Efeito Do Borneol Na Distribuição de Gastrodina para o Cérebro em Camundongos Via Administração Oral

24/12/2021 12:29 Efeito do borneol na distribuição de gastrodina para o cérebro em camundongos via administração oral
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Efeito do borneol na distribuição de gastrodina para o cérebro em camundongos via administração oral
Março de 2008 · Journal of Drug Targeting 16 (2): 178-84

DOI: 10.1080 / 10611860701794395
Fonte · PubMed
Autores:
Zheng Cai Shixiang Hou Yuanbo Li Binbin Zhao
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Citações (93) Referências (27)
Resumo
O borneol e a gastrodina são substâncias bioativas

derivadas da medicina tradicional chinesa. Neste artigo, foi Descubra a Mais de 20
investigado o efeito do borneol na distribuição de pesquisa do mundo milhões de
2
gastrodina no cérebro de camundongos por via oral. As membros
concentrações de gastrodina no plasma e as
concentrações de gastrodigenina (metabólito ativo da Mais de
gastrodina) no cérebro de camundongos foram 135
https://www.researchgate.net/publication/5577034_Effect_of_borneol_on_the_distribution_of_gastrodin_to_the_brain_in_mice_via_oral_administration 1/23
determinadas por cromatografia líquida de alta milhõesEntre
de de graça
Solicitar texto
performance completo
de fase Baixar citação
reversa, após administração Link de cópia publicações
intragástrica de gastrodina (200 mg kg (-1)) sozinha ou Mais de
combinada com diferentes doses (200, 400 e 600 mg kg
700 mil
(-1)) de borneol simultaneamente ou a mesma dose (400 projetos de
mg kg (-1)) de borneol administrada 20 e 40 min antes, pesquisa
respectivamente. Em comparação com a administração de
gastrodina isoladamente, a gastrodina coadministrada
com borneol pode ter sido rapidamente absorvida pelo
trato gastrointestinal; o tempo de pico de gastrodina no
plasma tornou-se mais curto (5-15 vs. 30 min); a
biodisponibilidade da gastrodigenina no cérebro aumentou
33,6-108,8%; e foi observado um efeito óbvio de
direcionamento ao cérebro. O efeito de aumento foi
atenuado quando a dose de borneol era muito alta (600 mg
kg (-1)), ou o intervalo de tempo entre a administração de
borneol e gastrodina era superior a 40 min. Os resultados Propaganda
indicam que o borneol pode acelerar a absorção da
gastrodina no trato gastrointestinal e promover sua
distribuição para o cérebro. Portanto, o borneol é um
promotor promissor para a entrega de drogas direcionadas
ao cérebro por via oral. O efeito de aumento foi atenuado
quando a dose de borneol era muito alta (600 mg kg (-1)),
ou o intervalo de tempo entre a administração de borneol e
gastrodina era superior a 40 min. Os resultados indicam
que o borneol pode acelerar a absorção da gastrodina no
trato gastrointestinal e promover sua distribuição para o
cérebro. Portanto, o borneol é um promotor promissor para
a entrega de drogas direcionadas ao cérebro por via oral. O
efeito de aumento foi atenuado quando a dose de borneol
era muito alta (600 mg kg (-1)), ou o intervalo de tempo
entre a administração de borneol e gastrodina era superior
a 40 min. Os resultados indicam que o borneol pode
acelerar a absorção da gastrodina no trato gastrointestinal
e promover sua distribuição para o cérebro. Portanto, o
borneol é um promotor promissor para a entrega de drogas
direcionadas ao cérebro por via oral.
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Citações (93) Referências (27)
... Evidências para melhorar a distribuição de drogas ao cérebro Um

