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fhnm setnPaper /cers

Subject
Relig End Senester Thay E
Code: 87612 / Pharmacology- III

Duration :3 hours
Total Marks : 75
0.IChoose the ONE best answer and write it
down 20 M
Sr
No Questions
Options
Ipratropium is used in treatment of asthma for which of a Beta 2 antagonistic
the following action?
b Beta 2 agonistic
C
Anticholinergic
d Anti-tussive
2 A drug used in treatment of COPD which increases a Corticosteroids
mucociliary clearance is:
b Tacrolimus
Theophylline
d Methotrexate
3 Which nasal decongestant is commonly used and has a Ephedrine
long duration of action?
b Epinephrine
Oxymetazoline
4 A drug which can be used for
d Propylhexedrine
liquification of viscid a Methotrexate
sputum is:
Ephedrine
C Carbocisteine
d Tacrolimus
The fixed dose combination of trimethoprim and a Cotrimoxazole
sulfamethoxazole is called:
b Sulfonamide
Quinolone
d Penicillin
6 Which of the following antibiotics acts by inhibiting a Chloramphenicol
bacterial protein synthesis by interfering with 'transfer
of the elongating peptide chain to the newly attached
aminoacyl-tRNA?
b Clindamycin
C
Tetracyclines
d Aminoglycosides
7 Vestibular ototoxicity is an adverse effect of: Aminoglycosides
b Quinolones
c Tetracycline
d Sulphonamides

27768 Page 1 of4

D530AAA63C21286AAF4CCOB17876EC19
 Pharmacology- III
/
Paper/Subject Code: 87612

inhibit which of the following to a Transpeptidases

Beta-lactam antibiotics
prevent cross linking ?
b mRNA reading
Phosphorylation
Protein synthesis
Artenisinin
can cause cinchonism?
9 Which ofthe following drugs
b Quinine
C Primaquine
d Atropine
Antimalarial
10 Levamisole is a nicotinic receptor agonist used as an:
b Anthelmintic
Antitubercular
d Antiamoebic
11 Which of the following azole antifungals is used only a Ketoconazole
topically?
b Econazole
Fluconazole
d Itraconazole
12 Diloxanide furoate is classified as an: a Anthelmintic
b Amoebicide
C
d
Antifungal
13 Which of the following isa microtubule damaging agent? Antiviral
Letrozole
b
Tamoxifen
C
d
Methotrexate
14 Infliximab is classified as: Vinblastine
Anti CD-3 antibody
b IL-1 receptor
c
antagonis
15 Cyclosporine acts on: d
IL-2 receptor antagons
TNFa inhibitor
b
CD3 Cells
CD8 Cells
BLymphocytes
CD4 Cells

27 Page 2of 4
 Paper / Subject Code:
87612/Pharumacology- IIi
16 Which of the
as well as an
following drug is used as anti-cancer agent a Atropine
immunosuppressant? b Vincristine
C
Tetracycline
Methotrexate
17 The Universal antidote is: Activated charcoal
b BAL

Dimercaprol
d Lime
18 Which of the following is a characteristic of acute a Sudden in onset
toxicity?
b Persistent over months
C Slowly changing
d Slowly occurring
19 Circadian rhythms are physical, mental., and behavioural a 24-hour cycle.
changes that follow a:
4-hour cycle.
C 12-hour cycle.
d 6-hour cycle.
20 The circadian rhythm is controlled by a group of cells in a Hypothalamus
the:

b Central Nervous System

c Brain Stem
d Pituitary Gland

20 M
following:
Q. II Answer Any Two from the
of action
Classify drugs used for the treatment of asthmawith examples. Give mechanism
1.
and ADR of any two classes.
of
anti-microbials based on their mechanism of action. Elaborate on mechanism
2. Classify rational use of antibiotics.
microbial resistance. Write a note on
drugs.
anti-malarial drugs with example. Ilustrate targets of antimalarial drugs.
3. Classify s s adverse effects, and
BIaction,
uses of 4-amino quinolone
Elaborate on mechanism of
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Page 3 of4
27768
D530AAA63C21286AAF4CCOB17876EC19
 N7612/Pharmacolgyl |
Paper/ Subhject Code:

Q. lAnswer Auy Seven

from the following
1. Write a short note on
Nasal decongeslants.
2. Classity Drugs used in mechanism of actionand
teatnent olof'peptie uleer, Give
etlects of Sucralfate.
ssy thoroquinolones, Describe theit mechanism of action, thernpeutie useN, and pi
adverse celects.

4. Classity anti-retroviral drugs, Describe the mechanism of action, therapeutic uses, and adve
ellectsof' nucleoside reverse transcriptase inhibitors (NRTIS).
$. Enlist the drugs used in leprosy and give adetailed account on Dapsone
6. Classify anticancer drugs. Write a note on vinca alkaloids.
7. Enlist disorders in which immune-suppressants are prescribed Write a note on interferoS,
8. Give details on the management of arsenic poisoning.
9, What is chronotherapy? Discuss about chronotherapy for diabetes mellitus
 24lnle2
Paper / Subject Code: 87612 /FC9F4FIECADS
Pharmacology- II1
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SDOBIADAAC9FBO756D3FC9F4FIECAD3CSL

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Total Marks: 75
(3 Hours)
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5DOBIADAAC9FBO756D3FC9E

