. Also for this
reason, I am very happy about the partnership between the Homeo
pathy Workshop of the Federal University of Rio de Janeiro and
GIRI. This year’s meeting will be already the second one our groups
Maria Olga Kokornaczyk
organize together. SCIENTIST PHARMACEUTICAL
RESEARCH.
I do hope that this meeting will be an inspiration and enrichment VEREIN FÜR KREBSFORSCHUNG.
especially for the youngest participants. SWITZERLAND.
Scientific
Program
15
PROCEEDINGS
V Internationa Homeopathy
Workshop and XXIV GIRI Meeting
Program
DECEMBER 2 (THURSDAY)
9:00 - 9:30 Madrigal Chorus
9:30 - 9:40 Welcome to XXIV GIRI MEETING Maria Olga Kokornaczyk
Welcome to V International
9:40 - 9:50 Carla Holandino
Homeopathy Workshop
Room 1 PRE-EVENT COURSES
Welcome Video and

Carla Holandino
Speaker’s Introduction
10:00 - 17:00
V International Homeopathy
Workshop Activities
Homeopathyc Pharmaceutical
Rinaldo Ferreira
Prescription
Sheila Garcia and
Room 2 10:00 - 17:00 Introduction to Floral Therapy
Janaine R. Garcia
Room 3 10:00 - 17:00 Epidemiology for “Normal People” Edgard Vilhena

16
PROCEEDINGS
DECEMBER 3 (FRYDAY)
9:00 - 9:05
Welcome to XXIV GIRI and to Maria Olga and
V International Homeopathy Workshop Carla Holandino
9:10 - 10:00 Opening lecture introduction Maria Olga
Homeopathy in the Manchanda and Anil

Health System of India Khurana
10:00 - 10:15 TAG AND QUESTIONS
10:15 - 10:30 BREAK
10:30 - 12:00 GIRI abstracts
FIRST SESSION Cideli de Paula Coelho

Basic Research and Homeopathy MODERATOR
Series of experiments performed

Room 1 10:30 - 10:45 with the droplet evaporation method Maria Olga Kokornaczyk
on low potencies
In vitro evaluation of the effects of
Priscila Inhauser Baltuille
Viscum album homeopathic preparations
do Prado
10:45 - 11:00 on murine melanoma cells
Viscum album L. homeopathic
Michelle Nonato
11:00 - 11:15 mother tinctures: Metabolome
de Oliveira Melo
and antitumor activity
Homeopathy on cultures of
11:15 - 11:30 Saccharomyces cerevisiae and Tania Aguiar Passeti
impact on fermentation
12:00 - 13:00 LUNCH BREAK
Luciana Lobo
12:45 - 13:00 Meditation with ZenCancer (ZenCancer Director)
GUIDE
13:00 - 13:50 Scientific Evidences of Homeopathy Ubiratan Adler
Homeopathy Evidence Map Leoni Bonamin

17
PROCEEDINGS
December 3 continued
GIRI abstracts
SECOND SESSION Vania Bucco

Biological models Moderator
Exposure of Artemia salina
to glyphosate and bioremediation Mirian Nagai
by isotherapy
14:00 - 14:15
Neurobehavioral assessment
Room 1 of Danio rerio intoxicated by Mercury
Cideli de Paula Coelho
and the use of Mercurius solubilis
Effect of homeopathy on
Mônica Filomena Assis de
14:30 - 14:45 soybean germination through soil
Souza
and seed treatment presented
Evaluation of homeopathy effects

associated with conventional
14:45 - 15:00 periodontal therapy in randomized Leila Mourão
treatment of diabetic and non-diabetic
patients with periodontitis
15:30 - 15:50 BREAK
Jose Carlos Tavares

MODERATOR
Round table: Challenges
Room 2 14:30 - 15:30 of the Brazilian Homeopathic Leandro Machado Rocha,
Pharmacopoeia Adriana Passos Oliveira
and Jane Manfron Budel
SPEAKERS
15:50 - 18:20
Scientific Research Presentation:
(synchronous videos and questions)
15:50 - 16:30 Section 1 (Rooms 1-4)

Room 1
Room 2
Room 3
Room 4
16:55 - 17:35 Section 2 (Rooms 1-4)
18:00 - 18:20 Section 3 (Rooms 1-4)

18
PROCEEDINGS
DECEMBER 4 (SATURDAY)
Leoni Bonamin
LECTURE MODERATOR
9:00 - 9:50 Guidelines for fundamental research Alexander Tournier,
into homeopathy Stephan Baumgartner
SPEAKERS
10:00 - 10:30 BREAK
Maria Olga and

10:30 - 12:00 Board GIRI meeting
Carla Holandino
12:00 - 13:00 LUNCH BREAK
Luciana Lobo
12:45 - 13:00 Meditation with ZenCancer (ZenCancer Director)
GUIDE
Igor Jerman
New tools in homeopathy research: MODERATOR
Room 1 13:00 - 13:50 The solvatochromic solvents and the Steven Cartwright and
homeopathy research Leoni Bonamin
SPEAKERS
13:50-14:00 TAG AND QUESTIONS
14:00 - 14:30 BREAK
GIRI abstracts
THIRD SECTION Adalberto von Ancken

General research, moderated by MODERATOR
Practical teaching of pathophysiology

14:30 - 14:45 to LAFFH at the IPD outpatient clinic Claudio Hansel Martins
of FMP/FASE: Historical Report
NMR ANALYSIS
Carla Holandino and
14:45 - 15:00 Potential and challenges as a
Daniela Beier
homeopathic basic research tool
Characterization of physicochemical
Sandra Augusta
15:00 - 15:15 markers for homeopathic medicines
Gordinho Pinto
and biological supernatant samples
19
PROCEEDINGS
Heteroisotherapics effect on the
15:15 - 15:30 treatment against smoking: Mary Lannes Salles Leite
a cognitivebehavioral approach
16:00 - 16:30 BREAK
Room 1 PRIZE SECTION

16:30 - 17:00 The Best Works of V International
Homeopathy Workshop
CLOSING CONFERENCE
17:00 - 17:40 Alexandre Henrique Leonel
Homeopathy and Ecology
17:40 - 18:00
Acknowledgments and Announcement
of Next GIRI Conference
Adriana Passos Oliveira
MODERATOR
Francisco José Freitas

(Physician)
Round table: Homeopathy and
the professional organization Leila Mourão
9:00- 9:50 (Dentist)
in Brazil: physicians, veterinarians,
pharmacists, and dentists. Fortune Homsani
(Pharmaceutic)
(Veterinary)
SPEAKERS

Room 2
10:00- 10:30 BREAK
Nina Cláudia Barbosa

MODERATOR
Rajesh Shah
(India)
Yvonne Fok
10:30- 12:00 Homeopathy on Covid-19 (Hong Kong)
Alexander Tournier
(HRI, London)
Maria Filomena Xavier
(Brasil)
SPEAKERS
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PROCEEDINGS
12:00- 13:00 LUNCH BREAK
Carla Holandino
MODERATOR
Mónica Mennet-von Eiff

(Head International Drug
ROUND TABLE Regulatory, Weleda AG, Switzerland)
13:00 -13:50 Perspectives of Homeopathic Ezequiel Viriato
Industry in the World (Pharmaceutical Manager
Almeida Prado Lab, Brazil)
Dorly Buch
(Bonaireswiss AG, Switzerland)
SPEAKERS
14:00-14:30 BREAK
Janaíne Martins
MODERATOR
ROUND TABLE:
Room 2 14:30- 16:00 Maria Isabel Almeida Prado
Homeopathy and health care Solange Gosik (ABRAH)
Raquel Kalile (ABRAH)
SPEAKERS
16:00-16:30 BREAK

MODERATOR
Francisco José Freitas

(Physician)
Round table: Homeopathy and
the professional organization Leila Mourão
9:00- 9:50 (Dentist)
in Brazil: physicians, veterinarians,
pharmacists, and dentists. Fortune Homsani
(Pharmaceutic)
(Veterinary)
SPEAKERS
10:00- 10:30 BREAK

21
PROCEEDINGS
Nina Cláudia Barbosa
MODERATOR
Rajesh Shah
(India)
Yvonne Fok
10:30- 12:00 Homeopathy on Covid-19 (Hong Kong)
Alexander Tournier
(HRI, London)
(ABRAH, Brazil)
SPEAKERS
12:00- 13:00 LUNCH BREAK
Carla Holandino
MODERATOR

(Head International Drug
ROUND TABLE Regulatory, Weleda AG)
Room 2 13:00 -13:50 Perspectives of Homeopathic Ezequiel Viriato
Industry in the World (Pharmaceutical Manager
Almeida Prado Lab)
Dorly Buch
(Bonaireswiss AG)
SPEAKERS
14:00-14:30 BREAK
Janaíne Martins
MODERATOR
ROUND TABLE:
14:30- 16:00 Maria Isabel Almeida Prado
Homeopathy and health care Solange Gosik (ABRAH)
Raquel Kalile (ABRAH)
SPEAKERS
16:00-16:30 BREAK
22
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events and
Speakers
23
PROCEEDINGS
Pre-Event Courses
Title Epidemiology for “Normal People”.
Aims To introduce various subjects including searching for evidence, cases and NOT cases, build-
ing evidence, clinical trials and observational studies.
Author Edgar Vilhena
Title Introduction to Floral Therapy.

Aims The following subjects were introduced: Fundamentals of Floral Therapy; Health-disease
process from the metaphysical point of view; Fundamental differences between Floral Ther-
apy and Homeopathy; Different floral systems and their particularities; Applications and
case studies in Floral Therapy; Quantum Floral: what are they and how are they indicated?
Authors Sheila Garcia and Janaíne Martins
Title Homeopathic Pharmaceutical Prescription.

Aims Prescription limits by pharmacists; Semiology; SOAP method: (SO) Search for information
(signs and symptoms); (A) Patient risk assessment, definition of therapeutic objective, tra-
ditional homeopathic repertorization and search for homeopathic medicines by symptoms
and syndromes, materia medica; (P) Referral to other health professionals and services, pre-
scription of non-pharmacological measures, prescription of drugs that do not require a
medical prescription; Clinical cases; Electronic or physical patient record; Pharmaceutical
Prescription.
Authors Rinaldo Ferreira
Speaker Notes at Opening Conference

Title Scientific Basis of Homeopathic Medicine
Abstract In the past few decades, the homeopathic system of medicine has been able to spark scien-
tific minds to explore the plausibility, action, and nature of this system especially on basic
and fundamental aspects. This increase in research activity is attributed to clinical efficacy
& safety of homeopathic medicines. Scientists are now keen to undertake experiments to
learn the basic nature and action of homeopathic medicines, which is evident from the
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growing number of publications every year from various countries. CCRH, since its incep-
tion has been collaborating with various institutes of excellence to utilize the potential of the
best of the brains, in order to yield the maximum results. These studies aim to understand
the biological effect of homeopathic medicines; animal experimentation to assess anti-viral
properties; physicochemical studies; to standardize and optimize the process of drug man-
ufacturing and to know the presence of nanoparticles in homeopathic medicines. Council
has got some leads in accumulating biological evidence refuting the criticism that the effect
of Homeopathic medicines is equivalent to placebo. The studies ranged from finding out
nanoparticles in Homeopathic preparations, mechanistic aspects about their actions
through specific pathways and, also, explored in the areas of stem cell differentiation follow-
ing application of potentized Homeopathic medicine. The presentation will include salient
findings of such studies.
Author Khurana, A
Title Integration of homeopathy in the

healthcare system in India.
Abstract Medical Pluralism is unique to health care system in India, wherein Ayurveda, Yoga, Natur-
opathy, Unani, Siddha, Sowa-Rigpa and Homeopathy (AYUSH), are recognized and admin-
istered by a dedicated Ministry of AYUSH, Govt. of India. The National Health Policy of In-
dia nurtures AYUSH systems, by strengthening infrastructure, teaching institutions,
ensuring quality control of drugs, capacity building of professionals and promoting quality
research. These systems have been integrated in primary health centers. Homeopathy is the
second most popular system being preferred by its users for reasons that are partly due to
increasing realization of its inherent virtues like ‘holism, harmless therapy and cost-effec-
tiveness’ but also partly due to the rising distrust for conventional medicine. As reported in
the National Health Profile, Homeopathy is popular and has 31% of the total AYUSH dispen-
saries. Even though homeopathic units are only 1/19th of allopathic units, the annual pa-
tient footfall in these is 1/5th of allopathic ones. At least 7 out of 10 diseases nationally rec-
ognized as burden belong in the category of commonly reported diseases in these
homeopathic dispensaries. The figures are even more for private practice, clinic consultation
with around 80% registered homeopathic physicians in private set-up. During the ongoing
COVID-19 pandemic, Homeopathic infrastructure was utilized as part of AYUSH based
public health measures. A published cross sectional mobile application-based study revealed
that Ayurveda and Homoeopathy were the most preferred systems. This model can be used
globally for the integration of Homoeopathy in health care as part of TCIM.
A u t h o r Raj Kumar Manchanda.

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Abstract Conferences
Title Experiences of New Homeopathic Industry
(Bonaireswiss AG) in Switzerland.
Abstract When the new Swiss Consular group presented itself in Curitiba, they invited us to go to São
Paulo. The new Swiss representative in Paraná scheduled the interviews and visits to the indus-
tries of homeopathic products in Switzerland. The reception was good, so in 2017 we opened a
company. And in sequence we signed contracts with accountants, pharmaceuticals, and industry.
The biggest difficulty was the filling out of many forms in German for inspections by Swissmedic.
Author Buchi, DF.
Title The future of homeopathy in the

Brazilian industry and worldwide.
Abstract We will cover topics explaining about regulations for Good Manufacturing and Control
Practices, which are the same for the Allopathic Industry and the Homeopathic Industry.
Another issue to be pointed out is the origin of homeopathic ingredients and the difficulty
of acquiring them. Pharmaceutical professionals working in both industries NEED to be
prepared for Industry 4.0. The generalist pharmacist 4.0 needs to know homeopathic thera-
py and pharmaceutical technology to interact in the 4th Industrial Revolution! It does not
matter if the pharmacist “believes” or “accepts” Homeopathy, it is a matter of knowledge and
information!
Author Viriato, EP.
Title Scientific Evidence in Homeopathy – The Evidence Map.

Abstract The evidence map in homeopathy was elaborated based on the analysis of systematic re-
views and meta-analyses in clinical research, published between 1991 and 2021, using the
PubMed, EMBASE, BVS, and CINAHL databases. This review process does eligible 51 sys-
tematic reviews and highlights the evidence of homeopathic effectiveness for several condi-
tions and also for specific medicines, such as fibromyalgia, otitis media, diarrhea, respiratory
infections, post-menopausal syndrome, gastrointestinal disorders, and attention deficit hy-
peractivity disorder (ADHD) in children.
Author Bonamin, LV.

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PROCEEDINGS
Title Homeopathy on COVID-19 - Results of the ABRAH

Covid-19 Protocol.
Abstract The lecture showed the result of ABRAH’s research protocol on the use of the homeopathic
medicine China officinalis as an immunomodulator during the COVID-19 pandemic. We
also brought several circumstantial homeopathic medicines for the manifestations of the
disease, which are also part of our study.
Author Xavier, MF.
Title Series of experiments performed with the droplet

evaporation method on low potencies.
Abstract Homeopathic preparations in low potencies, containing still measurable quantities of the
starting substance, constitute a unique research field in homeopathic basic research. Here a
series of experiments is presented carried out by means of the droplet evaporation method
(DEM), investigating the specificity of the method, and presumed effects of the succussion
procedure applied in the production of homeopathic preparations.
Authors Maria Olga Kokornaczyk, Sandra Würtenberger and Stephan Baumgartner
Title Perspectives of Homeopathic Industry in the World.

Abstract The homeopathic products have a strong foundation in Brazil, in Europe and in many other
countries. They have a strong legal frame in the EU Directive 2001/83 as well as in the regulation
for dynamized medicinal products in Brazil and other countries. The quality standards are well
covered by the European Pharmacopoeia and other national pharmacopoeias. The sector contin-
ues to work on appropriate standards to ensure the availability for patients on the markets.
Author Mennet, M.
Title Homeopathic treatment of Autism on the children

psychosocial care center Taboão da Serra – SP.
Abstract Homeopathic treatment initiated early, from early childhood, by psychiatrists, neurologists
and especially pediatricians, using a systemic and pathophysiological approach leads to bet-
ter outcomes for children with Autism, increased its biological capabilities of maintaining
health and self-care, and promotes health care humanization.
Author Gosik, MS.

