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HEMATOLOGIA VETERINÁRIA

Produção de Material Didático

MALENA NORO SILVA


orientadora: MARIA VIVINA B. MONTEIRO
HEMATOLOGIA VETERINÁRIA
PRODUÇÃO DE MATERIAL DIDÁTICO

MALENA NORO SILVA


orientadora: MARIA VIVINA B. MONTEIRO

BANCA EXAMINADORA

Prof. Dr. Frederico Ozanan Barros Monteiro - UFRA

Prof. Dr. José Ricardo dos Santos Vieira - UFPA


HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Agradecimentos

­ $VVHVVRULD GH (GXFDomR D 'LVWkQFLD $('L  H DR /DERUDWyULR GH 3HVTXLVD H


Experimentação em Multimídia da Universidade Federal do Pará (UFPA), especialmente
à Profª Drª Maria Ataide Malcher, Rose Pepe e toda a sua equipe que nos proporcionou
a concretização deste livro.

$RODERUDWyULRGH3DWRORJLD&OLQLFDGD8QLYHUVLGDGH)HGHUDO5XUDOGD$PD]{QLD 8)5$ 
especialmente as Profº Drº André Marcelo Conceição Menezes e toda a sua equipe
SURÀVVLRQDLVHUHVLGHQWHV TXHFHGHUDPRHVSDoRHPLFURVFySLRVSDUDDVSHVTXLVDVH
Dedicatória nos cederam materiais para concretizar nosso projeto.
'HGLFDPRVHVWHOLYURDWRGRVRVDOXQRVHSURÀVVLRQDLV
$RODERUDWyULRGH3DWRORJLD&OtQLFDH+RVSLWDO9HWHULQiULRGD8QLYHUVLGDGH)HGHUDOGR
de Medicina Veterinária para auxiliar no aprendizado/
Pará polo Castanhal que nos cedeu espaço para estudo e pesquisa, além de lâminas
HQVLQDPHQWRGD'LVFLSOLQD3DWRORJLD&OtQLFD9HWHULQiULD
dos animais atendidos para elaboração das fotos. E ao polo de Belém que nos cedeu
H QD URWLQD GH FRQVXOWyULRV FOtQLFDV DPEXODWyULRV H
espaço para estudo e pesquisa.
ODERUDWyULRVGDiUHD
À Profª Drª Maria Vivina Monteiro da UFPA, pela orientação e competência para a
elaboração deste livro.

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$R3URIž'U(GLOVRQ5RGULJXHV0DWRVHWRGDDVXDHTXLSHGR/DERUDWyULRGH3HVTXLVD
&DUORV$]HYHGRTXHFHGHXFRPPXLWRFDULQKRRPLFURVFySLRSDUDSURGXomRGDVIRWRV
$JUDGHFHPRVFRPPXLWRFDULQKRWRGRVTXHFRQWULEXtUDPSDUDDSURGXomRGHVWHOLYUR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Sumário

11 Apresentação
Lista de Siglas
13 Introdução
AIE Anemia Infecciosa Equina
14 &RPSRVLomRGRVDQJXH6LVWHPDKHPDWRSRLpWLFROtWLFR
ATP Adenosina trifosfato
CGH &RQWDJHP*OREDOGH+HPiFLDV 18 +HPiFLDV
CHGM &RQFHQWUDomRGH+HPRJORELQD*OREXODU0pGLD
21 7HPSRGHYLGDGDVKHPiFLDV+HPyOLVH
CHCM &RQFHQWUDomRGH+HPRJORELQD&RUSXVFXODU0pGLD
CID &RDJXODomR,QWUDYDVFXODU'LVVHPLQDGD 24 0RUIRORJLDQRUPDOGDVKHPiFLDV
DNA Ácido desoxirribonucleico
26 Tamanho das hemácias
DNNE 'HVYLR1XFOHDUGH1HXWUyÀORVj(VTXHUGD
EDTA Ácido etilenodiaminotetraacético 29 Cor das hemácias
EPO Eritropoietina
29 1RUPRFU{PLFDV
Fe Ferro
Hb +HPRJORELQD 29 +LSRFU{PLFDV
HCI Ácido clorídrico
29 +LSHUFU{PLFDV
HCM +HPRJORELQD&RUSXVFXODU0pGLD
HGM +HPRJORELQD*OREXODU0pGLD 29 0RUIRORJLDHSUHVHQoDGHLQFOXV}HV
Ht +HPDWyFULWR
30 7HUPRVWpFQLFRVUHODFLRQDGRVjPRUIRORJLDGDVKHPiFLDVHGLVWULEXLomRGDV
IFN-y ,QWHUIHURQJDPD KHPiFLDVQRHVIUHJDoRVDQJXtQHR
IL-1 Interleucina 1
IL-6 Interleucina 6 30 (OLSWyFLWRVRXRYDOyFLWRV
IRC ,QVXÀFLrQFLD5HQDO&U{QLFD 30 (VIHUyFLWRV
RDW Red Cell Distribution Widht
SMF 6LVWHPD0RQRFtWLFR)DJRFLWiULR 30 (VTXLVWyFLWRV
TNF Fator de necrose tumoral 30 'UHSDQyFLWRVRXKHPiFLDVIDOFLIRUPHV
UFC 8QLGDGH)RUPDGRUDGH&RO{QLD
VCM Volume Corpuscular Médio 30 'DFULyFLWRVRXKHPiFLDVHPIRUPDGHOiJULPDRXSHUD
VGM Volume Globular Médio 31 &pOXODVDOYRRXOHSWyFLWRV
31 (TXLQyFLWRVRXKHPiFLDVFUHQDGDV
31 $FDQWyFLWRV
31 &yUSXVFXORGH+HLQ]
32 &RUS~VFXORGH+RZHOOMROO\

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
6 7
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

32 &RUS~VFXORGH/HQW]RXLQFOXV}HVGH/HQW]RXLQFOXV}HVGD&LQRPRVH 61 Avaliação da resposta leucocitária

32 Rouleaux eritrocitário ou hemácias em rouleaux 62 $OWHUDo}HVTXDQWLWDWLYDVGRVOHXFyFLWRV

32 3RQWHDGREDVyÀORRXSRQWLOKDGREDVyÀOR 62 Leucocitose

32 $JOXWLQDomRGHKHPiFLDV 63 Leucopenia

37 Anemias 63 1HXWURÀOLD

40 &ODVVLÀFDomRFRPEDVHQRJUDXGHUHJHQHUDomRPHGXODU 64 Desvio à esquerda


41 &ODVVLÀFDomRPRUIROyJLFDGDVDQHPLDV 64 'HVYLRjHVTXHUGDUHJHQHUDWLYR
43 &ODVVLÀFDomRGDVDQHPLDVFRPEDVHQRPHFDQLVPRSDWRÀVLROyJLFR 65 'HVYLRjHVTXHUGDGHJHQHUDWLYR

43 $QHPLDVKHPRUUiJLFDV 65 Desvio à direita

44 Anemias hemolíticas 65 Neutropenia

46 $QHPLDVSRUGHÀFLrQFLDGHIHUUR 65 (RVLQRÀOLD

47 $QHPLDGHGRHQoDVLQÁDPDWyULDV 66 Eosinopenia

47 $QHPLDGDGRHQoDFU{QLFDUHQDO 66 Linfocitose

48 Eritrocitose/ Policitemia 66 Linfopenia

50 /HXFyFLWRV 66 Monocitose

53 Granulocitopoese 67 Monocitopenia

55 Monocitopoese 67 %DVRÀOLD

55 Linfocitopoiese 67 Basopenia

56 'HVFULomRHIXQo}HVGRV/HXFyFLWRVGRVDQJXHSHULIpULFR 69 $OWHUDo}HVPRUIROyJLFDVQRVOHXFyFLWRV

56 1HXWUyÀORV 69 /LQIyFLWRVUHDWLYRVOLQIyFLWRVDWtSLFRVRXLPXQyFLWRV

58 (RVLQyÀORV 69 /LQIyFLWRVJUDQXODUHV

59 %DVyÀORV 69 Cromatina sexual

59 /LQIyFLWRV 69 1HXWUyÀORVKLSHUVHJPHQWDGRVRXSROLOREyFLWRV

60 0RQyFLWRV 70 1HXWUyÀORVKLSRVHJPHQWDGRV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
8 9
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

APRESENTAÇÃO
70 1HXWUyÀORVWy[LFRVRXQHXWUyÀORVFRPJUDQXODo}HVWy[LFDV
70 Corpúsculo de Dohle
$3DWRORJLD&OtQLFDXWLOL]DPpWRGRVODERUDWRULDLVSDUDDX[LOLDUQRGLDJQyVWLFRSURJQyVWLFRHWUDWDPHQWR
70 0RQyFLWRVDWLYDGRV GDV GRHQoDV $ SULPHLUD GLVFLSOLQD GH SDWRORJLD FOtQLFD YHWHULQiULD IRL PLQLVWUDGD QD 8QLYHUVLGDGH GD
72 Plaquetas 3HQVLOYkQLDQRV(VWDGRV8QLGRVSRUYROWDGH1HVWHPHVPRSHUtRGRWDPEpPFRPHoDUDPDVXUJLU
RVSULPHLURVOLYURVGHDQiOLVHVFOtQLFDVDSDUWLUGHH[SHULrQFLDVHDQRWDo}HVUHDOL]DGDVQRVODERUDWyULRV
72 Trombocitopoese TXHHUDPXVDGDVSDUDHQVLQDUHPFXUVRVGHGLDJQyVWLFRODERUDWRULDO
74 $OWHUDo}HVQXPpULFDVGDVSODTXHWDV 2 WySLFR KHPDWRORJLD HVWi SUHVHQWH QDV HPHQWDV GDV GLVFLSOLQDV GH SDWRORJLD FOLQLFD YHWHULQiULD GH
76 7pFQLFDVKHPDWROyJLFDV$XODVSUiWLFDV XQLYHUVLGDGHVQDFLRQDLVHGHRXWURVSDtVHVSRUpPSRXFRVPDWHULDLVGLGiWLFRVVmRHVSHFtÀFRVSDUDiUHD
GHYHWHULQiULD/RJRVHID]QHFHVViULRDSURGXomRGHPDWHULDLVGLGiWLFRVHPDQiOLVHVFOtQLFDVYHWHULQiULDV
76 Roteiro de aula prática de coleta de amostras 2V REMHWLYRV GR WUDEDOKR IRUDP SURGX]LU PDWHULDO GLGiWLFR VREUH R WHPD GH KHPDWRORJLD YHWHULQiULD
GHPRQVWUDQGRGHIRUPDWHyULFDWpFQLFDVODERUDWRULDLVHDXODVSUiWLFDVTXHIRUDPFRPSLODGDVDSDUWLUGH
78 5RWHLURGHDXODSUiWLFDGHHVIUHJDoRVDQJXtQHR
PDWHULDLVXWLOL]DGRVQDGLVFLSOLQDGH3DWRORJLD&OtQLFDGRFXUVRGH0HGLFLQD9HWHULQiULDGD8QLYHUVLGDGH
80 5RWHLURGHDXODSUiWLFDGH+HPRJUDPDFRPSOHWR Federal do Pará, além de auxiliar e contribuir para o conhecimento nas outras áreas como a Clínica
0pGLFD9HWHULQiULDHGLVSRQLELOL]DQGRRPDWHULDOGHIRUPDJUDWXLWD
88 ,QWHUSUHWDomRGHKHPRJUDPDV
94 )RL UHDOL]DGD XPD DPSOD SHVTXLVD ELEOLRJUiÀFD XWLOL]DQGR OLYURV WH[WRV FOiVVLFRV DUWLJRV FLHQWtÀFRV
,QIRUPDo}HVTXDOLWDWLYDVTXHSRGHPYLUH[SUHVVDVQRVUHVXOWDGRVGRKHPRJUDPD
nacionais e internacionais e pesquisa documental do material da docente responsável pela disciplina.
96 4XHVW}HVGHSURYDFRQFXUVRV 2PDWHULDOGLGiWLFRHODERUDGRDERUGDWySLFRVVREUHDFRQVWLWXLomRGRVDQJXHKHPDWRSRLHVHKHPiFLDV
OHXFyFLWRVHSODTXHWDV7DPEpPIRUDPLQVHULGDVLOXVWUDo}HVVREUHRWHPDSURSRVWRHLPDJHQVGHOkPLQDV
105 Leitura complementar RULXQGDV GD URWLQD GR /DERUDWyULR GH 3DWRORJLD &OtQLFD 9HWHULQiULD GD 8)3$ (VSHUDVH TXH R PDWHULDO
108 REFERÊNCIAS BIBLIOGRÁFICAS SURGX]LGRSRVVDDX[LOLDURVDOXQRVQRDSUHQGL]DGRGDGLVFLSOLQDGH3DWRORJLD&OtQLFDGRFXUVRGH0HGLFLQD
9HWHULQiULDGDVLQVWLWXLo}HVGHHQVLQRVXSHULRUQR%UDVLOHHPSDtVHVGHOtQJXDSRUWXJXHVD$VVLPFRPR
113 $1(;2$9DORUHVGH5HIHUrQFLD (ULWURJUDPD/HXFRJUDPDH3ODTXHWRJUDPD GHFDQLQRV LQFHQWLYDUHFRQWULEXLUSDUDDSURGXomRGHRXWURVPDWHULDLVGLGiWLFRVQDiUHDGDKHPDWRORJLDHRXWUDV
felinos, bovinos, equinos, ovinos, caprinos e suínos iUHDVDÀQV
114 $1(;2%9DORUHVGH5HIHUrQFLD (ULWURJUDPD/HXFRJUDPD3URWHtQD7RWDOH3ODTXHWDV GH
peixe-boi (Trichechus manatus manatus)

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
10 11
HEMATOLOGIA VETERINÁRIA produção de material didático

01 INTRODUÇÃO

$3DWRORJLD&OtQLFDWDPEpPGHQRPLQDGDDQiOLVHVFOtQLFDVRXPHGLFLQDODERUDWRULDOpXPDHVSHFLDOLGDGH
GD SDWRORJLD TXH XWLOL]D PpWRGRV ODERUDWRULDLV SDUD DX[LOLDU QR GLDJQyVWLFR SURJQyVWLFR H WUDWDPHQWR
GDV GRHQoDV 6HJXQGR R &ROpJLR $PHULFDQR GH 3DWRORJLVWDV 9HWHULQiULRV RV SDWRORJLVWDV FOtQLFRV VmR
HVSHFLDOLVWDVQDViUHDVGHSDWRORJLDEiVLFDELRTXtPLFDVDQJXtQHDFLWRORJLDXULQiOLVHSDWRORJLDFLU~UJLFD
HKHPDWRORJLD

1DKLVWyULDGDSDWRORJLDFOtQLFDYHWHULQiULDDGHVFREHUWDGD)HEUHGR7H[DVWDPEpPFRQKHFLGDFRPR
EDEHVLRVH IRL FRQVLGHUDGD R PDUFR KLVWyULFR QD iUHD GD KHPDWRORJLD 3HOD SULPHLUD YH] GHVFREULXVH
TXHXPSURWR]RiULRSRGHULDVHUWUDQVPLWLGRSRUDUWUySRGHVFDXVDQGRDQHPLDQRVSDFLHQWHVLQIHFWDGRV
2HVWXGRGHVWDGRHQoDSHUPLWLXDDYDOLDomRGRVDQJXHGRVDQLPDLVFRPDVREVHUYDo}HVGHDOWHUDo}HV
PRUIROyJLFDVTXHRFRUUHPQRVHULWUyFLWRVQRVTXDGURVDQrPLFRV$VVLPRXWUDVGRHQoDVWUDQVPLWLGDVSRU
DUWUySRGHVFRPRDPDOiULDHDIHEUHDPDUHODWDPEpPSDVVDUDPDVHUGLDJQRVWLFDGDVHFRQWURODGDVFRP
RDX[tOLRGDSDWRORJLDFOtQLFDFRPrQIDVHQRVH[DPHVKHPDWROyJLFRV

(P  %XUQHWW R SLRQHLUR GD KHPDWRORJLD YHWHULQiULD GHVFUHYHX R VDQJXH GH YiULDV HVSpFLHV GH
DQLPDLVGRPpVWLFRV1RPHVPRSHUtRGRIRLFRQVWDWDGRTXHRKHPRJUDPDGRVSURFHVVRVLQÁDPDWyULRV
HP HTXLQRV p FDUDFWHUL]DGR SRU OHXFRFLWRVH H QHXWURÀOLD H TXH QD UHWLFXOLWH WUDXPiWLFD QRV ERYLQRV
REVHUYDVHQHXWURÀOLDDEVROXWDFRPFRQWDJHPGHJOyEXORVEUDQFRVQRUPDLV

3RU YROWD GH  IRL PLQLVWUDGD D SULPHLUD GLVFLSOLQD GH SDWRORJLD FOtQLFD QD )DFXOGDGH GH 0HGLFLQD
Veterinária da Universidade da Pensilvânia, Estados Unidos. Foi neste mesmo período que também
FRPHoDUDPDVXUJLURVSULPHLURVOLYURVGHDQiOLVHVFOtQLFDVDSDUWLUGHH[SHULrQFLDVHDQRWDo}HVUHDOL]DGDV
QRVODERUDWyULRVHTXHHUDPXVDGDVSDUDHQVLQDUHPFXUVRVGHGLDJQyVWLFRODERUDWRULDO

$GLVFLSOLQDGHSDWRORJLDFOtQLFDFRQWULEXLSDUDRGHVHQYROYLPHQWRGHXPFRQMXQWRGHKDELOLGDGHVTXH
LQFOXHPFRPSHWrQFLDVWpFQLFDV UHDOL]DomRHLQWHUSUHWDomRGRVH[DPHV FRPXQLFDomRHÀFD] GLVFXVVmR
GRV UHVXOWDGRV WURFD GH H[SHULrQFLDV HQWUH R FOtQLFR VROLFLWDQWH H R ODERUDWyULR  H WRPDGD GH GHFLVmR
(condução do caso clínico).

2 WySLFR KHPDWRORJLD HVWi SUHVHQWH QDV HPHQWDV GDV GLVFLSOLQDV GH SDWRORJLD FOLQLFD YHWHULQiULD HP
universidades nacionais e de outros países. Entretanto, apesar de existirem vários materiais didáticos
VREUHRDVVXQWRSRXFRVVmRHVSHFtÀFRVSDUDDiUHDGHYHWHULQiULD6RPDVHDLVVRRIDWRGHSRXFDV
universidades brasileiras disponibilizarem material didático de acesso livre e democrático para
complementar o aprendizado do corpo discente. Nesse contexto, se faz necessário a produção de
PDWHULDLVHPIRUPDGHOLYURGLJLWDOFRPrQIDVHHPKHPDWRORJLDYHWHULQiULD

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO


13
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

2 YROXPH VDQJXtQHR WRWDO WDPEpP FKDPDGR GH YROHPLD HTXLYDOH D DSUR[LPDGDPHQWH  GR
SHVR FRUSRUDO YDULDQGR FRP D HVSpFLH D LGDGH H D LQJHVWmR RXSHUGD GH iJXD 2 YROXPH VDQJXtQHR
SHUPDQHFHHVWiYHOSHODFRQVWDQWHSDVVDJHPGHOtTXLGRVLQWHUVWLFLDLVSDUDRPHLRYDVFXODUHYLFHYHUVD
$KLSRYROHPLDSRGHRFRUUHUHPVLWXDo}HVQDVTXDLVRFRUUHXPGHFUpVFLPRGRYROXPHVDQJXtQHRFRPR
QRVFDVRVGHKHPRUUDJLDSUREOHPDVUHQDLVHGHVLGUDWDomR4XDQGRFHUFDGHDGRVDQJXHp
02 COMPOSIÇÃO DO SANGUE/ SISTEMA HEMATOPOIÉTICO-LÍTICO SHUGLGRRFRUUHRFKDPDGRFKRTXHKLSRYROrPLFRTXHFRQVWLWXLXPDHPHUJrQFLDHSRGHOHYDURSDFLHQWH
DyELWR$KLSHUYROHPLDRFRUUHHPVLWXDo}HVGHLQJHVWmRDGPLQLVWUDomRRXUHWHQomRGHOtTXLGRVHVyGLR
em excesso.
2VDQJXHpXPWHFLGRÁXLGRHFRPRWDOpIRUPDGRSRUXPPHLRLQWHUFHOXODU SODVPD HSRUWUrVWLSRV $V FpOXODV VDQJXtQHDV WrP XP SHUtRGR GH YLGD FXUWR H GHOLPLWDGR H D TXDQWLGDGH GHVVDV FpOXODV
FHOXODUHV KHPiFLDVOHXFyFLWRVHSODTXHWDV REVHUYDGRVQD)LJXUD2SODVPDVDQJXtQHRpFRQVWLWXtGR QD FLUFXODomR PDQWrPVH HVWiYHO SRU DomR GH XP FRQMXQWR GH yUJmRV H WHFLGRV FKDPDGR VLVWHPD
SRUiJXDPLQHUDLVHOHWUyOLWRVYLWDPLQDVSURWHtQDVOLStGLRVHFDUERLGUDWRV&DGDWLSRFHOXODUGRVDQJXH KHPDWRSRLpWLFROtWLFR3DUWLFLSDPGHVVHVLVWHPDDPHGXODyVVHDREDoRRItJDGRRWLPRRVLQWHVWLQRV
WHPXPDIXQomRHVSHFtÀFDSDUDRRUJDQLVPR$VKHPiFLDVFDUUHLDPRVJDVHVVDQJXtQHRVRVOHXFyFLWRV RV ULQV R HVW{PDJR H RV PDFUyIDJRV GR 6LVWHPD 0RQRFtWLFR )DJRFLWiULR 60)  DQWHV GHQRPLQDGR
SDUWLFLSDPGDGHIHVDRUJkQLFDHDVSODTXHWDVDWXDPQRSURFHVVRGHKHPRVWDVLD 6LVWHPD 5HWLFXOR (QGRWHOLDO 1D WDEHOD  HVWmR GHVFULWRV RV yUJmRV H WHFLGRV TXH FRPS}H R VLVWHPD
KHPDWRSRLpWLFROtWLFRFRPVXDVUHVSHFWLYDVIXQo}HV

