Introduo

Psicofarmacologia

Lus Cmara Pestana

Instituto de Farmacologia da FML

3000 aC
1493 dC
1680
1803
1832
1848
1845

1853

1884

pio (Sumrios)
pio (Paracelsus)
pio "droga divina"
Morfina isolada e descrita (Serturner)
Codena (Robiquet)
Papaverina (Merck)
Haxixe na psicose modelo para o estudo
da insanidade mental (Moreau)
Brometos
Hidrato de cloral
Paraldedo
Cocana (Freud)

1917 - Malarioterapia (Wagner von Jauregg)

1927
JULIUS WAGNER-JAUREGG for
his discovery of the therapeutic
value of malaria inoculation in the
treatment of dementia paralytica.

1928 - Classificao dos

psicotrpicos (Lewin)

Euphorica
Phantastica
Hypnotica
Inebriantia
Exitantia

1930 Charpentier descreve a prometazina

como antihistamnico

1931 - Sen e Bose descrevem a Rauwolfia Serpentina na

teraputica da insanidade e como antihipertensor.

1933Choque insulnico (Manfred Sakel)

1934 - Convulsivoterapia com pentetrazol

1937 - Electroconvulsivoterapia (Cerletti e Bini)

1936 - Psicocirurgia (Egas Moniz)

1949 The prize was divided equally, one half

awarded to:
WALTER RUDOLF HESS for his discovery of the
functional organization of the interbrain as a
coordinator of the activities of the internal organs
and the other half to:
ANTONIO CAETANO DE ABREU FREIRE EGAS
MONIZ for his discovery of the therapeutic value
of leucotomy in certain psychoses.

1949 - Ltio (Cade)

1967 - Ltio (Schou)

 1952

Iproniazida como antidepressivo

(Robitzek)
Cloropromazina, caracterizao
dos efeitos, anestsico geral
(Laborit)
Isoniazida (Jean Delay)
Cloropromazina como antipsictico
(Delay e Deniker)
Meprobamato (Frankl)
"Tranquilizantes Major e Minor"

Jean DELAY (1907-1987)

Commandeur de la Lgion d'honneur

Commandeur des Arts et des Lettres
Grand officier de l'ordre national du mrite
Commandeur de la Sant publique

Prdcesseur : Georges Lecomte

Successeur : Jacques-Yves Cousteau

Mdecin psychiatre, essayiste, romancier

1955 - Clordiazepxido (Sternbach)

- II Congresso Mundial de Psiquiatria.

neurolptico
antidepressivo
ansioltico

1950 - Iproniazida (Crane)

1954 - Reserpina estudada (Weber, Delay e Kline)

1957 - Imipramina

1958 - Haloperidol

2000
The prize was awarded jointly to:
ARVID CARLSSON, PAUL GREENGARD
and ERIC KANDEL for their discoveries
concerning signal transduction in the
nervous system.

1965 - Hiptese catecolamnica das

perturbaes afectivas (Schildkraut)
1978 - Hiptese monoamnica das
perturbaes afectivas ( van Praag,
Schildkraut, Sachar e Baron)