27
PROCEEDINGS
Title Can Nosodes be potential candidates of

Immunization and Immunomodulation?
Abstract Since Immunization is currently made possible only by vaccination, both have become syn-
onymous. There must be other ways to induce immune response and immunomodulation
for the prevention and treatment of diseases. One of the learning’s from the journey of de-
veloping BiosimCovex (COVID-19 Nosode) is the proven evidence that it was shown COV-
ID-19 specific prophylactic efficacy. Clubbed with the author’s previous research, there are
adequate leads suggesting that the nosodes have untapped potentials for immunization and
immunomodulation if targeted research is pursued aggressively in collaboration with mul-
ti-system scientists.
Author Shah, R.
Title Recommendations for fundamental research into

homeopathic preparations.
Abstract The aim of this project is to provide recommendations to promote good quality, statistically
sound, reproducible basic research into specific effects of homeopathic preparations. For
this, we gathered input from experts in the field. Different key aspects of homeopathy re-
search are discussed. All these aspects together provide a strong foundation for building
meaningful research protocols which take account of the latest thinking in the field and
provide a backdrop for meaningful comparison and critique of research protocols.
Authors Alexander L. Tournier and Stephan Baumgartner
Title Homeopathy in primary care – the Petropolis case.

Abstract It was presented a case study on the Homeopathy Program for Family Health in Petrópolis
– RJ based on the analysis of documents and the report of the subjects involved. Homeo-
pathic medicines were produced, distributed, and used for some years, but nowadays only
the IRA nosodium has been utilized.
Author Kalile, R.
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Title Investigating homeopathic potencies using solvatochromic

dyes – history and development.
Abstract A methodology using solvatochromic dyes to investigate homeopathic potencies at a physi-
co-chemical level has been developed over the past 10 years. The history of this approach is
discussed, and significant results and advances presented. The chemistry of solvatochromic
dyes and other π-conjugated dipolar compounds as molecular reporters providing informa-
tion about the process of succussion is examined. A number of insights into the nature of
potencies have already been made using these compounds. These insights include the prob-
able electric-field-like nature of potencies and the finding that a common mechanism seems
to operate in the interaction between potencies and all dyes so far examined. This interac-
tion involves three steps – dye polarization, changes in dye ionization constants and chang-
es in dye aggregation levels. Recent experiments have revealed that the action of potencies
on solvatochromic dyes is context-dependent with potencies showing reversals of effect
depending upon conditions such as dye concentration and pH. Potencies seem to push dye
systems in the direction they are already tending towards and thereby mirror what happens
in clinical settings with patients and primary homeopathic drug actions (exacerbations of
symptoms). The implications of these results are discussed in relation to future studies. The
degree of effect of potencies on solvatochromic dyes has recently been shown to depend on
the natural logarithm of the succussion number (S/N) from 6c to CM. Plots of the magni-
tude of dye absorbance changes vs ln S/N are linear. As many processes in nature are ln de-
pendent, this may indicate that with potentisation we are dealing with a phenomenon that
occurs in nature but has yet to be discovered.
Author Cartwright, SJ.
Title A fresh look at the concept of Genus Epidemicus: findings

from the Clificol Project.
Abstract The Clificol® COVID-19 Support Project aimed at tackling some of the core questions in home-
opathy, including the notion of Genus Epidemicus. This concept was investigated by analyzing the
data collected from China, to explore whether presenting symptoms cluster into distinct groups.
The cluster analysis found two to be the optimum number of clusters in that population corre-
sponding to the two main remedies prescribed: Gelsemium and Bryonia. This was the first study
that investigated the notion of Genus Epidemicus by using modern statistical techniques. The
notion of a single COVID-19 Genus Epidemicus did not apply to this population.
Authors Alexander Louis Tournier; Yuen Ying Yvonne Fok; Robbert van Haselen
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Speaker Note at Closing Conference

Title Homeopathy and Ecology
Abstract The health of air, water, soil, plants, animals and men is the result of an integrated and dy-
namic process. In this sense, a therapeutic tool capable of acting at a subtle level is needed,
stimulating the organism to reestablish this dynamic, and Homeopathy is one of the possi-
bilities to do so, since this science, developed by Samuel Hahnemann, is able to dynamically
help the organism in order to improve their functions and sensations.
Author Leonel, AH.
Speakers and Moderators

Pharmacist (Universidade Federal Fluminense - UFF), homeopath, master in natural prod-
ucts chemistry (Universidade Federal do Rio de Janeiro - UFRJ), doctor of science (UFRJ
and University of Basel, Switzerland), associate professor at the UFRJ faculty of pharmacy,
member of the “Thematic Committee on Natural Products” of the Consortium Brazilian
Academic of Integrative Health. Member of the Ethics Committee in Clinical Research at
EEAN-HESFA-UFRJ and professor at (Associação Brasileira de Reciclagem e Assistência em
Homeopatia - ABRAH).
Alexander Tournier
BSc Phys, Imperial College London, Msc Advanced studies in Mathematics & Theoretical
Physics, Cambridge (Part 3), PhD Biophyiscs, Heidelberg LCHE, Licensed of the Center for
Homeopathic Education FSHom, Fellow of the Society of Homeopaths, UK. Dr Tournier
worked for 10 years at Cancer Research UK (5th institute worldwide for molecular biology)
as a researcher working on problems at the interface between biology, physics and mathe-
matics. Alex founded the Homeopathy Research Institute in 2007. Alex directed the Water
Research Lab in Heidelberg. Alex is currently a research associate at the Institute of Comple-
mentary and Integrative Medicine (IKIM), Faculty of Medicine, University of Bern, Bern,
Switzerland. Alex is representing the Homeopathic Research Institute. Dr Tournier was
HRI’s foundling member. HRI is dedicated to the evaluation of homeopathy using rigorous
scientific methods and communicating such work beyond usual academic circles.
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PROCEEDINGS
Alexandre Henrique Leonel

Pharmacist with specialization in Homeopathy, founder of Homeopatia Brasil
Soluções Sustentáveis.
Anil Khurana
Dr. Anil Khurana is Deputy Director General in Central Council for Research Homoeopathy
(CCRH) He has an experience of over 30 years in the Council and has worked in all the areas
of research i.e. clinical research, basic research, fundamental research, drug standardization,
clinical verification and drug proving. He has more than 70 research publications in various
national and international journals to his credits. He has undertaken Post-Doctoral Fellowship
in HIV AIDS at the University of California, Los Angeles, US. He has also acquired the qualifi-
cation of Bioethicist from ICMR-IGNOU (Joint course). Currently, he is one of the editors of
Indian Journal of Research in Homoeopathy, the official Journal of CCRH.
Carla Holandino
Full Professor at the Faculty of Pharmacy at UFRJ. Pharmaceuticals from UFRJ. PhD in Sci-
ences from the Carlos Chagas Filho Biophysics Institute (UFRJ). Master in Biophysics from
the Carlos Chagas Filho Biophysics Institute (UFRJ). Specialist in Homeopathic Pharmacy,
by Instituto Hanhemanniano do Brasil (IHB). Member of the Thematic Technical Commit-
tee on Homeopathy of the Brazilian Pharmacopoeia. Coordinator of the Natural Products
Committee of the Brazilian Academic Consortium of Integrative Health (CABSIN). Vice
President of the International Infinitesimal Research Group (GIRI).
Cideli Coelho
Veterinarian, Specialist and Master in Homeopathy, PhD in Sciences in the field of
Epidemiology applied to zoonoses-USP, Post-Doc (PhD) Environmental and Exper-
imental Pathology. Professor at the Master’s Program in Medicine and Animal Wel-
fare and at the Doctorate in Unique Health at Universidade Santo Amaro (UNISA).
Proprietary Partner High Dilution Science - www.hdscience.com.br. Member of the
board of AMVHB and of the Homeopathy Commission of CRMV/SP.
Dorly Buchi
Dorly de Freitas Buchi, renowned Brazilian researcher, holds a PhD in Biological Sciences (Bio-
physics) from UFRJ. Her solid academic background is reflected in the publication of several
scientific articles in the field of Cell Biology and Electron Microscopy. Professor, for more than
40 years at the Universidade Federal do Paraná (UFPR), she combines extensive experience in
higher education, and effective contributions in the sphere of university administration.
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PROCEEDINGS
Edgard Vilhena
Physician at FTESM, Intensivist at Postgraduate Studies in Rio de Janeiro, Homeopath at IHB, Mas-
ter’s Degree in Homeopathy at FACIS, Doctor in Health Sciences at USP – SP, Post-doctoral student
at UNIP in Environmental Pathology. Chief Executive Officer of Commit Consultoria Médica.
Ezequiel Paulo Viriato

Ezequiel Paulo Viriato, MSc - Degree in pharmacy from the Faculty of Pharmaceutical
Sciences, Universidade de São Paulo (USP). Master in Homeopathy from the Faculty of
Health Sciences of São Paulo, with specialization in Homeopathy. He is currently an under-
graduate degree and Teacher of Homeopathy Oswaldo Cruz University of São Paulo. He is
also a professor of postgraduate degree in Homeopathy and Regulatory Affairs of the Os-
waldo Cruz University of São Paulo. Member of the Brazilian Homeopathic Pharmacopeia.
Ex - Member of the Working Group on Herbal and Homeopathic Medicine of the Federal
Council of Pharmacy. He has extensive experience in Pharmaceutical Technology, with em-
phasis on Industrial Technology acting on the following topics: Production, Homeopathic
Industrial Technologies, Quality Assurance, GMP, Methods Validation and Process with
emphasis in Regulatory affairs and Registration of medicinal and homeopathic products at
ANVISA/BR. He is a member of the 8th chair of the Pharmacy section of the National
Academy of Pharmacy.
Fortune Homsani
Graduated in Pharmacy from UFF, specialist in Homeopathy from IHB and Master in Phar-
maceutical Sciences from UFRJ. Professor of the Specialization Course in Homeopathy at
the IHB. Pharmacist at UFRJ, and Technical Responsible of the Homeopathy Laboratory
Profª. Marta Cortes Duarte at the University Pharmacy of UFRJ.
Francisco José de Freitas

Graduated in Medicine Universidade Federal do Estado do Rio de Janeiro (UNIRIO).
PhD in Biosciences UNIRIO. Master’s Degree in Neurology UNIRIO. Professor and
Head of the Department of Homeopathy and Complementary Therapeutics UNIRIO.
Current Deputy Director of the School of Medicine and Surgery/UNIRIO. Member
of the Technical Chamber of Homeopathy of CREMERJ and of the Thematic Tech-
nical Committee of Homeopathy of the Brazilian Pharmacopoeia.
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PROCEEDINGS
Janaíne Martins
Homeopathic Pharmacist and Phytotherapist from Universidade Federal do Rio Grande do
Sul (UFRGS), Specialist in Floral Therapy IBEH/UERJ, Specialist in Drug Development
UCPel. President of the GTT PICs CRF-RS and Member of the Phytotherapy, Homeopathy
and Traditional Chinese Medicine GT of the Conselho Federal de Farmácia (CFF). Technical
consultant in the regulatory area and pharmaceutical R&D. Director of Janaíne R. Martins
Trainings. Master in Pathology UFCSPA. Speaker of the Pre-Event Course: Introduction to
Flower Therapy.
Jane Manfron Budel

Pharmacist, Specialist, Master and Doctor of Pharmaceutical Sciences at UFPR with post-
doc at the National Center for Natural Products Research, University of Mississippi, USA.
Associate Professor at UEPG in the discipline of pharmacognosy I. Permanent professor at
the PPGCF (UEPG/UNICENTRO) and PPGCS (UEPG). She works as a specialist in the field
of medicinal plants in thematic committees of the Brazilian Pharmacopoeia.
Leandro Machado Rocha

Graduated in Pharmacy from UFF (1984), Master in Natural Products Chemistry from
UFRJ (1991) and Ph.D. in Pharmacy from the Université de Lausanne - Switzerland - (1995).
He is coordinator of the Natural Products Technology Laboratory, of the Pharmaceutical
Technology Department of the Faculty of Pharmacy at UFF. He works at the Brazilian Phar-
macopoeia, where he is on the Management Committee and Coordinator of the Thematic
Committee on Homeopathy of the Brazilian Pharmacopoeia, which prepares the editions of
the Brazilian Pharmacopoeia, positions to which he was forwarded in 2021.
Leila Mourão
UFF Dentistry Degree, Post doctorate in Pharmaceutical Sciences at UFRJ, PhD in Dentistry
UERJ, Master’s Degree in UVA Dentistry, Coordination of Dentistry in Homeopathy ABRAH,
Professor Stricto Sensu at Universidade Veiga de Almeida (UVA).
Leoni Bonamin
Full Professor at Universidade Paulista (UNIP), since 1991, Doctor in Veterinary Medicine
- USP (1987), PhD in Experimental Pathology (USP and ENVL – France, 1995), Post-Doc-
torate in Environmental Pathology, (UNIP, 2015), President of GIRI (2002-2008), Deputy
Editor of Homeopathy – The Journal of Faculty of Homeopathy (since 2015).
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PROCEEDINGS
Luciana Lobo
Social entrepreneur, creator and founder of the ZENcancer Institute. Yoga and meditation
teacher with a master’s degree in microbiology from the Institute of Microbiology at UFRJ,
published in 2018. In 2019, the book is launched: What have I learned from my rebellious
cells? All activities and projects of ZenCancer Institute can be accessed at:
www.institutozencancer.com.br.

Doctoral Student in Public Health at IMS, UERJ (Institute of Social Medicine, Universidade do
Estado do Rio de Janeiro – UERJ). Master in Neurology from UFRJ (Federal University of Rio
de Janeiro). Postgraduate degree in homeopathy from ABRAH. Researcher with several lines
of research developed at the ABRAH school clinics. Visiting professor of elective courses in
homeopathy at UFF (Instituto de Saúde Coletiva, Department of Health in Society). Coordina-
tor of ABRAH courses in Rio de Janeiro. Professor of the Training, Updating and Continued
Instruction Courses in Homeopathy at ABRAH. Volunteer homeopathic physician at the Fof-
inhos e Saudáveis Project, from the Nossa Senhora Rainha da Paz Association of Jardim Fim
de Semana, which has a partnership with ABRAH’s assistance projects. Homeopathic physi-
cian at the Municipal Health Department of Rio de Janeiro. Specialization in Homeopathy at
IHB. Specialist in Hospital Administration by IMS/UERJ. Specialist in Public Administration
by FGV (Fundação Getúlio Vargas). Speaker at National and International Congresses.
Maria Olga Kokornaczyk

Maria Olga Kokornaczyk (born in Warsaw/Poland in 1976) studied nutrition sciences at the
Agricultural University in Warsaw. Inspired by the anthroposophical view on food quality
and the image-developing methods she was able to get to know during her study visits in
Fulda and Witzenhausen/Germany, she earned her PhD on the topic of copper-chloride bi-
ocrystallization according to Pfeiffer in Pisa/Italy. During her postdoctoral research at the
University of Bologna/Italy, she developed an analytical model based on pattern formation
in evaporating droplets (wheat seed model). After leaving Italy, she got a position at the So-
ciety for Cancer Research in Arlesheim/Switzerland, where she is further developing the
droplet evaporation method and investigating its possible applications in basic research in
homeopathy, pharmacological process development, and medical diagnosis.
Maria Solange Gosik

Doctor specializing in homeopathy and pediatrics. Training in Child Mental Health and
technical responsible for Capsinfantil Taboão da Serra. President, professor and coordinator
of ABRAH Courses. Homeopathic physician working in São Paulo – SP and Taboão da Serra.
Board of the Associação Abrigo Nossa Senhora Rainha da Paz since 2016.
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PROCEEDINGS