Tabela 1 ÐUJmRVHWHFLGRVGRVLVWHPDKHPDWRSRLpWLFROtWLFRHVXDVSULQFLSDLVIXQo}HV

ÓRGÃO OU TECIDO FUNÇÕES


0HGXODyVVHD +HPDWRSRLHVH(VWRTXHGHIHUUR KHPRVVLGHULQDHIHUULWLQD 
SDUDDVtQWHVHGDKHPRJORELQDQRVSUHFXUVRUHVHULWUyLGHV
Timo 'LIHUHQFLDomRGRV/LQIyFLWRV7
Baço 3URGXomRGHOLQIyFLWRV%VtQWHVHGHDQWLFRUSRVUHVHUYDWyULR
de hemácias e plaquetas, destruição de hemácias, estoque
de ferro.
6LVWHPD0RQRFtWLFR)DJRFLWiULR 60) 'HVWUXLomRGHFpOXODVVDQJXtQHDVDOWHUDGDVRXVHQHVFHQWHV
KHPRFDWDUHVH GHJUDGDomRGDKHPRJORELQDHVWRTXHGH
ferro.
)tJDGR Estoque de vit. B12 e ferro. Produção de proteínas e fatores
GDFRDJXODomRFRQYHUVmRGH%LOLUUXELQDOLYUHHP%LOLUUXELQD
FRQMXJDGD
(VW{PDJRHLQWHVWLQRV 3URGX]+&OHIDFLOLWDDDEVRUomRGH)HUURSURPRYHDUHGXomR
de ferro férrico (Fe+++) em ferroso (Fe++) que é mais fácil
a absorção. Produz fator intrínseco, facilitando assim a
absorção de vit. B12.
Figura 1 (OHPHQWRV FRQVWLWXLQWHV GR VDQJXH SODVPD VDQJXtQHR H HOHPHQWRV FHOXODUHV KHPiFLDV
OHXFyFLWRVHSODTXHWDV  Rins 3URGX]HULWURSRHWLQDHWURPERSRHWLQD'HJUDGDD
KHPRJORELQDH[FHVVLYDPHQWHÀOWUDGD([FUHomRGHELOLUUXELQD
FRQMXJDGDHRXWURVSURGXWRVGRPHWDEROLVPRFHOXODU
2VDQJXHFLUFXODQRLQWHULRUGRVYDVRVVDQJXtQHRV DUWpULDVDUWHUtRODVYHLDVHYrQXODV VHQGRERPEHDGR
SHORFRUDomRHWHPFRPRIXQo}HVSULQFLSDLVDQXWULomRHR[LJHQDomRGRVWHFLGRV$WUDYpVGRVDQJXHVmR
WUDQVSRUWDGRV RV QXWULHQWHV SURWHtQDV FDUERLGUDWRV OLStGLRV YLWDPLQDV  KRUP{QLRV H R R[LJrQLR 2  3RU PHLR GR VLVWHPD KHPDWRSRLpWLFROtWLFR VmR SURGX]LGDV DV FpOXODV VDQJXtQHDV SHOR SURFHVVR GH
QHFHVViULR DR PHWDEROLVPR FHOXODU 2 2 p FDUUHDGR GRV SXOP}HVSDUD RV WHFLGRV H R JiV FDUE{QLFR KHPDWRSRLHVH )LJXUD   H DV FpOXODV VHQHVFHQWHV SDUDVLWDGDV RX GHIHLWXRVDV VmR GHVWUXtGDV SRU
&2 QRVHQWLGRLQYHUVRRXVHMDGRVWHFLGRVSDUDRVSXOP}HV$OpPGHVVDVIXQo}HVRVDQJXHSDUWLFLSD KHPRFDWDUHVH$SURGXomRHDGHVWUXLomRGDVFpOXODVVDQJXtQHDVVmRHYHQWRVÀVLROyJLFRVTXHPDQWpP
GD UHJXODomR GD WHPSHUDWXUD FRUSRUDO UHFHEH RV SURGXWRV GR PHWDEROLVPR FHOXODU FDWDEyOLWRV  H RV RVFRQVWLWXLQWHVVDQJXtQHRVGHQWURGRVYDORUHVQRUPDLVSDUDFDGDHVSpFLH$OWHUDo}HVQHVVHVSURFHVVRV
FRQGX]HPSDUD RV yUJmRVGH PHWDEROL]DomRH H[FUHomR ULQV SXOP}HVH ItJDGR  SDUD TXHHOHVVHMDP FRQWULEXHP SDUD UHGXomR RX DXPHQWR GRV WLSRV FHOXODUHV GR VDQJXH GHFRUUHQWHV GRV SURFHVVRV
HOLPLQDGRVGRRUJDQLVPR SDWROyJLFRV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

DEFINIÇÕES IMPORTANTES

+HPDWRSRLHVH SDODYUD GHULYDGD GR JUHJR +DLPD  VDQJXH 3RLHVLV  FULDomR


SURGXomR TXHGHÀQHRSURFHVVRGHSURGXomRGDVFpOXODVVDQJXtQHDV

+HPRFDWDUHVHpRSURFHVVRSHORTXDODVKHPiFLDVHRXWURVHOHPHQWRVÀJXUDGRVGR
VDQJXHVmRHOLPLQDGRVGDFLUFXODomR

+HPyOLVHGHÀQHRSURFHVVRGHGHVWUXLomRSDWROyJLFRRXÀVLROyJLFRGDVKHPiFLDV
HSRGHRFRUUHUGHQWURGRYDVRVDQJXtQHR KHPyOLVHLQWUDYDVFXODU RXHPyUJmRV
ULFRVHPFpOXODVGR60) PDFUyIDJRV FRPREDoRHItJDGR KHPyOLVHH[WUDYDVFXODU 

$KHPDWRSRLHVHSRGHVHUFODVVLÀFDGDFRPRSUpQDWDOTXHRFRUUHGXUDQWHDYLGDLQWUDXWHULQDHSyVQDWDO
TXHRFRUUHDSyVRQDVFLPHQWR1DYLGDLQWUDXWHULQDRSULPHLURORFDOGHSURGXomRGDVFpOXODVVDQJXtQHDV Figura 2 3URFHVVRUHVXPLGRGDKHPDWRSRLHVHGHPRQVWUDQGRDVFpOXODVSURJHQLWRUDVSUHFXUVRUDVH
p R VDFR YLWHOtQLFR H SRVWHULRUPHQWH HVVD IXQomR p DVVXPLGD SHOR ItJDGR EDoR H PHGXOD yVVHD 1R maduras.
UHFpPQDVFLGRDSURGXomRGDVFpOXODVVDQJXtQHDVSDVVDDRFRUUHUQDPHGXODyVVHDGHWRGRVRVRVVRV
GRFRUSR­PHGLGDTXHRDQLPDOYDLFUHVFHQGRHFKHJDQGRjIDVHDGXOWDDSURGXomRGDVFpOXODVGR
VDQJXHRFRUUHDSHQDVQDPHGXODyVVHDGRVRVVRVFKDWRVRVVRVORQJRV HStÀVHV HHVWHUQR(PDOJXPDV
VLWXDo}HVQRVDQLPDLVDGXOWRVRItJDGRHREDoRSRGHPUHWRPDURSRWHQFLDOKHPDWRSRLpWLFRVHQGRHVVD
função denominada de hematopoiese extramedular.
DEFINIÇÕES IMPORTANTES
Geralmente, nos animais jovens a atividade hematopoiética é mais intensa, resultando em maiores
YDORUHVGHKHPiFLDVSODTXHWDVHOHXFyFLWRVTXDQGRFRPSDUDGRDRVYDORUHVKHPDWROyJLFRVGHDQLPDLV
$ KHPDWRSRLHVH H[WUDPHGXODU p GHÀQLGD FRPR XP PHFDQLVPR ÀVLROyJLFR
PDLVYHOKRV(VVDLQÁXrQFLDGDLGDGHVREUHRVYDORUHVKHPDWROyJLFRVIRLREVHUYDGDSDUDEXEDOLQRVH
FRPSHQVDWyULRTXHRFRUUHTXDQGRDPHGXODyVVHDQmRFRQVHJXHVXSULUDGHPDQGD
RYLQRVFULDGRVQD$PD]{QLD2ULHQWDO GHFpOXODVVDQJXtQHDVHRXWURVyUJmRVFRPREDoRHItJDGRUHWRPDPVHXSRWHQFLDO
hematopoiético. Geralmente está associada a:
$ KHPDWRSRLHVH RFRUUH D SDUWLU GH XPD FpOXOD PmH ´6WHP &HOOµ TXH SRGH GDU RULJHP D TXDOTXHU XP
• +HPRJORELQRSDWLDVFRQJrQLWDV
GRV WLSRV FHOXODUHV GR VDQJXH VHQGR SRU LVVR GHQRPLQDGD GH FpOXOD FRP FDSDFLGDGH SOXULSRWHQFLDO • $QHPLDVJUDYHV
(VVD ´6WHP &HOOµ SRU HVWtPXORV HVSHFtÀFRV VH GLIHUHQFLD HP SUHFXUVRUHV OLQIyLGHV H PLHOyLGHV TXH • Desordens de substituição medular adquiridas (leucemias, linfomas,
DSUHVHQWDPFDSDFLGDGHPXOWLSRWHQFLDO2VSUHFXUVRUHVOLQIyLGHVRULJLQDPRVOLQIyFLWRV7H%HQTXDQWRRV PLHORÀEURVH
RXWURVWLSRVFHOXODUHVGRVDQJXH KHPiFLDVJUDQXOyFLWRVPRQyFLWRVHSODTXHWDV VmRRULJLQDGRVDSDUWLU
GRVSUHFXUVRUHVPLHOyLGHV$VFpOXODVPXOWLSRWHQFLDLVRULJLQDPDVFpOXODVXQLSRWHQFLDLVTXHIRUPDPDV
XQLGDGHVIRUPDGRUDVGHFRO{QLDV 8)& TXHYmRGDURULJHPDRVGLIHUHQWHVWLSRVFHOXODUHV'HWDOKHVGD
IRUPDomR GDV KHPiFLDV HULWURSRLHVH  OHXFyFLWRV OHXFRSRLHVH  H SODTXHWDV WURPERFLWRSRLHVH  VHUmR
GHVFULWRVQRVWySLFRVVHJXLQWHV

CURIOSIDADE

(PFDPXQGRQJRVREDoRFRQWLQXDVXDDWLYLGDGHKHPDWRSRLpWLFDDSyVRQDVFLPHQWR
RXVHMDREDoRQmRVHWRUQDDSHQDVXPORFDOGHGHSyVLWRHGHVWUXLomRGHKHPiFLDV
e plaquetas como nas outras espécies animais.

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
16 17
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

03 HEMÁCIAIS

$VKHPiFLDVVmRDVXQLGDGHVPRUIROyJLFDVGDVpULHYHUPHOKDHVmRGHQRPLQDGDVWDPEpPGHHULWUyFLWRV
RXJOyEXORVYHUPHOKRV6mRDVFpOXODVPDLVQXPHURVDVGRVDQJXHFRUUHVSRQGHQGRDDSUR[LPDGDPHQWH
 GR YROXPH JOREXODU 6mR FRPSRVWDV SRU  GH iJXD  GH SURWHtQD KHPRJORELQD   GH
FDUERLGUDWRVHGHOLStGLRV$PHPEUDQDLVRODGDHPDOJXQVDQLPDLVpIRUPDGDSRUDSUR[LPDGDPHQWH
 GH iJXD  GH SURWHtQDV  GH OLStGLRV H  GH FDUERLGUDWRV 1RV PDPtIHURV DV KHPiFLDV
PDGXUDV VmR DQXFOHDGDV SRVVXHP IRUPDWR ELF{QFDYR H QmR DSUHVHQWDP RUJDQHODV SRU LVVR QmR
sintetizam proteínas. Entretanto, em aves, répteis, anfíbios e peixes o núcleo permanece durante toda a
vida celular.
2VHULWUyFLWRVSRUPHLRGDKHPRJORELQDDSUHVHQWDPFRPRSULQFLSDOIXQomRRWUDQVSRUWHGHR[LJrQLRGRV
SXOP}HVSDUDRVWHFLGRVHQRVHQWLGRLQYHUVRFDUUHLDPRJiVFDUE{QLFR$KHPRJORELQDpXPDSURWHtQD
FRQMXJDGDIRUPDGDSRUGXDVFDGHLDVGHJORELQDOLJDGDVDXPJUXSRSURVWpWLFRGHQRPLQDGRKHPHTXH
pIRUPDGRSRUIHUURHJUXSDPHQWRVSRUÀUtQLFRV7RGDDHQHUJLDGDKHPiFLDpXWLOL]DGDSDUDPDQWHUD
PRUIRORJLDFHOXODUDHVWUXWXUDGDPHPEUDQDDVDWLYLGDGHVHQ]LPiWLFDVHRXWUDVIXQo}HVSDUDJDUDQWLUD
GHPDQGDGHR[LJrQLRSDUDRVWHFLGRV Figura 3 Fatores estimulantes e inibidores da eritropoiese.

Atualmente existem evidências demonstrando que as hemácias participam também da resposta imune $(32pXPKRUP{QLRJOLFRSURWHLFRSURGX]LGRQRVULQV  HItJDGR  TXHDWXDFRPRSULQFLSDO
SRUPHLRGDDomRDQWLPLFURELDQDGDKHPRJORELQDPRGXODomRGDSUROLIHUDomRGHOLQIyFLWRV7HSURGXomR fator estimulante da eritropoiese, favorecendo a proliferação e diferenciação das células precursoras e
GHFLWRFLQDV(QWUHWDQWRDSULQFLSDOIXQomRGRVHULWUyFLWRVpSURWHJHUHWUDQVSRUWDUDKHPRJORELQDSDUD HVWLPXODQGRDVtQWHVHGHKHPRJORELQD1RVFmHVRVULQVVmRRV~QLFRVORFDLVGHSURGXomRGD(32(P
TXHHVWDSURWHtQDGHVHPSHQKHVXDIXQomRGHWUDQVSRUWHGHJDVHV3DUDLVVRQRVPDPtIHURVRQ~FOHRH RXWUDVHVSpFLHVRItJDGRWDPEpPSURGX]D(32QDIRUPDGHXPSUHFXUVRULQDWLYR
DVHVWUXWXUDVFLWRSODVPiWLFDVIRUDPVXEVWLWXtGRVSRUXPDVROXomRFRQFHQWUDGDGHKHPRJORELQD
Fatores nutricionais também são importantes para produção de hemácias. Para que a eritropoiese ocorra
A produção de hemácias é denominada eritropoiese que inicia ainda na vida uterina e, nos animais QRUPDOPHQWHVmRQHFHVViULRVPLQHUDLVSURWHtQDVHDOJXPDVYLWDPLQDVSULQFLSDOPHQWHDVGRFRPSOH[R
DGXOWRVRSULQFLSDOWHFLGRKHPDWRSRLpWLFRpDPHGXODyVVHD3DUDFRUUHWDSURGXomRHPDWXUDomRGDV %2IHUUR )H pLPSRUWDQWHSDUDVtQWHVHGHKHPRJORELQDHDVYLWDPLQDVGRFRPSOH[R%HIRODWRVVmR
KHPiFLDVpQHFHVViULRXPDPELHQWHPHGXODUtQWHJURSUHVHQoDGRVSUHFXUVRUHV FpOXODVSURJHQLWRUDV  LPSRUWDQWHVSDUDTXHDVPLWRVHVRFRUUDPGHIRUPDDGHTXDGDQDPHGXODyVVHD
participação de fatores estimulantes nutricionais e hormonais. São fatores estimulantes da eritropoiese
DOJXPDVLQWHUOHXFLQDV ,/ DHULWURSRHWLQD (32 RVKRUP{QLRVGDWLUHyLGHRVIDWRUHVGHFUHVFLPHQWRRV $SURGXomRGHKHPiFLDV HULWURSRLHVH QRVDQLPDLVDGXOWRVRFRUUHQDPHGXODyVVHDDSDUWLUGHXPD
DQGUyJHQRVHDKLSy[LDWHFLGXDO'URJDVPLHORWy[LFDVUDGLDomRLRQL]DQWHHVWUyJHQRVHDOJXPDVGRHQoDV ´6WHP&HOOµTXHVHGLIHUHQFLDHP8QLGDGH)RUPDGRUDGH([SORVmR(ULWUyLGHHSRVWHULRUPHQWHHP8)&
infecciosas e neoplásicas atuam como inibidores da eritropoiese, resultando em quadros de anemia (ULWUyLGHSRUHVWLPXODomRGDLQWHUOHXFLQDGRVKRUP{QLRVWLUHRLGLDQRVDQGUyJHQRVHGD(32LQLFLDQGR
)LJXUD  um processo de multiplicação celular com, em média, quatro mitoses.

CURIOSIDADE

Em ratos a vida média da EPO é de duas a cinco horas e em cães de sete a dez
horas. A secreção de EPO é estimulada por testosterona, tiroxina, vasopressina e
KRUP{QLRGRFUHVFLPHQWR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
18 19
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

1DPHGXODyVVHDRSUHFXUVRUPDLVLPDWXURGDVpULHYHUPHOKDpRUXEULEODVWR FpOXODJUDQGHFLWRSODVPD 3.1 Tempo de vida das hemácias/Hemólise


EDVRItOLFRQ~FOHRDUUHGRQGDGRIRUPDGRGHFURPDWLQDÀQDQXFOpRORVHDQpLVQXFOHDUHVEHPHYLGHQWHV 
$SyV XPD PLWRVH IRUPDPVH GRLV SUpUXEUtFLWRV TXH VmR VHPHOKDQWHV j FpOXOD DQWHULRU SRUpP QmR 2WHPSRGHYLGDGRVHULWUyFLWRVYDULDFRPDHVSpFLHDQLPDODSUHVHQoDGHLQFOXV}HVRXDOWHUDo}HVQD
apresentam nucléolo e nem anel nuclear. Com mais uma mitose, são formados dois rubrícitos basofílicos PRUIRORJLDGDFpOXODHDRFRUUrQFLDGHDOJXPDVGRHQoDVSULQFLSDOPHQWHDVKHPROtWLFDV
FpOXODV PHQRUHV H FRP FURPDWLQD PDLV FRQGHQVDGD  (P VHJXLGD RV UXEUtFLWRV EDVRItOLFRV VRIUHP 1DHVSpFLHFDQLQDRWHPSRGHYLGDGRHULWUyFLWRYDULDGHDGLDVVHQGRVHPHOKDQWHDRSHUtRGR
duas mitoses formando quatro rubrícitos policromáticos (nesta fase ocorre a maior parte da síntese de vida da hemácia humana (120 dias). Em felinos as hemácias duram, em média, 65 a 76 dias. O tempo
GHKHPRJORELQDHRFLWRSODVPDpPDLVDFLQ]HQWDGR 2VUXEUtFLWRVSROLFURPiWLFRVSRGHPRXQmRVRIUHU GHYLGDGRVHULWUyFLWRVGHHTXLQRVYDULDGHDGLDVGRVERYLQRVpGHDSUR[LPDGDPHQWHGLDV
mitose formando o metarrubrícito (fase de multiplicação e maturação). HGHFDSULQRVpGHGLDV$KHPiFLDFRPPHQRUWHPSRGHYLGDpDGDJDOLQKD GLDV HQTXDQWRD
2V PHWDUUXEUtFLWRV WDPEpP GHQRPLQDGRV PHWDUUXEUyFLWRV  QD IDVH GH PDWXUDomR SRVVXHP Q~FOHR do jacaré dura três anos.
SLFQyWLFRHFLWRSODVPDVHPHOKDQWHDRGRHULWUyFLWRPDGXURSRUpPXPSRXFRPDLVD]XODGR(PVHJXLGD 4XDQGRDVKHPiFLDVHVWmRVHQHVFHQWHVSDUDVLWDGDVFRPDOJXPDDOWHUDomRHQ]LPiWLFDRXPRUIROyJLFD
RPHWDUUXEUtFLWRSHUGHRQ~FOHRTXHpIDJRFLWDGRSHORVPDFUyIDJRVUHVLGHQWHVGDPHGXODyVVHDHVH HODVVmRUHWLUDGDVGHFLUFXODomRHGHVWUXtGDVSRUXPSURFHVVRGHQRPLQDGRKHPyOLVH2WHUPRKHPyOLVH
WUDQVIRUPDHPUHWLFXOyFLWR2UHWLFXOyFLWRpVHPHOKDQWHDRHULWUyFLWRPDGXURSRUpPDLQGDDSUHVHQWDQD VLJQLÀFDDGHVWUXLomRGDVKHPiFLDV KHPR VDQJXHOLVH TXHEUD FRPUXSWXUDGDPHPEUDQDSODVPiWLFD
VXDHVWUXWXUDDJUHJDGRVGHRUJDQHODV ULERVVRPRVPLWRF{QGULDVFRPSOH[RGHJROJL TXHVmRYLVXDOL]DGRV HOLEHUDomRGDKHPRJORELQD$KHPyOLVHSRGHRFRUUHUGHGXDVPDQHLUDVLQWUDYDVFXODURXH[WUDYDVFXODU
DSHQDVFRPDXWLOL]DomRGHFRORUDo}HVVXSUDYLWDLV D]XOGHEULOKDQWHFUHVLORXD]XOGHPHWLOHQR &RPD
SHUGDGDVRUJDQHODVRVUHWLFXOyFLWRVSDVVDPDVHUFKDPDGRVGHHULWUyFLWRVPDGXURV $ÀJXUDUHSUHVHQWDDKHPyOLVHH[WUDYDVFXODUGDVKHPiFLDVDVTXDLVVmRFDSWXUDGDVSHORVPDFUyIDJRV
HVSOrQLFRV TXH GLJHUHP D PHPEUDQD VHSDUDP R JUXSR KHPH GD KHPRJORELQD KLGUROLVDP D JORELQD
$WUDQVIRUPDomRGHUHWLFXOyFLWRVHPKHPiFLDVPDGXUDVRFRUUHSRUDomRGHXPDHQ]LPDGHQRPLQDGD UHPRYHP R )H H FDWDEROL]DP R JUXSR KHPH 2V DPLQRiFLGRV GD JORELQD H R )H VmR UHDSURYHLWDGRV H
SLULPLGLQD ·QXFOHRWLGDVH 31  TXH GHJUDGD DV RUJDQHODV DLQGD H[LVWHQWHV QRV UHWLFXOyFLWRV 1D SRGHPVHUUHXWLOL]DGRVSDUDVtQWHVHGHQRYDVKHPiFLDV2JUXSRKHPHGiRULJHPjELOLUUXELQD
intoxicação por chumbo (plumbismo) a atividade dessa enzima está inibida, diminuindo a sobrevida dos
HULWUyFLWRVHpUHVSRQViYHOSHODSUHVHQoDGHSRQWLOKDGREDVyÀORREVHUYDGRQDVKHPiFLDVQRSOXPELVPR 2ItJDGRHDPHGXODyVVHDWDPEpPSRGHPSDUWLFLSDUFRPRWHFLGRVRQGHRFRUUHKHPyOLVHH[WUDYDVFXODU
(QWUHWDQWRDDQDWRPLDGREDoRRWRUQDPDLVVHQVtYHOSDUDGHWHFWDUSHTXHQDVDOWHUDo}HVQDVKHPiFLDV
e retirar as células defeituosas da circulação.

CURIOSIDADES

1RVPDPtIHURVDVtQWHVHGHKHPRJORELQDVyRFRUUHDWpDIDVHGHUHWLFXOyFLWRV(P
HVSpFLHVFRPKHPiFLDVQXFOHDGDVDVtQWHVHGHKHPRJORELQDRFRUUHGXUDQWHWRGR
o período de vida das hemácias.