grande conjunto de evidências confirmou os efeitos do borneol na
melhoria da distribuição de drogas ao cérebro (Tabela 2). A co-
administração sistêmica com borneol produziu um aumento de 26-197%
nos valores de C max e AUC do cérebro dos agentes coadministrados
tetrametilpirazina (ligustrazina) (Liu et al., 2008; Xiao et al., 2008),
nimodipina (Wu et al. , 2014), gastrodin (Cai et al., 2008) , rifampicin (Wu
et al., 2004), geniposide and hyperforin (Yu et al., 2011b) compared to
the agents alone, indicating that the addition of borneol enhances the
transportation and bioavailability of drugs in the brain. Furthermore, the
brain bioavailability of geniposide was approximately five times greater
when it was given by intranasal co-administration with borneol than
when the drugs were given by intragastric co-administration . ...
... Borneol also increased the quantity and velocity of geniposide
permeating the brain and the effect reached the most obvious at 15 min
2
after both agents were given simultaneously via the intragastric route in
rats . Similar results were observed for borneol co-treatment with
gastrodin in mice (Cai et al., 2008) . The enhancing effects on the brain
bioavailability of gastrodigenin, an active metabolite of gastrodin,
Solicitar reached
texto completo Baixar
a peak level with borneol doses of 200-600 mg/kg, butLink
citação werede cópia
attenuated with doses above 600 mg/kg (Cai et al., 2008). ...
... Similar results were observed for borneol co-treatment with gastrodin
in mice (Cai et al., 2008). The enhancing effects on the brain
bioavailability of gastrodigenin, an active metabolite of gastrodin,
reached a peak level with borneol doses of 200-600 mg/kg, but were
attenuated with doses above 600 mg/kg (Cai et al., 2008) . When
borneol was given at different intervals, a robust enhancing effect on
This table is modified based on Zhao et al. (2012). ...
Borneol, a novel agent that improves central nervous system drug delivery by
enhancing blood–brain barrier permeability
Article Full-text available
Nov 2017 · DRUG DELIV
Qun-Lin Zhang · Bingmei M Fu · Zhang-Jin Zhang
View Show abstract
... Borneol, a terpene and bicyclic organic compound, is one of such

messenger drugs, which is frequently used in the treatment of epilepsy,
stroke and headache. It has been reported that borneol could improve
the nasal, cornea, transdermal and intestinal absorption of drugs,
accelerate the opening of the BBB and enhance the distribution of drugs
in brain tissue [19, 20]. ...
... 10 min after administration of 4% NaHCO 3 (0.5 ml), the rats were
administrated borneol at three different doses (150, 300, 500 mg/kg), 20
min later, the rats were administrated mixed micelles by oral. Meanwhile,
mixed micelles alone as borneol-free group, drug dissolved in 70%
ethanol as solvent control group were studied in parallel [19] . Blood
samples ($0.5 ml) were withdrawn from retro-orbital plexus at 5, 15, 30
min, 1, 2, 4, 6, 8 h post-dosing (n ¼ 5) and centrifuged at 6650 gÁmin À1
for 10 min. ...
... The absolute bioavailability (F) of the orally administrated micelles
was calculated. For brain targeting evaluation, drug targeting index (DTI)
was calculated using the following equation [19] : ...
Enhanced blood brain barrier transport of vinpocetine by oral delivery of mixed

micelles in combination with a message guider
2
Article
Feb 2017 · J DRUG TARGET
Jiaojiao Ding · Yujiao Sun · Jinfeng Li · Shirui Mao
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ViewtextoShow
completo
abstract Baixar citação Link de cópia
... INTRODUCTION Borneol (C 10 H 18 O), a traditional Chinese medicine,