Studied pharmacy at the University of Basel and made a PhD in phytochemistry and clinical
studies with herbal medicines. Today Head of International Regulatory Affairs, Pharma-
covigilance and Health Policy at Weleda AG in Switzerland. Member of the Homeopathic
Working Party (HOM WP) of the European Pharmacopoeia (Ph. Eur.). Board member in
various national and international complementary medicine associations. Board member
of ECHAMP (European Coalition of Homeopathic and Anthroposophic Medicinal Prod-
ucts), president of the pharmacist professional society for “Complementary Medicine and
Phytotherapy” (www.kmphyto.ch) at the Swiss pharmacists chamber pharmaSuisse,
amongst other representations.
Raj K. Manchanda
Graduated from Nehru Homoeopathic Medical College; New Delhi, M.D. (Hom) from Dr.
MPK Homoeopathic Medical College, Jaipur; Master degree in Health care administration
[M.B.A. (HCA)] from Delhi University, India. Conferred Honorary F.F. (Hom) by the Faculty
of Homoeopathy, UK and Honorary Doctorate in Traditional and Complementary Medicine
[PhD (TCM)] by Cyberjaya University College of Medical Sciences, Malaysia. Distinguished
experience of about 40 years, as clinician, researcher, teacher and health administration.
Worked in various positions in the Government sector, last being Director General, at Cen-
tral Council for Research in Homoeopathy, under Ministry of AYUSH, Government of India
(2012 to 2019). Provided supportive supervision as Principal Investigator/Co-PI to 30 clini-
cal, 22 fundamental, 40 verification, 20 drug proving studies and 3 public health programs.
30 MoUs with homoeopathic medical colleges and 10 MoUs with different organizations in
USA, UK, Mexico, Argentina, Canada, Armenia, Australia, Brazil, Germany and Israel were
signed for creating a network for National & International multicentric studies. Short-Term
Studentship in Homoeopathy (STSH) program and MD scholarship program were institut-
ed for inculcating research aptitude among students at Homeopathic colleges. As Chairman
of the sub-committee of Drug Technical Advisory Board, of Government of India, brought
amendments in the rules of Drug and cosmetic Act for popularizing and ensuring wide
availability of homeopathic drugs. As Director (AYUSH) spearheading several initiatives of
the Government in providing care to COVID-19 patients using AYUSH systems besides un-
dertaking 5 clinical research projects on data collection. 184 peer reviewed publications as
per the Google Scholar Citation report and coauthored a book: Textbook of Dermatology for
Homoeopaths in English and Spanish language.
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PROCEEDINGS
Rajesh Shah
Rajesh is a global homeopath, researcher, and an academician. He is in the book of world
records for treating patients from highest number of countries, the count is 180 coun-
tries. He has been seriously working on New Drug Discovery for about two decades. He has
developed over 150 new homeopathic medicines, including those from biological sources
such as HIV nosode, Hepatitis C nosode, Mycobacterium Tuberculosis nosode, Cancer no-
sode, Malaria nosode, E Coli Nosode, and more. He has also conducted double-blind, place-
bo-controlled Drug Provings, Clinical trials, experiments in animal models, plant models, as
well as in-vitro studies, in collaboration with reputed institutions such as Haffkin Institute,
ICT (UDCT), IIT-Bombay, Tata Memorial, Nair hospital, Mumbai University, etc. He has in-
troduced 17 steps scientific method of development of new nosodes. He is working on re-
vamping all major homeopathic nosodes. He has also defined Force parameters for Stan-
dardization of Potentization. His studies have demonstrated Bathochromic effects due to
potentization. His research papers on New Drug Discovery are published in peer-reviewed,
international journals. He is an author of several books. He has conducted seminars and work-
shops for homeopathic and allopathic doctors in India, USA, England, Belgium, Holland,
Greece, Sweden, Norway, Japan, Croatia, and other countries. He is an author of several books.
Recently, he has developed and researched on COVID-19 Nosode, conducted double-blind
placebo-controlled trials, and demonstrated its prophylactic and immunomodulatory efficacy.
Raquel Kalile
Graduation in Veterinary Medicine from Universidade Federal Rural do Rio de Janeiro
(UFRRJ) (2002) and in Medicine from UNESA (2012). Specialization in Veterinary Home-
opathy at IHB (2005) and in Homeopathy at ABRAH (2014). Executive MBA in Health from
Fundação Getúlio Vargas (FGV) (2013). Specialization in Strategic Health Management for
the Executive Management from the University of Miami (2014). Medical Residency in Oc-
cupational Medicine by Instituto Nacional do Câncer (INCA) (2015). Master’s Degree in
Family Health by UNESA (2019). Professor of ABRAH courses in Rio de Janeiro. Physician
at the Occupational Health Center of the Public Ministry of Rio de Janeiro. Homeopathic
doctor working in Rio de Janeiro and Petrópolis.
Rinaldo Ferreira
Pharmacy from Universidade Federal de Santa Catarina (UFSC), Specialization Homeopa-
thy from AMHPr and Associação Brasileira de Farmácias Homeopáticas (ABFH), Masters
from UFSC, Doctorate from Universidad de Sevilla and UNB. Pharmacist Pharmacy Ho-
meopathic Visnature, Financial Director AFPFB, President Farma & Farma. Member CTTH-
om Brazilian Pharmacopoeia. CFF Technical Consultant. Member of the ABF SBBE Com-
mission. Professor Instituto Equilibra and Instituto Racine. General Consultant Dr Care.
36
PROCEEDINGS
Sheila Garcia
Associate Professor at the Faculty of Pharmacy at UFRJ until 2018, having been responsible
for the disciplines of Homeopathy and Quality Control. She has worked as a Floral Therapist
since 2015 with Bach, Desert, Saint Germain, Alaska, California and Minas systems. Healing
facilitator since 2017.
Stephan Baumgartner
Head of Homeopathy Department & Deputy Director, Institute of Complementary and Inte-
grative Medicine, University of Bern, Switzerland. Senior Lecturer at the Faculty for Health,
University of Witten-Herdecke, Germany. Research Scientist at the Faculty for Health, Uni-
versity of Witten-Herdecke, Germany. Research Fellow at the Dept. for Mathematics and As-
tronomy (Goetheanum, Dornach, Switzerland). PhD in Environmental Sciences (Federal In-
stitute of Technology, Zurich, Switzerland). Post-Doc in the Dept. for Environmental Physics
(EAWAG Aquatic Research, Dübendorf, Switzerland). Senior Research Scientist in the Dept.
for Basic Research (Hiscia Research Institute of the Society for Cancer Research, and at the
Institute of Complementary Medicine IKOM, University of Bern, Switzerland).
Steven Cartwright
Dr. Cartwright has a PhD in molecular biology from Edinburgh University followed by fel-
lowships and positions in medical research at the Universities of California, Santa Cruz and
Oxford. He studied Homeopathy at the College of Homeopathy in London and the School of
Homeopathy in Devon and was registered with the Society of Homeopaths in 1999 and for
over 20 years. Since January 2010, he has been a member of the Alliance of Registered Ho-
meopaths (ARH), focusing on research, together with practicing. Since 2009 he has been
carrying out experimental work on homeopathic medicines at the Cherwell Innovation
Centre in Oxfordshire.
Ubiratan Cardinalli Adler

Physician, Specialist in Homeopathy, Ph.D., with Post-doctorate at the Institute of Social
Medicine, Epidemiology and Health Economics, Charité University, Berlin. Leader of the
CNPq Research Group Homeopathy and Integrative Medicine in the SUS. Professor, Depart-
ment of Medicine, Universidade Federal de São Carlos (UFSCar/SP).
37
PROCEEDINGS
Yvonne Fok
MB ChB., MSc Epidemiology and Biostatistics. Liga Medicorum Homoeopathica Interna-
tionalis (LMHI) — NVP in China. HK Association of Homeopathy — Research Officer. U.K.
School of Homeopathy — Course Manager. CCRH — Indian Journal of Research in Home-
opathy— Editorial Advisory Board. Living Homeopathy Ltd., Hong Kong — Assistant to
President. Dr Yvonne furthered her study and clinical experience with homeopathic and
nutritional therapy under School of Health and School of Homeopathy (UK) after she grad-
uated from her medical training in The Chinese University of Hong Kong. She was also
trained in epidemiology and biostatistics and got her MSc degree from the same university.
As Hong Kong was one of the first regions to experience the pandemic, Yvonne has been
deeply involved in the Clificol project and its management from the beginning.
38
PROCEEDINGS
Oral
presentation
abstracts
FIRST SESSION
BASIC RESEARCH AND HOMEOPATHY
40
PROCEEDINGS
Series of experiments performed with the droplet

evaporation method on low potencies
Maria Olga Kokornaczyk 1 B a c k g r o u n d : Homeopathic preparations in low potencies, containing
still measurable quantities of the starting substance, constitute a unique
Sandra Würtenberger 2
research field in homeopathic basic research. Results and discussion:
Stephan Baumgartner 1,3 Here a series of experiments is presented carried out by means of the
droplet evaporation method (DEM), inve stigating the specificity of the
method, and presumed effects of the succussion procedure applied in the
production of homeopathic preparations.
1 Society for Cancer Research, Hiscia

Institute, 4144 Arlesheim, Switzerland
2 Scientific & Regulatory Affairs, Hevert-
Arzneimittel GmbH & Co. KG, 55569
Nussbaum, Germany
3 Institute of Integrative Medicine,
University of Witten/Herdecke, 58313
Herdecke, Germany
41
PROCEEDINGS
In vitro evaluation of the effects of

Viscum album homeopathic preparations
on murine melanoma cells
Priscila Inhauser B a c k g r o u n d : Viscum album extract (VA) is a complementary treat-

Baltuille do Prado 1* ment in cancer, with in vitro and in vivo cytotoxic effects on several tu-
mor types when applied in phytochemical doses. However, highly diluted
Carla Holandino 2,3
ethanolic homeopathic preparations’ effects and mechanisms need fur-
Stephan Baumgartner 3,4,5 ther study. Aims: To assess the in vitro effects of highly diluted VA from
the subspecies V. album abietis and V. album album at different potency
Thaís Cristina da Silva 1
levels in different dilution ratios on murine melanoma cells. Methodology:
Leoni Villano Bonamin 1 The VA mother tinctures (MT) from Abies alba (MTA) and Quercus robur
(MTQ) were prepared with summer and winter samples, harvested in
Elizabeth Cristina Pérez Hurtado 1
Switzerland. They were submitted to homeopathic ethanolic maceration
and a subsequent dynamization process. MTA, MTQ and the following
respective potencies were tested in B16F10 murine cells: 3 DH, 12 DH, 30 DH,
6 CH, 12 CH, 200 CH, 2 LM, 3 LM and 5 LM. Dynamized water, dynam-
ized and non-dynamized ethanol, and carboplatin were used as control
groups. The mitochondrial activity and cell viability analysis were per-
formed at 1, 24, 48 and 72 hours by in vitro incubation. MTA and MTQ
harvested in summer, as well as 12 DH, 200 CH and 5 LM potencies were
1 Experimental and Environmental
also tested to cell apoptosis and necrosis markers, reactive oxygen spe-
Pathology, Universidade Paulista – UNIP cies (ROS) production, inflammatory cytokines profile, cell morphology,
2 Pharmacy College, Federal University of
Rio de Janeiro – UFRJ and migratory capacity. Results and discussion: MTA and MTQ induced
Institute, Arlesheim, Switzerland
a decrease in cell metabolism and higher cytotoxicity within 1 hour, with
4 University of Witten/Herdecke, Institute of significant morphological changes and increased production of ROS and
Integrative Medicine, Herdecke, Germany
5 University of Bern, Institute of inflammatory cytokines. Both homeopathic dilutions 12 DH and 5 LM
Complementary and Integrative Medicine,
Bern, Switzerland
showed an influence on cell metabolism, cell replication, and oxidative
*Correspondence to: pribvet@hotmail.com stress modulation with inflammatory cytokines, mitosis, and migration
pattern changes. On the other hand, Quercus robur and Abies alba 200
CH increased cytotoxicity effects and ROS levels, respectively. Conclusion:
The in vitro effects of Viscum album homeopathic solutions in melano-
ma cells highlight the promising antitumor potential and reinforce the
need for further research to better understand their mechanisms of action.
K e y w o r d s : Mistletoe, Viscum album, Abies alba, Quercus robur,

high dilutions, antitumoral potential.
42
PROCEEDINGS
Viscum album L. homeopathic mother tinctures:

metabolome and antitumor activity
Michelle Nonato de Oliveira Melo1,2* B a c k g r o u n d : Viscum album L. is a semi parasitic plant with anticancer
activity attributed to the aqueous extracts. However, European V. album
Adriana Passos Oliveira 1
ethanolic extracts (VAE) have demonstrated in vitro activity in tumor
Rafael Garrett 2 models. Aims: Evaluate the metabolic profiles of fifty VAE harvested
Patrícia Zancan 3
during summer and winter seasons and their anticancer activity through
2D and 3D models. Methodology: VAE were prepared by maceration
Alan Clavelland Ochioni 3 from: V. album ssp. album growing on Malus domestica, Quercus sp. and
Mirio Grazi 4 Ulmus sp.; V. album ssp. austriacum from Pinus sylvestris; V. album ssp.
abietis from Abies alba. Chemical analyses were performed using liquid
Hartmut Ramm 4 chromatography coupled to high resolution mass spectrometry and Par-
Tim Jäger 4 tial Least Squares Discriminant Analysis (PLS-DA) was performed in the
Metaboanalyst 4.0. The anticancer potential of selected VAE was evaluat-
Stephan Baumgartner 4,5 ed in 2D and 3D models (MDA-MB-231 cancer cells) by MTT, crystal
Carla Holandino 1 violet and glycolytic pathway analysis. Results and discussion: The first
3 principal components in PLS-DA explained 60% and 40% of data vari-
ation in positive and negative modes respectively. Three groups were
formed and showed chemical similarity among V. album subspecies.
Compounds responsible for group separation were tentatively identified
as: pinobanksin or naringenin hexoside; isorhamnetin-3-hexoside, me-
glutol and different amino acids. The summer VAE at 0.5% v/v induced
higher cytotoxic damage than winter preparations, and Abies alba and
Quercus sp. VAE, promoted 49% and 42% tumor viability reduction of
1 Multidisciplinary Laboratory of tumor viability in 3D model (72h incubation), respectively. MDA-
Pharmaceutical Sciences, Faculty of
Pharmacy, Universidade Federal do Rio de
MB-231 glycolytic pathway in the 2D model showed a decrease in the
Janeiro, Rio de Janeiro - RJ, Brazil glucose consumption and extracellular lactate production. Also, PFK
2 Metabolomics Laboratory, (LabMeta/
LADETEC), Chemistry Institute, (6-phosphofructo-1-kinase) and PK (Pyruvate kinase) activities were in-
Universidade Federal do Rio de Janeiro,
Rio de Janeiro - RJ, Brazil
hibited by Abies alba and Quercus sp. VAE at 48h of incubation. Conclu-
3 Laboratório de Oncobiologia Molecular sion: VAE extracts showed different metabolomes and the glycolytic
(LabOMol), Faculty of Pharmacy,
Universidade Federal do Rio de Janeiro, pathway should be an important target involved in the inhibition of tu-
Rio de Janeiro - RJ, Brazil
mor growth by these extracts.
Institute, Arlesheim, Switzerland
†Society for Cancer Research, Hiscia K e y w o r d s : Viscum album, anticancer, metabolome, glycolysis
Institute, Arlesheim, Switzerland, in
memorian
5 Institute of Integrative Medicine, University
of Witten-Herdecke, Herdecke, Germany
*michellenonato.far@gmail.com
43
PROCEEDINGS
Homeopathy on cultures of Saccharomyces

cerevisiae and impact on fermentation
Vinícius Crescêncio Queiroz 1* B a c k g r o u n d : Studies have shown that homeopathy modulates the ac-
tivity of both single and multi-celled organisms; therefore, we proposed
Roberto Lopes de Almeida 2
a study to evaluate the action of Arnica montana and the nosode of fun-
Susana Nogueira Diniz 3 gus Saccharomyces cerevisiae (S. cerevisiae) on in vitro growth, and on the
Tânia Aguiar Passeti 4
fermentation of S. cerevisiae in brewer’s wort. Methodology: 250 μL of
medication in 30% alcohol were placed in 5 mL of Sabouraud Broth (SB)
Audrey de Souza Marquez 3,5 or wort, with 20 μL of fungus at 0.5 McFarland turbidity followed by
1:100 dilution. Fungal growth was evaluated via spectrophotometer at
600 nm or cell count in Neubauer chamber, in a kinetic of 1 to 5 days’
incubation at 25ºC. The production of alcohol by the fungus was evaluat-
ed using the BRIX index in the same kinetic. Cultures of 1x107fungi/mL
were previously incubated with medication for 5 days and, afterwards,
placed in 20 mL of fresh wort, incubated at 25ºC for 7 days and evaluated
for growth and sugar consumption. Results and discussion: The SB re-
sults revealed that after 2 days incubation with Arnica 30 CH, an increase
1 Pharmacy student at ABC Medical School
of Santo André, SP, Brazil
in fungal growth was observed (p<0.0001), while with nosode 6 and 30
2 Professor ABC Medical School of Santo CH there was a reduction in growth after 2- and 5-days incuba-
André, SP, Brazil
3 Professional Master’s Program in tion(p<0.001). The fungi incubated with Arnica 30 CH exhibited increased
Pharmacy. Anhanguera University of São
Paulo, UNIAN. São Paulo, SP, Brazil
sugar consumption after 2- and 5-days incubation (p<0.05), while the
4 Biotechnology and Innovation in Health nosode 30 CH resulted in lower sugar consumption after 2- and 3-days
and Pharmacy Graduate Program
Anhanguera University of São Paulo, incubation (p<0.05). The results for fungal growth and sugar consump-
UNIAN. São Paulo, SP, Brazil
5 Center of Research in Health Sciences.
tion with the wort were like those using SB. Fungal cultures previously
University of Northern Paraná, UNOPAR. incubated with homeopathic medication and subsequent incubation
Londrina - PR, Brazil
viniciuscresq@gmail.com with fresh wort indicated a loss of distinction, both in terms of fungal
audrey.marquez@unopar.br
growth and sugar consumption. These data may suggest the action from
homeopathic medication only when in contact with the cells. Conclu-
sion: The treatment of the fungus S. cerevisiae using Arnica and S. cerevi-
siae nosode produced a significant modulation in fungal growth and
sugar consumption.
K e y w o r d s : Homeopathy, Saccharomyces cerevisiae, in vitro fermentation