2V UHWLFXOyFLWRV H SROLFURPDWyÀORV VmR R PHVPR WLSR FHOXODU SRUpP UHFHEHP


GHQRPLQDo}HV GLIHUHQWHV GH DFRUGR FRP D FRORUDomR XWLOL]DGD SDUD SUHSDUR
GR HVIUHJDoR 4XDQGR VmR XVDGRV FRUDQWHV WULF{PLFRV D FpOXOD p FKDPDGD GH
SROLFURPDWyÀOR 4XDQGR R HVIUHJDoR p FRUDGR FRP FRUDQWHV VXSUDYLWDLV D]XO GH
EULOKDQWHFUHVLORXD]XOGHPHWLOHQR DVFpOXODVVmRGHQRPLQDGDVUHWLFXOyFLWRV

2V UHWLFXOyFLWRVSROLFURPDWyÀORV VmR RV ~OWLPRV HVWiJLRV LPDWXURV DQWHV GD


hemácia madura. O aumento desses tipos celulares na circulação é tecnicamente
GHQRPLQDGRGHUHWLFXORFLWRVHRXSROLFURPDWRÀOLDHRFRUUHHPDOJXPDVHVSpFLHV
QRVFDVRVGHDQHPLDUHJHQHUDWLYD

Figura 4 3URFHVVRUHVXPLGRGDKHPyOLVHHGHVWLQRGDELOLUUXELQDQRRUJDQLVPR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
20 21
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

1DKHPyOLVHLQWUDYDVFXODUDUXSWXUDGDVKHPiFLDVRFRUUHGHQWURGRYDVRVDQJXtQHRFRPOLEHUDomRGD
KHPRJORELQD TXH YDL VHU FRQMXJDGD FRP RXWUD SURWHtQD SODVPiWLFD D KDSWRJORELQD (VVH FRQMXJDGR
KHPRJORELQDKDSWRJORELQD pIDJRFLWDGRSRUPDFUyIDJRVGREDoRPHGXODyVVHDRXItJDGRUHVXOWDQGR
QDPHWDEROL]DomRGRJUXSRKHPHSURGX]LQGRELOLUUXELQD4XDQGRDKHPyOLVHLQWUDYDVFXODUpPXLWRLQWHQVD
RFRUUHVDWXUDomRGDKDSWRJORELQDHDKHPRJORELQDOLYUHpÀOWUDGDSHORVJURPpUXORVUHQDLVUHVXOWDQGRHP IMPORTANTE SABER
KHPRJORELQ~ULD SUHVHQoDGHKHPRJORELQDQDXULQD 2H[FHVVRGHKHPRJORELQDOLYUHQRSODVPDWDPEpP
FDXVDKHPRJORELQHPLDTXHWRUQDRSODVPDYLVLYHOPHQWHDYHUPHOKDGR'HVVDIRUPDDKHPRJORELQHPLD Tipos de Icterícia:
HDKHPRJORELQ~ULDVmRVLQDLVGHKHPyOLVHLQWUDYDVFXODU1HVVHWLSRGHKHPyOLVHWDPEpPSRGHRFRUUHU
excesso de síntese de bilirrubina, resultando em icterícia. Pré-hepática ou hemolítica²2FRUUHSRUVXSHUSURGXomRGHELOLUUXELQDH[FHGHQGR
DFDSDFLGDGHGRItJDGRHPFRQMXJDUHH[FUHWDURSLJPHQWR1HVVHWLSRGHLFWHUtFLD
$ ELOLUUXELQD XP SLJPHQWR DPDUHODGR HQFRQWUDGR QR SODVPD VDQJXtQHR p R SULQFLSDO SURGXWR GD SUHGRPLQD D ELOLUUXELQD OLYUH RX LQGLUHWD 2 DQLPDO JHUDOPHQWH HVWi DQrPLFR
GHJUDGDomR GDV KHPiFLDV $ KHPyOLVH p UHVSRQViYHO SRU PDLV GH  GH WRGD ELOLUUXELQD SURGX]LGD UHVXOWDGRGDKHPyOLVHH[FHVVLYD
QR RUJDQLVPR VHQGR R UHVWDQWH SURYHQLHQWH GD GHJUDGDomR GRV FLWRFURPRV H GD PLRJORELQD 3DUD • 2 MHMXP SURORQJDGR HP HTXLQRV H IHOLQRV SRGH UHVXOWDU HP LFWHUtFLD SUp
hepática, pois a mobilização do tecido adiposo resulta em acúmulo de ácidos
SURGXomRGHVVHSLJPHQWRQRLQWHULRUGRVPDFUyIDJRVRJUXSRKHPHpFOLYDGRSRUDomRHQ]LPiWLFDGD
JUD[RVQRItJDGR(VVHViFLGRVJUD[RVFRPSHWHPFRPDELOLUUXELQDSDUDOLJDomR
heme-oxidase formando a biliverdina. A biliverdina é convertida em bilirrubina através de uma reação
FRP DV OLJDQGLQDV UHVXOWDQGR HP IDOKDV QD FDSWDomR H FRQVHTXHQWHPHQWH
enzimática catalisada pela biliverdina-redutase. Em aves e répteis a atividade da biliverdina-redutase é FRQMXJDomRHH[FUHomR
PXLWREDL[DGHVVDIRUPDQHVVDVHVSpFLHVRSULQFLSDOSLJPHQWRIRUPDGRpDELOLYHUGLQD
Hepática ou por lesão hepatocelular  2FRUUH QDV OHV}HV KHSiWLFDV GLIXVDV
2V PDFUyIDJRV GR 60) OLEHUDP D ELOLUUXELQD QD IRUPD QmR FRQMXJDGD GHQRPLQDGD WDPEpP GH LQÁDPDomR GHJHQHUDo}HV FLUURVH WXPRUHV HWF  FRP IDOKDV QD FDSWDomR
bilirrubina indireta ou bilirrubina livre. Essa forma da bilirrubina é lipossolúvel e necessita ser carreada FRQMXJDomR H H[FUHomR 1HVVH WLSR GH LFWHUtFLD SRGH SUHGRPLQDU D ELOLUUXELQD
QRSODVPDOLJDGDjDOEXPLQD3DUDTXHSRVVDVHUH[FUHWDGDGRRUJDQLVPRDELOLUUXELQDOLYUHQHFHVVLWDVHU GLUHWDRXFRQMXJDGD*HUDOPHQWHRVDQLPDLVDSUHVHQWDPDOWHUDo}HVQRVH[DPHV
PHWDEROL]DGDQRItJDGR bioquímicos que avaliam a função hepática.
2ItJDGRpRyUJmRTXHSDUWLFLSDGDPHWDEROL]DomRHH[FUHomRGDELOLUUXELQDHPWUrVIDVHVFDSWDomR Pós-hepática ou colestáticaRFRUUHSRUDOWHUDo}HVQDVYLDVELOLDUHVLPSHGLQGRD
FRQMXJDomRHH[FUHomR$ELOLUUXELQDQmRFRQMXJDGDpUHPRYLGDGDDOEXPLQDHFDSWDGDSHORVKHSDWyFLWRV secreção da bilirrubina no intestino e sua posterior eliminação nas fezes. Nesses
DSDUWLUGDOLJDomRFRPSURWHtQDVGHQRPLQDGDVOLJDQGLQDV1RVKHSDWyFLWRVDELOLUUXELQDVHFRQMXJDFRPR FDVRV SUHGRPLQD D ELOLUUXELQD FRQMXJDGD 2 H[FHVVR GH ELOLUUXELQD SRGH VHU
iFLGRJOLFXU{QLFRVHQGRGHQRPLQDGDGHELOLUUXELQDFRQMXJDGDRXGLUHWD$FRQMXJDomRWRUQDDELOLUUXELQD HOLPLQDGRQDXULQD ELOLUUXELQ~ULD HDVIH]HVÀFDPGHVFRUDGDV IH]HVDFyOLFDV 
XPDPROpFXODKLGURVVRO~YHOHSRUWDQWRPDLVIiFLOGHVHUH[FUHWDGDGRRUJDQLVPR$ELOLUUXELQDFRQMXJDGD
pVHFUHWDGDDWLYDPHQWHSHORVKHSDWyFLWRVSDUDRLQWHULRUGRVFDQDOtFXORVELOLDUHVHÀFDDUPD]HQDGDQD
vesícula biliar até ser excretada no intestino.
1RLQWHVWLQRDELOLUUXELQDFRQMXJDGDVRIUHDomRGHHQ]LPDVEDFWHULDQDV EHWDJOLFXURQLGDVHV UHVXOWDQGR
HVWHUFRELOLQDVTXHVmRHOLPLQDGDVQDVXDPDLRUSDUWH  QDVIH]HVGDQGRVXDFRUFDUDFWHUtVWLFD8PD 3.2 Morfologia normal das hemácias
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sendo excretada na urina. SUySULR VDQJXH XWLOL]DQGR XP PLFURVFySLR SULPLWLYR (P  +RSSH6H\HU GHPRQVWURX D IXQomR GD
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HVVHSLJPHQWRVHDFXPXODQRRUJDQLVPRFDXVDQGRLFWHUtFLDTXHFRQVLVWHQDSLJPHQWDomRGHDPDUHOR KHPiFLDVHPYHUWHEUDGRVGHPRQVWUDQGRTXHH[LVWHXPDJDPDYDULDGDGHWDPDQKRHIRUPDVSDUDRV
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podendo causar anemia e excesso de produção de bilirrubina. A hiperbilirrubinemia supera a capacidade 3DXO(KUOLFKXPEDFWHULRORJLVWDDOHPDRHPGHVHQYROYHXRVFRUDQWHVWULFU{PLFRVSDUDDYDOLDomR
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descritas por vários pesquisadores, porém a determinação das causas ou mecanismos de formação
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MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

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das anormalidades que possam ocorrer.
$ PDLRULD GRV PDPtIHURV DSUHVHQWDP JOyEXORV YHUPHOKRV UHGRQGRV ELF{QFDYRV YDULDQGR
consideravelmente em tamanho. As menores hemácias são observadas na espécie caprina, enquanto
a mais semelhante à hemácia humana é a canina. Os camelídeos (camelos, lhamas, dromedários e
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IMPORTANTE SABER

Esfregaço sanguíneo ou extensão sanguínea:

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que é distendida sobre uma lâmina de microscopia. Depois de confeccionado, o
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QDGHWHFomRGHKHPRSDUDVLWDV1RKHPRJUDPDFRPSOHWRRHVIUHJDoRVDQJXtQHR peixe-boi, D. +HPiFLDV GH SULPDWDV E. +HPiFLDV GH ERYLQRV F. +HPiFLDV GH HTXLQRV G. +HPiFLDV
pXWLOL]DGRSDUDID]HUDDYDOLDomRPRUIROyJLFDGDVFpOXODVVDQJXtQHDVHUHDOL]DUD de bubalinos, H.+HPiFLDVGHFDSULQRVI.+HPiFLDVGHDYHVJ.+HPiFLDVGHFRHOKRVK.+HPiFLDVGH
FRQWDJHPGLIHUHQFLDOGHOHXFyFLWRV quatis.

3.3 Tamanho das hemácias


A mensuração do tamanho das hemácias pode ser feita a partir da determinação direta do diâmetro da
célula, entretanto essa não é uma forma prática e pode ser afetada por vários fatores (área da leitura do
HVIUHJDoRHIHLWRGRKHPDWyFULWRHH[SHULrQFLDGRDQDOLVWD 'HVVDIRUPDSDUDHVWLPDWLYDGRWDPDQKR
das hemácias é utilizado um índice hematimétrico denominado Volume Globular Médio (VGM) ou Volume
Corpuscular Médio (VCM). A determinação do tamanho das hemácias é importante para auxiliar na
compreensão das causas das anemias.
$OJXPDVHVSpFLHVDSUHVHQWDPÀVLRORJLFDPHQWHKHPiFLDVPHQRUHVFRPSDUDGDVFRPDVGHFmHVFRPR
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MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

&RP D XWLOL]DomR GR 9*0 DV KHPiFLDV SRGHP VHU FODVVLÀFDGDV HP QRUPRFtWLFDV PDFURFtWLFDV H
microcíticas. As hemácias normocíticas estão dentro do intervalo de referência do VGM para a espécie,
por exemplo, caprinos apresentam VGM entre 16 a 25 fL, enquanto no peixe boi o intervalo de referência
para o VGM é de 114 a 140 fL. O volume celular é inversamente proporcional ao número de hemácias,
ou seja, em espécies com VGM reduzido (ex. caprinos) o número de células vermelhas é bem elevado.
$PDFURFLWRVHRFRUUHTXDQGRH[LVWHXPSUHGRPtQLRGHKHPiFLDVJUDQGHV PDFURFtWLFDV TXHDXPHQWDPR
9*02HOHYDGRQ~PHURGHFpOXODVLPDWXUDV UHWLFXOyFLWRVSROLFURPDWyÀORV GHÀFLrQFLDGH9LWDPLQD% IMPORTANTE SABER
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co-fator importante para síntese de Vit. B12, também causa macrocitose. Um exemplo de macrocitose Wintrobe, em 1933, desenvolveu os índices hematimétricos Volume Globular
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*OREXODU0pGLD &+*0 TXHIRUQHFHPLQIRUPDomRVREUHRWDPDQKRRFRQWH~GRHD
A microcitose ocorre quando há predominância de hemácias pequenas (microcíticas), diminuindo o VGM. FRQFHQWUDomRGHKHPRJORELQDUHVSHFWLYDPHQWH
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de Fe pode-se observar também microcitose. Em bezerros saudáveis observa-se frequentemente 29*0R&+*0HR+*0VmRFDOFXODGRVDSDUWLUGHIyUPXODVPDWHPiWLFDVTXH
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$SHVDUGDVKHPiFLDVGHXPDHVSpFLHQmRVHUHPWRGDVH[DWDPHQWHGRPHVPRWDPDQKRDVYDULDo}HV GDVDQHPLDVHFDOFXODGRVSRUWRGRVRVPRGHUQRVDQDOLVDGRUHVKHPDWROyJLFRV
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hemácias com diferenças marcantes de tamanho utiliza-se para descrever esse achado o termo )yUPXODVSDUDFiOFXORVGRVtQGLFHVKHPDWLPpWULFRV
DQLVRFLWRVHTXHVLJQLÀFDGLIHUHQoDGHWDPDQKR$DQLVRFLWRVHpIUHTXHQWHPHQWHREVHUYDGDQDVDQHPLDV 9*0RX9&0 I/  9*  RXKHPDWyFULWR[
  QžGHHULWUyFLWRV PLOK}HV—/
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que são maiores que as células maduras. Nessa situação são visualizadas hemácias de diferentes
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WDPDQKRV )LJXUD E  ,  1DV DQHPLDV IHUURSULYDV SRGHVH REVHUYDU DQLVRFLWRVH H D GXSOD SRSXODomR
celular é constituída por hemácias de tamanho normal e hemácias microcíticas. +*0RX+&0 SJ  +HPRJORELQD JG/ [
 QžGHHULWUyFLWRV PLOK}HV—/
$DQLVRFLWRVHSRGHVHUREVHUYDGDSHORKHPDWRORJLVWDSRUPHLRGDDYDOLDomRGRHVIUHJDoRVDQJXtQHR
(QWUHWDQWR RV PRGHUQRV FRQWDGRUHV KHPDWROyJLFRV DXWRPDWL]DGRV FDOFXODP XP tQGLFH GHQRPLQDGR SJ SLFRJUDPDV
´5HGFHOOGLVWULEXWLRQZLGKWµ 5': TXHFRUUHVSRQGHDRFRHÀFLHQWHGHYDULDomRGRYROXPHJOREXODUPpGLR
(VGM) e é um índice numérico de anisocitose. A utilização do RDW avalia a anisocitose com mais precisão, &+*0RX&+&0 JG/  +HPRJORELQD JG/ [
pois é mais sensível que o VGM e, por ser um índice numérico, retira a subjetividade do analista.  9*RXKHPDWyFULWR  

JG/ JUDPDVSRUGHFLOLWUR

'HWHUPLQDomRGD&RQFHQWUDomRGH+HPRJORELQD +E

A concentração desta proteína é obtida pelo método espectrofotométrico da


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Intervalo de referência: FKDPDGRHVSHFWURIRW{PHWUR$FLDQRPHWDHPRJORELQDpRUHVXOWDGRGDFRQYHUVmR
GDKHPRJORELQDSHORUHDWLYRGH'UDENLQ
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dos resultados obtidos para o animal (paciente) com os intervalos de referência (IR)
estabelecidos para cada espécie animal.

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padronizadas, cálculos estatísticos e representam uma estimativa dentro da qual
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

3.4 Cor das hemácias Termos técnicos relacionados à morfologia das hemácias e
distribuição das hemácias no esfregaço sanguíneo

$FRORUDomRWtSLFDGDVKHPiFLDVpGDGDSHORWHRUGHKHPRJORELQDGDFpOXOD*HUDOPHQWHDFpOXODPDGXUD Eliptócitos ou ovalócitos - São células ovais com uma zona central pálida. Aparecem em animais com
FRQWpPGRWHRUGHKHPRJORELQDHQTXDQWRRVUHWLFXOyFLWRV ~OWLPRHVWiJLRLPDWXUR DSUHVHQWDP GHIHLWRVGHPHPEUDQDGRVHULWUyFLWRV2VRYDOyFLWRVVmRPDLRUHVTXHRVHULWUyFLWRVQRUPDLVPDGXURVH
FHUFDGH3DUDHVWLPDUDFRQFHQWUDomRGHKHPRJORELQDpXWLOL]DGRRtQGLFHKHPDWLPHWULFR&+*0 DSUHVHQWDPPHPEUDQDEHPGHOJDGDFRPWHQGrQFLDDGREUDUVHIDFLOPHQWH(PFDPHOtGHRVRVHULWUyFL-
&+&0 HGHDFRUGRFRPUHVXOWDGRVREWLGRVDVFpOXODVVmRFODVVLÀFDGDVHP WRVVmRÀVLRORJLFDPHQWHRYDLV )LJXUD²& 
Normocrômicas ²&RQFHQWUDomRGHKHPRJORELQDGHQWURGRVYDORUHVGHUHIHUrQFLDSDUDHVSpFLH
Esferócitos²6mRHULWUyFLWRVHPIRUPDHVIpULFDTXHSHUGHUDPDIRUPDELF{QFDYDGHYLGRjSHUGDGDPHP-
Hipocrômicas &RQFHQWUDomRGHKHPRJORELQDDEDL[RGRVYDORUHVGHUHIHUrQFLDSDUDHVSpFLH brana celular sem perda de citoplasma, levando ao aumento de tensão da membrana celular e maior
IUDJLOLGDGHRVPyWLFDGDPHVPD'HYLGRDLVVRQmRDSUHVHQWDPSDOLGH]FHQWUDO(VVDVFpOXODVSRGHP
Hipercrômicas  &RQFHQWUDomR GH KHPRJORELQD JOREXODU PpGLD DFLPD GRV YDORUHV GH UHIHUrQFLD SDUD DSDUHFHUHPTXDQWLGDGHVHOHYDGDVHPDQLPDLVFRPDQHPLDKHPROtWLFDLPXQRPHGLDGD2VHVIHUyFLWRV
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+HPiFLDVSRGHPVHWRUQDUKLSHUFU{PLFDDSHQDVVHSHUGHUHPVXDPHPEUDQDRXiJXDLQWUDFHOXODUSRUpP UHFRQKHFLGRVGHYLGRRVHULWUyFLWRVQRUPDLVQmRDSUHVHQWDUHPSDOLGH]FHQWUDO$HVSpFLHFDQLQDpDTXH
HVVDVDOWHUDo}HVUDUDPHQWHHOHYDPR&+*0HPRX6mRFDXVDVGHIDOVDKLSHUFURPLDDSUHVHQoDGH SHUPLWHFRPPDLVIDFLOLGDGHDREVHUYDomRGHHVIHUyFLWRV )LJXUD²%HD²& 
RYDOyFLWRVHVIHUyFLWRVRXHPVLWXDo}HVHPTXHRSODVPDVDQJXtQHRHVWHMDKHPROLVDGR
Esquistócitos²2VHVTXLVWyFLWRVTXHWDPEpPVmRFRQKHFLGRVFRPRHVTXL]yFLWRVVmRIUDJPHQWRVGH
3.5 Morfologia e presença de inclusões HULWUyFLWRV TXH VXUJHP GHYLGR j GHWHULRUDomR PHFkQLFD QD FLUFXODomR SRU DQRUPDOLGDGHV PLFURYDVFX-
ODUHV$SUHVHQoDGHUHGHGHÀEULQDQRVLVWHPDPLFURYDVFXODUpXPGRVPRWLYRVFRPXQVGHSUHVHQoDGH
$VDOWHUDo}HVQDPRUIRORJLDGDVKHPiFLDVUHFHEHPRQRPHGHSRLTXLORFLWRVHRXSHFLORFLWRVH$OJXPDV HULWUyFLWRVIUDJPHQWDGRV IRUPDomRGHHVTXL]yFLWRV 7DPEpPSRGHPVHUREVHUYDGRVHPDQLPDLVFRP
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LQGX]LGDSRUDJHQWHVR[LGDQWHV DOJXQVPHGLFDPHQWRVDOLPHQWRVHSURGXWRVTXtPLFRV  L]DPDVVtQGURPHVIDOFrPLFDVGHFRUUHQWHVGDSUHVHQoDGHKHPRJORELQD6QRVKXPDQRV2VGUHSDQyFL-
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WURPERFLWRSHQLDHVXVSHLWRGH&RDJXODomR,QWUDYDVFXODU'LVVHPLQDGD &,' pPDLVUHOHYDQWHGRTXHHP Hemoglobina S: e XPD DOWHUDomR KHPDWROyJLFD KHUHGLWiULD 2 WUDoR IDOFLIRUPH
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(P HVIUHJDoR GH VDQJXH GH FmHV VDXGiYHLV p REVHUYDGR XP SHTXHQR Q~PHUR   GH HULWUyFLWRV XPGRVSDLVRJHQHGDKHPRJORELQD$HGRRXWURRJHQHSDUDDKHPRJORELQD6(P
SROLFURPDWyÀORV UHWLFXOyFLWRV  DOpP GH KHPiFLDV QXFOHDGDV PHWDUUXEUyFLWRV  H RFDVLRQDOPHQWH animais é uma condição rara.
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suprir a necessidade desse tipo celular.
Dacriócitos ou hemácias em forma de lágrima ou pera²(VVDVKHPiFLDVVHGHIRUPDPSULQFLSDOPHQWH
(P UXPLQDQWHV p UDUD D REVHUYDomR GH UHWLFXOyFLWRV HP HVIUHJDoRV VDQJXtQHRV PHVPR QD DQHPLD QREDoRRXPHGXODyVVHDTXDQGRVRIUHPHVWLUDPHQWRDOpPGRVOLPLWHVGHHODVWLFLGDGHDRSDVVDUHP
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GHUHWLFXOyFLWRV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
28 29
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Células-alvo ou leptócitos²3RGHPVHUFKDPDGDVWDPEpPGHFRGyFLWRVHDSUHVHQWDPXPDiUHDFHQWUDO HPHVIUHJDoRVVDQJXtQHRVFRUDGRVFRPFRUDQWHVVXSUDYLWDLVFRPRRD]XOGH0HWLOHQR