is widely used and has a variety of pharmaceutical effects, including
hypoglycemia enhancement, antiviral, antibacterial, anti-tumor,
neuroprotective, and anti-angiogenic effects. Previous studies have
shown that borneol could enhance the absorption of co-administered
drugs in the nasal cavity and gastrointestinal tract, and promote drug
distribution to the brain [3, 7,10,16,21,37]. However, owing to their
various physical and chemical properties, the dose of the co-
administered drugs, and other factors, the interactions that occur
between borneol and co-administered drugs are not always predictable.
...
... We speculate that the increase in the tissue distribution of florfenicol
may be the major reason for the higher plasma concentrations of
florfenicol detected at 12 hr and 24 hr in the borneol-treated group and
may also have caused the significant increases in the MRT (0-t) and t
1/2z values of florfenicol that group. Numerous studies have reported
that borneol can enhance the distribution of co-administered synthetic
drugs into tissues, such as the kidney and brain [3, 8,34,35,36]. Our
findings are similar to those reported in these previous studies. Based on
the results of this study, we will continue to examine the effects of
borneol on the tissue distribution of florfenicol in vivo. ...
Effects of Borneol influences the pharmacokinetics of florfenicol through

regulation of CYP1A2, CYP2C11, CYP3A1, and MDR1 mRNA expression levels…
Article
Jun 2021 · J VET MED SCI
Xuting LI · Sicong LI · Bin Wang · Ge LIANG
View Show abstract
... Borneol (Figure 1), Chinese materia medica monomer (molecular

weight 154.24), is extracted from Dryobalanops aromatica Gaertn f. and
Blumea balsamifera DC, and is widely used for the treatment of
cardiovascular and cerebrovascular diseases in China. Previous studies 2
showed that borneol was able to improve the permeability of BBB by a
physiological process, enhance penetration and accumulation of some
drugs into the brain such as tetramethylpyrazine phosphate, gastrodin,
puerarin, geniposide, kaempferol and nimodipine, and increase the brain
Solicitar bioavailability
texto completoof these drugs [12]Baixar citação
[13] [14][15][16][17][18][19]. Link de cópia
The
mechanisms of borneol opened BBB focused on loosening the
endothelial tight junctions, increasing the number and volume of
pinocytosis, and decreasing the mdr1a and mdr1b expression in
hippocampus and hypothalamus [20][21][22]. ...
... 2015, 16, page-page 2 of cardiovascular and cerebrovascular diseases
in China. Previous studies showed that borneol was able to improve the
permeability of BBB by a physiological process, enhance penetration and
accumulation of some drugs into the brain such as tetramethylpyrazine
phosphate, gastrodin, puerarin, geniposide, kaempferol and nimodipine,
and increase the brain bioavailability of these drugs [12] [13] [14][15][16]
[17][18][19]. The mechanisms of borneol opened BBB focused on
loosening the endothelial tight junctions, increasing the number and
volume of pinocytosis, and decreasing the mdr1a and mdr1b expression
in hippocampus and hypothalamus [20][21][22]. ...
Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated

Mechanism in a Blood Brain Barrier in Vitro Model
Nov 2015 · INT J MOL SCI
Xiang Fan · Lijuan Chai · Han Zhang · Xiumei Gao
View Show abstract
... Although considerable advancements have been made in drug delivery

to the CNS, the clinical application of CNS drugs is still limited by their
poor bioavailability due to the BBB (Denora et al., 2009). Borneol
promotes the penetration and accumulation of neuroprotective drugs
such as gastrodin, puerarin, kaempferol, and nimodipine, increases the
bioavailability of these drugs, thereby exerting an indirect
neuroprotective effect (Cai et al., 2008; Gao et al., 2010;Wu et al.,
2014a;Zhang et al., 2015). The mechanism of this effect is closely
related to the regulation of P-gp. ...
... Borneol is a naturally occurring product in a class of "orificeopening"
agents used in TCM for resuscitative purpose, and is widely used as an
upper ushering drug for various brain diseases in many Chinese herbal
formulae (Zhang et al., 2017a;Chen et al., 2019). This is consistent with 2
the findings of many scholars that borneol has a beneficial effect on
increasing the bioavailability, tissue distribution, and blood concentration
of other drugs, and making other drugs transport through BBB easier
(Xiao et al., 2007; Cai et al., 2008; Lu et al., 2011). Heat-clearing is a
Solicitar traditional effect of borneol as aBaixar
texto completo resuscitation-inducing
citação Link de cópia
aromatic
medicine . ...
Progress in Borneol Intervention for Ischemic Stroke: A Systematic Review