SECOND SESSION
BIOLOGICAL MODELS
45
PROCEEDINGS
Exposure of Artemia salina to glyphosate

and bioremediation by isotherapy
Mirian Nagai B a c k g r o u n d : Artemia salina, an ecotoxicity bioindicator, is a micro-
crustacean belonging to the order Anostraca. Glyphosate is an herbicide
Andreia Pinto
widely used to control weeds. However, its intoxication can cause serious
Adalberto Von Ancken damage to human health and the balance of the environment, given its
Ednar Coimbra
effects as an endocrine disruptor. Objective: verify the possible protec-
tion of the artemia exposed to glyphosate by the addition of its isothera-
Sandra Pinto pic into water, by means of the evaluation of the behavioral and morpho-
Suham Nowrooz logical features of nauplii and of the physical properties of remedies and
treated water, to elucidate the involved mechanisms. Methodology: Ar-
Ivana Sufredini temia salina cysts were kept in culture bottles containing artificial sea
Maria Martha Bernardi water containing glyphosate at LC 10 (lethal concentration 10%), to pro-
mote hatching within 48 hours. The isotherapic preparations were insert-
Leoni Bonamin* ed in each bottle at 10% of the total water volume. Part of the nauplii was
distributed in transparent tubes, being 10 nauplii per tube and 6 tubes
per group, for behavioral analysis, and part was collected for a detailed
morphological analysis, under an optical microscope. About 80 to 270
nauplii were analyzed per group. The reserved water was divided into
aliquots for physicochemical analysis, that is, evaluation of the water di-
pole behavior by Cartwright’s method. Results: Gly 6 CH presented selective
effects on nauplii hatching (p=0.02) and on defected/healthy ratio
Universidade Paulista (UNIP), (p=0.001), representing some protective action. This result was depen-
São Paulo, Brazil dent on the salinity of water and presented correspondence with the ef-
*Supervisor: leonibonamin@gmail.com
fects on solvatochromic dyes, indicating that charges and ions can be
critical factors involved in the mechanism of action. Conclusion: We
concluded that the use of isotherapics could be a plausible tool to reduce
the environmental impact of the indiscriminate use of glyphosate, since
these results can be reproduced in further studies.
K e y w o r d s : Artemia salina, glyphosate, isotherapic,

homeopathy, eco-toxicity
F i n a n c i a l S u p p o r t : CAPES-PROSUP
46
PROCEEDINGS
Neurobehavioral assessment of
Danio rerio intoxicated by Mercury
and the use of Mercurius solubilis
Marco Aurélio Gonçalves Manzoli 1 B a c k g r o u n d : Mercury is used in various industries. Part of Mercury’s
industrial waste is discharged into the environment, rivers and their trib-
Rafael Acordi Santos 1
utaries, thus contaminating aquatic animals. Aim: to evaluate Mercu-
Elaine Bido 1 ry-induced behavioral changes in Zebrafish (Danio rerio) by the analysis
of locomotor activity and parameters related to neurotoxicity and to ver-
Henrique Carvalho Vieira 1
ify whether ultra-diluted substances can decrease neurobehavioral ef-
Cideli de Paula Coelho 1,2* fects and toxicity. Methodology: The fishes were separated into 4 moni-
toring aquariums with 8 fishes each, with temperature, pH controlled,
until the time of the toxicological experiments. 0.5 mL of Mercury 6 CH,
30 CH and distilled water (positive control) were added per liter of water
in each aquarium containing 6 liters of water, then 3 mL of medication
per aquarium, the white control received no medication and the toxic
agent. After 1 hour the drugs were added, toxic mercury (200 μg/L), 4 mL
per aquarium was added and remained so for 24 hours. All the experi-
1 Santo Amaro University (UNISA),
ment was run in blind, and the drugs identified by codes. The animals
São Paulo, Brazil were subjected to behavioral tests (Open Field-locomotion; Vertical
2 High Dilution Science (HD Science),
São Paulo, Brazil Open Field for neurotoxicity evaluation and Light and Dark Test), and
*cpcoelho@prof.unisa.br each stage was recorded for later evaluation of movements and neurobe-
havioral changes. ANOVA was performed, followed by Tukey test, with p
<0.05. Results: Mercury produced an anxiogenic effect in animals that
were submitted to it without medication. In the vertical open field, there
was an increase in erratic movements (1.25 ± 1.0) and tremors (0.87 ±
0.35) compared to the control (0.12 ± 0.35 and 0.25 ± 0.46 respectively),
proving the toxic effect. Fishes which received the medication at 6 CH
and 30 ch showed tremors and erratic movements similar to control.
Conclusion: 200 μg/L mercury in water can cause neurobehavioral dis-
turbances in fishes, and animals receiving Mercurius 6 CH and 30 CH
ultra-diluted drug did not show neurotoxicity.
K e y w o r d s : Ultra-diluted Drug, Danio rerio, Mercury, Open field.
E t h i c a l c o m m i t t e e : Protocol CEUA/UNISA: 07/2016.

47
PROCEEDINGS
Effect of homeopathy on soybean germination

through soil and seed treatment
Monica Filomena Assis de Souza 1* B a c k g r o u n d : Homeopathy is a technique approved by the MAPA for
organic production systems. Experiments demonstrating the effective-
Kácio Gomes de Macedo¹
ness of homeopathy in agriculture are essential. Aims: To evaluate the
David Junior de Oliveira Pereira¹ effects of homeopathic treatment on soybean seed germination. Meth-
Leonardo Américo Souza Barbosa 2
odology: The experiment was performed in MS-Brazil. An area of 70m²
was used, divided into two comparison plots of 30m² each. The soil of
Graciela Andreia Flis Machado¹ plot 1 (treated group) was treated with 5.25kg of powdered Lithothamni-
Pedro Henrique de Souza Cucco² um mixed with 250ml of 30% hydroalcoholic solution (HS) containing
homeopathic ingredients. The soil of plot 2 (control group) was treated
Marco Antonio Cucco² with the same preparation but without homeopathic ingredients. Addi-
Karine Bonucielli Brum 3 tionally, the 400 seeds assigned to plot 1 were treated with 0,3ml of a
solution made up of 10ml of 30% HS with homeopathic ingredients di-
luted in 300ml of water. The 400 seeds assigned to plot 2 were treated
with 0.3ml of a solution made up of 10ml of HS without homeopathic
ingredients diluted in 300ml of water. The homeopathic ingredients
Sulph 9 CH, Mag-c 12 CH, and Calc-p 9 CH were used on soil and seed
treatment. The selection and prescription of those ingredients followed
Materia Medica instructions. The experiment was conducted using ran-
domized design and 400 seeds per group were sown. Results and discus-
1 Associate Degree in Agriculture, Escola sion: In plot 1, an average of 11 seeds per m² germinated, adding up to
Estadual São Gabriel, MS
2 Sigo Procedimentos Homeopáticos LTDA 330 germinated seeds at a percentage of 82.5%. In plot 2, an average of 7
3 Universidade Federal de Mato Grosso do Sul
*monica.rt@sigohomeopatia.com.br
seeds per m² germinated, adding up to 210 germinated seeds at a per-
centage of 52.5%. The frequency of seed germination in both groups was
assessed by the Chi-square test to check for significant difference
(p<0.05). There was a statistical difference (p<0.05) in the seed germina-
tion in the treated group (n=330) compared to the control group (n=210).
Conclusion: Homeopathic compounds can be used as a viable treatment
for soybean germination.
K e y w o r d s : Glycine max, seed quality, agroecology, agrohomeopathy,

quantum agriculture.
48
PROCEEDINGS
Evaluation of homeopathy effects associated with

conventional periodontal therapy in randomized treatment
of diabetic and non-diabetic patients with periodontitis
Leila Mourão 1* B a c k g r o u n d : Periodontitis and Diabetes Mellitus type 2 (DMII) are
chronic diseases treated by conventional practices and traditional medicine.
Miriam Alhanathi 2
In many cases, when conventional medicine cannot offer a satisfactory treat-
Romeu Carillo Jr 3 † ment, it increases the demand for alternative therapies in chronic conditions.
Antonio Canabarro 4 The aim of this randomized study was to compare and to evaluate for one
year the effects of homeopathy on clinical and serologic parameters as an
Carla Holandino 5 adjunct of conventional periodontal therapy in individuals with periodonti-
tis and DMII. Methodology: 85 individuals, of both genders, between 35 and
70 years old, participated in this randomized study, of which 70 were eligible
in the Institute of Endocrinology and Diabetes of Rio de Janeiro-Brazil. They
were divided into two groups G-1: individuals with periodontitis without
systemic conditions and G-2: individuals with periodontitis and DMII. Both
groups received homeopathic treatment and were evaluated in clinical and
laboratorial examinations. The medication used was chosen based on the
similarity principle, following the Berberis 6 CH protocol (2 tablets, 2 times a
1 University Veiga de Almeida, Brazilian
Association of Recycling and Assistance day for 45 days), Mercurius Solubilis / Belladona / Hepar Sulfur 6 CH (2 tab-
in Homeopathy (ABRAH), Post-doctor lets, 3 times a day for 15 days) and Pyrogenium 200 CH (single weekly dose,
Student, Pharmaceutical Sciences, UFRJ
2 University Veiga de Almeida 2 weeks). Medications are prescribed in diluted low concentration doses for
3 Brazilian Association of Recycling and
Assistance in Homeopathy (ABRAH) in all signs and symptoms, while biotherapy (Pyrogenium) is used for chronic
Homeopathy, UNIFESP stimulation. Results: Both groups showed significant improvements through-
†Brazilian Association of Recycling and
Assistance in Homeopathy (ABRAH), in out the study, regarding clinical and laboratorial parameters, at a 1 year base-
memorian
4 Universidade do Estado do Rio line: reductions in total cholesterol, triglycerides, glucose, glycated hemoglo-
de Janeiro (UERJ) bin, uric acid and CPR. Statistical and descriptive analyses were performed.
5 Universidade Federal do
Rio de Janeiro (UFRJ) The data obtained after laboratory analysis were tabulated and then submit-
*leilamourao@hotmail.com
ted to the SPSS 17.0 software for Windows (SPSS Inc., Chicago, IL), and sig-
nificance level with p <0.05. For most of the parameters analysed, G-1 per-
formed better than G-2 (p<0.05). Conclusion: After 1 year of follow-up this
clinical trial suggests that homeopathy therapy, as an adjunct of periondontal
treatment, improves local and systemic parameters and can provide better
health condition.
K e y w o r d s : Periodontal therapy, periodontitis, diabetes mellitus,

homeopathy and Dentistry.
E t h i c a l c o m m i t t e e a p p r o v a l : 1.756.716.
THIRD SESSION:
GENERAL RESEARCH
50
PROCEEDINGS
Practical teaching of pathophysiology

to LAFFH at the IPD outpatient clinic of
FMP/FASE: Historical Report
Claudio Hansel Martins B a c k g r o u n d : Undergraduate students of UNIFASE/FMP, through the

Academic League of Human Physiology and Pathophysiology (Liga
Victor Tito Sperduto 1
Acadêmica de Fisiologia e Fisiopatologia Humana - LAFFH), participate in
Roberta Malher Bernardo a supervised internship to outpatient at the Infectious and Parasitic Diseas-
es Service of FMP/FASE, authorized by Clinical Direction (October 2018).
Thaís Ferreira do
Patients received conventional therapy in addition to complementary ther-
Espírito Santo Pires
apy with Homeopathy, for external use for cleaning skin lesions and mod-
Marcia Cristina Braga ulating inflammatory responses, whose mechanisms of action are already
Nunes Varricchio 1*. described in the scientific literature and authorized by ANVISA. Aims:
Make an approach of undergraduate students to Homeopathic pathophys-
iology. Methodology: The supervised clinical internship of LAFFH stu-
dents is in two service rooms with 6 students in each, based on prior ap-
pointment due to spontaneous demand, with medical records registered
by the IPD outpatient service secretary. Outpatient clinical care addresses
the pathophysiology and miasms of the symptoms and signs of neglected
chronic parasitic diseases prevalent in our country, identified by anamne-
1 Faculdade de Medicina de Petrópolis –
sis and physical examination. They are correlated to biological activities in
Rio de Janeiro, Brazil (FMP/Fase) plant chemistry classes, besides official homeopathic pharmacopeia. So,
* varichio2@gmail.com
the external use of Ledum palustre 6 CH was chosen for the cleansing of
skin lesions with torpid evolution at IPD. Results and discussion: Two pa-
tients with edema and varicose ulcers were treated with the ointment of-
fered. Edema extension which was +++/4+ to both patients diminished to
+/4+ in 30 days of interval. Indeed, ulcers remained at the same shape and
size, but their bases were cleaned, without purulence. Novel clinical ses-
sions did not occur because of social distancing needed. Conclusion: It has
developed a positive perception among patients and students about the
action of homeopathic remedies. The practical teaching activity initiated
encourages students in clinical reasoning about complementary therapeu-
tic association with Homeopathy for patients whose evolution is below the
expected prognosis with conventional therapy. The clinical observation
project will be elaborated to the research ethics committee.
K e y w o r d s : Practical teaching; Neglected Diseases; Homeopathy;

Pathophysiology; LAFFH.
51
PROCEEDINGS
NMR analysis: potential and challenges as

a homeopathic basic research tool
Carla Holandino* 1 B a c k g r o u n d : Homeopathic ultra-diluted solutions surpass the thresh-
old of matter dispersion and, consequently, their chemical constitution is
Daniela Wendhausen Beier* 1,2
similar to inert solvent. Nevertheless, randomized clinical trials have
Míriam Fragoso 1,2 shown that the clinical effects of these homeopathic medicines are supe-
Cintia Sias Coube Bastos 1,2
rior to placebo. Nuclear magnetic resonance (NMR) is one of the most
promising techniques to detect physicochemical alterations induced by
Vânia Emerich Bucco de Campos 1,3 homeopathic procedures. Aims: To investigate T2 NMR relaxation times
Adriana Passos Oliveira 1 of Zincum metallicum and lactose dynamized samples. Methodology:
Zincum metallicum samples were ground until 6 DH using lactose as ex-
Júlia Neves dos Santos 4 cipient. Subsequently, these samples were dynamized with ultrapure wa-
Lucas Henrique Silva 4 ter to produce 8 DH, 9 DH, 10 DH and 11 DH. Lactose dynamized sam-
ples (6 DH-11 DH) were used as control. Aliquots of 540µl of each sample
Ana Paula Canedo Valente 4 were diluted with 60µl of deuterated water (D2O) in 5 mm tubes. The
analyses were carried out in Bruker Ascend TM 500 MHZ spectrometer
at 288 K. Results and discussion: The Zincum metallicum and lactose T2
relaxation times were very similar, except for Zincum metallicum 8dH,
which presented a value of 1.226 in comparison to 1.036 of lactose 8dH.
The following T2 values were registered: 1.287 – 9 DH; 1.413 – 10 DH;
1.467 – 11 DH, and 1.303 – 9 DH; 1.400 – 10 DH; 1.350 -11 DH, for Zin-
cum metallicum and lactose, respectively. The differences detected in 8
1 Laboratório Multidisciplinar de DH samples are probably due to the presence of lactose in the first dilu-
Ciências Farmacêuticas and Pesquisa & tion step, in which 1 part of 6 DH triturated mixture is diluted in 9 parts
Desenvolvimento em Práticas Integrativas
e Complementares, Faculdade de of water, to prepare 7 DH. Following this homeopathic procedure, these 8
Farmácia, UFRJ
2 Instituto Hahnemanniano do Brasil, IHB DH solutions remain around 1% of lactose which could be influenced by
3 Fundação Centro Universitário Estadual the T2 values registered. Conclusion: These preliminary results showed
da Zona Oeste, UEZO
4 Centro Nacional de Ressonância Magnética the possibility to apply the NMR technique to evaluate the influence of
Nuclear Jiri Jonas (CNRMN- UFRJ)
*Carla Holandino - cholandino@gmail.com dynamization in the relaxation parameters. Further studies should be
Daniela Beier daniela.w.beier@gmail.com carried out with other potencies and/or other homeopathic substances,
in addition to the evaluation of T1 and the T1/T2 parameters, as previ-
ously described by other groups.
K e y w o r d s : Proton Magnetic Nuclear Resonance, T2 values,

Homeopathic remedies, Zincum metallicum,
ultradiluted solutions.
52
PROCEEDINGS
Characterization of physicochemical
markers for homeopathic medicines and
biological supernatant samples
Sandra Augusta Gordinho Pinto B a c k g r o u n d : Solvatochromic dyes are probes to detect variations on
the dipole moment of solvents after the insertion of homeopathic poten-
Ana Carla Aparicio
cies. Recent studies have shown they can be useful tools in laboratory
Jefferson Souza and field studies to detect the activity of homeopathic remedies. Objec-
tive: Determine whether solvatochromic dyes can be a diagnostic tool
Suham N Mohammad
for cells infected by different agents and/or markers to identify the activ-
Ivana B Suffredini ity of homeopathic medicines. Methodology: Ethilicum 1 CH, Silicea
terra 6, 30, 200 CH; Zincum metallicum 6, 30, 200 CH and Phosphorus 6,
Steven J Cartwright
30 and 200 CH were analyzed by pouring the samples (in a 1:60 rate) into
Leoni Villano Bonamin* 1 a series of seven dyes (rhodamine, ET 33, ET 30, coumarin 7, NN DMIA,
Nile red, methylene violet) diluted in absolute ethanol using pre-estab-
lished working concentrations. Oscillations of dye absorbance were ob-
served at visible light spectrophotometer according to the remedy and
potency. Water and succussed water were used as controls. In a second
moment, the absorbance profile of the remedies will be compared with
those of biological samples (supernatants) and checked with the biolog-
ical effect previously obtained from each treatment. Supernatants of
Universidade Paulista - UNIP,
RAW 264.7 macrophages stimulated by Calmette-Guérin bacilli (BCG)
São Paulo, Brazil or infected with Encephalitozoon cuniculi will be analyzed. Results: Pre-
Presenter: sandraagp@hotmail.com
*supervisor: leonibonamin@gmail.com liminary results have shown that Silicea terra 6 CH, Phosphorus 30 and
200 CH and Zincum metallicum 6, 30 and 200 CH reduced the absor-
bance of methylene violet (p=0.01). Repetitions and analysis of superna-
tants are expected to be performed in the next steps of the study. Future
perspectives: Establish a pattern of reactivity of the studied medicines
with different dyes and the putative relation with the corresponding su-
pernatants, as an attempt to obtain a “physicochemical signature” for
each kind of infection and/or treatment.
K e y w o r d s : Homeopathy, spectrophotometry, solvatochromic dyes.