N.B.: (1) Allquestions are compulsory. 31ADAAC9FBO756D3FC9F4FIEC

(2) Figureson the right indicate fullmarks.
20 M
oL Choose the ONE best answer and write it down
3IADAACOFBO756D3FCYFAFlÉCAD3C5DOB!ADAACe
B0756D3FC9F4FIECAD3CsBIADAAC
Penicillins act by: A

A. Inhibiting cellwall synthesis of bacteria

CSDOBI
B. Inhibiting DNA gyrase
DAAC9B0756D3}-C9F4FIECAD3CSDOBIADAAC9FB0756D3F
3ECOF
C. Inhibiting 30S ribosomal unit
D. Inhibiting folic acid synthesis
2. What ismeant by antibiotic resistance?
A. It means our body has become resistant to the antibiotic
B. It means the bacteria have developed resistance for the antibiotic
be elevated
C. It means that the antibiotic concentration has to AD3
the antibiotic's side effects
D. It means that our body has become resistant to
3. The benefit of bulk forming laxatives is:
ECAD3C5DOBIADCYFBO756D3FCOFFIECA
AAC9FBO7561cO4Fi
use
intestines into the body so are safe for long-term
A. That they are not absorbed from the
laxatives
B. They are potent
C. They are quick in action
patients with kidney failure
D. They may be used safely in
4. Amphetamine acts by:
levels in brain
A. Enhancing serotonin
cannabinoid receptors
B. By antagonizing
diet
C. Byincreasing the bulk in
Stimulating norepinephrine release or blocking its reuptake
D.
5. Montelukast inhibits which receptors?
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A. Histamine
B. Leukotriene
C. PAF
D. Bradykinin
is prescribed as:
6. The drug ambroxol
enhancer
A. Bronchial secretion
antagonist
B. Alpha-2adrenergic
C. Mucolytic
SDoBLADAAC
\DCSDOBIAD
D. Respiratory stimulant

Page 1 of4
13346.
 Paper/ Subject Code: 87612
4F / Pharmacolog
IEC

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cotrimoxazole is:
sulphamethoxazole
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and trimethoprim in
7. Ratio of

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neonates is:
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to chloramphenicol in
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8. An adverse reaction AD3CSLDOBL
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9. Triple drug therapy used as immunosuppressant consists of: 9FB0

C. Tacrolimus+ Methotrexate+ Prednisolone

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10. Which of the following is triazole class of antifungal drug?
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C. Ketoconazole
D.Miconazole
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D.Persistent over months

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12. The antineoplastic agent that is classified asan alkylating agent is:
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D. Busulfan
13. Aside effect of ethambutol is:

B. Nausea, vomiting and diarrhea

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C. Hypersensitivity and urticarial

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D. Loss of color vjsion due to optic
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neuriis
 'per/ SujtC ode 8761271

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An exAmple of:
B.Chronie toxlcity
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C.Sub acute toxieity
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plperazlnes
lnhibits tubulin polyerlzation
B. Inhibits glucose uptake
C.Acts as ÜABA
agonist to paralyze the worms
n Uncouples Oxidative
phosplorylation
11. Brltlsh antl lewlslte is CFBIT561D3F
used aN An Antldote for:
A.Arscnie polsoning BiADAAC9FBO756D3FK
B. Silver poisoning
C.Mercury poisoning
D.Lend poisoning
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18, Melatonla plays a role in:

A. Hunger) SDOB1A
BDigestion
C. Growth
D. Sleep cycle
19. The risk of asthmatie
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attacks is higher between:
A. 4.00 amm-5,00 am

B. S,00pm-6.00 pm
CI1.00am-12 noon
D.I.00 pm -12.00 arn
20. Whlch of the following is amechanism for multidrug
resistance in cancer chemotherapy?
A. Decreased activity of DNA repair pathways
B. Decreascd sensitivity of dilydrofolate reductase
C.Increased synthesisDOBLADAAC9FBoT56.5
of cell surface glycoprotein P-170
iD.DIncreased
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13346 Page 3of 4

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Paper /Subject Code: 87612/ Pharmacology- III

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Q. II. Answer any TWO of the following:

1.
20 M
Classify appetite suppressant drugs with their nmechanism of action and adverse effects. 9F4FlECAD

. Write a short note on the aminoglycoside class of antibiotics mentioning classitication with
examples, mechanism of action, adverse effects and clinical uses. D3FC9e
3. Discuss about the site of action of antimalarial drugs, Elaborate on 30756D31
the mechanism of action,
adverse effects and uses of OF4FI
4-aminoquinoline drugs.
Q. III. Answer any
SEVEN out of the following questions:
1. Classify pOBIADFB0756D
drugs used in the treatment of constipation with examples. Discuss briefly the
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pharmacology of osmotic
2. Write a short note on purgatives
3.
corticosteroids used in thetreatrnent asthma.
of
Discuss various mechanisms by which bacteria acquire
4. Writea note on first line therapy used
resistance against antibiotics,
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in tubercûlosis. 3
Add0 a' note on the
unwanted effects of rifampicin. mechanism ADAAC
of action and
5. Write a note on
chemotherapy of amoebiasis.
6. Classify
immunosuppressant drugs with
7.Classify anticancer agents. Describethe examples.Add noteon Calcineurin inhibitors.
a
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pharmacology of vinca alkaloids in detail
8. Explain mutagenicity aandgenotoxicity with
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9. Describe the symptoms and

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management of opioid poisoning.