Article
May 2021
Yong Li · Mihong Ren · Jiajun Wang · Jian Wang
View Show abstract
... Natural borneol (NB) as a safer form of borneol was widely used for
flavorant and a valuable medical material [13]. Studies demonstrated
that NB effectively enhanced the bioavailability of poorly permeable
drugs through improving cell permeability, opening of blood-brain barrier
(BBB) and accelerating drug distribution in brain tissue [14, 15]. Recent
studies showed that NB had the potential to enhance the anticancer
efficacy of chemo-drugs against human cancers [16][17][18][19]. ...
... However, the clinical application of DOX in human glioma is limited by
the development of BBB [25,26]. Natural borneol (NB), a monoterpenoid
natural product, has the potential to promote drug absorption and open
BBB to accelerate drug distribution in brain tissue [14, 15]. Recently, the
synergistic anticancer action of NB has been widely studied by
researchers [18,27]. ...
Enhanced anticancer efficiency of doxorubicin against human glioma by natural

borneol through triggering ROS-mediated signal

Oct 2019 · BIOMED PHARMACOTHER
Wen-Qiang Cao · Ying Li · Ya-jun Hou · Xiao-Yan Fu
View Show abstract
... Considering the mucosa stimulus and hepatotoxicity of SB, NB has

more potential for further commercial applications. NB effectively
improves the permeability of drugs by regulating intestinal mucous or 2
blood-brain barrier (Cai et al. 2008; Duan et al. 2016;Xing et al. 2016). NB
can also enhance the efficacy of chemo-drugs against various cancer
cell lines by increasing the intracellular drug accumulation and
modulating ROS-mediated DNA damage with the involvement of MAPKs
Solicitar activation and Akt inactivation Liu
texto completo 2018;Meng et al. 2018).Link
et al.citação
Baixar ... de cópia
... Considerable evidence showed that novel chemosensitizers could
effectively improve the anticancer effects of cisplatin and reduce the
undesirable adverse effects (Zhang et al. 2014;Gong et al. 2018;Wandee
et al. 2019;Zhou et al. 2019). Recently, researchers have focussed on the
synergistic properties of NB that can effectively improve cell
permeability, open BBB, and accelerate drug distribution in tumour tissue
(Cai et al. 2008; Duan et al. 2016;Xing et al. 2016). The synergistic
potential of NB in chemo-sensitization is being concerned. ...
Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis

by triggering ROS-mediated oxidative damage and regulation of MAPKs and…
Dec 2020 · PHARM BIOL
Xiao-Qian Zhai · Ji-Wei Ma · Wen-Qiang Cao · Xiao-Yan Fu
View Show abstract
... The solvents used to extract GAS, HBA, parishin, N 6 -(4-

hydroxybenzyl) adenine riboside (NHBA) in biological samples have
included ethanol [29,30], methanol [31][32] [33] [34], acetonitrile [35][36]
[37], n-butyl alcohol [38], methanol-acetonitrile (1:4) [39,40], aqueous
ammonia-ether (1:4) [41], ethanoldichloromethane [42], methanol-
dichloromethane [43], diethyl ether [44] and ethyl acetate [45]. The
volume of solvent used was about 3-5 fold greater than that of the
samples. ...
... The solvents used to extract GAS, HBA, parishin, N 6 -(4-
hydroxybenzyl) adenine riboside (NHBA) in biological samples have
included ethanol [29,30], methanol [31][32] [33] [34], acetonitrile [35][36]
[37], n-butyl alcohol [38], methanol-acetonitrile (1:4) [39,40], aqueous
ammonia-ether (1:4) [41], ethanol-dichloromethane [42], methanol-
dichloromethane [43], diethyl ether [44] and ethyl acetate [45]. ...
Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its