53
PROCEEDINGS
Heteroisotherapic effects on the treatment against

smoking: a cognitive behavioral approach
Mary Lannes Salles Leite B a c k g r o u n d : The most common way of consuming nicotine is in tobacco
cigarettes. Nicotine causes intense addiction. The National Cancer Institute
Fortune Homsani
coordinates and executes the Tobacco Control Program in Brazil, through
Juliana Patrão de Paiva actions that encourage the adoption of healthier lifestyles. In this context,
homeopathy has used Heteroisotherapic medicines formulated according to
Rafael Tritany
the homeopathic pharmaceutical technology with scientific evidence of effi-
Carla Holandino cacy in the detoxification of substances and metals, and in the desensitization
of foods or medicines. Aims: Promote the importance of the cognitive-be-
havioral approach in combination with the homeopathic treatment against
smoking. Methodology: In the initial phase of the randomized double-blind
clinical study (CEP / HUCFF / UFRJ 65622916.2.0000.5257), the effective-
ness of the 6 CH heteroisotherapeutic drug was assessed. Volunteers were
recruited and in-person welcoming meetings, using the cognitive-behavioral
approach, were carried out to inform them about the risks of smoking and
the benefits of quitting. In addition, they were supported and guided during
the smoking cessation process so that they could deal with the withdrawal
Laboratório Multidisciplinar de syndrome, the psychological dependence and the constraints associated with
Ciências Farmacêuticas and Pesquisa &
Desenvolvimento em Práticas Integrativas smoking. Results and discussion: 84 participants were selected according to
e Complementares, Faculdade de Farmácia,
Universidade Federal do Rio de Janeiro, Rio de the inclusion criteria and were divided by randomization into two groups:
Janeiro, RJ-Brasil the Test Group (heteroisotherapic medication) and the Control Group (ho-
meopathic medication Nux vomica 6 CH). Both groups will be followed for
12 months. The combination of the following approaches has led to a signifi-
cant increase in the cessation rate: I. Prepare the smoker for solving his own
issues; II. Stimulate skills to resist temptations to smoke; III. Prepare to pre-
vent relapse; IV. Prepare to deal with stress. Studies show that, regardless of
the duration of these approaches, there is an increase in the abstinence rate.
Moreover, the longer the total approach time (frequency multiplied by the
time spent on each contact), the higher the abstinence rate. On the other
hand, from a total approach time of 90 minutes on, there is no further in-
crease in the abstinence rate. Conclusion: The partial results obtained so far
demonstrate that the cognitive-behavioral approach played a decisive role in
the groups performance, favoring the treatment adherence as well as the
group cohesion around the Project’s objective, contributing to the effective-
ness of the medicine, a decreased anxiety, improved sleep, cessation or de-
crease in the number of cigarettes smoked per day and the abstinence rate.
K e y w o r d s : Heteroisotherapic, Tobacco, Behavior, Homeopathy.

Poster presentation
abstracts
FIRST SESSION
CLINICAL STUDIES
56
PROCEEDINGS
Control of Rhipicephalus microplus ticks in

dairy cattle using homeopathic therapy
Lucas Seikichi Nascimento Oshiro 1 B a c k g r o u n d : The negative impact of Rhipicephalus microplus infesta-
tions on cattle farming is well-known. The main control method is the
Elton Bock Correa 1
use of ixodicides, which have as side effects the environmental contami-
Mônica Filomena Assis de Souza 2* nation, the selection of resistant lineages, and toxicity. Their use is also
prohibited in systems that produce organic and agroecological food.
Marco Antonio Cucco²
Such factors reinforce the importance of strengthening research related
Pedro Henrique de Souza Cucco² to the application of homeopathic principles in animal production. Aim:
Raquel Soares Juliano 3 In this setting, this work aimed at assessing the efficacy of the homeo-
pathic therapy to control Rhipicephalus microplus ticks in dairy cattle.
Karine Bonucielli Brum 4 Methodology: 63 crossbred and Girolando breed cows, 1 and 9 years of
age, naturally infested by ticks and created under a semi-intensive sys-
tem in three farms (1, 2 and 3) were assayed. The animals were divided
into three control groups and three treated groups, using the drug product
EndectoSigo® (Psorinum 12 CH, Sulphur 12 CH, Ledum palustre 12 CH,
Cina 12 CH e Apis mell. 7 CH) at a dose of 10 g/animal/day added to
mineral and/or food supplement. The visual counting of teleogines with
the size equal to or higher than four millimeters in diameter was per-
1 Faculdade de Ciências Agrárias e Exatas
formed in the neck or udder area of the animal. Pluviometry and regis-
da Grande Dourados - UNIGRAN tration of ixodicide baths were performed as well. The means obtained
2 Sigo Procedimentos Homeopáticos LTDA
3 EMBRAPA Pantanal were compared by using ANOVA test and Tukey’s test. Results: The mean
4 Universidade Federal de Mato Grosso do
Sul - UFMS
number of teleogines on farm 1 was significantly lower (p<0.05) in the
* monica.rt@sigohomeopatia.com.br treatment group. As for farms 2 and 3, there was no statistical difference
between the groups (treated and control); however, it was observed that
two ixodicide baths were required in the control group (farm 2). The plu-
viometry did not interfere with the manifestation. Conclusion: It was
concluded that the homeopathic treatment has the efficacy required to
control this tick in cattle and can be an alternative to the use of chemical
ixodicides.
K e y w o r d s : Ticks, agroecology, ultra-diluted, epidemic genius,

teleogines.
E t h i c a l c o m m i t t e e : Protocol number 068/18.

57
PROCEEDINGS
Evaluation of the effectiveness of Arnica

montana 6 CH in the control of postoperative
myalgia by isometric effort in dentistry
Rosy de Oliveira Nardy 1,2* B a c k g r o u n d : Arnica montana 6 CH is a medicine indicated for inflam-
matory and painful conditions, especially in muscle structures. The RDC
Adriana Marques Nunes ²
/ TMD Axis II questionnaire is a validated tool for the diagnosis of Tem-
Leonardo dos Santos Barroso 2,3 poromandibular Muscle Dysfunction. Objective: This multicenter, ran-
domized and controlled study, approved by Human or Animal Research
Cristina Garani Schneider Guimarães2
Ethics Committee UniFOA - CAAE: 48680015.3.0000.5237 aimed to ver-
ify the clinical performance of Arnica montana 6 CH in contractures and
muscle pain triggered by isometric stress. Methodology: 70 patients un-
derwent prolonged dental treatment sessions, and they were selected af-
ter clinical examination and positive responses to the RDC / TMD ques-
tionnaire to confirm signs and symptoms of Temporomandibular Muscle
Dysfunction at the first consultation. Randomly, Arnica montana 6 CH
was prescribed for 35 patients called group I, and placebo for 35 patients
1 Associação Brasileira de Reciclagem e called group II, at a dose of 5 globules, 03 times a day, for 1 week. In the
Assistência em Homeopatia (ABRAH)
2 Centro Universitário de Volta Redonda second endodontic consultation, after 15 days, a new clinical examina-
(UniFOA) - Volta Redonda/RJ
3 Universidade de Taubate (UNITAU) -
tion was performed at the beginning and end of the prolonged dental
Taubaté/SP; consultation with crossing of data from the RDC questionnaire, to mon-
* rosynardy@gmail.com
itor the prevalence of TMD muscle signs and symptoms. The data were
tabulated and analyzed. Statistical analysis: The test t de Student was
used for paired samples, significant at the level ≤ 0.05%. Results: An-
amnetic data from the RDC questionnaire, 86% of the individuals in the
GI had lower pain and muscle contracture rates in the second consulta-
tion, compared with 22% in the GII. Conclusion: The drug Arnica mon-
tana 6 CH proved to be effective in preventing muscle changes and clin-
ical symptoms resulting from isometric efforts with a statistically
significant difference (p ≤ 0.05).
K e y w o r d s : Isometry, Thermography, Homeopathy, Endodontics,

Arnica montana 6 CH.
58
PROCEEDINGS
The use of homeopathy and flower therapy

as an aid in the treatment of climacteric symptoms:
an integrative review
Camila Faria de Amorim Pereira 1,2* B a c k g r o u n d : Climacteric is characterized as the set of symptoms that
usually start in the period of transition from the reproductive phase to
female senility, and directly impacts woman’s quality of life. Currently,
the treatments approved by the FDA for this pathology mainly involve
the use of antidepressants and hormone replacement, both having side
effects. Clinical studies carried out in 2002, showed an increased risk of
breast cancer, and other pathologies related to the prolonged use of these
drugs. The impact of the studies resulted in a greater interest in comple-
mentary and alternative medicines (CAMs), such as the use of homeop-
athy and flower remedies for the treatment of climacteric symptoms.
1 Instituto de Biofísica Carlos Chagas Filho, Aims: This abstract aims to present an integrative review on the use of
Centro de Ciências da Saúde, Universidade
Federal do Rio de Janeiro, Rio de Janeiro, homeopathy and flower remedies in the treatment of climacteric symp-
RJ-Brasil toms, in order to identify its main scientific evidence. Methodology: For
2 Laboratório Multidisciplinar de Ciências
Farmacêuticas, Faculdade de Farmácia, this, methodology consisted of research in the databases Web of Science,
Universidade Federal do Rio de Janeiro,
Rio de Janeiro, RJ-Brasil Google Scholar, HomeoIndex, LILACS and SciELO. The inclusion criteria
* cfapereira2011@gmail.com were original human studies, totally available, and published in the last
10 years in Portuguese, English and Spanish, presenting the use of floral
remedies or homeopathic treatment. Results and Discussion: The main
homeopathic medicines used were Lachesis mutus, Belladona, Sepia offi-
cinalis, Sanguinaria canadensis and Sulfur. The main flower remedies
were Cherry plum, Agrimony, Gentian, Walnut, Olive and Larch. The
findings in this review demonstrate a positive outcome trend in favor of
the effectiveness of these practices through the studies evaluated, en-
couraging the expansion of new designs and research that fully contem-
plate the principles of these practices. Conclusion: Thus, this work con-
tributes to the advancement in the understanding of each one of these
rationalities, making this work a source of consultation for health profes-
sionals and for future research, resulting in a strengthening of CAMs in
the field of health.
K e y w o r d s : Homeopathy, flower remedies, menopause, climacteric, CAMs.

59
PROCEEDINGS
Lycopodium as a treatment for Urate Deposition

(gout) in birds: case report
Cideli de Paula Coelho 1,2* B a c k g r o u n d : A 3-year-old male cockatiel (Nymphicus hollandicus)
was diagnosed with joint arthritis due to hyperucemia syndrome. The
Adalberto Von Ancken 2,3
bird presented deposition of urate crystals on the synovial membrane
Sonia Regina Pinheiro 2 with inflammation of joints and tendons (tufts), causing listlessness, an-
orexia, and lameness, with difficulty in keeping perched or moving. Lab-
oratory tests displayed an increase in uric acid and creatinine phosphoki-
nase levels, and leukocytosis despite lymphopenia. Unsuccessfully, the
animal had been treated with allopathic medicine for 2 months, without
a favorable response and still developing stressful reaction to handling.
Methodology: High dilution therapy was attempted with 2 globules of
Lycopodium clavatum 30 CH /bid and Arnica montana 30 CH /bid /oral.
The most expressive tufts were removed with daily cleaning of the affect-
1 Santo Amaro University (UNISA),
São Paulo, Brazil ed area; a new diet was established, and perches were removed, allowing
2 High Dilution Science (HD Science),
São Paulo, Brazil the bird to remain on a flat surface until regression of symptoms. The
3 Paulista University (UNIP), medication was continued for 30 days. On the second appointment, al-
São Paulo, Brazil
*cpcoelho@prof.unisa.br though the caregiver reported episodes of probable pain, there was an
improvement in behavior with normal appetite. Lyc 30 CH /sid was con-
tinued and Arn 30 CH /bid to qid, depending on pain episodes, for over
30 days. The tutor authorized the case report through a consent form.
Results and discussion: Follow-up laboratory tests were performed ev-
ery three months for one year, reaching normal levels for uric acid (3.5-
11 mg/dL) and CK (30-245mg/dL) on the third measurement. The bird
presented no formation of new tufts along the second month of treat-
ment. After 12 months, the animal ingests homeopathic globules sponta-
neously and presents stable clinical presentation (Lyc 30 CH / sid / 3 times
a week) with no recurrence and without side effects nor stressful behavior.
Conclusion: In view of these results, it is considered that homeopathic
treatment is an option to be considered in the treatment of joint arthritis
from hyperuricemia syndrome in birds.
K e y w o r d s : Homeopathy, joint, urate crystals, Nymphicus hollandicus.

60
PROCEEDINGS
Evolution of clinical symptoms of Covid-19 in

healthcare professionals treated with China officinalis
Maria Solange Gosik 1,6 B a c k g r o u n d : Homeopathy has been very effective in pre-
venting and treating the symptoms of many viral epidemics
Maria Filomena Xavier Mendes 2,6*
since the 19th and 20th centuries. So far, no preventive or
Leticia Marilia de Almeida Werneck dos curative allopathic medications have been found for
Santos 3,6 Covid-19. The search for therapeutic alternatives such as
Danielle da Silva Barbas 4,6 Homeopathy is essential. Aims: to describe the signs and
symptoms of professionals in the health and essential areas
Domingos José Vaz do Cabo 5,6 after the use of China officinalis at two Hospitals in São Pau-
Hristos Strastis 6 lo and one Hospital in Brasília. Additionally, the evolution of
symptomatic cases was compared to the general pattern of
Isabella Sebusiani Duarte Takeuti 6 the local population. Methodology: The study design was a
Leila Cristina dos Santos Mourão7,6 time series with questionnaire analysis before and after the
use of the homeopathic medicine. After approved by the Eth-
Luciana Valentini de Melo 8 ics and Research Committee (CAAE 31802720.0.0000.5442),
Renata Rodrigues Garcia Lino 6 the homeopathic intervention China officinalis 6 CH was
used in a dosage of six drops per day. Results and discus-
William Brunelli 9,6
sion: The total of 718 participants was analyzed and 126
Adriana Passos Oliveira 10,6 (17.5%) showed symptoms which 65.1% of these had a con-
firmed test for covid-19. Among the symptomatic ones, a
Paulo de Oliveira11
total of 24 (19%) evolved with Severe Acute Respiratory
Romeu Carillo Jr 6† Syndrome, although no deaths and admission to the Inten-
sive Care Unit (ICU) were registered. TabNet date of Severe
Acute Respiratory Syndrome (SARS) and Flu-like syndrome
1 Psychosocial Care Center for Children and Youth of Taboão
da Serra; Sao Paulo, SP, Brazil
for the local population were compared to the evolution of
2 Municipal Health Department, Rio de Janeiro, RJ, Brazil symptomatic participants. The symptomatic cases treated
3 Family Health Strategy – Rio de Janeiro State University, Brazil
4 Department of Child and Adolescent Medicine, Faculty of with China officinalis had a typical clinical course of cases
Medicine, University of Brasília, DF, Brazil
5 Sírio-Libanês Hospital, Bela Vista, São Paulo, SP, Brazil
of flu-like. China officinalis is supposed to stimulate the
6 Brazilian Association of Recycling and Assistance in self-regulation system, increasing the individual’s nonspe-
Homeopathy (ABRAH), São Paulo, SP, Brazil
†Brazilian Association of Recycling and Assistance in cific immunity. Conclusion: The results indicate that China
Homeopathy (ABRAH), São Paulo, SP, Brazil, in memorian
7 Stricto Sensu Postgraduate Program in Dentistry, Veiga de
officinalis 6 CH used by health professionals and essential
Almeida University, Rio de Janeiro, Brazil activities contributed to the health promotion during the
8 Faculty of Pharmacy, Health Sciences Center, Federal
University of Rio de Janeiro, RJ, Brazil coronavirus pandemic.
9 Municipal University of Medicine of São Caetano, Centro São
Paulo, SP, Brazil
10 University of Évora, PT, Portugal
K e y w o r d s : Homeopathy, Medicine, coronavirus,
11 Padre Bento Hospital Complex, Guarulhos, São Paulo,SP Brazil SARS-CoV-2.
* msgosik@uol.com.br
SECOND SESSION
CHEMICAL AND PHYSICAL STUDIES
62
PROCEEDINGS
Wine preservation using potassium metabisulphite