GHFRORUDomRDXPHQWDGDQRPHLRGDiUHDGHSDOLGH]GRFLWRSODVPD2VHULWUyFLWRVHPDOYRVHIRUPDP $SUHVHQoDGHJUDQGHTXDQWLGDGHGH&RUS~VFXORVGH+HLQ]OLJDGRVjPHPEUDQDGDVKHPiFLDVSURYRFD
devido ao excesso de membrana em relação ao volume do citoplasma e podem estar presentes em ani- ULJLGH]GDVPHVPDVFDXVDQGRIUDJPHQWDomRHDSULVLRQDPHQWRQREDoRRQGHVmRIDJRFLWDGDV
PDLVFRPXPDSRVVtYHOHQIHUPLGDGHKHSiWLFD )LJXUD²$HD²% 
Corpúsculo de Howell-Jolly²6mRUHVWRVGHIUDJPHQWRVQXFOHDUHVTXHQmRIRUDPWRWDOPHQWHHOLPLQDGRV
Equinócitos ou hemácias crenadas²6mRKHPiFLDVHVSLFXODGDV$VHVStFXODVVmRJHUDOPHQWHGHWDPD- no processo da etritropoiese, são chamados também de micronúcleos. A presença desses corpúsculos é
QKRXQLIRUPHTXHGLIHUHQFLDRVHTXLQyFLWRVGRVDFDQWyFLWRV DSUHVHQWDPHVStFXODVGHWDPDQKRLUUHJXODU FRPXPHPSDFLHQWHVHVSOHQHFWRPL]DGRVSRLVXPDGDVIXQo}HVGREDoRpUHWLUDUGDFLUFXODomRKHPi-
HPDLRUHV 2VHTXLQyFLWRVSRGHPVHIRUPDUQDVVHJXLQWHVVLWXDo}HV )LJXUD²(  cias defeituosas, parasitadas e senescentes. Em casos de anemia falciforme, podem ser observados
DSyVDRFRUUrQFLDGHÀEURVHHVSOrQLFD2XWURVWLSRVGHDQHPLDVSRGHPDSUHVHQWDURVFRUS~VFXORVGH
$UWHIDWR'HYLGRDRHQYHOKHFLPHQWRGRVDQJXHFRQFHQWUDo}HVH[FHVVLYDVGH('7$ GHVLGUDWDRV +RZHOO-ROO\DQHPLDVKHPROtWLFDVHPJHUDODQHPLDPHJDOREOiVWLFDHHPFDVRVGHDWURÀDHVSOrQLFD )LJ-
HULWUyFLWRV DXPHQWRGRS+HGLPLQXLomRGR$73 R$73pLPSRUWDQWHSDUDPDQWHUDIRUPDGRV XUD²/ 
HULWUyFLWRV 
'URJDV'URJDVFRPRVDOLFLQDWRVIHQLOEXWD]RQDIXURVHPLGDDJHQWHVTXLPLRWHUiSLFRVFRPRD 3RGHPVHUREVHUYDGRVQDVDQHPLDVUHJHQHUDWLYDVHPWRGDVDVHVSpFLHV(PFDVRVGHFRPSURPHWLPHQWR
doxorrubicina. GDIXQomRHVSOrQLFD XVRGHFRUWLFRVWHURLGHVHHVSOHQHFWRPLD GLVSODVLDHULWUyLGH SRRGOHVWR\VHPLQLD-
7UDQVWRUQRV'HSOHomRGRVHULWUyFLWRV²4XDQGRRVHTXLQyFLWRVVmRREVHUYDGRVHPVDQJXHIUHV- WXUDQmRDQrPLFRVFRPPDFURFLWRVHKHUHGLWiULDDXPHQWRGRQ~PHURGHFRUS~VFXORVGH+RZHOO-ROO\FRP
FREHPWUDWDGRLQGLFDPGHSOHomRGHHOHWUyOLWRV5HGXomRGHSRWiVVLR . LQWUDFHOXODUHEDL[R DOJXQVDQRUPDLVHIUDJPHQWDGRV VtQGURPHPLHORGLVSOiVLFD PLHORSODVLDSULPiULDSRGHQGRWDPEpPVHU
WHRUGHVyGLRSURYRFDGHVLGUDWDomRGRVJOyEXORVYHUPHOKRVFRPXPHPFDYDORVGHHQGXURFRP REVHUYDGRVDOJXQVFRUS~VFXORVDQRUPDLVHIUDJPHQWDGRV 
GHSOHomRHOHWUROtWLFDDRVXDURXHPFDVRGHGLDUUHLD GLVW~UELRVJDWURLQWHVWLQDLVFRPRHPFROLWH 
'RHQoDUHQDO&mHVTXHDSUHVHQWDPGRHQoDUHQDOHPSDUWLFXODUJORPHUXORQHIULWHSRGHPDSUH- 2VFRUS~VFXORVGH+RZHOO-ROO\SRGHPWDPEpPVHUREVHUYDGRVHPHVIUHJDoRVGHVDQJXHGRVDQLPDLV
VHQWDUHTXLQyFLWRV3RUpPQmRVHFRQKHFHRVHXPHFDQLVPRGHIRUPDomR saudáveis.
Envenenamento por serpentes: Envenenamentos por serpentes como cascavel e coral podem
SURYRFDUIRUPDomRGHHTXLQyFLWRVGHQWURGHKRUDVDSyVDSLFDGD Corpúsculo de Lentz ou inclusões de Lentz ou inclusões da Cinomose ²&RUUHVSRQGHDRHIHLWRFLWRSiWL-
2XWURV $ SUHVHQoD GH HTXLQyFLWRV QR VDQJXH WDPEpP SRGH VHU SURYRFDGD SRU TXHLPDGXUDV FRGRYtUXVGDFLQRPRVHVREUHDVFpOXODVVDQJXtQHDVJHUDQGRXPDLQFOXVmRHRVLQRItOLFDTXHSRGHVHU
JUDYHVHPFDYDORVHSRUSLFDGDVGHDEHOKDV REVHUYDGDQRFLWRSODVPDGHKHPiFLDVHOHXFyFLWRV$SUHVHQoDGHVVHFRUS~VFXORpSDWRJQRP{QLFDSDUD
FLQRPRVHHVXDREVHUYDomRpPDLVIUHTXHQWHQDIDVHDJXGDGDGRHQoDGHYLGRDRIHQ{PHQRGDYLUHPLD
eLPSRUWDQWHUHVVDOWDUTXHDSUHVHQoDGHHTXLQyFLWRVQRVDQJXHpIUHTXHQWHPHQWHYLVWDFRPRDUWHIDWRV $QmRYLVXDOL]DomRQmRSRGHVHUXVDGDSDUDGHVFDUWDUDVXVSHLWDGDGRHQoD )LJXUDE²- 
GHVDQJXH´YHOKRµRXDUPD]HQDGRRXVHMDVmRFRQVLGHUDGRVGHSRXFDUHOHYkQFLDSDWROyJLFDQDPDLRULD
dos casos. Rouleaux eritrocitário ou hemácias em rouleaux1RVHVIUHJDoRVVDQJXtQHRVQDiUHDDSURSULDGDSDUD
OHLWXUD DV FpOXODV VH GLVWULEXHP HP PRQRFDPDGDV $V KHPiFLDV DSUHVHQWDP FDUJD HOpWULFD QHJDWLYD
Acantócitos²2VDFDQWyFLWRVVmRFpOXODVFRPSURWXEHUkQFLDVP~OWLSODVGHIRUPDLUUHJXODUHFRPDSDUrQ-
GHWHUPLQDGDSULQFLSDOPHQWHSHORiFLGRVLiOLFRFRQWLGRHPDOJXPDVJOLFRSURWHtQDVGHPHPEUDQD'HVVD
FLDGHGHGRV(ODVVHIRUPDPQRVDQJXHGHYLGRDOWHUDo}HVUHODFLRQDGDVDRFROHVWHUROHIRVIROLStGHRVQDV
IRUPDDVKHPiFLDVVRIUHPXPIHQ{PHQRGHUHSXOVmRGHQRPLQDGRSRWHQFLDO]HWDID]HQGRFRPTXHHV-
PHPEUDQDVGRVHULWUyFLWRV6mRREVHUYDGRVHPDQLPDLVFRPHQIHUPLGDGHVKHSiWLFDVHKHPDQJLRVDUFR-
VDVFpOXODVDSDUHoDPVHSDUDGDVXPDGDVRXWUDV(PDOJXPDVVLWXDo}HVFRPRH[HPSORHPSURFHVVRV
PD3RGHPVHUREVHUYDGRVWDPEpPDVVRFLDGRVFRPDQRUPDOLGDGHVOLStGLFDVLQGX]LGDVSRUGLVIXQo}HV
LQÁDPDWyULRVHLQIHFFLRVRVRDXPHQWRGDVSURWHtQDVSODVPiWLFDVID]FRPTXHHVVHSRWHQFLDO]HWDVHMD
UHQDLV )LJXUD²'HD²$ 
perdido e as hemácias se distribuam uma sobre as outras, sendo esse achado denominado Rouleaux
HULWURFLWiULR )LJXUD²,HD²' 
2VDFDQWyFLWRVVmRPDLVREVHUYDGRVHPFmHVHJDWRVPDVSRGHPVHUYLVWRVWDPEpPHPRXWUDVHV-
SpFLHVFRPPHQRUUHOHYkQFLDGLDJQyVWLFD (PHTXLQRVDIRUPDomRGHURXOHDX[HULWURFLWiULRpÀVLROyJLFDHQmRWHPUHODomRFRPDXPHQWRQDFRQFHQ-
tração de proteínas plasmáticas. As hemácias de búfalos e felinos também apresentam uma tendência
Córpusculo de Heinz²5HIHUHVHjR[LGDomRGDKHPRJORELQDFDXVDGDSRUDJHQWHVR[LGDQWHV DOJXQV de formação de rouleaux.
DOLPHQWRVPHGLFDPHQWRVFRPSRVWRVTXtPLFRVHWF (PUHODomRjKHPRJORELQDRVJDWRVVmRPDLVVXV-
FHWtYHLVDOHV}HVR[LGDWLYDVSRLVDKHPRJORELQDIHOLQDFRQWHPRLWRJUXSRVVXOItGULFRVR[LGiYHLVHSRUHVVH 3RQWHDGREDVyÀORRXSRQWLOKDGREDVyÀOR²5HIHUHVHjSUHVHQoDGHSHTXHQDVLQFOXV}HVEDVRItOLFDV
PRWLYR&RUS~VFXORVGH+HLQ]SRGHPVHUYLVWRVHPKHPiFLDVGHJDWRVVDXGiYHLV*DWRVTXHFRQVRPHP FRQWHQGR51$ DJUHJDGRVGHULERVVRPRV GLVSHUVDVSHORFLWRSODVPDGDKHPiFLD6mRREVHUYDGRVHP
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DPHPEUDQDGDVKHPiFLDVFRUDGRVFRP:ULJKWVmRPDLVIiFHLVGHYLVXDOL]DU6mRPHOKRUHVREVHUYDGRV )LJXUD²- 

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
30 31
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Aglutinação de hemácias²eDSUHVHQoDGHDJUHJDGRVGHKHPiFLDV JUXPRVHULWURFLWiULRV GHYLGRD F. 'DFULyFLWRV +HPiFLDV HP IRUPD GH OiJULPD RX SHUD G. +HPiFLDV IDOFLIRUPHV RX 'UHSDQyFLWRV
SUHVHQoDGHSRQWHVGHDQWLFRUSRVeXPDFKDGRVXJHVWLYRGHDQHPLDKHPROtWLFDLPXQRPHGLDGDHRFRUUH +HPiFLDVHPIRUPDGHIRLFHRXPHLDOXDH.(VTXLVWyFLWRVRXHVTXL]yFLWRV)UDJPHQWRVGHHULWUyFLWRV
WDPEpPHPWUDQVIXV}HVFRPVDQJXHLQFRPSDWtYHLV3RGHPVHUREVHUYDGRVHPOkPLQDVGHHVIUHJDoR por deterioração mecânica. I. Rouleaux eritrocitário ou hemácias em rouleaux. J. Ponteado basofílico.
VDQJXtQHR PLFURVFySLR RXDROKRQ~GHQWURGRWXERGHFROHWDFRP('7$QRTXDOSRGHVHIRUPDUGHYLGR 3UHVHQoDGHSHTXHQDVLQFOXV}HVEDVRItOLFDVFRQWHQGR51$ DJUHJDGRVGHULERVVRPRV GLVSHUVDSHOR
RWHPSRGHFROHWDGRVDQJXH GHPRUDSDUDFROKHURPDWHULDO RXKRPRJHQHL]DomRLQDGHTXDGD )LJXUD FLWRSODVPD . &RUS~VFXOR GH +HLQ] 2[LGDomR GD KHPRJORELQD FDXVDGDV SRU DJHQWHV R[LGDQWHV L.
D²( &RUS~VFXORGH+RZHOO-ROO\5HVWRVGHIUDJPHQWRVQXFOHDUHV

CURIOSIDADE

Deseritropoiese: Termo técnico utilizado para denominar uma desordem na


produção ou maturação das hemácias, fazendo com que ocorra a produção de
KHPiFLDV FRP DOWHUDo}HV PRUIROyJLFDV 2FRUUH SULQFLSDOPHQWH HP DOJXPDV
DQHPLDVKHPROtWLFDVFRQJrQLWDV

Síndrome mielodisplásica: &RPS}HP XP JUXSR GH GRHQoDV KHPDWROyJLFDV


RULJLQDGDV QD PHGXOD yVVHD D SDUWLU GH XPD PXWDomR GDV FpOXODV SURJHQLWRUDV
VWHPFHOO TXHUHVXOWDHPKHPDWRSRLHVHLQHÀFD]GLVSODVLDGHXPRXPDLVWLSRV
FHOXODUHV KHPiFLDVOHXFyFLWRVHSODTXHWDV 1RVDQJXHSHULIpULFRSRGHPDSDUHFHU
FpOXODVFRPDOWHUDo}HVPDUFDQWHV$VDQHPLDVGHVHULWURSRpWLFDVVmRH[HPSORVGH
síndrome mielodisplásica

Figura 7a. $OWHUDo}HVPRUIROyJLFDVGRVHULWUyFLWRV&RORUDomRSDQyWLFRUiSLGRA.$FDQWyFLWRVH(TXLQyFL-


WRV HP HVIUHJDoR VDQJXtQHR GH FmR 6mR REVHUYDGRV QD LPDJHP RV DFDQWyFLWRV ÁHFKDV EUDQFDV  H
HTXLQyFLWRV VHWDVSUHWDV DSUHVHQWDQGRPDLVSURMHo}HVGHPHPEUDQDV REMHWLYDGH[ B. Células
HPDOYRHPHVIUHJDoRVDQJXtQHRGHFmR REMHWLYDGH[ C.(VIHUyFLWRV KHPiFLDVHPIRUPDWRGHHV-
IHUD HPHVIUHJDoRVDQJXtQHRGHFmR REMHWLYDGH[ D. Presença de rouleaux (hemácias empilhadas)
HPVDQJXHGHFmR REMHWLYDGH[ E.3RQWRVGHDJOXWLQDomRREVHUYDGRVHPHVIUHJDoRVDQJXtQHRGH
cão, F.3UHVHQoDGHSROLFUyPDWyÀOR KHPiFLDVMRYHQV VXJHULQGRXPDDQHPLDUHJHQHUDWLYDYLVXDOL]DGDV
HPHVIUHJDoRVDQJXtQHR REMHWLYDGH[ 
Figura 6 7HUPRV WpFQLFRV UHODFLRQDGRV j PRUIRORJLD GDV KHPiFLDV A. /HSWyFLWRV RX FpOXODVDOYR
B. (VIHUyFLWRV C. (OLSWyFLWRV RX RYDOyFLWRV D. $FDQWyFLWRV E. (TXLQyFLWRV RX KHPiFLDV FUHQDGDV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
32 33
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

04 ANEMIAS

$SDODYUDDQHPLDGHULYDGRJUHJR DQDXVrQFLDKDHPLDVDQJXH VHQGRSRUWDQWR´DXVrQFLDGHVDQJXHµ


(QWUHWDQWRDXVrQFLDGHVDQJXHpLQFRPSDWtYHOFRPDYLGDVHQGRHVVHWHUPRHPSUHJDGRHUURQHDPHQWH
VHIRULQWHUSUHWDGRDRSpGDOHWUD'HVVDIRUPDQD0HGLFLQD9HWHULQiULDHQD0HGLFLQD+XPDQDDDQHPLD
UHÁHWHXPDUHGXomRQD&RQWDJHP*OREDOGH+HPiFLDV &*+ QR+HPDWyFULWR +W HQDFRQFHQWUDomRGH
+HPRJORELQD +E (VVDVDOWHUDo}HVVmRYLVWDVQRHULWURJUDPDTXHpDSDUWHGRKHPRJUDPDTXHDYDOLD
a série vermelha.

IMPORTANTE SABER
Figura 7b. G.5HWLFXOyFLWRVHPHVIUHJDoRGHVDQJXHFDQLQRUHSUHVHQWDGRVSHODVVHWDV5HWLFXOyFLWRV
VmRKHPiFLDVMRYHQVTXHVXJHUHXPDDQHPLDUHJHQHUDWLYDYLVXDOL]DGDVHPHVIUHJDoRVDQJXtQHR RE- Tipos de Icterícia:
jetiva de 100x) coradas com corante supravital (Azul de Cresil Brilhante), H. +HPiFLDVFRPKLSRFURPLD
HPHVIUHJDoRVDQJXtQHRGHFmR REMHWLYDGH[ I. $QLVRFLWRVHOHYHHPHVIUHJDoRVDQJXtQHRERYLQR Hemograma: ([DPH ODERUDWRULDO TXH WHP SRU ÀQDOLGDGH DQDOLVDU DV FpOXODV
REMHWLYDGH[ 9LVXDOL]DomRGHFpOXODVGHGLIHUHQWHVWDPDQKRVVHQGRXPDFKDGRVXJHVWLYRGHDQH- VDQJXtQHDV KHPiFLDV OHXFyFLWRV H SODTXHWDV  (VVH H[DPH LQFOXL GDGRV
PLDUHJHQHUDWLYDJ.&RUS~VFXORGH/HQW]HPHVIUHJDoRVDQJXtQHRGHFmR REMHWLYDGH[ LGHQWLÀFDGR TXDQWLWDWLYRVHTXDOLWDWLYRVHpGLYLGLGRHPWUrVSDUWHVHULWURJUDPDOHXFRJUDPDH
SHODVHWD7DPEpPFKDPDGRGHLQFOXV}HVGH/HQW]RXLQFOXV}HVGHFLQRPRVH3RGHVHUREVHUYDGRHP SODTXHWRJUDPD
FLWRSODVPDGHKHPiFLDVHOHXFyFLWRVeSDWRJQRP{QLFDSDUDDFLQRPRVH
Eritrograma: 3DUWH GR KHPRJUDPD XWLOL]DGD SDUD DYDOLDU D VpULH YHUPHOKD RX
VHMDDVKHPiFLDV2HULWURJUDPDpFRPSRVWRSHODFRQWDJHPJOREDOGHKHPiFLDV
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KHPDWLPpWULFRV 9*0&+*0+*0H5': 

Contagem Global de Hemácias (CGH): Exame que determina a quantidade de


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PDQXDLV FRQWDJHPHPKHPRFLW{PHWUR RXHPHTXLSDPHQWRVDXWRPDWL]DGRV

Hematócrito (Ht): ([DPH TXH ID] SDUWH GR HULWURJUDPD H SHUPLWH GHWHUPLQDU R
SHUFHQWXDORFXSDGRSHODVKHPiFLDVGHQWURGRVDQJXH'HWHUPLQDGRSHODVWpFQLFDV
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KHPRJORELQD HP XP YROXPH GH VDQJXH 'HWHUPLQDGR SHOR PpWRGR GD
FLDQRPHWDKHPRJORELQD

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
34 35
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

$DQHPLDSRGHVHUFODVVLÀFDGDFRPRYHUGDGHLUD DEVROXWD RXIDOVD UHODWLYD 1DDQHPLDIDOVD UHODWLYD  $OJXQVIDWRUHVGHYHPVHUOHYDGRVHPFRQVLGHUDomRGXUDQWHDDYDOLDomRGRKHPRJUDPDGRDQLPDOSRLV