Constituents
2
Jul 2017 · MOLECULES
Jinyi Wu · Bingchu Wu · Chunlan Tang · Jinshun Zhao
View Show abstract

View Show abstract
... Borneol is bicyclic monoterpenoid alcohol with an antibacterial and

anti-inflammatory effect. Furthermore, previous studies confirmed the
role of penetration enhancer to improve oral bioavailability and increase
the drug distribution in some tissues (37) (38)(39). Particularly, borneol
has been reportedly used as a biologically active natural product in cell
signal transduction, such as elevate the level of ROS, arrest the cell cycle,
and regulate the apoptosis signal pathway (101). Furthermore, borneol
can participate in reversing multidrug resistance by inhibiting the
expression of P-gp (128). ...
Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified

Nanocarrier Drug Delivery System
Nov 2021
Jinxiu Li · Qian Xie · Rong Ma · Jian Wang
View Show abstract
... Verapamil is extensively characterized as a P-gp inhibitor to increase

oral bioavailability [19,39]. In addition, our previous work and some
reports have showed that BO was effective in inhibiting the P-gp-
mediated efflux pump [2, 40, 41]. As shown in Figure 6, compared with
R123, the fluorescence intensity of Ver+R123 increased markedly. ...
Folate and Borneol Modified Bifunctional Nanoparticles for Enhanced Oral

Absorption
Sep 2018
Yifan Yang · Yunzhi Yin · Jun Zhang · Qi Shen
View Show abstract
... borneol can enhance the absorption of gastrodin in the

gastrointestinal tract and promote its distribution to the brain (Cai et al.,
2008) and significantly enhance the oral bioavailability of rifampicin
Solicitar (Cheng, Wu, & Feng, 2001). Research
texto completo Baixarhas Link de cópia
also demonstrated that
citação
borneol was effective in inhibiting the P-gp-mediated efflux system,
thereby improving the intestinal absorption of drugs (He et al., 2011). ...
Investigating the bioavailabilities of olerciamide A via the rat's hepatic, gastric
and intestinal first‐pass effect models
Feb 2019 · BIOPHARM DRUG DISPOS
Chengcheng Zhao · Zheming Ying · Dong Hao · Guanlin Yang
View Show abstract
... SB consists of D-borneol and isoborneol, while NB contains only D-

borneol [11][12][13][14][15]. A growing body of evidence confirms that
borneol is able to loosen intercellular tight junctions, and thus open the
BBB and enhance the distribution of drugs in the brain [16] [17][18].
Therefore, borneol is believed to be an effective and promising adjuvant
that can improve drug delivery to the brain. ...
Optimization of the Preparation Conditions of Borneol-Modified Ginkgolide

Liposomes by Response Surface Methodology and Study of Their Blood Brain…
Jan 2018 · MOLECULES
Zhiyang Lv · Yuwei Yang · Jie Wang · Liuqing Di
View Show abstract
... Gastrodin in rats is consistent with a one-compartment model

(15, 16). The peak of gastrodin occurred within 45 min, and rapid decay
occurred after 1 h, indicating that gastrodin was not stored in the body,
has a high absorption speed in the intestinal tract and exerts a rapid
effect. ...
2
The pharmacokinetics of Tiangou antihypertensive capsule in rat in vivo
Article
Nov 2016
Solicitar texto completo
Ji‑Zheng Baixar
Song · Ling‑Jun Li · Li Ji · Yan Ruicitação Link de cópia
View Show abstract
... Borneol (BO), a traditional Chinese medicine that is extracted from

Cinnamomum camphora (L.), is a cyclic terpene alcohol that is widely
used as a resuscitation-inducing agent. Studies have shown that BO is
able to assist drugs in crossing various physiologic barriers, such as the
blood-brain barrier, cornea, skin, and mucous membrane [10] [11][12]
[13]. To the best of our knowledge, BO can be used as a PE as well
[14,15]. ...
Influence of Temperature on Transdermal Penetration Enhancing Mechanism of