high dilution: a preliminary study
Joni Stolberg 1* B a c k g r o u n d : Changes on relevant sensory characteristics after wine is
bottled are made by chemical reaction amid substances of wine or by
Ketlin Schneider 1
microbial contaminants. Potassium metabisulphite has good properties
Wilson Taybar Assumpção 1 to avoid degradation of wine, but it could be toxic. Aim: To evaluate po-
Pedro Boff 2
tassium metabisulphite highdilution as an alternative agent for wine
preservation. Methodology: Manego Longo red variety grapes (2018/2019)
were used in order to produce the wine. The fermentation of wine took
place in one wood barrel and it lasted six months. After that, three differ-
ent treatments were prepared: WC, control wine; WH, samples of wine
added to dynamized potassium metabisulphite (30 CH); WM, wine add-
ed to 24 mg/L potassium metabisulphite. The samples were bottled in 50
mL Falcon tubes (ten for each treatment) and kept in a cool box. The
parameters total acidity (TA), color intensity (CI) and polyphenol total
1 Federal University of Santa Catarina –
Campus of Curitibanos, Brazil
index (PTI) were analyzed in duplicates every three months. Variance
2 EPAGRI – Laboratory of Plant Health and analysis was performed on the data and the average values were com-
Homeopathy/Lages Experimental Station,
Brazil pared using Tukey test (p>0,05). Wine preliminary evaluation (color, ap-
*joni.stolberg@ufsc.br
pearance, aroma and taste) was performed by two referees. Results and
discussion: The results found after six months since the beginning of the
work have showed no difference among the samples in terms of CI and
PTI. Total acidity results in the sixth month presented a smaller average
value to WH and WM (81.5 ± 0.71 mEq/L and 81.0 ± 1.41 mEq/L, re-
spectively) when compared to the total acidity of the WC (86.0 ± 1.41
mEq/L), despite no difference among them being statistically significant.
Wine preliminary evaluation showed that control wine (WC) has had
prominent acid taste e change of color, if compared to other treatments.
Conclusion: No wine degradation related to color intensity or polyphe-
nol total index has been presented by now; however, sensory attributes,
like taste and color, for the samples treated by potassium metabisulphite
30 CH have showed preservation effects to wine.
K e y w o r d s : High dilution, total acidity, color, red wine.
F inancia l s u p p o rt: Fundação de Amparo a Pesquisa e Inovação do

Estado de Santa Catarina - FAPESC
THIRD SESSION
HOMEOPATHIC TEACHING AND PRACTICE
64
PROCEEDINGS
Comparative analysis for quality control

of mother tinctures in Brazilian reports
Hayla da Silva Pinheiro 1* B a c k g r o u n d : Quality control of homeopathic mother tincture begins
with the analysis of the raw material. Once the product is obtained, some
Andréa Durão Neves¹
organoleptic characteristics and Physicochemical properties such as ap-
Gleyce Moreno Barbosa 2 pearance, colour, odor, density, dry residue, alcohol content and chemical
Vânia Emerich Bucco de Campos 3,4
marker are evaluated. In Brazil, mother tinctures from different suppliers
may have high variability in terms of the specifications described in the
homeopathic pharmacopoeia. Objective: The aim of the present study
was to compare mother tinctures’ quality control from different pharma-
ceutical suppliers based on Brazilian Homeopathic Pharmacopoeia 3rd
edition. Methodology: Five mother tinctures were selected according to
the high number of requests in the pharmacies and, also its monographs
are in the Brazilian Homeopathic Pharmacopoeia (FHB) 3rd edition. The
report of analysis of the product was provided by three homeopathic
1 Instituto Hahnemanniano do Brasil - IHB;
2 Universidade Federal Fluminense;
pharmacies from the city of Rio de Janeiro. The information in the re-
3 Fundação Centro Universitário Estadual ports were evaluated and compared to its monograph. Results and dis-
da Zona Oeste
4 Laboratório Multidisciplinar de cussion: In this study, it was found that the number of laboratories that
Ciências Farmacêuticas and Pesquisa &
Desenvolvimento em Práticas Integrativas
provide homeopathic pharmaceutical ingredients is rather low. In addi-
e Complementares, tion, in some reports, a number of identification tests was not described
Faculdade de Farmácia, UFRJ
*hayla_pinheiro@hotmail.com properly when compared to the monograph. Besides that, some informa-
vaniabucco@gmail.com tion diverges from the pharmacopoeia, for example, absence of dry resi-
due testing, replacement of the part of the plant used to prepare the
mother tincture and results that do not meet pharmacopoeia specifica-
tions. As can be seen, the quality and effectiveness of homeopathic med-
icines prepared from these tinctures may be compromised. Conclusion:
In order to guarantee consumer protection and the quality and effective-
ness of medicines, governments and regulatory agencies should require
greater commitment from suppliers in the production of homeopathic
inputs.
K e y w o r d s : Homeopathic mother tincture, quality control,

analysis report.
65
PROCEEDINGS
Teaching and practice in Homeopathy via

pharmacobotany and pathophysiology
Claudio Hansel Martins*
B a c k g r o u n d : Semiology, Clinical Pathophysiology, Phytotherapy and
Patrícia Musmanno Homeopathy were taught through active methodology by the Moodle
platform (HL) also using apps for monitoring injuries through SAPB site,
Sandra Ávila Gaspar
building rationality for the external topic use of homeopathic and herbal
Josiane Bentes medicines. At the 7th Infirmary of General Hospital Santa Casa de Mi-
sericordia in Rio de Janeiro, the clinical medical team of the Benoit Mure
Rosana Ximenes
Nucleus of Assistance Teaching and Research, made a medicinal plant
Denise Nagamatsu garden with the agricultural/environmental educator, and community
leaders. Undergraduate students from UNIFASE/FMP Academic League
Fábio Tavares
of Physiology and Pathophysiology planted Calendula Officinalis seed-
Fabio Bolognani lings, destined to research in pharmacobotany and to be in touch with
Marcia Cristina Braga pharmacotechnical prepares. Aims: To follow-up the study since from
Nunes Varricchio 1 seedling of Calendula Officinalis till to prepare of HUD. Methodology:
To prepare medicinal garden: plant seedlings of Calendula off in accor-
dance with good agricultural techniques. At first: Three seeds in ten pots,
made in triplicate (N = 90), to obtain explants of quality analyzed whose
evaluation was about plant development (explants percentual: weight,
size, viability, morphology). To visit pharmacy-school to learn how to
prepare matrix extracts and High Ultra-Diluted Solutions (HUD) of Ca-
lendula off 6 DH. Results and discussion: The stages of teaching semiol-
ogy and practice in pharmacobotany, besides cultive plant have been
Faculdade de Medicina de Petrópolis –
Rio de Janeiro, Brazil (FMP/Fase), Estação 4x4, completed. Viability was impaired because of lack of irrigation during 4
7ª Enfermaria do Hospital Geral Santa Casa
da Misericórdia RJ/BR months (50%). Weight and size were minor than usual but with no statis-
*claudiohasn@gmail.com tical significance (p>0.05). Morphology was maintained. Unfortunately,
varichio2@gmail.com
the visit to pharmacy-school couldn’t be performed at this period. Con-
clusion: Through hybrid learning and face-to-face activities completely
realized, students had qualitative perception of the relevance about mor-
phology and quality of plant development, chemistry plant production,
aiming for resolute actions based upon pathophysiology of chronic dis-
eases. Because of pandemic, it was described just a preliminary experience.
After returning to normal activities the experiment will be repeated.
K e y w o r d S : Medicinal plant garden, Pathophysiology,

Pharmacobotany, Homeopathy, Calendula officinalis.
66
PROCEEDINGS
La Gioconda Effect, Homeopathy and Self-

Organizing Factors of Biofield methodology
Silvio Leite Monteiro da Silva* 1 B a c k g r o u n d : The phenomenon of people’s attraction to Homeopathy
throughout its history is a known fact by all homeopaths. This attraction
is noted in polarization of people’s opinions, some for and some against.
People in favor of Homeopathy use dynamic drugs and contribute to the
area, for example, the development of the methodology Self-Organizing
Factors of Biofield (BioFAO). In contrast, people against Homeopathy try
to stop its use and feed endless discussions. Despite be aware of these
events, there was no prior description about the whole process identified
Universidade Federal do Estado
as an effect to make easy the development of an appropriate response.
do Rio de Janeiro (UNIRIO) This understanding was published in a brief explanation of the phenom-
*silvioleite@gmail.com
enon exemplified by development of BioFAO. Due to similar behavior of
people that happened with another great work, which is a famous paint-
ing, the phenomenon was called La Gioconda Effect. Aims: The purpose
of this paper is to describe the La Gioconda Effect. Methodology: After
comparing both Homeopathy’s and Mona Lisa’s histories found at bib-
liographic review, the La Gioconda Effect was revealed, described quali-
tatively, and published. Results and discussion: The relationship be-
tween people with Homeopathy showed several similarities with people
and Mona Lisa. Both works survived on a secular scale, influenced gen-
erations, have a period of social acceptance, many people show extreme
interest in the use, education, research and dissemination of them. A re-
markable example of the development of Homeopathy is the creation of
BioFAO, which is a protocol with a complex of dynamic dugs. The de-
scription of La Gioconda Effect helps to understand the history and devel-
opment of Homeopathy, as well as people’s behavior. Conclusion: La Gio-
conda Effect demonstrates people’s attraction to Homeopathy.
K e y w o r d s : La Gioconda Effect, History and Development of

Homeopathy, Behavior.
F i n a n c i a l s u p p o r t : The Instituto BioFAO generously offered the

subscription to the V Workshop Internacional de
Homeopatia da UFRJ / XXXIV GIRI meeting
where this abstract is presented.
67
PROCEEDINGS
Lycopodium clavatum as a homeopathic treatment

in Magellanic penguins (Spheniscus magellanicus)
Franscinne Brait Narita 1,2,4* B a c k g r o u n d : Uric acid is the main form of excretion of nitrogenous
components in birds. The assessment verification samples control and
Hugo Gallo 1,3
check of uric acid concentrations is widely used to detect kidney disease.
Cideli de Paula Coelho 4 High concentrations (up to five times) of uric acid in plasma can lead to
the precipitation of this acid in the form of crystals, which accumulate in
the tissues, mainly in the synovial joints and the viscera surface. Aims:
Report the evolution of homeopathic treatment in increased uric acid in
Magellanic penguins (Spheniscus magellanicus) from Santo André Mu-
nicipal Zoo. Methodology: 12 animals showed an increase in uric acid
(reference values 0.3-16.1 mg/dL) and received homeopathic treatment
with Lycopodium clavatum 6 CH. The protocol established was the ad-
1 Instituto Argonauta para Conservação ministration of two globules of Lycopodium clavatum 6 CH, once a day,
Costeira e Marinha, São Paulo, Brazil
2 Sabina Escola Parque do Conhecimento,
inside fishes offered in the animal’s beak. Treatment started on
São Paulo, Brazil 25/09/2019. On 30/10/2019, a new blood sample was collected, those
3 Aquário de Ubatuba, São Paulo, Brazil
4 Santo Amaro University, who were not discharged were kept on treatment and new collections
São Paulo, Brazil
*franscinne.institutoargonauta@gmail.com
were made on 27/11/2019 and 17/12/2019. Results: 8 animals had an
average uric acid of 20.45mg /dl and responded to the 35-days treatment,
normalizing the biochemical values with an average of 12.24 mg /dl. Two
animals with 18.27 mg /dl were discharged in 62 days with 11.70 mg /dl
and another two penguins with 19.85 mg /dl were discharged in 82 days
later with 9.57 mg /dl of uric acid. Conclusion: Homeopathy proved to be
successful in the treatment of increased uric acid in Magellanic penguins,
easy to administer, affordable and without side effects.
K e y w o r d s : Homeopathy, High Dilutions, Sea birds, Uric acid.

68
PROCEEDINGS
Analysis of homeopathic remedies prepared at

UFRJ University Pharmacy in 2018
Lucas Fernandes Muniz da Silva B a c k g r o u n d : The quality of homeopathic remedies is important for
their reproducibility and for achieving therapeutic effects. Within this con-
Fortune Homsani
text, the Homeopathic Laboratory (named in honor of Professor Marta
Adriana Passos Oliveira * Cortês Duarte) from the Federal University of Rio de Janeiro (Faculty of
Pharmacy) has the challenge of offering services with excellence in terms
of compounding remedies, analyzing prescriptions, alongside patient
awareness of the particularities of homeopathic medicine. Aims: The aim
of this project is to gather information regarding the profile of homeopath-
ic prescriptions prepared at UFRJ University Pharmacy. Methodology: The
following data — prescribed drugs, dosage form, potency and others —
were collected during the period from April to October 2018. Results: 209
Universidade Federal do Rio de Janeiro (UFRJ), prescriptions were received resulting in 394 different homeopathic reme-
Faculty of Pharmacy dies. 65% of these prescriptions came from the private system (255 reme-
*adrianapassos@pharma.ufrj.br
dies), whereas 35% came from the public system (139 remedies). The re-
search also indicated the top-five prescribed drugs: Aconitum napellus
(14%), Arnica montana (14%), Arsenicum album (12%), Calcarea carboni-
ca (12%) and Dulcamara (9%). The most prescribed dosage forms were
granules/powder (31.9%), soft tablets (31.7%) and pills (22.1%). Conclu-
sion: The profile of remedies prepared was identified, supporting the de-
velopment of a standard operating procedure when analyzing prescrip-
tions. The monographs of most prescribed drugs identified were included
in the official compendium published by the University Pharmacy from
the Federal University of Rio de Janeiro.
K e y w o r d s : Homeopathy, homeopathic prescribing, homeopathic

remedies, University Pharmacy, UFRJ.
69
PROCEEDINGS
In vitro evaluation of Sporothrix

brasiliensis biotherapic
Amanda Ribeiro Ricardo Brito 1* B a c k g r o u n d : Sporothrix brasiliensis is one of the most virulent zoono-
ses which affect animals and humans. This fungus is responsible for the
Lais Cavalcanti dos Santos
Velasco de Souza 2
subcutaneous infection, and its contamination is possible through trau-
ma to the skin. Sporotrichosis is highly prevalent in felines. Furthermore,
Andrea Regina de Souza Baptista 2 Rio de Janeiro appears to have the highest occurrence of cases. Objec-
Leandro Machado Rocha 3 tives: This study aims to evaluate the in vitro efficacy of Sporothrix brasil-
iensis biotherapic, with and without an association to allopathic medi-
Gleyce Moreno Barbosa 4* cine commonly used in the treatment. Methodology: Conidium cells of
Sporothrix brasiliensis were cultured in Potato dextrose agar (PDA) for 5
to 7 days and yeast cells in Brain heart infusion (BHI) for 3 to 5 days.
After incubation, the cells were scraped with a drigalski handle and fil-
tered using a cell strainer into a tube and centrifuge for 5 minutes at
3,000 RPM. The cells were resuspended with Phosphate buffered saline
(PBS), centrifuge again, and finally resuspended in PBS. After preparing
the inocule, the microplates were prepared. There were 5 groups in vitro.
1 Pharmacy Student, Federal The first one was the control group, only fungi. The second was the treat-
Fluminense University
2 Investigation of Microorganism Center,
ment of fungi with homeopathic medicine (Sporothrix brasiliensis 30dH).
Federal Fluminense University The third group was homeopathic medicine in association with itracon-
3 Pharmacy Faculty, Federal
Fluminense University azole. The fourth was the treatment with itraconazole only. And the last
4 Pharmacy Faculty, Federal
Fluminense University
group was the fungi with dynamized distilled water 30DH. Sporothrix
*amandabrito@id.uff.br; brasiliensis 30 DH was prepared according to Brazilian Homeopathic
gleycemorenobarbosa@id.uff.br
Pharmacopeia. Results and discussions: The experiments are still in
progress, and the results are being analyzed through Analysis of variance
(ANOVA) to determine statistically significant differences. Recent MIC
results demonstrated no growth in the higher concentration of biothera-
pics associated with itraconazole. There was also no growth in the higher
concentration of itraconazole and itraconazole with water. Conclusion:
Experiments are being made to verify the efficacy of biotherapic on spo-
rotrichosis treatments.
K e y w o r d s : Sporothrix brasiliensis, biotherapic, in vitro.