ocorre uma hemodiluição, causada pelo aumento do volume plasmático, resultando em uma falsa H[LVWHPVLWXDo}HVHPTXHDVDOWHUDo}HVREVHUYDGDVQRHULWURJUDPDVmRÀVLROyJLFDV6mRH[HPSORVGH
UHGXomRQDFRQWDJHPJOREDOGHKHPiFLDV &*+ QRKHPDWyFULWR +W HQDFRQFHQWUDomRGHKHPRJORELQD YDULDo}HVÀVLROyJLFDVQRVSDUkPHWURVHULWURFLWiULRV
+E 3RGHRFRUUHUXPDIDOVDDQHPLDHPDQLPDLVJHVWDQWHVODFWDQWHVÀOKRWHVHHPFDVRVGHWHUDSLDV
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YHUPHOKDVUHVXOWDQGRHPDOWHUDo}HVGRHULWURJUDPDFDUDFWHUL]DGDVSRUGLPLQXLomRGD&*+GR+WHGD GDPDLRUDWLYLGDGHKHPDWRSRLpWLFDGDPHGXODyVVHD2VDQLPDLVMRYHQVSRGHPWHU9*0PDLV
+E HOHYDGRH&+*0PDLVEDL[RHPGHFRUUrQFLDGRPDLRUQ~PHURGHUHWLFXOyFLWRVREVHUYDGRVQR
VDQJXHSHULIpULFR
A anemia é, quase sempre, um distúrbio secundário relacionado a uma causa primária como, por exemplo, 6H[R²*HUDOPHQWHRVPDFKRVDSUHVHQWDPPDLRUHVtQGLFHVHULWURFLWiULRV &*++WH+E TXDQGR
QDDQHPLDIHUURSULYDTXHpRFDVLRQDGDSHODGHÀFLrQFLDGHIHUURFRPFRQVHTXHQWHGLPLQXLomRGDSURGXomR FRPSDUDGRV jV IrPHDV SRLV RV DQGUyJHQRV WHVWRVWHURQD  VmR HVWLPXODQWHV GD HULWURSRLHVH
GHKHPiFLDV2XWURH[HPSORGHDQHPLDpDFDXVDGDSRUSDUDVLWDVJDVWULQWHVWLQDLVKHPDWyIDJRVFRPRR HQTXDQWRRVHVWUyJHQRVVmRLQLELGRUHV$LQÁXrQFLDGRVH[RMiIRLREVHUYDGDSDUDSULPDWDVQmR
+DHPRQFKXVFRQWRUWXVHPUXPLQDQWHVHDLQIHFomRSRU$QFLORVWRPDHPFmHV$HVSROLDomRVHYHUDSRU KXPDQRVRQGHRVPDFKRVDSUHVHQWDUDPPDLRUHVYDORUHVSDUD&*++WH+E3DUDFDLWLWXVRYL-
HFWRSDUDVLWDV FDUUDSDWRVSXOJDVPRVFDGRFKLIUH SRGHUHGX]LUDTXDQWLGDGHGHKHPiFLDVR+WHD QRVHE~IDORVRVH[RQmRLQÁXHQFLRXRVYDORUHVGRHULWURJUDPD
FRQFHQWUDomRGH+EFDUDFWHUL]DQGRDQHPLD$OJXPDVGRHQoDVLQIHFFLRVDVWDPEpPSURYRFDPDQHPLD $OWLWXGH²(PORFDLVGHHOHYDGDDOWLWXGHDWHQVmRGHR[LJrQLRpPHQRUHSRGHUHVXOWDUHPXPD
como a panleucopenia felina, cinomose, leishmaniose, parvovirose, anemia infecciosa equina (AIE), VLWXDomR GH KLSy[LD $ KLSy[LD WHFLGXDO HVWLPXOD D VtQWHVH GH HULWURSRLHWLQD TXH YDL DWXDU QD
babesiose, anaplasmose, leptospirose, dentre outras. PHGXODyVVHDHVWLPXODQGRDHULWURSRLHVHUHVXOWDQGRHPDXPHQWRQD&*++WH+E
5DoD2VFDYDORVVDQJXtQHRV DSWLGmRSDUDFRUULGD DSUHVHQWDPPDLRUQ~PHURGHHULWUyFLWRVHP
$OpPGHVVDVFDXVDVDSHUGDGHVDQJXHSRUKHPRUUDJLDDJXGDRXFU{QLFDpFDXVDIUHTXHQWHGHTXDGURV relação aos cavalos linfáticos (usados para tração) devido à necessidade de maior demanda de
de anemia em animais domésticos e silvestres. A destruição das hemácias nos processos hemolíticos R[LJrQLRGXUDQWHDWLYLGDGHVDHUyELFDV$OJXPDVUDoDVGHFmHVGHFRUULGDWDPEpPDSUHVHQWDP
WDPEpP JHUD DQHPLD QRV DQLPDLV 'HVVD IRUPD R WUDWDPHQWR GDV DQHPLDV HQYROYH R GLDJQyVWLFR H PDLVHULWUyFLWRVHPUHODomRDRVRXWURVFmHV
resolução da causa primária que está provocando o quadro anêmico.  &mHVGDUDoDSRRGOHSULQFLSDOPHQWHRVWR\VDSUHVHQWDPKHPiFLDVPDFURFtWLFDVHQTXDQWRHP
2V VLQWRPDV H VLQDLV FOtQLFRV REVHUYDGRV QRV DQLPDLV DQrPLFRV VmR EHP DEUDQJHQWHV H SRGHP VHU $NLWDVDVKHPiFLDVVmRÀVLRORJLFDPHQWHPLFURFtWLFDV$SUHVHQoDGHPHWDUUXEUyFLWRV KHPiFLDV
FODVVLÀFDGRVHPFDXVDV nucleadas) é normalmente observada em cães das raças Daschund e Shinauzers.
([HUFtFLR²$SUDWLFDGHH[HUFtFLRDQWHVGDFROHWDGHVDQJXHSDUDUHDOL]DomRGRKHPRJUDPDSRGH
aumentar os índices eritrocitários. A contração esplênica, que pode ocorrer durante o exercício,
5HGXomRGDYROHPLD YROXPHVDQJXtQHR  OLEHUDSDUDRVDQJXHSHULIpULFRDVKHPiFLDVHSODTXHWDVTXHÀFDPHVWRFDGDVQREDoR'HVVD
Palidez das mucosas IRUPDpLPSRUWDQWHUHDOL]DUDFROHWDGHVDQJXHSDUDKHPRJUDPDHPDQLPDLVGHVFDQVDGRV
3DOLGH]GRVyUJmRVHWHFLGRV (VWDGRVÀVLROyJLFRV²1DJHVWDomRHQDODFWDomRSRGHRFRUUHUUHWHQomRGHOtTXLGRVUHVXOWDQGR
em hemodiluição que pode causar uma anemia relativa ou falsa.
+LSy[LD UHGXomRGRIRUQHFLPHQWRGH2SDUDRVyUJmRVHWHFLGRV
&LDQRVH²FRORUDomRDUUR[HDGDGDVPXFRVDVHH[WUHPLGDGHV (VVDV YDULDo}HV ÀVLROyJLFDV GHYHP VHU OHYDGDV HP FRQVLGHUDomR SDUD D FRUUHWD LQWHUSUHWDomR GR
Intolerância ao exercício / Apatia HULWURJUDPD([FOXtGDVHVVDVSRVVLELOLGDGHVHXPDYH]FRQVWDWDGDXPDDQHPLDYHUGDGHLUDpLPSRUWDQWH
'LVSQHLDSDUDFRPSHQVDUDPHQRUFRQFHQWUDomRGHR[LJrQLRGHFRUUHQWHGRPHQRUQ~PHURGH WHQWDUHOXFLGDUVXDSURYiYHOFDXVD6mRFDXVDVGHDQHPLDVKHPRUUDJLDV DJXGDVHFU{QLFDV GRHQoDV
KHPiFLDVTXHDWUDYpVGDKHPRJORELQDVmRDVFpOXODVUHVSRQViYHLVSHODR[LJHQDomRGRVWHFL- KHPROtWLFDVGRHQoDVLQIHFFLRVDVGRHQoDVPHWDEyOLFDVQHRSODVLDVFDUrQFLDGHQXWULHQWHVHVVHQFLDLV
dos. SDUDSURGXomRGHKHPiFLDVDGPLQLVWUDomRGHPHGLFDPHQWRVPLHORWy[LFRV
'LVIXQomRGHyUJmRVHWHFLGRV5HGXomRGHIRUQHFLPHQWRGHR[LJrQLRSDUDWHFLGRVLPSRUWDQWHV
FRPR WHFLGR QHUYRVR +LSy[LD KHSiWLFD WDPEpP SRGH FDXVDU OHV}HV FRP H[WUDYDVDPHQWR GH
enzimas.
0HFDQLVPRVGHFRPSHQVDomRGRRUJDQLVPR
Aceleração do pulso, taquicardia. Pelo menor número de hemácias, a velocidade da circulação
DXPHQWDSDUDFRPSHQVDUDIDOWDGH2HQXWULHQWHVSDUDRVyUJmRV
'LVSQHLDWDPEpPSRGHVHULQFOXtGDFRPRXPPHFDQLVPRFRPSHQVDWyULRGRRUJDQLVPRIUHQWH
DXPDVLWXDomRGHDQHPLDSRLVHVWiKDYHQGRXPGpÀFLWQDR[LJHQDomRGRVWHFLGRVTXHSDUD
FRPSHQVDUDXPHQWDDWD[DUHVSLUDWyULD
(VVHVVLQDLVSRVVLELOLWDPRGLDJQyVWLFRFOtQLFRGHDQLPDLVDQrPLFRV(QWUHWDQWRRGLDJQyVWLFRODERUDWRULDO
pRPDLVLPSRUWDQWHHVHJXURSDUDFRQÀUPDUDVDQHPLDV3DUDRGLDJQyVWLFRODERUDWRULDOpXWLOL]DGRR
KHPRJUDPDFRPSOHWRRQGHpDYDOLDGRRHULWURJUDPD

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
36 37
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

GH FpOXODV LPDWXUDV QR VDQJXH SHULIpULFR UHWLFXOyFLWRVSROLFURPDWyÀORV PHWDUUXEUyFLWRV  6mR VLQDLV
GH DQHPLDV UHJHQHUDWLYDV D REVHUYDomR GH DQLVRFLWRVH PDFURFLWRVH UHWLFXORFLWRVH SROLFURPDWRÀOLD
SUHVHQoD GH SRQWLOKDGR EDVyÀOR FRUS~VFXORV GH +RZHOO-ROO\ H PHWDUUXEUyFLWRV 1D YHWHULQiULD DV
HVSpFLHVGLIHUHPQDVXDUHVSRVWDUHJHQHUDWLYDHHVWDVGLIHUHQoDVGHYHPVHUOHYDGDVHPFRQVLGHUDomR
SDUDGHWHUPLQDUVHXPDDQHPLDpUHJHQHUDWLYDRXQmR
(PFmHVJDWRVHVXtQRVVmRVLQDLVGHDQHPLDVUHJHQHUDWLYDVDREVHUYDomRGHDQLVRFLWRVHUHWLFXORFLWRVH
SROLFURPDWRÀOLDSUHVHQoDGHFRUS~VFXORVGH+RZHOO-ROO\HPHWDUUXEUyFLWRV1HVVDVHVSpFLHVDPHGXOD
yVVHD DWLYD OLEHUD PXLWDV FpOXODV LPDWXUDV SULQFLSDOPHQWH UHWLFXOyFLWRVSROLFURPDWyÀORV QR VDQJXH
SHULIpULFR'HVVDIRUPDDFRQWDJHPGHUHWLFXOyFLWRVp~WLOSDUDHVWDEHOHFHUVHDUHVSRVWDpUHJHQHUDWLYD
RXQmR$HOHYDGDTXDQWLGDGHGHFRUS~VFXORVGH+RZHOO-ROO\SRGHGHQRWDUDRFRUUrQFLDGHKHPDWRSRLHVH
H[WUDPHGXODUSRLVyUJmRVFRPRItJDGRHEDoRSRUQmRVHUHPRVWHFLGRVHVSHFLDOL]DGRVQDKHPDWRSRLHVH
OLEHUDPKHPiFLDVDLQGDFRPIUDJPHQWRVGHQ~FOHRV
(PHTXLQRVDPHGXODyVVHDQRUPDOPHQWHQmROLEHUDUHWLFXOyFLWRVQRVDQJXHSHULIpULFR$VVLPQHVVD
HVSpFLHUHWLFXORFLWRVHSROLFURPDWRÀOLDQmRVmRREVHUYDGRVFRPRUHVSRVWDUHJHQHUDWLYD(PFDVRVPXLWR
UDURVGHSHUGDGHVDQJXHDJXGDRXDQHPLDKHPROtWLFDDOJXQVSRXFRVSROLFURPDWyÀORVHPHWDUUXEUyFLWRV
SRGHP VHU HQFRQWUDGRV QR VDQJXH $ PHGXOD yVVHD HTXLQD WDPEpP SRGH OLEHUDU PDFUyFLWRV
QRUPRFU{PLFRV0DFUyFLWRVVmRRVJOyEXORVYHUPHOKRVMRYHQV PDLRUHVGRTXHDVKHPiFLDVPDGXUDV TXH
VHFRUDPFRPRFpOXODVPDGXUDV QRUPRFU{PLFRV (VWHVJHUDOPHQWHpR~QLFRVLQDOGHUHJHQHUDomRHP
FDYDORVDQrPLFRVHTXDQGRPXLWRQXPHURVRVSRGHPDXPHQWDUR5':H9*0+HPRJUDPDVVHULDGRVH
Figura 8 +HPRSDUDVLWDV DXPHQWR FRP REMHWLYD GH [  FRUDQWH 3DQyWLFR UiSLGR A e B. Babesia RH[DPHGDPHGXODyVVHDSRGHPVHUXWLOL]DGRVSDUDDYDOLDURJUDXGHUHJHQHUDomRHULWUyLGHHGHWHUPLQDU
VSSSDUDVLWDQGRKHPiFLDVYLVXDOL]DGDVHPHVIUHJDoRVDQJXtQHRGHXPFmRLGHQWLÀFDGDVSHODVVHWDV VHDDQHPLDpRXQmRUHJHQHUDWLYD(QWUHWDQWRRPLHORJUDPDSRUVHUXPH[DPHLQYDVLYRQmRpXWLOL]DGR
C. 3UHVHQoDGH'LURÀODULDLPPLWLVHPHVIUHJDoRGHVDQJXHGHXPFmRD.3UHVHQoDGH'LURÀODULDVSSHP QDURWLQDGHDYDOLDomRGDUHVSRVWDHULWUyGHUHJHQHUDWLYD
HVIUHJDoRVDQJXtQHRGHSULPDWDV (PUXPLQDQWHVRVUHWLFXOyFLWRVSROLFURPDWyÀORVWDPEpPQmRVmRREVHUYDGRVQRVDQJXHSHULIpULFRGH
DQLPDLVVDXGiYHLV1HVVDVHVSpFLHVHPDQLPDLVFRPVHYHUDVDQHPLDKHPRUUiJLFDVRXKHPROLWLFDVD
3DUDWHQWDUHVFODUHFHURPHFDQLVPRFDXVDGRUGRTXDGURDQrPLFRpIXQGDPHQWDOFRQKHFHUDVFODVVLÀFDo}HV UHVSRVWDUHWLFXORFLWiULDpSHTXHQD6HQGRDVVLPDTXDQWLÀFDomRGHUHWLFXOyFLWRVQmRIRUQHFHLQIRUPDo}HV
GDVDQHPLDV$FODVVLÀFDomRSRGHVHUIHLWDFRPEDVHQRJUDXGHUHJHQHUDomRPHGXODU UHJHQHUDWLYDRX DGLFLRQDLVSDUDDYDOLDUVHDDQHPLDpUHJHQHUDWLYDRXQmR1DVDQHPLDVUHJHQHUDWLYDVSRGHPVHUYLVWRV
QmRUHJHQHUDWLYD QDDYDOLDomRPRUIROyJLFD 9*0H&+*0 HQRPHFDQLVPRSDWRÀVLROyJLFR SROLFURPDVLDPDFUyFLWRVSRQWLOKDGREDVyÀORHFRUS~VFXORVGH+RZHOO-ROO\

&ODVVLÀFDomRFRPEDVHQRJUDXGHUHJHQHUDomRPHGXODU &ODVVLÀFDomRPRUIROyJLFDGDVDQHPLDV

$V DQHPLDV SRGHP VHU FODVVLÀFDGDV GH DFRUGR FRP D UHVSRVWD GD PHGXOD yVVHD HP GRLV WLSRV $DYDOLDomRPRUIROyJLFDGDVDQHPLDVpUHDOL]DGDDWUDYpVGDLQWHUSUHWDomRGRVUHVXOWDGRVGRVtQGLFHV
UHJHQHUDWLYDVHDUUHJHQHUDWLYDV$YDOLDomRGDUHVSRVWDPHGXODUpXPSDVVRLQLFLDOQDFDUDFWHUL]DomRGH KHPDWLPpWULFRV 9*0 H &+*0  H[SUHVVRV QR KHPRJUDPD $V KHPiFLDV QRUPDLV VmR UHIHULGDV FRPR
uma anemia. QRUPRFtWLFDVHQRUPRFU{PLFDVRXVHMDR9*0HR&+*0HVWmRGHQWURGRVLQWHUYDORVGHUHIHUrQFLDSDUD
1DV DQHPLDV UHJHQHUDWLYDV D SURGXomR GH KHPiFLDV QD PHGXOD yVVHD PDQWHPVH QRUPDO RX SRGH HVSpFLH&RPEDVHQDLQWHUSUHWDomRGHVVHVtQGLFHVDVKHPiFLDVSRGHPVHUFODVVLÀFDGDVHP
HVWDUDXPHQWDGDSDUDWHQWDUUHVWDEHOHFHUDUHGXomRGHVVDVFpOXODVQRVDQJXHSHULIpULFR$VDQHPLDV Macrocíticas: VGM acima do intervalo de referência.
UHJHQHUDWLYDVVmRFDXVDGDVSRUKHPRUUDJLDVRXKHPyOLVH1HVVDVVLWXDo}HVDUHGXomRQDTXDQWLGDGH Microcíticas: VGM abaixo do intervalo de referência.
GH KHPiFLDV QR VDQJXH HVWLPXOD D SURGXomR GH HULWURSRLHWLQD (32  TXH YDL DWXDU QD PHGXOD yVVHD +LSRFU{PLFDV&+*0DEDL[RGRLQWHUYDORGHUHIHUrQFLD
favorecendo a proliferação e diferenciação das células precursoras. +LSHUFU{PLFDV&+*0DFLPDGRLQWHUYDORGHUHIHUrQFLD1mRH[LVWHKLSHUFURPLDYHUGDGHLUDSRLV
1DVDQHPLDVDUUHJHQHUDWLYDVDPHGXODyVVHDQmRFRQVHJXHPDQWHURXDXPHQWDUSURGXomRGHKHPiFLDV KiXPJUDXGHVDWXUDomRGDKHPRJORELQDGHQWURGDFpOXOD6HRFRUUHUJHUDOPHQWHpGHYLGRD
HPFRQVHTXHQFLDGHOHV}HVQDPHGXODyVVHDRXFDUrQFLDGHVXEVWUDWRVQHFHVViULRVjHULWURSRLHVH (32 XPHUURDQDOtWLFRRXRFRUUrQFLDGHKHPyOLVHHOLSHPLD$SUHVHQoDGHHVIHUyFLWRVRXGHKHPi-
IHUURYLWDPLQDVGRFRPSOH[R%KRUP{QLRVGHQWUHRXWURV  FLDVFRPFRUS~VFXORGHKHLQ]WDPEpPSRGHDFDUUHWDUHPIDOVRDXPHQWRGR&+*0

1R HULWURJUDPD DSDUHFHP LQIRUPDo}HV LPSRUWDQWHV SDUD GLIHUHQFLDU HVVHV GRLV WLSRV GH DQHPLDV $ $V DOWHUDo}HV REVHUYDGDV QRV tQGLFHV KHPDWLPpWULFRV SRGHP DMXGDU QD LQWHUSUHWDomR GR SURYiYHO
DYDOLDomR GD FDSDFLGDGH GH UHJHQHUDomR HULWUyLGH p IHLWD JHUDOPHQWH SHOD REVHUYDomR GD SUHVHQoD PHFDQLVPRFDXVDGRUGDVDQHPLDV(VWDFODVVLÀFDomRpXPDH[FHOHQWHDERUGDJHPLQLFLDOHPXPSDFLHQWH

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
38 39
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

DQrPLFR H SRGH OHYDU UDSLGDPHQWH jV LQYHVWLJDo}HV DGHTXDGDV SDUD GHWHUPLQDU D FDXVD GD DQHPLD
Tabela 2 &ODVVLÀFDomRPRUIROyJLFDGDVDQHPLDVHLQWHUSUHWDomRFOtQLFD
(Tabela 2).
As anemias Normocíticas/Normocrômicas indicam falta de resposta medular. Nessas anemias VGM CHGM Interpretação clínica
REVHUYDVHSRXFDRXQHQKXPDUHVSRVWDGDPHGXODyVVHD DUUHJHQHUDWLYDV (VVHWLSRGHDQHPLDRFRUUH
HP GRHQoDV FU{QLFDV FRPR DV GRHQoDV UHQDLV GLPLQXLomR QD VtQWHVH GH (32  GRHQoDV HQGyFULQDV Normocítica 1RUPRFU{PLFD 1mRUHJHQHUDWLYDVDQHPLDVGDVGRHQoDVFURQLFDV
KLSRWLUHRLGLVPR²DWLUR[LQDHVWLPXODDHULWRSRLHVHKLSRDGUHQRFRUWLFLVPR²RVKRUP{QLRVGDVDGUHQDLV Normocítica +LSRFU{PLFD ,QtFLRGDGHÀFLrQFLDGHIHUUR
também estimulam a eritropoiese), doenças hepáticas, doenças infecciosas que promovem depressão
Macrocítica +LSRFU{PLFD $QHPLDVUHJHQHUDWLYDVKHPRUUDJLDHKHPyOLVH
GD PHGXOD yVVHD OHLVKPDQLRVH HUOLFKLRVH SDUYRYLURVH FLQRPRVH DQHPLD LQIHFFLRVD HTXLQD HWF 
QHRSODVLDV PHWiVWDVHQDPHGXODyVVHD HHPFDVRVGHFDUrQFLDGHQXWULHQWHVQHFHVViULRVjSURGXomR Macrocítica 1RUPRFU{PLFD 'HÀFLrQFLD GH YLWDPLQD % IRODWRV FREDOWR HP
de hemácias (anemias carenciais). ruminantes, Mielose eritrêmica, Macrocitose em
poodles
As anemias Macrocíticas/Hipocrômicas VmR VXJHVWLYDV GH DXPHQWR QD DWLYLGDGH HULWURSRpWLFD QD
PHGXODyVVHD DQHPLDVUHJHQHUDWLYDV HGHQRWDPHPFmHVJDWRVHVXtQRVDXPHQWRQDOLEHUDomRGH Microcítica 1RUPRFU{PLFD 'HÀFLrQFLDGHIHUUR&mHVGDUDoDDNLWD
UHWLFXOyFLWRVSDUDRVDQJXHSHULIpULFR2VUHWLFXOyFLWRVFRQWULEXHPSDUDRDXPHQWRGR9*0 VmRFpOXODV Microcítica +LSRF{PLFD 'HÀFLrQFLDGHIHUURFREDOWRHYLWDPLQD%3HUGD
PDLRUHV HUHGXomRGR&+*0SRLVDSUHVHQWDUDPDSUR[LPDGDPHQWHDPHQRVGHKHPRJORELQDTXH GHVDQJXHFU{QLFD
RHULWUyFLWRPDGXUR$VDQHPLDVKHPRUUiJLFDVHKHPROtWLFDVVmRWLSLFDPHQWHUHJHQHUDWLYDV
As anemias Microcíticas/Hipocrômicas HVWmR UHODFLRQDGDV j GHÀFLrQFLD GH )H IHUUR  H 9LWDPLQD %
SLULGR[LQD 1DGHÀFLrQFLDGHIHUURRFRUUHDOWHUDomRQDVtQWHVHGHKHPRJORELQDDSDUHFHQGRKHPiFLDV &ODVVLÀFDomRGDVDQHPLDVFRPEDVHQRPHFDQLVPRSDWRÀVLROyJLFR
KLSRFU{PLFDVQDFLUFXODomR3RUpPDSHVDUGHRFRUUHUUHGXomRQDVtQWHVHGHKHPRJORELQDQmRRFRUUH
redução na síntese de DNA, ocorrendo as mitoses e produzindo a liberação de hemácias menores na a) Anemias hemorrágicas
FLUFXODomRFDXVDQGRPLFURFLWRVH(VVHWLSRGHDQHPLDpFDUDFWHUtVWLFRGDVSHUGDVGHVDQJXHFU{QLFDFRPR
SRUH[HPSORHPFDVRVGH~OFHUDVJiVWULFDVTXHSURPRYHPSHUGDGHVDQJXHSHORWUDWRJDVWULQWHVWLQDO 6mRFRPXQVHPDQLPDLV(ODVRFRUUHPGHYLGRjSHUGDGHVDQJXHGHIRUPDDJXGDRXFU{QLFDSRGHQGR
QHRSODVLDVGHVRUGHQVGDFRDJXODomRLQIHVWDomRSRUHQGRHHFWRSDUDVLWDVTXHFRQWULEXHPSDUDDSHUGD VHUH[WHUQDRXLQWHUQD3RGHPRFRUUHUGHYLGRDWUDXPDVSHUGDH[FHVVLYDGHVDQJXHHPSURFHGLPHQWRV
de ferro. FLU~UJLFRVGHIHLWRVKHPRVWiWLFRVLQWR[LFDomRSRUDQWLFRDJXODQWHVGRHQoDVKHSiWLFDV UHGXomRGRVID-
WRUHVGHFRDJXODomR OHV}HVJDVWURLQWHVWLQDLVHQHRSODVLDVFRPVDQJUDPHQWRFDYLWiULR
$V DQHPLDV FODVVLÀFDGDV FRPR Macrocíticas/Normocrômicas HVWmR UHODFLRQDGDV FRP GHÀFLrQFLD
GH 9LWDPLQD % H ÉFLGR )yOLFR TXH VmR HVWLPXODGRUHV GDV GLYLV}HV FHOXODUHV GXUDQWH R SURFHVVR GH $DQHPLDKHPRUUiJLFDRFRUUHWDPEpPHPFRQVHTXrQFLDGHGRHQoDVSDUDVLWiULDVDH[HPSORGDSHGLFX-
HULWURSRLHVH&RPDGHÀFLrQFLDGHVVDVYLWDPLQDVQmRKiVtQWHVHQRUPDOGH'1$RFRUUHQGRDOWHUDo}HV ORVHERYLQDLQIHVWDo}HVJUDYHVSRUSXOJDVHFDUUDSDWRVHPÀOKRWHVGHFmHVHJDWRVLQIHFomRSRUDQFLORV-
QDV GLYLV}HV FHOXODUHV H GHIHLWRV QD PDWXUDomR GDV FpOXODV 'HVVD IRUPD VmR OLEHUDGDV QR VDQJXH WRPtGHRVHPÀOKRWHVGHFmHVHKHPRQFRVHHPSHTXHQRVUXPLQDQWHV
SHULIpULFRFpOXODVPDLRUHV PDFUyFLWRV DXPHQWDQGRR9*0$SURGXomRGHKHPRJORELQDpQRUPDOSRU
LVVRDDQHPLDpQRUPRFU{PLFD6mRFDXVDVGHVVHWLSRGHDQHPLDGRHQoDVPLHORSUROLIHUDWLYDVGRHQoDV 1RV DQLPDLV PDLV YHOKRV SRGHP RFRUUHU KHPRUUDJLDV FU{QLFDV GHYLGR D QHRSODVLDV JUDVWURLQWHVWLQDLV
KHSiWLFDVXVRGHGURJDVLQLELGRUDVGHiFLGRIyOLFRGLVW~UELRVQXWULFLRQDLVDQHPLDPHJDOREOiVWLFDSRU FDXVDQGRGHÀFLrQFLDGHIHUURRXWDPEpPDSUHVHQoDGHWURPERFLWRSHQLDFU{QLFDLPXQRPHGLDGD$VXV-
GHÀFLrQFLDGHYLWDPLQD%HiFLGRIyOLFR(PUXPLQDQWHVDGHÀFLrQFLDGH&REDOWR FRIDWRUSDUDVtQWHVH SHLWDGHWXPRUHVLQWHVWLQDLVFRPVDQJUDPHQWRGHYHVHUFRQVLGHUDGDHPUHVXOWDGRVGHKHPRJUDPDVXJ-
de Vitamina B12) pode causar esse tipo de anemia. HVWLYRGHGHÀFLrQFLDGHIHUUR KLSRFURPLDHPLFURFLWRVH 
As anemias Microcíticas/Normocrômicas VmR REVHUYDGRV QR LQtFLR GD GHÀFLrQFLD GH )H e QRUPDO e LPSRUWDQWH UHVVDOWDU TXH RFRUUH XPD DQHPLD DVVRFLDGD j KLSRSURWHLQHPLD HP FDVR GH KHPRUUDJLD
REVHUYDUPLFURFLWRVHHQRUPRFURPLDHPFmHVGDUDoD$NLWD TXHRFRUUHXQDVDKRUDVSUHFHGHQWHV2XVRGHVRURLQMHWiYHOSDUDDXPHQWDURYROXPHVDQJXtQHR
1DWDEHODHVWmRUHVXPLGRVRVWLSRVHDLQWHUSUHWDomRGDVDQHPLDVFRPEDVHQDFODVVLÀFDomRPRUIROyJLFD HHVWDELOL]DUDSUHVVmRVDQJXtQHDID]FRPTXHRFRUUDXPDGLOXLomRVDQJXtQHDUHVXOWDQGRHPDQHPLDH
hipoproteinemia.