Borneol: A Multi-Scale Study
Jan 2017 · INT J MOL SCI
Qianqian Yin · Ran Wang · Shufang Yang · Xinyuan Shi
View Show abstract
... 9 In many prescriptions of traditional Chinese medicine (TCM), certain

drugs are considered to be messengers introducing the active
ingredients to the target part of human body. 10 According to the theory
of TCM, BO can direct drugs to the upper body parts and be widely used
as a messenger for drugs to treat cardiovascular and cerebrovascular
diseases. It can also reversibly open the tight junction of the BBB when
seen from the grounds of modern medicine. ...
Enhanced permeability of blood–brain barrier and targeting function of brain via

borneol-modified chemically solid lipid nanoparticle
Mar 2018 · INT J NANOMED
Hui Song · Man Wei · Nan Zhang · Wensheng Zheng
2
View Show abstract
... Furthermore, its strong fatsoluble active ingredients made it a quite
Solicitar good
texto penetration
completo enhancer. Several Baixar citação
lines Link de
of evidence have revealed thatcópia
borneol could increase the concentration of other agents in brain tissues
such as gastrodin and edaravone (Cai et al., 2008; Wu et al., 2014). The
penetration enhancing effects of borneol can be acted via the reaction of
the lipophilic fraction with the lipid parts of cell membranes, and thus
influence the bioactivity of enzymes, carriers, ion channels, and
receptors (Gabbanini et al., 2009). ...
Additive Neuroprotective Effect of Borneol with Mesenchymal Stem Cells on

Ischemic Stroke in Mice
Jan 2018
Xiao-guang Zhang · Chang Shan · Jia-Zhen Zhu · Yan Wang
View Show abstract
... However, as a hydrophilic molecule, DSS is poorly soluble in lipidic

matrices and difficult to enter cells by crossing the cell membrane (Dong,
Wang, & Zhu, 2009). According to the principle of TCM combinatorial
formulations (Qiu, 2007;Zhao et al., 2015), borneol is believed to improve
the bioavailability of principal therapeutic agents (Cai et al., 2008; Chen
et al., 1990;Yang et al., 2009). In our previous studies in rabbits, the
bioavailability of DSS was found to increase, and the tissue distribution
was improved by co-administration of borneol (Zheng, Zhao, Fang, et al.,
2007;Liu et al., 2008). ...
Tanshinol borneol ester (DBZ), a novel synthetic small molecule angiogenesis

stimulator inspired by botanical formulations for angina pectoris
Article
May 2019 · BRIT J PHARMACOL
Sha Liao · Liwen Han · Xiaopu Zheng · Xiaohui Zheng
View
... I n the pharmacokinetics experiments, the SD rats \Vere randomly 2

divided into four groups (n= 6), each group received oral administration
of osthole (300 mg/kg), and \Vere then given the follo,ving treatments:
The control group \Vas given an oral dose \v ith extra 5o/ o T\veen-80
(400 1ng/kg) and the (+)-borneol, (-) -borneol and synthetic borneol
Solicitar groups
texto completo Baixar
\Vere given oral doses \vith citação
an extra 400 mg/kg borneol. Link
Thede cópia
dosage of borneol and osthole applied \Vas based on that of a previous
study (27) . Blood samples \Vere collected at 5, 15, 30, 45, 60, 90, 120,
240, 360, 480 and 720 min follo,ving oral administration from the
suborbital venous plexus of the rat eye socket vein. ...
Different effects of (+)‑borneol and (‑)‑borneol on the pharmacokinetics of

osthole in rats following oral administration
Article
Apr 2017 · Mol Med Rep
Dan-Dan Luo · Xiao-Ying Chen · Zhen Biao Zhang · Zi-Ren Su
View Show abstract
... Based on the TCM theories, BOR is considered an upper guiding drug
in traditional Chinese formulations to significantly increase drug
concentration in the brain. Indeed, BOR was shown to enhance drug
accumulation in brain tissues and bioavailability, e.g. in the case of
geniposide [6] . ...
Borneol enhances the antidepressant effects of asiaticoside by promoting its