FOURTH SESSION
IN VITRO STUDIES
71
PROCEEDINGS
Macrophage activity regulation by high dilution

of aspirin and its possible mechanism
Adalberto do Carmo Braga B a c k g r o u n d : Under LPS-stimulus, platelets can activate macrophage
von Ancken 1* by a cell-to-cell contact or through cytokine degranulation. Rebound ef-
fects of antithrombotic agents, such as prostanoids and COX inhibitors
Francisco Eizayaga 2
can lead to thrombosis, infarct, and stroke. Aspirin has been prescribed
Leoni V. Bonamin 3 for decades due to its powerful antiplatelet action, but it is also related to
paradoxical effects such as withdrawal syndrome peaks, resistance, and
thrombogenesis. Ultra-diluted aspirin can also produce the same effect
in one hour, regardless of Cox-2, by still unknown pathways. Antithrom-
botic effects of aspirin are also reversed by its high dilutions. Aims: This
study aims to characterize the effects of aspirin 15 CH on macrophages
challenged with LPS, a Cox-2 activator. Methodology: RAW 264.7 mac-
rophages were sown in 24 wells plates using R10 medium, boosted with
1 UNIP, Brazil 1μg/ml LPS and treated with aspirin 15 CH and controls. The activity was
2 Universidad de Maimônides, Argentina evaluated after 24 hours. Supernatants were evaluated for cytokines, ni-
3 *acbvonancken@hotmail.com
tric oxide, and dielectric oscillations, through solvatochromic dyes (Cart-
wright’s method). Results and discussion: macrophage spreading was
increased by aspirin 15 CH, a LPS-like effect. Paradoxically, a significant
reduction of this effect was noted when both, LPS and aspirin 15 CH,
were added. Succussed water reversed the effect of LPS, leading to TNF
(p<0.05) production close to baseline levels. Also, the single treatment
with succussed water inhibited IL-10 production (p<0.05), but aspirin
200 µg/mL (positive control) highly increased it (p<0.0001), showing the
validity of the model. Nitric oxide production was strengthened by LPS
presence (p<0.0001), as expected, but partially downregulated after
treatment with aspirin 200 µg/mL, water and sucussed water. A pilot
study with solvatochromic dyes showed no significant difference among
treatments. Conclusion: The main data suggest that aspirin 15 CH in-
creases macrophage activity but presents a paradoxical effect when
mixed with LPS. On the other hand, succussed water itself has modulato-
ry effects on macrophages.
K e y w o r d s : LPS, homeopathy, solvatochromic dyes, cytokines, NO.

72
PROCEEDINGS
Homeopathic medicine activity on the

growth of Gram-negative bacteria
Everton Tadeu Prado 1,3* B a c k g r o u n d : Homeopathy is a therapy that uses medications prepared
with infinitesimal and dynamized dilutions. Current studies demon-
Tania Aguiar Passeti 2
strate in vitro activity of homeopathy on gram-positive bacteria such as
Susana Nogueira Diniz 3 Staphylococcus aureus and Streptococcus pyogenes. Among bacterial in-
Audrey de Souza Marquez 3,4*.
fections, urinary tract infection (UTI) is frequent, leads to later conse-
quences and the main causal agent is Escherichia coli (E. coli). In other
publications, it has been reported inactivity of homeopathy on E. coli
cultures. Due to the divergence in the literature, the objective of this
study was to evaluate gram-negative bacteria growth under homeopathy
treatment. Method: The medicines Atropa belladona, Cantharis, Staphys-
agria and Colibacillinum were tested at 6 CH, 12 CH and 30 CH in E. coli
ATCC 25922 and EPEC (Enteropathogenic Escherichia coli) ATCC 43887.
The bacterial strain was prepared at 0.5 McFarland turbidity, then dilut-
1 Pharmacist, Professor in Health ed 1:10 in saline solution, and 10 µL of that preparation poured into
Undergraduate Courses. Anhanguera
Faculty of São José dos Campos. São José
tubes containing 3 mL of Brain Heart Infusion (BHI) broth, followed by
dos Campos, SP, Brazil the addition of 250 µL of each homeopathic medicine, respectively. From
2 Biotechnology and Innovation in Health
and Pharmacy Graduate Program. each tube, 150 µL was transferred to the wells of the flat-bottom plate.
Anhanguera University of São Paulo,
UNIAN. São Paulo, SP, Brazil. E-mail:
Bacterial growth was evaluated in a spectrophotometer at 600 nm, in the
tania.passeti@japta.com.br periods of 6, 12, 16 and 20 hours of incubation. Result and discussion:
3 Professional Master’s Program in
Pharmacy. Anhanguera University of São The results showed no inhibition of bacterial growth under the studied
Paulo, UNIAN. São Paulo, SP, Brazil. E-mail:
susana.diniz@anhanguera.com
conditions. These data corroborate with other studies that indicate the
4 Center of Research in Health Sciences. absence of action of homeopathy on E. coli cultures. Considering other
University of Northern Paraná, UNOPAR.
Londrina - PR, Brazil research, it can be suggested that homeopathic medicines have direct ac-
*etprado@gmail.com
audrey.marquez@unopar.br
tivity on the growth of Gram-positive and not Gram-negative bacteria.
Evaluating the two bacterial groups, it is possible to assume that the dif-
ference in homeopathy activity could be linked to differences in bacterial
wall structure. This hypothesis should be further evaluated by other tests
and protocols with the same bacterial strains. Conclusion: The homeo-
pathic medicines tested showed no direct activity on the growth of
Gram-negative bacteria cultures.
K e y w o r d s : Homeopathy, Escherichia coli, Urinary Tract Infection,

Gram-positive bacteria, Gram-negative bacteria.
73
PROCEEDINGS
Carcinosinum produces phenotypic

changes of 4T1 tumor cells in vitro
Thaís Cristina da Silva B a c k g r o u n d : Considering that there are few published studies that
specifically address the exclusive use of Carcinosinum in different poten-
William Alves dos Santos
cies and, most of them focused on genotypic and clinical effects, the pres-
Sandra Augusta Gordinho Pinto ent study was proposed to identify possible phenotypic changes, includ-
ing viability, expression of HER-2 and metastatic abilities, using 4T1 cells
Elizabeth Cristina Perez Hurtado
in vitro as a model. Methodology: Carcinosinum was tested in different
Leoni Villano Bonamin * homeopathic potencies (12 CH; 30 CH; 200 CH) mechanically prepared
using sterile pure water. The final dilutions were inserted into the culture
medium in a volume equal to 10%, at the time of cell seeding. As a con-
trol, sterile pure water not dynamized was used. All treated cells were
cultured in 25 mL flasks, with cell density of 1 x 105 cells/mL. After 24
hours of treatment, cells were analyzed for apoptosis index using Annex-
in V kit and the Countess® system. The morphology of 4T1 cells was
monitored by staining cell smears with hematoxylin-eosin and Giemsa
Universidade Paulista, São Paulo, Brazil methods. HER-2 expression was assessed by immunocytochemistry and
*leonibonamin@gmail.com
metalloproteinase activity was assessed by zymography. The determina-
tion of the cytokine profile was performed using Cytometric Bead Array
(CBA). The samples were evaluated in quadruplicate and the data were
analyzed by one-way ANOVA. Results and discussion: Carcinosinum 30
CH presented the highest apoptotic index and reduction of MMP-9-Pro
expression; Carcinosinum 200 CH produced the highest positivity for
HER-2 and no specific effect was seen after the treatment with Carcinosi-
num 12 CH. No change in cytokine expression was seen among treat-
ments. Conclusions: We conclude that Carcinosinum 30 CH and 200 CH
can change phenotypic features important to tumor development in vi-
tro. The clinical meaning of these data deserves further investigation.
K e y w o r d s : Carcinosinum, 4T1 cells, homeopathy, in vitro model

cancer, breast adenocarcinoma.
74
PROCEEDINGS
Evaluation of the in vitro fungicidal activity

of the dynamized essential oil of Aloysia
polystachya before and after freezing
Talita Thomaz Nader 1* B a c k g r o u n d : The method of preserving substances of natural origin
should not only maintain the microbiological safety of the product but
Camila Yamasita Henrique 1
also the integrity of its therapeutic potential. Essential oils obtained from
Alexandre Henrique Leonel 1 plants are complex mixtures of substances and it is suggested to keep
them under refrigeration for better conservation. On the other hand, ho-
Ana Maria Soares Pereira 2
meopathic mother tincture prepared from plants is kept at room tem-
perature. Aim: This work aimed to evaluate if the freezing process chang-
es the in vitro antifungal activity potential of the homeopathic preparation
Aloysia polystachya 1 CH against Candida albicans. Methodology: The
inoculum of C. albicans ATCC 10231 was cultivated in culture medium
Sabouraud (Himedia®), standardized on a spectrometer and distributed
in a 96-well plate. Then, A. polystachya 1 CH was added to the wells, pre-
pared according to the Brazilian Homeopathic Pharmacopoeia (FHB, 3rd
1
Homeopatia Brasil, Brazil
2
Universidade de Ribeirão Preto (Unaerp), edition) from A. polystachya essential oil. An aliquot of this homeopathic
Brazil preparation was frozen and after 40 days it was submitted to the same
*talitanader@hotmail.com
methodology for evaluation of the antifungal activity. After incubation,
the plates were read with triphenyltetrazolic (TTC) (Vetec®). Results and
discussion: The results of the in vitro evaluation showed that the freezing
process retained the antifungal activity of the dynamized essential oil of
A. polystachya 1 CH against C. albicans. Conclusion: Under the condi-
tions evaluated in this study, the freezing method presented as a viable
method of conservation of dynamized plant material.
K e y w o r d s : Candida albicans, Aloisia polystachya, homeopathy,

high dilution, conservation.
75
PROCEEDINGS
Environmental parameters modulate lead

chloride toxicity on Artemia salina
Suham Nowrooz Mohammad Background: Different environmental conditions can influence the effects of
toxic agents on living beings. Recently, a series of experiments performed
Andreia Adelaide Gordinho Pinto
in Artemia salina submitted to different kinds of intoxication have shown
Mirian Yaeko Nagai that both, isotherapic and succussed water can change Artemia salina’s
Ednar Nascimento Coimbra
bio resilience at different levels. Moreover, it seems to vary according to
the circalunar cycle. Aims: To verify if circalunar phases and water agita-
Ivana Barbosa Suffredini tion can modify the toxicity of lead chloride on Artemia salina in vitro.
Giovani Bravin Peres Methodology: Artemia salina cysts were exposed to seawater containing
0.04% of lead chloride (equal to EC10 or 10% effective concentration, pre-
Maria Martha Bernardi viously determined in a pilot study) in 96-well culture plates. Thirty-six
Leoni Villano Bonamin1 experimental repetitions were performed in four series to observe the
possible effects of adding stirred water, the so-called succussed water, and
the moon phases. The hatched cysts were recorded after 48 hours using a
digital microscope (1000x magnification) to identify the hatching per-
centage and the viability and mobility of the born nauplii. Results: The
exposition of cysts to PbCl2 led to an increase in the hatching rate, and it
was more evident during the full moon (p = 0.00014). The addition of
succussed water into the seawater medium reduced this effect to the base-
line levels. An increase in mobility was seen in nauplii born from exposed
cysts during the full moon (p = 0.00077), but this effect was not affected
Graduation Program in Environmental
and Experimental Pathology, Universidade by the treatment with succussed water. Discussion: Although the effects
Paulista - UNIP, São Paulo, Brazil
of lead chloride EC10 on the increase of nauplii hatching were expected,
two environmental variables changed the sensitivity of cysts to this harm-
ful stimulus. The circalunar cycle varied the hatching rate according to the
moon phase, even in laboratory conditions, and the addition of succussed
water into the medium reduced the hatching rate, even with different in-
tensities according to the moon phase. The organization of nano and mi-
crobubbles generated after the succussion of water could be related to this
protective effect and can explain, at least partially the effects of high dilut-
ed preparations on this biological context. Conclusion: Environmental
factors, such as the circalunar cycle and products of water agitation, can
modulate the adaptative control of hatching in Artemia salina exposed to
lead chloride at EC10.
K e y w o r d s : Ecotoxicology, microcrustacean, circalunar cycle,

water agitation.
FIFTH SESSION
IN VIVO STUDIES
77
PROCEEDINGS
Stress - another possible mechanism of

neurotoxicity in neurodegenerative diseases
Maria Filomena Xavier Mendes 1* B a c k g r o u n d : The literature associates oxidative stress with the produc-
tion of free radicals, which lead to neurodegeneration. They present in-
Paulo de Oliveira 2
numerable hypotheses, among which are abnormalities in the function-
Maria Solange Gosik 3 ing of the hypothalamic-pituitary-adrenal axis, neurotoxic effects and
Renata Garcia Lino 1
neuronal oxidative damage. Clinical observation has shown that in neu-
rodegenerative diseases such as Multiple Sclerosis (MS) and Amyo-
Raquel Bruno Kalile 1 trophic Lateral Sclerosis (ALS) there is a report of prolonged or violent
Danielle da Silva barbas 4 emotional stress preceding the symptoms. Aims: Using the Carillo Com-
plex Systems Model, present some possibilities on how stress can con-
Romeu Carillo Jr. 5 tribute to neurodegeneration. Methodology: Nine cases of ALS and six
cases of MS were evaluated, pathologies already classified as belonging to
syphilinism. Literature review on stress and neurotoxicity carried out.
Results and discussion: Syphilinism are an instability with a predomi-
nantly intrinsic origin to the system with a chronic caracter. This diathe-
sis characterized by a dissipative deficiency, predominantly hepatic, to
the processing of certain elements or potentially toxic substances with
exogenous origin or endogenous Such non-processed substances are un-
1 ABRAH – Associação Brasileira de
stable factors in the system, with greater affinity for certain tissues, like
Reciclagem e Assistência em Homeopatia. the nervous system. Among the toxins, we find alcohol, esters, formalde-
Rio de Janeiro, Brazil
2 University of Évora, Portugal; Internship hyde, aloe, ketones, aldehydes, etc. The final hepatic metabolism of corti-
at ABRAH in partnership with IMT
3 ABRAH. Taboão da Serra - SP, Brazil
sol results in cortic acids and cortol, which use the same enzymatic sys-
4 ABRAH; University of Brasilia – tem as alcohol, and can be considered syphilinic toxins. Ethanol can act
UNB; Brazil
5 ABRAH – São Paulo, Brazil directly at the circadian rhythm, disrupting it and generating stressful
* filoabrah@yahoo.com.br
substances such as cortisol, regardless of an external event, increasing
the toxin level. The inflammatory process generated by the production of
free radicals and metabolic abnormalities, including the reduction of
neuropeptide Y that modulates inflammatory activity in the nervous sys-
tem, leads to changes that can result in neurodegeneration. Conclusion:
Inflammation caused by toxins from prolonged/violent emotional stress
can lead to several changes in syphilinic individuals, due to failure in the
dissipative process, including neurodegeneration.
K e y w o r d s : Stress, neurotoxicity, Complex Sistems Model, Syphilinism.