$VDQHPLDVKHPRUUiJLFDVVmRGHFDUiWHUUHJHQHUDWLYRSRLVGHYLGRDSHUGDVDQJXtQHDRFRUUHVLWXDomR
GHKLSy[LDWHFLGXDOFRPFRQVHTXHQWHDXPHQWRQDVtQWHVHGH(32TXHYDLHVWLPXODUDPXOWLSOLFDomRH
GLIHUHQFLDomRGRVSUHFXUVRUHVHULWUyLGHV(QWUHWDQWRRVVLQDLVGHDQHPLDUHJHQHUDWLYDQRKHPRJUDPD
DQLVRFLWRVHSROLFURPDWRÀOLDPHWDUUXEUyFLWRVHWF VyVmRYLVWRVJHUDOPHQWHDSyVKRUDVGRLQtFLRGD
KHPRUUDJLD

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
40 41
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

$OJXQV PHGLFDPHQWRV SRGHP LQLELU R PHWDEROLVPR GRV HULWUyFLWRV RX GHVQDWXUDU H SUHFLSLWDU D
KHPRJORELQD$KHPyOLVHRFRUUHSRUGLVW~UELRQDWUDPDSURWHLFDFRPSOH[DGRHULWUyFLWRTXHHQYROYHD
SURGXomRGHHQHUJLDDSDUWLUGRPHWDEROLVPRGDJOLFRVH2XVHMDTXDLVTXHUDOWHUDo}HVQRVFRPSRQHQWHV
GDPHPEUDQDTXHSURPRYHPUHVLVWrQFLDHÁH[LELOLGDGHSRGHPSURYRFDUDKHPyOLVH
IMPORTANTE SABER
0HGLFDPHQWRV TXH FRQWrP R[LGDQWHV IRUWHV H[ DVSLULQD  H R SURSLOHQRJOLFRO DGLWLYR GH DOLPHQWRV
Intervalo de referência: FRPHUFLDLVSDUDDQLPDLV SRGHPLQGX]LUDGHVQDWXUDomRGDKHPRJORELQDIRUPDomRGHFRUS~VFXORGH
+HLQ] H GHFUpVFLPR QD PHLDYLGD GDV KHPiFLDV SURYRFDQGR DQHPLD KHPROtWLFD 3HQLFLOLQD H D VXOID
2JUDXGHDQHPLDGHVHUDYDOLDGRWDPEpPHPFRQMXQWRFRPDFRQFHQWUDomRGH trimetropim têm sido associadas à anemia hemolítica em cavalos.
proteínas plasmáticas. Quando a proteína plasmática está aumentada, o animal
pode estar desidratado e a anemia pode ser mais severa do que os índices $LQJHVWmRRXFRQWDWRFRPDOJXPDVVXEVWkQFLDVTXtPLFDVSRGHSURYRFDUDJUHVVmRR[LGDWLYDDRVHULWUyFLWRV
eritrocitários indicam. SRUVREUHFDUJDDRDPELHQWHGHUHGXomR$IRUPDomRGHPHWDPRJORELQDpXPSUpUHTXLVLWRLPSRUWDQWH
QRGHVHQYROYLPHQWRHSUHFLSLWDomRGHKHPRJORELQDGHVQDWXUDGDHIRUPDomRGRFRUS~VFXORGH+HLQ]TXH
(P DQHPLDV KHPRUUiJLFDV D SURWHtQD SODVPiWLFD WDPEpP HVWi VHQGR SHUGLGD SRGHVHUREVHUYDGRHPOkPLQDVGHHVIUHJDoRVVDQJXtQHRVQDURWLQD
podendo resultar em hipoproteinemia.
$V FHERODV FRQWrP XP DJHQWH FDXVDGRU GH DQHPLD KHPROtWLFD R[LGDWLYD TXH DIHWD HTXLQRV ERYLQRV
Nas anemias hemolíticas pode não haver alteração na concentração de proteínas. FmHV H JDWRV 2V ERYLQRV SRGHP DSUHVHQWDU FRPR VLQDLV FOtQLFRV SDOLGH] LFWHUtFLD IUDTXH]D H
KHPRJORELQ~ULD
(PFmHVSRGHRFRUUHULQWR[LFDomRSRU]LQFRSRUPHLRGDLQJHVWmRGHPRHGDVURVFDVRXRXWURVPDWHULDLV
semelhantes, apresentando sinais clínicos de palidez e icterícia.
b) Anemias hemolíticas Em bovinos, ovinos e suínos pode ocorrer intoxicação por cobre quando o mesmo excede a capacidade
GHOLJDomRGDVSURWHtQDVWUDQVSRUWDGRUDV(PFmHVSRGHRFRUUHUXPDFULVHKHPROtWLFDGHYLGRjOLEHUDomR
Anemia hemolítica ocorre devido à destruição (lise) anormal e excessiva das hemácias de maneira GHFREUHQRVHVWiJLRVÀQDLVGHGRHQoDVKHSiWLFDV1RVHVIUHJDoRVVDQJXtQHRVSRGHPVHUREVHUYDGRV
LQWUDYDVFXODU QRLQWHULRUGRVYDVRVVDQJXtQHRV RXH[WUDYDVFXODU HPyUJmRVULFRVHPFpOXODVGR60)  FRUS~VFXORV GH +HLQ] HVTXL]yFLWRV H R SODVPD SRGH HVWDU KHPROLVDGR GHYLGR D LQWHQVD KHPyOLVH
1D OLVH LQWUDYDVFXODU RV HULWUyFLWRV OLEHUDP D KHPRJORELQD QR SODVPD H HVWD VH OLJD D KDSWRJORELQD intravascular.
TXHpXPDGDVSURWHtQDVSODVPiWLFDV(PVHJXLGDRVKHSDWyFLWRVUHPRYHPRFRPSOH[RKHPRJORELQD $OJXQVERYLQRVSRGHPDSUHVHQWDUXPDGLHWDGHÀFLHQWHHPIyVIRURTXHUHVXOWDHPXPDDQHPLDKHPROtWLFD
KDSWRJORELQDTXHpGHJUDGDGRHGiRULJHPDELOLUUXELQD$SUHVHQoDGHKHPRJORELQHPLDHKHPRJORELQ~ULD hipofosfatêmica, e esses servem como indicadores de distúrbio nutricional no rebanho. Vacas com
SRGHPVHULQGLFDGRUHVGHKHPyOLVHLQWUDYDVFXODUFDVRDOLEHUDomRGHKHPRJORELQDVXSHUHDTXDQWLGDGH KHPRJORELQ~ULDQRSyVSDUWRSRGHPDSUHVHQWDUHVWHWLSRGHDQHPLD(VVHVDQLPDLVDSUHVHQWDPFRPR
GHKDSWRJORELQD VLQWRPDVQDFULVHKHPROtWLFDSDOLGH]LFWHUtFLDVDQJXHDTXRVRHGHPDSXOPRQDUHFROHo}HVGHOtTXLGRV
$PDLRULDGDVFDXVDVGHDQHPLDKHPROtWLFDRFRUUHGHPDQHLUDH[WUDYDVFXODUSRUIDJRFLWRVHGRVHULWUyFLWRV QDVFDYLGDGHVRUJkQLFDVDOpPGHKHSDWRPHJDOLD
GHIRUPDSDUFLDORXFRPSOHWDSHORVPDFUyIDJRV4XDQGRRFRUUHDIDJRFLWRVHSDUFLDORVHULWUyFLWRVSHUGHP 2V HULWUyFLWRV DOWHUDGRV VmR IDJRFLWDGRV SRU PDFUyIDJRV RX GHVWUXtGRV SRU KHPyOLVH LQWUDYDVFXODU
XPDIUDomRGDVXDPHPEUDQDRVWRUQDQGRPHQRVÁH[tYHLVVmRFKDPDGRVGHHVIHUyFLWRVHWHQGHPDVHU SRU DSUHVHQWDUHP DOWHUDo}HV SRU PHLR GH DJUHVV}HV R[LGDWLYDV FRPR D SHUGD GH FiWLRQV SHUGD GD
UHWLGRVQREDoRHItJDGR1DDQHPLDKHPROtWLFDH[WUDYDVFXODURSULQFLSDOVLQDOFOtQLFRpDLFWHUtFLDTXH ÁH[LELOLGDGHGDPHPEUDQDHÀ[DomRGHLPXQRJOREXOLQDVjVSURWHtQDVQDVPHPEUDQDV
RFRUUHSRUHOHYDGDSURGXomRGHELOLUUXELQDTXHVXSHUDDFDSDFLGDGHKHSiWLFDGHFRQMXJDomRHH[FUHomR
0XLWRV DJHQWHV LQIHFFLRVRV FRPR YtUXV EDFWpULDV ULTXpWVLDV H SURWR]RiULRV SRGHP FDXVDU DQHPLD
$ DQHPLD KHPROtWLFD SRGHVHU DYDOLDGD WDPEpP HP FRQMXQWR FRP RKLVWyULFR GR DQLPDO SRU PHLR GD hemolítica nos animais. A anemia infecciosa equina, a leptospirose, a babesiose, a erliquiose, a
anamnese e realização do exame físico completo com a observação das mucosas pálidas ou ictéricas, WULSDQRVVRPtDVHDKHPREDUWRQHORVHLQIHFo}HVSyVHVWUHSWRFyFLFD FDXVDGRUGDS~USXUDKHPRUUiJLFD
KHSDWRPHJDOLDHVSOHQRPHJDOLDHKLSHUWHUPLDHPDOJXPDVDQHPLDVGHFDUiWHULQIHFFLRVR  TXHpXPDYDVFXOLWHDJXGDLPXQRPHGLDGDVHFXQGiULDjLQIHFomRSRUStreptococcus equi HLQIHFo}HV
$VDQHPLDVKHPROtWLFDVWrPYiULDVFDXVDVHSRGHPVHUFODVVLÀFDGDVFRPRDGTXLULGDVHKHUHGLWiULDV causadas por Clostridium perfringens são exemplos de doenças que causam anemia hemolítica.
$VDQHPLDVKHPROtWLFDVKHUHGLWiULDVVmRUDUDVHJHUDOPHQWHFDXVDGDVSRUGHIHLWRVLQWUDFHOXODUHVTXH
UHVXOWDPGHGHÀFLrQFLDVHQ]LPiWLFDVHRXDQRPDOLDVQDVtQWHVHGRKHPHGHSURWHtQDVGRFLWRHVTXHOHWR
e da membrana plasmática.
As anemias hemolíticas adquiridas são o tipo mais comum e podem ter diversas causas como: infec-
FLRVDV PLFURDQJLRSiWLFD DXWRLPXQHV SRU DJHQWHV R[LGDQWHV SRU PHGLFDPHQWRV WUDQVIXV}HV LQFRP-
patíveis, etc.

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
42 43
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

G $QHPLDGHGRHQoDVLQÁDPDWyULDV

1DDWXDOLGDGHRFkQFHUDGRHQoDKHSiWLFDHDGRHQoDJDVWURLQWHVWLQDOVmRFRQVLGHUDGDVGRHQoDVFU{QL-
FDVHLQÁDPDWyULDVTXHSRGHPFRPSURPHWHUDHULWURSRLHVHOHYDQGRDXPDDQHPLDFKDPDGDGHDQHPLD
IMPORTANTE SABER
GHGRHQoDVLQÁDPDWyULDVSRUVHUHPPHGLDGDVSRUFLWRFLQDVLQÁDPDWyULDV 71),)1\,/H,/ PHVPR
TXHQmRKDMDHYLGrQFLDFOtQLFDRXODERUDWRULDOGHLQÁDPDomRQRDQLPDO
(PDOJXQVFDVRVDGLIHUHQFLDomRHQWUHDQHPLDVKHPRUUiJLFDVHKHPROLWLFDV
SRGHVHUUHDOL]DGDFRPEDVHQDFRUUHWDLQWHUSUHWDomRGRHULWURJUDPDHP eXPDGDVFDXVDVPDLVFRPXQVGHDQHPLDDUUHJHQHUDWLYDSURYRFDQGRXPDOHYHDPRGHUDGDDQHPLD
conjunto com o exame clínico e anamnse. QRUPRFtWLFDHQRUPRFU{PLFD9iULRVPHFDQLVPRVVmRUHVSRQViYHLVSHODDQHPLDPDVRVPHFDQLVPRV
SULQFLSDLVVmRDGLPLQXLomRQDYLGD~WLO KHPyOLVHH[WUDYDVFXODU HQDSURGXomRGDVKHPiFLDV
$VDQHPLDVKHPROtWLFDVVmRPDLVUHVSRQVLYDVTXHDVDQHPLDVKHPRUUiJLFDV
SRLVQDDQHPLDKHPRUUiJLFDRIHUURpSHUGLGRQmRÀFDQGRGLVSRQtYHOSDUD A diminuição da vida útil das hemácias pode resultar no rápido desenvolvimento de anemia nos animais
D HULWURSRHVH 1D DQHPLD KHPROtWLFD R IHUUR p UHDSURYHLWDGR H R JUDX GH TXHDSUHVHQWDPLQÁDPDomRDJXGD(VVDGLPLQXLomRQDYLGD~WLOGDVKHPiFLDVpFDXVDGDSRUFLWRFLQDV
UHJHQHUDomRpEHPPDLVLQWHQVRVHQGRREVHUYDGRXPPDLRUQ~PHURGH LQÁDPDWyULDVHOHV}HVR[LGDWLYDVTXHLQGX]HPDOLJDomRGHDXWRDQWLFRUSRVSDUDDVXSHUItFLHGDVPHV-
UHWLFXOyFLWRVSROLFURPDWyÀORVPHWDUUXEUyFLWRVHDQLVRFLWRVHPDLVLQWHQVD PDVSURYRFDQGRDIDJRFLWRVHSRUPDFUyIDJRV$VFLWRFLQDVVLPXOWDQHDPHQWHVXSULPHPDUHVSRVWDGD
PHGXODyVVHD

$VXSUHVVmRGDHULWURSRLHVHSRUFLWRFLQDVLQÁDPDWyULDVFDXVDDGLPLQXLomRQDSURGXomRGHKHPiFLDV
SULQFLSDOPHQWHHPHVWDGRVLQÁDPDWyULRVFU{QLFRV(PJDWRVDDQHPLDSRGHVHGHVHQYROYHUPDLVUDSLG-
amente devido o tempo de vida das hemácias ser mais curto nessa espécie (60 dias), quando compara-
F $QHPLDVSRUGHÀFLrQFLDGHIHUUR
GDDVKHPiFLDVFDQLQDV GLDV $VFLWRFLQDVLQÁDPDWyULDVSRGHPLQLELUDHULWURSRLHVHSRUPHLRGD
GLPLQXLomRGDGLVSRQLELOLGDGHGHIHUURSRULQLELomRGLUHWDGHFpOXODVSURJHQLWRUDVHULWUyLGHVSRULQLELomR
2FRUUHTXDQGRRIHUURWRUQDVHOLPLWDQWHSDUDDHULWURSRLHVH2IHUURpXPFRPSRQHQWHHVVHQFLDOGRJUXSR
RXOLEHUDomRQDSURGXomRGH(32HSRUUHGXomRGDDWLYLGDGHELROyJLFDGD(32
KHPHGDKHPRJORELQDHQDVXDDXVrQFLDDKHPRJORELQDQmRSRGHVHUSURGX]LGDHPTXDQWLGDGHVVXÀ-
FLHQWHV$VXDGHÀFLrQFLDSRGHUHVXOWDUHPXPDDQHPLDPLFURFtWLFDHKLSRFU{PLFD
e) Anemia da doença renal crônica
$GHÀFLrQFLDGHIHUURHPDQLPDLVDGXOWRVpFDXVDGDSULQFLSDOPHQWHSHODSHUGDGHVDQJXHFRQVWDQWH
$LQVXÀFLrQFLDUHQDOFU{QLFD ,5& pDGRHQoDUHQDOPDLVFRPXPHPFmHVHJDWRVLGRVRV(VWDVtQGURPH
FDXVDGDVSRUSUREOHPDVFU{QLFRVHQmRVRPHQWHSRUXPDGLHWDSREUHHPIHUUR$VFDXVDVLPSRUWDQWHV
pFDUDFWHUL]DGDSHODLQFDSDFLGDGHGHIXQFLRQDPHQWRGRVULQVGHYLGRjSHUGDSURJUHVVLYDGRVQpIURQV
GHSHUGDGHVDQJXHSRUGRHQoDFU{QLFDVmRKHPRUUDJLDVSRUWXPRUHVQRWUDWRJDVWURLQWHVWLQDOHGLVW~U-
dentro de um período de meses a anos. Na IRC também é relativamente comum o desenvolvimento de
ELRVGHFRDJXODomR
DQHPLDQRUPRFtWLFDQRUPRFU{PLFD DUUHJHQHUDWLYD TXHPXLWDVYH]HVIDYRUHFHDPDQLIHVWDomRGHOHWDU-
JLDIUDTXH]DPXVFXODUDQRUH[LDHSHUGDGHSHVR2IDWRUSULQFLSDOGRDSDUHFLPHQWRGDDQHPLDQD,5&p
Em contrapartida, os animais jovens por crescerem e se desenvolverem rapidamente, tem tendência
a diminuição da síntese de EPO pelos rins.
DGHVHQYROYHUGHÀFLrQFLDGHIHUURPDLVIDFLOPHQWH$VUHVHUYDVGHIHUURQRVDQLPDLVMRYHQVWHQGHPD
VHU SHTXHQDV SRLV R OHLWH PDWHUQR p SREUH QHVVH PLQHUDO H RUiSLGR FUHVFLPHQWR H[LJH D H[SDQVmR
$GRHQoDUHQDOFU{QLFDSRGHUHVXOWDUHPDQHPLDSRUYiULRVIDWRUHVFRPRSULQFLSDOPHQWHSHODGLPLQXLomR
GRYROXPHVDQJXtQHR/HLW}HVHEH]HUURVSRGHPGHVHQYROYHUGHÀFLrQFLDGHIHUURVHPSHUGDGHVDQJXH
GDSURGXomRHDWLYLGDGHGH(32RXSRUPHLRGHFLWRFLQDVLQÁDPDWyULDVTXHVmRLQGX]LGDVSHODGRHQoD
DQRUPDO )LOKRWHV GH FmHV H JDWRV LQIHVWDGRV SRU SXOJDV FDUUDSDWRV RX DQFLORVWRPtGHRV WDPEpP VmR
UHQDO$SURGXomRGHWR[LQDVXUrPLFDVSRGHUHGX]LUDYLGD~WLOGDVKHPiFLDVFDXVDQGRKHPyOLVHH[WUDYDV-
VXVFHSWtYHLVGHVHUHPDQrPLFRVSRUGHÀFLrQFLDGHIHUUR
FXODU2XWURIDWRUTXHSRGHOHYDUDDQHPLDpDKHPRUUDJLDFU{QLFDHPDQLPDLVTXHVRIUHPIUHTXHQWH-
mente de úlceras orais devido a uremia.
$LQWR[LFDomRSRUFKXPERSRGHUHVXOWDUHPDQHPLDVHFXQGiULDSRUGHÀFLrQFLDGHIHUURSRLVRFKXPERLQ-
LEHDLQFRUSRUDomRGHIHUURQRDQHOSRUÀUtQLFRGRJUXSDPHQWRKHPH1HVWHFDVRRDQLPDOQmRDSUHVHQWD
YHUGDGHLUDPHQWHXPDGHÀFLrQFLDGHIHUURXPDYH]TXHRVHVWRTXHVGHIHUURHVWmRQRUPDLVHVRPHQWH
QmRSRGHVHUXWLOL]DGRSDUDVtQWHVHGHKHPRJORELQD3RUWDQWRHPYH]GHVHUXWLOL]DGRSDUDDVtQWHVHGH
KHPHRIHUURÀFDDFXPXODGRQDVKHPiFLDVFRPRVLGHUyFLWRV

O tratamento é feito com a suplementação de ferro oral (na forma ferrosa). Porém, esta prática tem sido
recentemente questionada, pois a absorção de ferro oral pode aumentar o ferro no plasma e estimular
a liberação de hepcidina que inibe a absorção de ferro no intestino por até 48 horas. Pode ser feita a
DSOLFDomRLQWUDPXVFXODUGHIHUURRXDGPLQLVWUDUVDQJXHSRUWUDQVIXVmRHPFDVRVGHDQHPLDVVHYHUDV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
44 45
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