distribution into the brain
Article
Mar 2017 · NEUROSCI LETT
Tianheng Hou · Xiaobo Li · Chongsheng Peng
View Show abstract
... Among them, borneol was one of the major compounds quantified in
the BEO using NCSD (11.66 ± 0.22%), which is significantly higher than
that using SD (10.69 ± 0.16%). Borneol as a bicyclic monoterpene has
been widely evaluated for antinociceptive, anti-inflammatory, and
antibacterial activities, as a bioactive substance derived from various
herbs (Cai et al., 2008; Tabanca et al., 2001). As one of major
compounds in the BEO, borneol was indicated to be a bioconversion 2
product from pinene, and such a bioconversion would be normally
conducted inside the cell of Cinnamomum camphora chvar. ...
Extraction
Solicitar of Cinnamomum camphora
texto completo chvar.
Baixar Borneol essential oil Link
citação usingdeneutral
cópia
cellulase assisted-steam distillation: optimization of extraction, and analysis o…
Article
Dec 2019 · IND CROP PROD
Hang Yu · Xiaona Ren · Yuliang Liu · Weirong Yao
View
... 13 In addition, isoborneol has been proven to cross 14 or assist other

drugs in crossing the blood-brain barrier. 15 However, there is little
research on its action mechanism. The whole genome expression data
of MCF-7 cells treated with/or without isoborneol were assessed using
microarray technology (Table S1). ...
Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell

Formation in Macrophages
Jan 2020
Yunfei Wang · Zhengrong Li · Boxue Liu · Shoude Zhang
View Show abstract
... Bingpian contains monoterpenoid constituents and is included in 63

CHM prescriptions according to the Chinese Pharmacopoeia. Its wide
use as an assistant in CHM is due to its ability to improve percutaneous
absorption, enhance oral bioavailability, and facilitate passage of herbal
formulation through the blood brain barrier [59] [60][61]. ...
Synergism of Chinese Herbal Medicine: Illustrated by Danshen Compound

Jan 2016 · EVID-BASED COMPL ALT
Xuefeng Su · Zhuoting Yao · Shengting Li · He Sun
View Show abstract 2
... 14 Moreover, based on the TCM theories, BO is an upper guiding drug,

Solicitar which
texto completo
has the effect of targetingBaixar citação
the drug Link
to the brain to enhance de cópia
the
efficacy. 15 Mr. Tang's team research showed that BO and lactoferrin
co-modified nanoparticles encapsulated drug can effectively enhance
dopamine delivery into the brain for the treatment of Parkinson's
disease. 16 In addition, BO can enhance the ability of other drugs to
penetrate the blood-brain barrier (BBB) to improve bioavailability and
enhance the distribution of drugs in BBB. 17 The above all suggest that
borneol as a supplementary drug has potential value for the treatment of
brain diseases. ...
Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes

for Treatment of Cerebral Ischemia-Reperfusion Injury
Aug 2020 · INT J NANOMED
Yulu Zhang · Songyu Liu · Jinyan Wan · Nan Li
View Show abstract
... Unfortunately, the gavaged dosage of GAS and HBA could not
decrease immobility time in the FST (data not shown). To the best of our
knowledge, the range of oral dosage of GAS and HBA is from 60 to 400
mg/kg bw Cai et al., 2008; Zhang et al., 2014;Xie et al., 2007) and 25-100
mg/kg bw (Yu et al., 2010;Lim et al., 2007), respectively, in animal
experiments. GAS (100 and 200 mg/kg bw) improved neurogenesis in
the hippocampus of SD rats through upregulation of BDNF expression
under chronic unpredictable stress (CUS) . ...
Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin

and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal…
Article
Feb 2016 · J ETHNOPHARMACOL
Wei-Cheng Chen · Yi-Syuan Lai · Shih-Hang Lin · Lee-Yan Sheen
View Show abstract