78
PROCEEDINGS
Effect of homeopathy on quality of corncobs

naturally exposed to sugarcane virus
Mônica Filomena Assis de Souza 2* Background: The use of pesticides is damaging to the health of farmers and
consumers as their use is associated with numerous diseases. Homeopa-
Kácio Gomes de Macedo 1
thy is one of the techniques for organic agriculture currently authorized
David Junior de Oliveira Pereira¹ by the MAPA. Aims: To assess the effect of homeopathic compounds on
Graciela Andreia Flis Machado¹
corncob quality in pesticide-free cultures. Methodology: The experi-
ment was performed in, MS-Brazil. Two culture fields were used, each
Leonardo Américo Souza Barbosa 2 30m2 in size. The homeopathic group treatment consisted of 1ml of 30%
Larissa Wolff Gonçalves² hydroalcoholic solution with homeopathic ingredients. This solution was
diluted into 30ml of water and then sprayed onto 100 seeds. The control
Pedro Henrique de Souza Cucco² group was submitted to the same protocol excluding the homeopathic
Marco Antonio Cucco² ingredients. The homeopathic ingredients used were Sulph 9 CH, Mag-c
12 CH, and Calc-p 9 CH, prescribed according to Materia Medica instruc-
Karine Bonucielli Brum 3 tions. Evaluation was performed at harvest by comparing the average
weight of 1000 kernels per group, obtained from weighing of 3000 ker-
nels per group. In addition, a number of corncobs from both groups were
qualitatively evaluated as “good” or “bad.” Statistics analysis used the
T-test to compare the kernel weight averages and the Fisher’s exact test to
analyze the corncob quality frequency. Both groups were naturally in-
fected by a virus from a neighboring sugarcane field, causing qualitative
and quantitative losses on both groups. Results and discussion: The av-
1 Agriculture and Husbandry Technical erage weight of 1000 kernels from the treated group (329 g) was not sig-
Course, Escola Estadual São Gabriel, MS
[State School São Gabriel, State of Mato nificantly greater (p=0.06) than the average weight of 1000 kernels from
Grosso do Sul] the non-treated group (308 g). It was observed that 71 out of 158 (44.9%)
3 Universidade Federal de Mato Grosso do Sul corncobs from the homeopathic treatment group were classified as
[Federal University of Mato Grosso do Sul]
*monica.rt@sigohomeopatia.com.br “good” while zero out of 50 (0%) corncobs from non-treated group were
classified as “good”, resulting in significant difference (p<0.01). Conclusion:
Homeopathic compounds can be used as a feasible treatment for health
and productivity in corn crop.
K e y w o r d s : Zea mays, kernel quality, agroecology, agrohomeopathy,

quantum agriculture.
79
PROCEEDINGS
Influence of homeopathy on the quality of

eggs stored for different periods of time
Monica Filomena Assis de Souza³* B a c k g r o u n d : The purpose of this trial was to assess the influence of
homeopathy products on the diet of quails based on egg quality when
Wellington dos Santos 1
submitted to different storage periods. Methodology: Two hundred, 45-
Jean Kaique Valentim 2 day old Japanese quails and 80% of production were used, in a complete-
Rodrigo Garófallo Garcia²
ly randomized design comprised of a 4x3 factorial, and 4 diets (basal
feed, inert vehicle and 2 homeopathic products: Fertsigo® (Sulphur 10
Maria Fernanda de CH, Sepia 15 CH) and Ovosigo® (Belladonna 12 CH, Silicea 12 CH, Na-
Castro Burbarelli² trum mur. 30 CH, Calcarea phos. 30 CH, Sulphur 12 DH) and 3 storage
Felipe Cardoso Serpa 2 periods (0 days, 7 days and 14 days) with ten repetitions of three eggs per
treatment. The weight, percentages of yoke, albumen and shell, albumen
Gisele Aparecida Felix² height and yolk color, specific gravity, Haugh unit, yolk index and shell
Gabriella Galvão Pizarini thickness were evaluated. The data were submitted to variance analysis to
do Nascimento² verify whether there was an interaction effect between homeopathy fac-
tors and storage time, and when absent, the isolated effects. Results and
Bruna de Souza Eberhart¹
discussion: an interaction between the homeopathic products and time
Pedro Henrique de Souza Cucco 3 was found for the parameters of albumen height and yolk, Haugh unit
and yolk index, which reduced over time. For egg weight, yolk, albumen
Marco Antonio Cucco 3
and shell, a significant effect (p<0.05) was found only in the case of ho-
Karine Bonucielli Brum 4 meopathy for the percentages of albumen and shell. For egg and albu-
men weights, yolk and albumen percentages, specific gravity and colo-
rimetry there was an effect for time, however these parameters reduced
over the storage time in days. The addition of the homeopathic based
products Ovosigo® and FertSigo® are indicated for the diets of Japanese
quail during the laying phase since it resulted in better weights for the
egg and its components. Conclusion: The different homeopathic prod-
ucts did not have an influence on conserving the quality of the Japanese
1 Departamento de Zootecnia, Universidade quail eggs during the periods evaluated.
Federal da Grande Dourados, MS
2 Faculdade de Ciências Agrárias e Exatas K e y w o r d s : Quail farming, organic products, ultra-highly diluted
da Grande Dourados - UNIGRAN
3 Sigo Procedimentos Homeopáticos LTDA remedies, egg weight, egg production.
4 Universidade Federal de Mato Grosso do Sul
*monica.rt@sigohomeopatia.com.br E t h i c a l c o m m i t t e e : Protocol number 052/18.
80
PROCEEDINGS
High Dilution in Dyslipidemia treatment

in Dogs and Rabbits
Bruna Scardoeli 1* B a c k g r o u n d : Excess weight causes disorders in locomotor, cardiore-
spiratory and reproductive systems and increases the incidence of endo-
Cideli de Paula Coelho 1, 2
crinopathies, as well it can often cause dyslipidemias, leading to athero-
sclerosis. Aims: Report the evolution of homeopathic treatment in 4
overweight patients, being 2 female dogs and 2 female rabbits with hy-
pertriglyceridemia, analyzing the values in biochemical test. Methodology:
Homeopathic treatment was chosen, based on the principle of similitude,
using Cholesterinum due to its action to decrease cholesterol and tri-
glyceride levels. Results and discussion: the same protocol was made for
all of the four patients, included 2 globules of Cholesterinum 30 CH di-
1 High Dilution Science (HD Science), rect in its mouth, every 12 hours for 30 days. The first dog attended on
São Paulo, Brazil
2 Santo Amaro University, São Paulo, Brazil 01/09/2019, presented 328 mg/dL of triglycerides, decreasing this level to
*bruna@esecon.com.br
132 mg/dL after just one month treating. The second dog attended on
04/05/2019, presented higher hypertriglyceridemia with 617 mg/dL that
decreased to 259 mg/dL. Likewise, on 02/06/2019, the first rabbit attend-
ed, presented 445 mg/dL of triglycerides, which reduced to 337 mg/dL,
while the second rabbit, on 06/27/2019, presented 372 mg/dL of tri-
glycerides, decreasing to 274 mg/dL after. Although the values of choles-
terol in all patients were in agreement with the reference, the treatment
still proved improvements. In the beginning of the treatment, the first
dog showed 207 mg/dL of cholesterol and in the end, it reduced to 170
mg/dL, as well with the second dog with 218 mg/dL in the beginning and
200 mg/dL after. Regarding rabbits, the first one presented initial value of
60 mg/dL, which decreased to 52 mg/dL, while the second started with
57 mg/dL and went to 41 mg/dL. Conventionally, Bezafibrate is indicated
as a lipid-lowering agent, but it is contraindicated in patients with liver
or kidney failure, vesicular diseases and for pregnant or lactating. Con-
clusion: Dyslipidemia can be controlled with High dilution. (The ex-
posed information is consented by the tutors)
K e y w o r d s : Homeopathy, Dyslipidemia, Triglycerides,

Cholesterol, Overweight.
Honorable mention
82
PROCEEDINGS
FIRST SESSION: CLINICAL STUDIES
Evaluation of the effectiveness of Arnica

montana 6 CH in the control of postoperative
myalgia by isometric effort in dentistry
Rosy de Oliveira Nardy 1,2*
Adriana Marques Nunes² 1 Associação Brasileira de Reciclagem

e Assistência em Homeopatia (ABRAH);
Leonardo dos Santos Barroso 2,3 2 Centro Universitário de Volta Redonda (UniFOA) -
Volta Redonda/RJ;
Cristina Garani Schneider Guimarães 2 3 Universidade de Taubate (UNITAU) - Taubaté/SP
SECOND SESSION: CHEMICAL AND PHYSICAL STUDIES
Wine preservation using potassium

metabisulphite high dilution:
a preliminary study
Joni Stolberg 1
Ketlin Schneider 1
1 Federal University of Santa Catarina – Campus of
Wilson Taybar Assumpção 1 Curitibanos, Brazil
2 EPAGRI – Laboratory of Plant Health and
Pedro Boff 2 Homeopathy/Lages Experimental Station, Brazil
83
PROCEEDINGS
THIRD SESSION: HOMEOPATHIC TEACHING AND PRACTICE
Analysis of homeopathic remedies prepared

at UFRJ University Pharmacy in 2018
Lucas Fernandes Muniz da Silva
Fortune Homsani
Universidade Federal do Rio de Janeiro (UFRJ),
Adriana Passos Oliveira Faculty of Pharmacy
FOURTH SESSION: in vitro STUDIES
Carcinosinum produces phenotypic changes

of 4T1 tumor cells in vitro
Thaís Cristina da Silva
William Alves dos Santos
Sandra Augusta Gordinho Pinto
Elizabeth Cristina Perez Hurtado
Leoni Villano Bonamin Universidade Paulista, São Paulo, Brazil

84
PROCEEDINGS
FIFTH SESSION: in vivo STUDIES
Effect of homeopathy on soybean germination

through soil and seed treatment
Monica Filomena Assis de Souza
Kácio Gomes de Macedo¹
David Junior de Oliveira Pereira¹
Leonardo Américo Souza Barbosa²
Graciela Andreia Flis Machado¹
Pedro Henrique de Souza Cucco²
Marco Antonio Cucco² 1 Associate Degree in Agriculture, Escola Estadual São Gabriel, MS
Karine Bonucielli Brum³ 3 Universidade Federal de Mato Grosso do Sul
85
PROCEEDINGS
Best work prizes

86
PROCEEDINGS
Lycopodium clavatum as a homeopathic

treatment in Magellanic penguins
(Spheniscus magellanicus)
Franscinne Brait Narita 1,2,4 1 Instituto Argonauta para Conservação Costeira e Marinha, São
Paulo, Brazil
Hugo Gallo 1,3 2 Sabina Escola Parque do Conhecimento,São Paulo, Brazil
3 Aquário de Ubatuba, São Paulo, Brazil
Cideli de Paula Coelho 4 4 Santo Amaro University, São Paulo, Brazil
XXXIV GIRI - GROUPE INTERNATIONAL

DE RECHERCHE SUR I’INFINITÉSIMAL
Viscum album L. homeopathic mother tinctures:

Metabolome and antitumor activity
Michelle Nonato de Oliveira Melo 1,2
Rafael Garrett 2
1 Laboratório Multidisciplinar de Ciências Farmacêuticas
and Pesquisa & Desenvolvimento em Práticas Integrativas
Patrícia Zancan 3 e Complementares, Universidade Federal do Rio de Janeiro,
Faculdade de Farmácia, Rio de Janeiro, Brazil
Alan Clavelland Ochioni 3 2 Metabolomics Laboratory, (LabMeta/LADETEC), Chemistry
Institute, Universidade Federal do Rio de Janeiro, Rio de
Mirio Grazi 4 Janeiro, Brazil
3 Laboratório de Oncobiologia Molecular (LabOMol),
Universidade Federal do Rio de Janeiro, Faculdade de
Hartmut Ramm 4 Farmáciao, Rio de Janeiro, Brazil
4 Society for Cancer Research, Hiscia Institute, Arlesheim,
Tim Jäger 4† Switzerland
4 †Society for Cancer Research, Hiscia Institute, Arlesheim,
Stephan Baumgartner 4,5 Switzerland, in memorium
5 Institute of Integrative Medicine, University of Witten-
Carla Holandino 1 Herdecke, Herdecke, Germany
87
PROCEEDINGS
Acknowledgments
We are grateful to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) which
funded the V International Workshop on Homeopathy of the UFRJ and the XXXIV GIRI (Groupe
International de Recherche sur L’Infinitésimal Workshop Internacional), by the following Grant:
Edital PAEP, number 88887.470551/2019-00.
88
PROCEEDINGS
Financial Supports
We are very grateful to everyone who supported this event with the respective in-
scription donation. As a special tribute, we listed in alphabetical order all the 54
names. This funding was used with the conference expenses and will be applied to
support the homeopathic fundamental research conducted by our group at UFRJ.
Adalberto do Carmo Braga von Ancken

Ana Lúcia Freire Allemão de Andrade Ribeiro
André Luiz Timotheo de Lima
Andreia Adelaide G Pinto
Bruna Krepki Rodrigues da Costa
Camila Faria de Amorim Pereira
Carla Holandino
Chana de Medeiros da Silva
Christiane Ribeiro
Clailson Henriques de Almeida Farias
Clarissa Waldige Mendes Nogueira
Claudio Hansel Martins
Daniela Beier
Daniela Franco Lopes
Ednar do Nascimento Coimbra
Elaine Galm Carneiro de Souza
Eneida Janiscki Da Lozzo
Erica Pacheco
Érica Santos Nardy
Fernanda Marques Peixoto
Gabriela Harumi Sasaqui
Gleyce Moreno Barbosa
Jussara S. Jorge Giorgi
Larissa Béja
Leila Cristina dos Santos Mourão
Letícia Marília de Almeida Werneck dos Santos
Lisoni Muller Morsch
89
PROCEEDINGS
Livia Maria Scheffer Kummel

Lucas Rodrigues de Lima
Marcos Claudio Rodrigues Monteiro
Maria Cristina Azevedo Franco
Maria Cristina Ferreira Silva
Maria de Fatima Teixeira Marimon
Maria Filomena Xavier Mendes
Marianne Aparecida Ferreira de Souto
Marina Tavares Gregolin
Mario Sergio Giorgi
Mary Lannes Salles Leite
Miriam Fragoso
Mirian Yaeko Dias de Oliveira Nagai
Mônica Filomena Assis de Souza
Natália Cavasini Guerra Mosel
Patrícia Guimarães Musmano
Paulo de Souza Botelho
Priscila Inhauser Baltuille
Raquel Bruno Kalile
Renata Rodrigues Garcia Lino
Richard Gameiro Esteves
Silvio Leite Monteiro da Silva
Suham Nowrooz Mohammad
Tânia Aguiar Passeti
Thais Cristina da Silva
Valéria Santos Cugler
Vanessa Maia Rangel
90
PROCEEDINGS
The companies, pharmacies, associations listed below

participated as sponsors and partners
91
PROCEEDINGS
Institutional Supports

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V INTERNATIONAL WORKSHOP ON HOMEOPATHY OF UFRJ &

XXXIV GIRI - Groupe International de Recherche sur I’Infinitésimal

The scientific evidences of

DECEMBER, 2-4, 2021

The scientific evidences of

Tatyane Barbosa Philippi - Bibliotecária CRB 14/735

In vitro evaluation of the effects of Viscum album homeopathic preparations

Viscum album L. homeopathic mother tinctures: metabolome and antitumor activity...............................42

Homeopathy on cultures of Saccharomyces cerevisiae and impact on fermentation....................................................43

XXXIV GIRI ABSTRACTS ............................................................................................................................................................................................................................................................44

Exposure of Artemia salina to glyphosate and bioremediation by isotherapy...................................................................45

Neurobehavioral assessment of Danio rerio intoxicated by Mercury and

Effect of homeopathy on soybean germination through soil and seed treatment......................................................47

Evaluation of homeopathy effects associated with conventional periodontal therapy

XXXIV GIRI ABSTRACTS

NMR analysis: potential and challenges as a homeopathic basic research tool...............................................................51

Characterization of physicochemical markers for homeopathic medicines

Heteroisotherapic effects on the treatment against smoking: a cognitive

Control of Rhipicephalus microplus ticks in dairy cattle using homeopathic therapy.......................................56

Evaluation of the effectiveness of Arnica montana 4 CH in the control of

The use of homeopathy and flower therapy as an aid in the treatment of

Lycopodium as a treatment for Urate Deposition (gout) in birds: case report....................................................................59

Evolution of clinical symptoms of Covid-21 in healthcare professionals treated

SCIENTIFIC RESEARCH PRESENTATION

Wine preservation using potassium metabisulphite high dilution: a preliminary study............................62

SCIENTIFIC RESEARCH PRESENTATION

Comparative analysis for quality control of mother tinctures in Brazilian reports................................................64

Teaching and practice in Homeopathy via pharmacobotany and pathophysiology...............................................65

La Gioconda Effect, Homeopathy and Self-Organizing Factors of Biofield methodology.........................66

Lycopodium clavatum as a homeopathic treatment in Magellanic

Analysis of homeopathic remedies prepared at UFRJ University Pharmacy in 2.016........................................68

In vitro evaluation of Sporothrix brasiliensis biotherapic...............................................................................................................................................69

SCIENTIFIC RESEARCH PRESENTATION

Homeopathic medicine activity on the growth of Gram-negative bacteria..............................................................................72

Carcinosinum produces phenotypic changes of 4T-1 tumor cells in vitro..................................................................................73

Evaluation of the in vitro fungicidal activity of the dynamized essential

Environmental parameters modulate lead chloride toxicity on Artemia salina.............................................................75

SCIENTIFIC RESEARCH PRESENTATION

Stress - another possible mechanism of neurotoxicity in neurodegenerative diseases....................................77

Effect of homeopathy on quality of corncobs naturally exposed to sugarcane virus............................................78

High Dilution in Dyslipidemia treatment in Dogs and Rabbits.......................................................................................................................80

Evaluation of the effectiveness of Arnica montana 4 CH in the control of

SECOND SESSION: CHEMICAL AND PHYSICAL STUDIES

THIRD SESSION: HOMEOPATHIC TEACHING AND PRACTICE..........................................................................................................83

FOURTH SESSION: IN VITRO STUDIES.......................................................................................................................................................................................................83

FIFTH SESSION: IN VIVO STUDIES.......................................................................................................................................................................................................................84

XXXIV GIRI - GROUPE INTERNATIONAL DE RECHERCHE SUR I’INFINITÉSIMAL...........................86

I N S T I T U T I ONA L SU P P ORT S .............................................................................................................................................................................................. 91

The idea of GIRI is to provide connections, give possibilities to

9:00 - 9:30 Madrigal Chorus

9:30 - 9:40 Welcome to XXIV GIRI MEETING Maria Olga Kokornaczyk

Welcome Video and

Room 3 10:00 - 17:00 Epidemiology for “Normal People” Edgard Vilhena

9:10 - 10:00 Opening lecture introduction Maria Olga

Homeopathy in the Manchanda and Anil

10:15 - 10:30 BREAK

10:30 - 12:00 GIRI abstracts

FIRST SESSION Cideli de Paula Coelho

Series of experiments performed

12:00 - 13:00 LUNCH BREAK

13:00 - 13:50 Scientific Evidences of Homeopathy Ubiratan Adler

Homeopathy Evidence Map Leoni Bonamin

SECOND SESSION Vania Bucco