$SROLFLWHPLDYHUGDGHLUDVHFXQGiULDRFRUUHJHUDOPHQWHGHYLGRDRDXPHQWRQDSURGXomRGH(32UHVXO-
WDQWHGHVLWXDo}HVGHKLSy[LDWHFLGXDO(VVHWLSRGHSROLFLWHPLDRFRUUHHPGRHQoDVFDUGLRYDVFXODUHVH
UHVSLUDWyULDV3RGHRFRUUHUWDPEpPDVVRFLDGDDQHRSODVLDVSURGXWRUDVGH(32 FDUFLQRPDKHSDWRFHOX-
lar, hepatoblastoma em cavalos, cânceres renais, tumores nasais em cavalos) ou doença renal (hidrone-
IURVHFLVWRVUHQDLV TXHHVWLPXODPDSURGXomRGH(32VHPKLSy[LD
05 ERITROCITOSE / POLICITEMIA
$OJXQVWXPRUHVFRPRQRWXPRUQDVDOGHPDQHLUDHFWySLFDVHFUHWDPFLWRFLQDVRTXHH[SOLFDDSURGXomR
de EPO em locais inesperados. Neoplasias produtoras de epinefrina, como no feocromocitoma, também
$ SROLFLWHPLD WDPEpP GHQRPLQDGD HULWURFLWRVH p FRQVLGHUDGD R FRQWUDULR GD DQHPLD 3DUD DOJXQV SRGHPUHVXOWDUHPXPDHULWURFLWRVH2XWUDVFDXVDVFRPRDVGRHQoDVHQGyFULQDVGHFmHVHJDWRVSRGHP
DXWRUHV R WHUPR SROLFLWHPLD RX SROLJOREXOLD VLJQLÀFD R DXPHQWR GR Q~PHUR GH FpOXODV VDQJXtQHDV WDPEpPDSUHVHQWDUXPDXPHQWRQRQ~PHURGHHULWUyFLWRV1RVFmHVHVVHDXPHQWRSRGHVHUREVHUYDGR
VHMDP KHPiFLDV SODTXHWDV RX OHXFyFLWRV 1R KHPRJUDPD D HULWURFLWRVH p FDUDFWHUL]DGD SRU HOHYDomR HPFDVRVGHKLSHUDGUHQRFRUWLFLVPRRXH[FHVVRGHDQGURJrQLRVHQRVJDWRVHPFDVRVGHKLSHUWLUHRLGLV-
GDFRQWDJHPJOREDOGHKHPiFLDV &*+ GRKHPDWyFULWR +W HGDFRQFHQWUDomRGHKHPRJORELQD +E $ PRHDFURPHJDOLD
SROLFLWHPLDSRGHVHUFODVVLÀFDGDFRPRIDOVD UHODWLYD RXYHUGDGHLUD DEVROXWD 
1DSROLFLWHPLDUHODWLYDQmRRFRUUHXPDYHUGDGHLUDHOHYDomRQRVtQGLFHVHULWURFLWiULRV &*++WH+E H
sim uma hemoconcentração resultante de desidratação ou contração esplênica. A principal causa de
policitemia na clínica veterinária é a desidratação. A perda de líquidos, inclusive do leito vascular, resulta
HPDXPHQWRGRVYDORUHVGDVpULHYHUPHOKDGRKHPRJUDPDHWDPEpPQDFRQFHQWUDomRGHSURWHtQDV2V
OHXFyFLWRVHSODTXHWDVQmRVmRDOWHUDGRVQRVFDVRVGHGHVLGUDWDomR

IMPORTANTE SABER

$ FRQWUDomR HVSOrQLFD SRGH UHVXOWDU HP DXPHQWR GD PDVVD HULWUyLGH H


FRQVHTXHQWHHULWURFLWRVHSRLVDVKHPiFLDVTXHÀFDPHVWRFDGDVQREDoR
SRGHPVHUODQoDGDVQDFRUUHQWHVDQJXtQHD$FRQWUDomRHVSOrQLFDRFRUUH
frequentemente, durante o esforço mediado por epinefrina. Em equinos jo-
YHQVHVWUHVVDGRVJHUDOPHQWHRFRUUHFRQWUDomRHVSOrQLFDMiTXHDSUHVHQ-
tam um baço muscular, sendo menos provável de acontecer em vacas, cães
HJDWRV(VVHIHQ{PHQRQmRHVWiDVVRFLDGRDRDXPHQWRGHSURWHtQDWRWDO

Na policitemia absoluta ocorre um aumento verdadeiro na produção de hemácias, mediada ou não por
(32TXHUHVXOWDHPHOHYDomRQRVYDORUHVGH+H+WH+E$SROLFLWHPLDYHUGDGHLUDSRGHVHUFODVVLÀFDGD
como primária ou secundária. A policitemia verdadeira primária é uma doença raramente descrita em
animais. Pode ser uma doença familiar ou neoplásica. A eritrocitose primária neoplásica é observada em
FDVRVGH3ROLFLWHPLD9HUDTXHpXPDGHVRUGHPPLHORSUROLIHUDWLYDFU{QLFD OHXFHPLDHULWUyLGHFUyQLFD 
$3ROLFLWHPLD9HUDpXPDFRQGLomRQHRSOiVLFDHPTXHDSURGXomRGHJOyEXORVYHUPHOKRVpDXW{QRPD
LQGHSHQGHQWHGDFRQFHQWUDomRGH(32eUDUDPHQWHUHODWDGDHPDQLPDLVHDPXWDomRQRJHQH-DQXV
.LQDVH  -$.  DLQGD QmR IRL LGHQWLÀFDGD HP DQLPDLV DIHWDGRV *HUDOPHQWH p XP GLDJQyVWLFR SRU
HOLPLQDomRGHRXWUDVFDXVDVGHHULWURFLWRVHVHFXQGiULDRXDXPDXPHQWRUHODWLYRQRKHPDWyFULWR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
46 47
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

´SRROVµ  PHGXODU VDQJXtQHR H WHFLGXDO 2 FRPSDUWLPHQWR PHGXODU QD PHGXOD yVVHD  p GLYLGLGR HP
FRPSDUWLPHQWRPLWyWLFR SUROLIHUDomRRXPXOWLSOLFDomR HGHPDWXUDomR DUPD]HQDPHQWRRXHVWRTXH 1R
VDQJXHXPDSDUWHGRVOHXFyFLWRVHQFRQWUDVHDGHULGDDRHQGRWpOLRYDVFXODU FRPSDUWLPHQWRPDUJLQDO H
RXWUDIUDomRQROHLWRYDVFXODU FRPSDUWLPHQWRFLUFXODQWH 1DFROHWDGHVDQJXHVmRREWLGDVDVFpOXODVGR
FRPSDUWLPHQWRFLUFXODQWH2FRPSDUWLPHQWRWHFLGXDOFRUUHVSRQGHDRWRWDOGHOHXFyFLWRVTXHPLJUDUDP
06 LEUCÓCITOS SRUGLDSHGHVHSDUDRVWHFLGRVRQGHGHVHPSHQKDPVXDVIXQo}HVGHGHIHVDRUJkQLFD )LJXUD 
2 SURFHVVR GH SURGXomR GH OHXFyFLWRV p GHQRPLQDGR OHXFRSRLHVH RX OHXFRFLWRSRLHVH H RFRUUH QD
PHGXOD yVVHD D SDUWLU GH XPD FpOXOD SOXULSRWHQFLDO FKDPDGD GH ´6WHP &HOOµ TXH GHSHQGHQGR GH
2VOHXFyFLWRVRXJOyEXORVEUDQFRVID]HPSDUWHGRVLVWHPDLPXQLWiULRSDUWLFLSDQGRGDUHVSRVWDLPXQH HVWtPXORVDSURSULDGRVRULJLQDRVGLIHUHQWHVOHXFyFLWRV$OHXFRSRLHVHFRPSUHHQGHDJUDXORFLWRSRLHVH
LQDWDHHVSHFtÀFDHHVWmRSUHVHQWHVQRVDQJXHQDOLQIDHPyUJmRVOLQIRLGHVHYiULRVWHFLGRVFRQMXQWLYRV OLQIRFLWRSRLHVHHPRQRFLWRSRLHVH )LJXUD 
$SUHVHQWDPVHFRPRXPJUDQGHJUXSRGHFpOXODVFRPYDULDGDVIRUPDVWDPDQKRVQ~PHURVHIXQo}HV
HVSHFtÀFDV2VOHXFyFLWRVGHDFRUGRFRPVXDVFDUDFWHUtVWLFDVPRUIROyJLFDVHWLQWRULDLVVmRGLYLGLGRVHP
GRLVJUXSRVSROLPRUIRQXFOHDUHVHPRQRQXFOHDUHV )LJXUD 
2V SROLPRUIRQXFOHDUHV WDPEpP GHQRPLQDGRV GH JUDQXOyFLWRV DSUHVHQWDP R Q~FOHR SROLPRUIR FRP
GLIHUHQWHVIRUPDVIHLMmRDOWHUHVOREXODGRFLUFXODUHWF HRFLWRSODVPDFRPJUkQXORVFRQWHQGRHQ]LPDV
KLGUROtWLFDV1RVPDPtIHURVRVJUDQXOyFLWRVVmRUHSUHVHQWDGRVSHORVQHXWUyÀORVEDVyÀORVHHRVLQyÀORV
(P RXWUDV HVSpFLHV FRPR UHSWHLV H DYHV RV KHWHURÀORV VmR R WLSR FHOXODU TXH FRUUHVSRQGHP DRV
QHXWUyÀORVGRVPDPtIHURV
2VPRQRQXFOHDUHVRXDJUDQXOyFLWRVQmRDSUHVHQWDPJUkQXORVYLVtYHLVQRFLWRSODVPDHVHXVQ~FOHRVVmR
GHIRUPDHQGHQWDGDRXDUUHGRQGDGDVmRUHSUHVHQWDGRVSHORVPRQyFLWRVHOLQIyFLWRV

Figura 10 &RPSDUWLPHQWRVGRVOHXFyFLWRVQRRUJDQLVPR&RPSDUWLPHQWRPHGXODUTXHVHGLYLGHPLWyWLFR
(proliferação e multiplicação) e de maturação (armazenamento e estoque), compartimento circulante
IUDomRQROHLWRYDVFXODU HFRPSDUWLPHQWRPDUJLQDO OHXFyFLWRVDGHULGRVDRHQGRWpOLRYDVFXODU 
Figura 9 &ODVVLÀFDomRGRVOHXFyFLWRV2VSROLPRUIRQXFOHDUHVDSUHVHQWDPQ~FOHRSROLPRUIRHRFLWRSODVPD
FRPJUkQXORVFRQWHQGRHQ]LPDVKLGUROtWLFDV EDVyÀORVHRVLQyÀORVHQHXWUyÀORV 2VPRQRQXFOHDUHVQmR
DSUHVHQWDPJUkQXORVYLVtYHLVQRFLWRSODVPDHVHXVQ~FOHRVDSUHVHQWDPIRUPDHGHQWDGDRXDUUHGRQGDGD
PRQyFLWRVHOLQIyFLWRV 

2VOHXFyFLWRVVmRSURGX]LGRVQDPHGXODyVVHDHOLEHUDGRVQRVDQJXHSHULIpULFRGHRQGHPLJUDPSDUD
RVWHFLGRV$VVLPDVFpOXODVEUDQFDVHVWmRGLVWULEXtGDVQRRUJDQLVPRHPWUrVJUDQGHVFRPSDUWLPHQWRV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
48 49
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

0RQRFtWLFD HGHSRLVDSHQDVHP8)&0LHORFtWLFD *UDQXORFtWLFD 3RUHVWtPXORVHVSHFtÀFRVVmRSURGX]LGRV


RV GLIHUHQWHV WLSRV FHOXODUHV D SDUWLU GDV XQLGDGHV IRUPDGRUDV GH FRO{QLDV QHXWURItOLFD HRVLQRItOLFD H
basofílica.
$VHTXrQFLDGHPDWXUDomRGRVJUDQXOyFLWRVLQFOXLRVVHJXLQWHVWLSRVFHOXODUHVPLHOREODVWRSUyPLHOyFLWR
PLHOyFLWRPHWDPLHOyFLWRFpOXODHPEDVWmRHFpOXODVHJPHQWDGD FpOXODPDGXUD 2VWUrVSULPHLURVWLSRV
FHOXODUHVSDUWLFLSDPGRFRPSDUWLPHQWRGHPXOWLSOLFDomRHVRIUHPPLWRVHV$SDUWLUGRVPHWDPLHOyFLWRV
não ocorrem mais mitoses, apenas maturação para célula em bastão. As células em bastão, ou
EDVWRQHWHVDPDGXUHFHPDWpFpOXODVHJPHQWDGDTXHUHSUHVHQWDDFpOXODPDGXUD
2VQHXWUyÀORVVmRRVJUDQXOyFLWRVPDLVDEXQGDQWHVHPWRGDVDVHVSpFLHV$GLIHUHQFLDomRHQWUHFpOXODV
HP EDVWmR LPDWXUDV  H FpOXOD VHJPHQWDGD PDGXUD  Vy WHP LPSRUWkQFLD SDUD QHXWUyÀORV SRLV HVVH
JUDQXOyFLWR SDUWLFLSD FRPR SULPHLUD OLQKD GH GHIHVD GR RUJDQLVPR IUHQWH D SURFHVVRV LQIHFFLRVRV H
LQÁDPDWyULRV
6mRIDWRUHVHVWLPXODQWHVSDUDSURGXomRGHQHXWUyÀORVRVIDWRUHVTXLPLRWiWLFRVSURGX]LGRVQRORFDOGD
LQIHFomR RX LQÁDPDomR LQWHUOHXFLQDV IDWRUHV HVWLPXODGRUHV GH FRO{QLD GH JUDQXOyFLWRV H PRQyFLWRV
OLQIRFLQDVHFLWRFLQDV2VIDWRUHVHVWLPXODQWHVGHFRO{QLDDWXDPGLUHWDPHQWHQDVFpOXODVKHPDWRSRLpWLFDV
DXPHQWDQGRDSUROLIHUDomRGLIHUHQFLDomRHIXQomRFHOXODU2VQHXWUyÀORVXPDYH]TXHVDHPGRVDQJXH
SDUDRVWHFLGRVQmRUHWRUQDPPDLVSDUDFRUUHQWHVDQJXtQHD(OHVVmRGHVWUXtGRVQRVWHFLGRVRXSHUGLGRV
DWUDYpVGHVHFUHo}HVHH[FUHo}HV )LJXUD 

Figura 11 (VTXHPD UHVXPLGR GD OHXFRSRLHVH RX OHXFRFLWRSRLHVH 2FRUUH QD PHGXOD yVVHD D SDUWLU
de uma célula pluripotencial chamada de “Stem Cell”, que, dependendo de estímulos apropriados,
RULJLQD RV GLIHUHQWHV OHXFyFLWRV $ OHXFRSRLHVH FRPSUHHQGH D JUDQXORFLWRSRLHVH OLQIRFLWRSRLHVH H
PRQRFLWRSRLHVH $V FpOXODV PLHORLGHV PXOWLSRWHQWHV RULJLQDP RV QHXWUyÀORV HRVLQyÀORV H EDVyÀORV
JUDQXOyFLWRVSROLPRUIRQXFOHDUHV (DVFpOXODVOLQIRLGHVPXOWLSRWHQWHVRULJLQDPRVPRQyFLWRVHOLQIyFLWRV
DJUDQXOyFLWRVPRQRQXFOHDUHV 

Granulocitopoiese

1DJUDQXORFLWRSRLHVHVmRSURGX]LGRVRVQHXWUyÀORVHRVLQyÀORVHEDVyÀORV1DSURGXomRGRVJUDQXOyFLWRV Figura 12 )DWRUHVHVWLPXODQWHVHGHSUHVVRUHVGDJUDQXORSRLHVH)DWRUHVHVWLPXODQWHVUHSUHVHQWDGRV


D´6WHP&HOOµVHGLIHUHQFLDHP8QLGDGH)RUPDGRUDGH&RO{QLD 8)& 0LHORPRQRFtWLFD *UDQXORFtWLFD SHORVLQDOSRVLWLYR  HIDWRUHVGHSUHVVRUHVUHSUHVHQWDGRVSHORVLQDOQHJDWLYR  

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
50 51
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

WLSRVFHOXODUHVFRPRDVFpOXODVGH.XSIIHURVKLVWLyFLWRVPDFUyIDJRVDOYHRODUHVHPDFUyIDJRVGREDoR
PHGXODyVVHDHOLQIRQRGRV

CURIOSIDADE $SURGXomRHPDWXUDomRGRVPRQyFLWRVGXUDHPPpGLDWUrVGLDVVHQGRHVWLPXODGDSRUFLWRFLQDVHIDWRUHV
GHFUHVFLPHQWRFRPRRIDWRUHVWLPXODQWHGHFRO{QLDGHJUDQXOyFLWRVHPRQyFLWRV(VVHVPRQRQXFOHDUHV
2V WUrV WLSRV GH JUDQXOyFLWRV VmR QRPHDGRV H GLIHUHQFLDGRV FRP EDVH QDV XPDYH]TXHVDHPGDFRUUHQWHVDQJXtQHDQmRUHWRUQDPPDLV
FDUDFWHUtVWLFDV WLQWRULDLV FRQIHULGDV SHOD DÀQLGDGH GRV JUkQXORV FLWRSODVPiWLFRV
secundários a corantes ácidos ou básicos.
Linfocitopoiese
• 1HXWUyÀORV2VJUkQXORVFLWRSODVPiWLFRVQmRWrPDÀQLGDGHSRUFRUDQWHViFLGRV
RXEiVLFRV2VJUkQXORVSULPiULRVSRGHPVHUFRUDGRVEDVRÀOLFDPHQWH $OLQIRFLWRSRLHVHRXOLQIRSRLHVHRFRUUHQDPHGXODyVVHDHHPyUJmRVOLQIRLGHVFRPRWLPROLQIRQRGRV
• (RVLQyÀORV 2V JUkQXORV FLWRSODVPiWLFRV DSUHVHQWDP DÀQLGDGH SRU FRUDQWHV EDoREXUVDGH)DEULFLXVSODFDVGH3H\HUHWRQVLODV2VOLQIyFLWRV7H%HPEULRORJLFDPHQWHVmRGHULYDGRV
iFLGRVHVHFRUDPHRVLQLÀOLFDPHQWH DODUDQMDGRV  GDPHGXODyVVHDHPDWXUDPQRWLPRHPHGXODyVVHDUHVSHFWLYDPHQWH1DVDYHVDPDWXUDomRGROLQIyFLWR
• %DVyÀORV 2V JUkQXORV FLWRSODVPiWLFRV DSUHVHQWDP DÀQLGDGH SRU FRUDQWHV %RFRUUHQDEXUVDGH)DEULFLXV8PD´6WHP&HOOµSOXULSRWHQWHVHGLIHUHQFLDHP´6WHP&HOOµOLQIyLGHHHP
EiVLFRVHVHFRUDPEDVRÀOLFDPHQWH D]XODGRV  VHJXLGDHPOLQIREODVWR(VWHVRVOLQIREODVWRVVRIUHPPLWRVHVIRUPDQGRRSUyOLQIyFLWRHHPVHJXLGDR
OLQIyFLWRPDGXUR
$GLIHUHQFLDomRHQWUHOLQIyFLWRV%H7QmRSRGHVHUUHDOL]DGDDSDUWLUGDVVXDVFDUDFWHUtVWLFDVPRUIROyJLFDV
QR HVIUHJDoR VDQJXtQHR 3DUD GLIHUHQFLDU HVVHV GRLV WLSRV FHOXODUHV p QHFHVViULR XWLOL]DU DQWLFRUSRV
$SURGXomRHDPDWXUDomRGRVHRVLQyÀORVWDPEpPRFRUUHPQDPHGXODyVVHDRQGHVmRREVHUYDGRVRV monoclonais que reconhecem os marcadores celulares expressos na membrana citoplasmática.
PHVPRVWLSRVFHOXODUHVGHVFULWRVSDUDQHXWUyÀORV(QWUHWDQWRRVHRVLQyÀORVQmRSRGHPVHULGHQWLÀFDGRV
DQWHVGRHVWiJLRGHPLHOyFLWRRQGHDSUHVHQoDGHJUkQXORVHRVLQRItOLFRVFDUDFWHUL]DHVVHWLSRFHOXODU $SURGXomRGRVOLQIyFLWRVGHSHQGHGRJUDXHWLSRGHHVWLPXODomRDQWLJrQLFD$OJXQVDQWtJHQRVHVWLPXODP
$ LQWHUOHXFLQD  ,/  p D SULQFLSDO FLWRFLQD TXH HVWLPXOD D SURGXomR GH HRVLQyÀORV $ ,/ H R IDWRU RVOLQIyFLWRV%DVHWUDQVIRUPDUHPSODVPyFLWRVTXHVmRFpOXODVSURGXWRUDVGHLPXQRJOREXOLQDV2XWURV
HVWLPXODQWHGHJUDQXOyFLWRVHPRQyFLWRVWDPEpPHVWLPXODPDHRVLQRSRLHVH DQWtJHQRVHVWLPXODPOLQIyFLWRV7TXHSURGX]HPOLQIRFLQDVHSDUWLFLSDPGHUHVSRVWDLPXQHFHOXODU

2V EDVyÀORV VmR UDURV HP PXLWRV DQLPDLV H VXD SURGXomR RFRUUH HP SDUDOHOR FRP RV QHXWUyÀORV H 2VOLQIyFLWRVDSUHVHQWDPXPORQJRWHPSRGHYLGDHVmRRV~QLFRVOHXFyFLWRVTXHUHFLUFXODPRXVHMDHOHV
HRVLQyÀORVHQWUHWDQWRRHVWRTXHGHVVHWLSRFHOXODUQDPHGXODyVVHDpPtQLPR9iULDVFLWRFLQDVHVWmR SRGHPUHWRUQDUSDUDFRUUHQWHVDQJXtQHD2IHQ{PHQRGHUHFLUFXODomRpGHJUDQGHLPSRUWkQFLDELROyJLFD
HQYROYLGDVQDSUROLIHUDomRHPDWXUDomRGRVEDVyÀORVLQFOXLQGR,/,/HIDWRUHVWLPXODQWHGHFRO{QLD SRLVSURSRUFLRQDXPPHFDQLVPRGHGLVWULEXLomRJHQHUDOL]DGDGHFpOXODVOLQIyLGHVFRPSURPHWLGDVFRP
GHJUDQXOyFLWRVHPRQyFLWRV D UHVSRVWD LPXQH VLVWrPLFD H HVSHFtÀFD &RPR UHVXOWDGR XP JUDQGH Q~PHUR GH OLQIyFLWRV SRGH VHU
H[SRVWRDXPDQWtJHQRGHSRVLWDGRORFDOPHQWHQRWHFLGR(VWDVFpOXODVDQWLJHQLFDPHQWHH[SRVWDVSRGHP
VHUWUDQVSRUWDGDVSRUYiULRVOXJDUHVQRFRUSRSDUDSURSDJDUHPRQWDUXPDYLJRURVDUHVSRVWDLPXQH
Monocitopoese

2VPRQyFLWRVVHRULJLQDPGHXPD´6WHP&HOOµPLHOyLGHTXHVHGLYLGHHP8)&*UDQXORFtWLFD0RQRFtWLFD 6.1 Descrição e funções dos Leucócitos do sangue periférico