2
Galeola to Gymadenia
Chapter
Aug 2016
Eng Soon Teoh
View Show abstract
Antitumor Monoterpenes
Chapter
Sep 2015
Janaina Fernandes
View Show abstract
In vivo effect of borneol on rat hepatic CYP2B expression and activity

Article
Nov 2016 · CHEM-BIOL INTERACT
Xiang-tao Huang · Jing-ya Chen · Jun-jun Wang · Yong Chen
View Show abstract
Borneol as Sublimable Agent in Floating Matrix Tablet

Article
Dec 2014
Worawut Kriangkrai · Satit Puttipipatkhachorn · Pornsak Sriamornsak ·
S. Sungthongjeen
View Show abstract
UPLC-TOF-MS based profiling approach in evaluation of effect of borneol on

pharmacokinetics of Tanshinone IIA in mice
Article
Jun 2014
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Efeito Do Borneol Na Distribuição de Gastrodina para o Cérebro em Camundongos Via Administração Oral

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24/12/2021 12:29 Efeito do borneol na distribuição de gastrodina para o cérebro em camundongos via administração oral

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Março de 2008 · Journal of Drug Targeting 16 (2): 178-84

Zheng Cai Shixiang Hou Yuanbo Li Binbin Zhao

Citações (93) Referências (27)

O borneol e a gastrodina são substâncias bioativas

Para ler o texto integral

Citações (93) Referências (27)

... Evidências para melhorar a distribuição de drogas ao cérebro Um

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... Borneol, a terpene and bicyclic organic compound, is one of such

Enhanced blood brain barrier transport of vinpocetine by oral delivery of mixed

... INTRODUCTION Borneol (C 10 H 18 O), a traditional Chinese medicine,

Effects of Borneol influences the pharmacokinetics of florfenicol through

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... Borneol (Figure 1), Chinese materia medica monomer (molecular

Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated

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... Although considerable advancements have been made in drug delivery

Progress in Borneol Intervention for Ischemic Stroke: A Systematic Review

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Enhanced anticancer efficiency of doxorubicin against human glioma by natural

Article Full-text available

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... Considering the mucosa stimulus and hepatotoxicity of SB, NB has

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis

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... The solvents used to extract GAS, HBA, parishin, N 6 -(4-

Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its

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... Borneol is bicyclic monoterpenoid alcohol with an antibacterial and

Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified

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... Verapamil is extensively characterized as a P-gp inhibitor to increase

Folate and Borneol Modified Bifunctional Nanoparticles for Enhanced Oral

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... borneol can enhance the absorption of gastrodin in the

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... SB consists of D-borneol and isoborneol, while NB contains only D-

Optimization of the Preparation Conditions of Borneol-Modified Ginkgolide

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... Gastrodin in rats is consistent with a one-compartment model

... Borneol (BO), a traditional Chinese medicine that is extracted from

Influence of Temperature on Transdermal Penetration Enhancing Mechanism of

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... 9 In many prescriptions of traditional Chinese medicine (TCM), certain

Enhanced permeability of blood–brain barrier and targeting function of brain via

Additive Neuroprotective Effect of Borneol with Mesenchymal Stem Cells on

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... However, as a hydrophilic molecule, DSS is poorly soluble in lipidic

Tanshinol borneol ester (DBZ), a novel synthetic small molecule angiogenesis

... I n the pharmacokinetics experiments, the SD rats \Vere randomly 2

Different effects of (+)‑borneol and (‑)‑borneol on the pharmacokinetics of

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Borneol enhances the antidepressant effects of asiaticoside by promoting its

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... 13 In addition, isoborneol has been proven to cross 14 or assist other

Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell

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... Bingpian contains monoterpenoid constituents and is included in 63

Synergism of Chinese Herbal Medicine: Illustrated by Danshen Compound

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