HHPVHJXLGDHP8)&0RQRFtWLFDRULJLQDQGRRPRQREODVWR2PRQREODVWRVRIUHPLWRVHTXHGiRULJHP
1HXWUyÀORV
D GRLV SUyPRQyFLWRV H HVWHV VRIUHP GXDV PLWRVHV RULJLQDQGR RV PRQyFLWRV PDGXURV 2V PRQyFLWRV
VDQJXtQHRVDRPLJUDUHPSDUDRVWHFLGRVUHFHEHPRQRPHGHPDFUyIDJRV2VPDFUyIDJRVLQFOXHPYiULRV
$ PHGXOD yVVHD OLEHUD RV QHXWUyÀORV PDGXURV QR VDQJXH SHULIpULFR RV TXDLV PLJUDP SRU PHLR GR
HQGRWpOLR YDVFXODU SDUD RV WHFLGRV RQGH SDUWLFLSDP GD UHVSRVWD LQÁDPDWyULD DJXGD H VmR D SULPHLUD
OLQKDGHGHIHVDGRRUJDQLVPRFRQWUDDJHQWHVEDFWHULDQRV(OHVUHDOL]DPIDJRFLWRVHHDSUHVHQWDPDomR
EDFWHULFLGDSRUpPWDPEpPSRGHPFRPEDWHUIXQJRVOHYHGXUDVDOJDVSDUDVLWDVHYtUXV )LJXUD 
6mRFRQVLGHUDGRVRVOHXFyFLWRVPDLVDEXQGDQWHVQRVDQJXHSHULIpULFRGHFmHVHJDWRV1RVQHXWUyÀORV
VHJPHQWDGRVRQ~FOHRVHGLYLGHHPYiULRVORERVFRPDSUR[LPDGDPHQWHWUrVDFLQFRORERVSRUQ~FOHR2
GLkPHWURGRVQHXWUyÀORVYDULDGHD—P

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
52 53
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

(RVLQyÀORV

2V HRVLQyÀORV WDPEpP GHQRPLQDGRV GH DFLGyÀORV DSUHVHQWDP IXQomR H RULJHP VHPHOKDQWH DRV
QHXWUyÀORV3RVVXHPDomRIDJRFtWLFDHEDFWHULFLGDSRUpPVmRPHQRVHÀFD]HVQHVVHVSURFHVVRVTXHRV
QHXWUyÀORV(VVHVJUDQXOyFLWRVVmRLPSRUWDQWHVQDDomRFRQWUDSDUDVLWDVPXOWLFHOXODUHVHSDUWLFLSDPGDV
UHDo}HVDOpUJLFDVHDQDÀOiWLFDV )LJXUD 
$SUR[LPDGDPHQWH  D  GRV OHXFyFLWRV FLUFXODQWHV VmR HRVLQyÀORV 0RUIRORJLFDPHQWH HVVDV FpOXODV
DSUHVHQWDP R Q~FOHR SROLPyUÀFR FRP JUDQGH TXDQWLGDGH GH JUkQXORV FLWRSODVPiWLFRV TXH VH FRUDP
HRVLQRÀOLFDPHQWH JUDQXODo}HV DODUDQMDGDV  2V HRVLQyÀORV GH HTXLQRV VmR EHP FDUDFWHUtVWLFRV H
DSUHVHQWDPJUDQGHVJUkQXORVFLWRSODVPiWLFRV

Figura 13 1HXWUyÀORVLGHQWLÀFDGRVSHODVVHWDVFRUDQWH3DQyWLFRUiSLGRA.3UHVHQoDGHQHXWUyÀORV
VHJPHQWDGRVHPVDQJXHSHULIpULFRFDQLQR REMHWLYDGH[ B.3UHVHQoDGHQHXWUyÀORVHJPHQWDGRHP
VDQJXHSHULIpULFRIHOLQR REMHWLYDGH[ C. 3UHVHQoDGHQHXWUyÀORVHJPHQWDGRHPVDQJXHSHULIpULFR
de caprino (objetiva de 100x), D. e E.3UHVHQoDGHQHXWUyÀORVEDVWRQHWHVHPVDQJXHSHULIpULFRFDQLQR
LGHQWLÀFDGRSHODVHWD1HXWUyÀOREDVWRQHWHQDSULPHLUDLPDJHPLGHQWLÀFDGRSHODÁHFKDFRPDXPHQWRGH
[1DVHJXQGDLPDJHPLGHQWLÀFDGDSHODÁHFKDFRPDXPHQWRGH[ Figura 14 (RVLQyÀORVLGHQWLÀFDGRVSHODVÁHFKDVHPHVIUHJDoRVDQJXtQHRFDQLQR $ IHOLQR % HTXLQR
& HSULPDWD ' $XPHQWRFRPREMHWLYDGH[&RUDQWH3DQyWLFRUiSLGR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
54 55
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

%DVyÀORV

2V EDVyÀORV HVWmR SUHVHQWHV QR VDQJXH SHULIpULFR HP SHTXHQD TXDQWLGDGH 6mR UDURV GH VHUHP
HQFRQWUDGRVHPH[DPHGHHVIUHJDoRVDQJXtQHR$VIXQo}HVGHVVHWLSRFHOXODUDLQGDQmRHVWmRWRWDOPHQWH
HVWDEHOHFLGDV SRUpP HVSHFXODVH TXH HVVDV FpOXODV SDUWLFLSHP MXQWDPHQWH FRP RV HRVLQyÀORV GH
SURFHVVRVDOpUJLFRV )LJXUD 
$SUHVHQWDPWDPDQKRFRPSDWtYHOFRPRVQHXWUyÀORVDSUHVHQWDQGRFLWRSODVPDOLJHLUDPHQWHDUUR[HDGRH
SUHVHQoDGHJUkQXORVFLWRSODVPiWLFRVEDVRItOLFRV D]XODGRV $SUHVHQWDPQ~FOHRVHJPHQWDGR

Figura 16 /LQIyFLWRVLGHQWLÀFDGRVSHODVVHWDV FRUDQWH3DQyWLFRUiSLGR A. 3UHVHQoDGHOLQIyFLWRVHP


VDQJXHSHULIpULFRFDQLQR DXPHQWRFRPREMHWLYDGH[ B./LQIyFLWRHPVDQJXHSHULIpULFRFDQLQR DX-
mento com objetiva de 40x), C./LQIyFLWRHPVDQJXHSHULIpULFRIHOLQR DXPHQWRFRPREMHWLYDGH[ 
Figura 15 3UHVHQoD GH EDVyÀOR LGHQWLÀFDGR SHOD ÁHFKD HP HVIUHJDoR VDQJXtQHR GH XP IHOtGHR VHO-
D./LQIyFLWRHPVDQJXHSHULIpULFRGHDYH DXPHQWRFRPREMHWLYDGH[ E. e F./LQIyFLWRVHPVDQJXH
YDJHP Puma yagouaroundi $XPHQWRFRPREMHWLYDGH[&RUDQWH3DQyWLFRUiSLGR periférico de caprino (aumento com objetiva de 100x), G.3UHVHQoDGHOLQIyFLWRVHPVDQJXHSHULIpULFRGH
bubalino (aumento com objetiva de 100x).
Linfócitos
Monócitos
2VOLQIyFLWRVVmRRVOHXFyFLWRVPDLVDEXQGDQWHVGRVDQJXHGHUXPLQDQWHVHGHVHPSHQKDPXPSDSHO
LPSRUWDQWH QD GHIHVD RUJkQLFD 2V OLQIyFLWRV 7 VmR RV SULQFLSDLV UHVSRQViYHLV SHOD LPXQLGDGH FHOXODU 2VPRQyFLWRVMXQWDPHQWHFRPRVRXWURVOHXFyFLWRVFRODERUDPQDIDJRFLWRVHHHOLPLQDomRGHWHFLGRV
GRRUJDQLVPRHDWXDPHVWLPXODQGRRXDWHQXDQGRDSURGXomRGHDQWLFRUSRVSHORVOLQIyFLWRV% 2 V mortos ou lesados, materiais estranhos, debris celulares, na destruição de células cancerosas e contribui
OLQIyFLWRV%VmRUHVSRQViYHLVSHODLPXQLGDGHKXPRUDOHGmRRULJHPDRVSODVPyFLWRVTXHVLQWHWL]DPRV SDUDHUHJXODomRGDLPXQLGDGHGRRUJDQLVPR
DQWLFRUSRV )LJXUD  $PHGXODyVVHDOLEHUDRVPRQyFLWRVQRVDQJXHSHULIpULFRQDDXVrQFLDGDLQÁDPDomRRXHPUHVSRVWD
(PHVIUHJDoRVDQJXtQHRRVOLQIyFLWRVVHDSUHVHQWDPHPYDULDGDVIRUPDVGHYLGRjVIRUoDVPHFkQLFDV j LQÁDPDomR H DSyV VXD GLVWULEXLomR QRV WHFLGRV DGMDFHQWHV VH WUDQVIRUPDP HP PDFUyIDJRV 2V
aplicadas a eles durante a confecção da lâmina e pelo contato com as hemácias. O tamanho dos PDFUyIDJRV VmR UDUDPHQWH HQFRQWUDGRV QR VDQJXH SRUpP SRGHP VHU REVHUYDGRV QR HVIUHJDoR
OLQIyFLWRVpEHPYDULiYHOSULQFLSDOPHQWHHPUXPLQDQWHV(OHVSRGHPYDULDUHPSHTXHQRVLQWHUPHGLiULRV VDQJXtQHRGHDQLPDLVFRPHUOLTXLRVHKLVWRSODVPRVHHOHLVKPDQLRVH
HJUDQGHVOLQIyFLWRV 2VPRQyFLWRVVmRRVPDLRUHVOHXFyFLWRVHDSUHVHQWDPXPJUDQGHFLWRSODVPDEDVRItOLFRSUHVHQoDGH
2V OLQIyFLWRV SHTXHQRV VmR FRQVLGHUDGRV DTXHOHV HP TXH R Q~FOHR GR OLQIyFLWR FDEH GHQWUR GH XP JUkQXORVÀQRVFRPDSDUrQFLDGHJUmRVGHYLGURHQ~FOHRLUUHJXODUSRGHQGRVHURYDORXHPIRUPDWRGHULP
QHXWUyÀOR 2V OLQIyFLWRV LQWHUPHGLiULRV VmR FRQVLGHUDGRV DTXHOHV HP TXH R Q~FOHR GR OLQIyFLWR p GR RXIHLMmR2VPRQyFLWRVVmREHPYDULDGRVQDVXDIRUPD WDPDQKRHDSDUrQFLD HSRGHPVHUFRQIXQGLGRV
PHVPRWDPDQKRGHXPQHXWUyÀOR(RVOLQIyFLWRVJUDQGHVVmRDTXHOHVHPTXHRQHXWUyÀORSRGHFDEHU FRPRVQHXWUyÀORVHPEDVWmR(PUXPLQDQWHVJUDQGHVOLQIyFLWRVSRGHPVHUFRQIXQGLGRVFRPPRQyFLWRV
GHQWURGRQ~FOHRGROLQIyFLWR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
56 57
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

IMPORTANTE SABER

Leucograma: 3DUWH GR KHPRJUDPD XWLOL]DGD SDUD DYDOLDU D VpULH EUDQFD


RXVHMDRVOHXFyFLWRV2OHXFRJUDPDpFRPSRVWRSHOD&RQWDJHPJOREDOH
GLIHUHQFLDOGHOHXFyFLWRV

&RQWDJHP*OREDOGH/HXFyFLWRV &*/ ([DPHTXHGHWHUPLQDDTXDQWLGDGH


GHOHXFyFLWRVHPXPYROXPHGHVDQJXH [3—/ $TXDQWLÀFDomRSRGHVHU
UHDOL]DGDDWUDYpVGHPpWRGRVPDQXDLV FRQWDJHPHPKHPRFLW{PHWUR RX
em equipamentos automatizados.

Contagem Diferencial de leucócitos: também denominada de leucometria


HVSHFtÀFD 4XDQWLÀFD FDGD WLSR OHXFRFLWiULR HP YDORUHV UHODWLYRV   H
absolutos (x 103—/ 

Figura 17 3UHVHQoDGHPRQyFLWRLGHQWLÀFDGRSHODÁHFKDHPVDQJXHSHULIpULFRFDQLQR$XPHQWRFRP
REMHWLYDGH[&RUDQWH3DQyWLFRUiSLGR

6.3 Alterações quantitativas dos leucócitos


6.2 Avaliação da resposta leucocitária
3DXO(KUOLFKHPIH]DSULPHLUDREVHUYDomRGRHVIUHJDoRVDQJXtQHRHHVWDEHOHFHXDGLVWULEXLomR
SHUFHQWXDO GRV OHXFyFLWRV VHQGR HVVD FKDPDGD GH FRQWDJHP UHODWLYD (P  9LFWRU 6FKLOOLQJ
2WHUPR/HXFRQpXWLOL]DGRSRUDOJXQVDXWRUHVSDUDGHVLJQDURWRWDOGHOHXFyFLWRVGRRUJDQLVPRLQFOXLQGR XP KHPDWRORJLVWD DOHPmR FRORFRX QD URWLQD D IyUPXOD OHXFRFLWiULD H GHVGH HQWmR RV UHVXOWDGRV GR
WRGDVDVFpOXODVEUDQFDVHQFRQWUDGDVQDPHGXODyVVHDVDQJXHHWHFLGRV2VOHXFyFLWRVVmRFpOXODVTXH OHXFRJUDPDVmRH[SUHVVRVFRPRFRQWDJHPJOREDO OHXFyFLWRVWRWDLV HHVSHFtÀFD UHVXOWDGRVH[SUHVVRV
HVWmRHPFRQVWDQWHVDOWHUDo}HVQXPpULFDVHPRUIROyJLFDVSDUDSRGHUHPGHVHPSHQKDUVXDVIXQo}HVQD para cada tipo celular).
UHVSRVWDLQÁDPDWyULDHQDGHIHVDRUJkQLFDFRQWUDGLIHUHQWHVSDWyJHQRV YtUXVEDFWpULDVSDUDVLWDVHWF 
1D OHXFRPHWULD HVSHFtÀFD R YDORU HQFRQWUDGR SDUD FDGD OHXFyFLWR p H[SUHVVR FRPR YDORU SHUFHQWXDO
2OHXFRJUDPDpDSDUWHGRKHPRJUDPDTXHSHUPLWHDYDOLDUDVDOWHUDo}HVQXPpULFDV TXDQWLWDWLYDV H FRQWDJHPUHODWLYD HYDORUHVDEVROXWRV$LQWHUSUHWDomRGROHXFRJUDPDGHYHVHPSUHTXHSRVVtYHOVHU
PRUIROyJLFDV TXDOLWDWLYDV GROHXFRQHPUHVSRVWDDGLYHUVDVFRQGLo}HVFOtQLFDV(VVHH[DPHpPXLWR UHDOL]DGDOHYDQGRHPFRQVLGHUDomRRVYDORUHVDEVROXWRVSRLVHVWHVVmRPDLVFRQÀiYHLV
XWLOL]DGRQDSUDWLFDFOtQLFDHGHJUDQGHLPSRUWkQFLDSDUDDX[LOLRQRGLDJQyVWLFRGHGRHQoDVLQÁDPDWyULDV
SDUDVLWiULDVEDFWHULDQDVQHRSOiVLFDVDOpUJLFDVGHQWUHRXWUDV$OpPGHGRHQoDVVLVWrPLFDVVLWXDo}HV $VDOWHUDo}HVTXDQWLWDWLYDVGRVOHXFyFLWRVVmRLGHQWLÀFDGDVTXDQGRRVYDORUHVH[FHGHPRXHVWmRDEDL[R
GHHVWUHVVHDJXGRRXFU{QLFRWDPEpPSRGHPDFDUUHWDUHPDOWHUDo}HVQDFRQWDJHPJOREDOHGLIHUHQFLDO GRVLQWHUYDORVGHUHIHUrQFLDSDUDHVSpFLH$VDOWHUDo}HVQXPpULFDVGROHXFRJUDPDVmRGHVLJQDGDVSRU
GHOHXFyFLWRV WHUPRVWpFQLFRVHVSHFtÀFRVSDUDFDGDOHXFyFLWR2VVXÀ[RV´ÀOLDµH´FLWRVHµVmRLQGLFDWLYRVGHDXPHQWR
HQTXDQWRRVXÀ[R´SHQLDµpLQGLFDWLYRGHUHGXomR
1RSURFHVVRLQÁDPDWyULRDJXGRHQDVLQIHFo}HVEDFWHULDQDVRFRUUHDXPHQWRQDSURGXomRGHOHXFyFLWRV
SULQFLSDOPHQWHGHQHXWUyÀORVTXHVmRRWLSRFHOXODUUHTXHULGRSDUDGHIHVDRUJkQLFDQHVVDVVLWXDo}HV
(PGRHQoDVDOpUJLFDVHSDUDVLWiULDVRFRUUHHVWtPXORSDUDSUROLIHUDomRGRVSUHFXUVRUHVGHHRVLQyÀORV Leucocitose
UHVXOWDQGRHPDXPHQWRGHVVHWLSRFHOXODUQRVDQJXHSHULIpULFR1DVLQIHFo}HVYLUDLVSRGHRFRUUHUWDQWR
DXPHQWRFRPRUHGXomRQRQ~PHURGHOLQIyFLWRVQRVDQJXHSHULIpULFR /HXFRFLWRVHpRDXPHQWRQRQ~PHURGHOHXFyFLWRVSRUYROXPHGHVDQJXHFLUFXODQWHePDLVFRPXPTXH
DFRQWHoDXPDOHXFRFLWRVHGHYLGRDXPDOLQIRFLWRVH DXPHQWRGRVOLQIyFLWRV RXQHXWURÀOLD DXPHQWRGRV
QHXWUyÀORV SRLVHVVHVVmRRVOHXFyFLWRVPDLVQXPHURVRVHPWRGDVDVHVSpFLHVGRPpVWLFDV(QWUHWDQWR
SRGH KDYHU OHXFRFLWRVH SRU HRVLQRÀOLD DXPHQWR GRV HRVLQyÀORV RX PDLV UDUDPHQWH SRU PRQRFLWRVH
DXPHQWRGRVPRQyFLWRV 3RUVHUHPFpOXODVUDUDVQRVDQJXHSHULIpULFRRDXPHQWRQDVFRQWDJHQVGH
EDVyÀORV EDVRÀOLD pLQFRPXP

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
58 59
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

$OHXFRFLWRVHSRGHVHUSDWROyJLFDRXÀVLROyJLFD$OHXFRFLWRVHSDWROyJLFDRFRUUHHPUHVSRVWDDGRHQoDV YHQHQRV(PSDFLHQWHVFRPDQHPLDVKHPRUUiJLFDVRXKHPROtWLFDVSRGHVHREVHUYDUXPDOHYHQHXWURÀOLD
LQIHFFLRVDV LQÁDPDWyULDV DXWRLPXQHV SDUDVLWiULDV DOpUJLFDV RX QHRSOiVLFDV 1HVVDV VLWXDo}HV D SRU HVWtPXORV LQHVSHFtÀFRV VREUH RV SUHFXUVRUHV GH OHXFyFLWRV QD PHGXOD yVVHD 2 SyVRSHUDWyULR D
PHGXODyVVHDpHVWLPXODGDDSURGX]LUFpOXODVGHGHIHVD OHXFyFLWRV TXHVmRHQYLDGDVSDUDRVDQJXHH HQGRWR[HPLDDXUHPLDHDVOHXFHPLDVVmRVLWXDo}HVTXHSRGHPFDXVDUQHXWURÀOLD
HPVHJXLGDPLJUDPSDUDRVWHFLGRVTXHVmRVHXVORFDLVGHDWXDomRQDGHIHVDRUJkQLFD
Desvio à esquerda
(PVLWXDo}HVGHHVWUHVVHDJXGR PHGLDGRSRUDGUHQDOLQD RXFU{QLFR DXPHQWRGRFRUWLVRO SRGHRFRUUHU
OHXFRFLWRVHQRKHPRJUDPD$DGUHQDOLQDSURPRYHDGHVPDUJLQDomRGRVOHXFyFLWRVGRFRPSDUWLPHQWR $UHVSRVWDLQLFLDOGDPHGXODyVVHDDRVSURFHVVRVLQIHFFLRVRVRXLQÁDPDWyULRVpRDXPHQWRQDSURGXomR
PDUJLQDOSDUDRFRPSDUWLPHQWRFLUFXODQWHUHVXOWDQGRHPOHXFRFLWRVHQHXWURÀOLDRXOLQIRFLWRVH(PIHOLQRV GHOHXFyFLWRVSULQFLSDOPHQWHQHXWUyÀORVSRLVVmRDVFpOXODVUHTXHULGDVSDUDGHIHVDRUJkQLFDQHVVDV
domésticos o efeito do estresse, por exemplo, no momento da coleta, pode resultar em leucocitose mais VLWXDo}HV 2 WHUPR GHVYLR j HVTXHUGD WDPEpP GHQRPLQDGR GH GHVYLR PDWXUDWLYR RX GHVYLR QXFOHDU
PDUFDQWHSRLVDUHODomRHQWUHRQ~PHURGHOHXFyFLWRVQRVFRPSDUWLPHQWRVPDUJLQDOHFLUFXODQWHpGH GHQHXWUyÀORVjHVTXHUGD '11( RFRUUHTXDQGRKiDXPHQWRQRQ~PHURGHQHXWUyÀORVHPEDVWmR RX
(PJDWRVWDPEpPpIUHTXHQWHDOLQIRFLWRVHFRPRUHVSRVWDDHVWUHVVHDJXGR SUHFXUVRUHVPDLVMRYHQVFRPRPHWDPLHOyFLWRVHPLHOyFLWRV QRKHPRJUDPD
2 DXPHQWR GRV QtYHLV GH FRUWLFRLGHV HQGyJHQRV H H[yJHQRV SRGH UHVXOWDU HP OHXFRFLWRVH QHXWURÀOLD (VVHWHUPRIRLFULDGRSRU9LWRU6FKLOOLQJTXHHVWDEHOHFHXXPGLDJUDPDGHPDWXUDomRGRVQHXWUyÀORV
PDGXUD VHP FpOXODV LPDWXUDV  HRVLQRSHQLD H OLQIRSHQLD FDUDFWHUL]DQGR R FKDPDGR KHPRJUDPD GH RQGHDVFpOXODVLPDWXUDVORFDOL]DPVHjHVTXHUGDGRGLDJUDPD )LJXUD 2VDQJXHSHULIpULFRFRQWpP
HVWUHVVH 2V FRUWLFRLGHV UHGX]HP D GLDSHGHVH SDVVDJHP GRV OHXFyFLWRV GR VDQJXH SDUD RV WHFLGRV  XPQ~PHURUHGX]LGRGHQHXWUyÀORVLPDWXURV EDVW}HV $OLEHUDomRDXPHQWDGDGHVVDVFpOXODVLPDWXUDV
ID]HQGRFRPTXHDXPHQWHRQ~PHURGHVVDVFpOXODVQRVDQJXHSHULIpULFR$OpPGLVVRRFRUWLVROWDPEpP GDPHGXODyVVHDFDUDFWHUL]DR'11(HRFRUUHTXDQGRDXPHQWDDGHPDQGDGHQHXWUyÀORVSDUDRVWHFLGRV
FDXVDOLQIyOLVHHGLPLQXLDUHFLUFXODomRGRVOLQIyFLWRVUHVXOWDQGRHPOLQIRSHQLD2XWURDFKDGRFRPXPQR RXHPFDVRVGHOHXFHPLDVDJXGDVRXFU{QLFDV
KHPRJUDPDGHHVWUHVVHpDHRVLQRSHQLDHHPFmHVpIUHTXHQWHDRFRUUrQFLDGHPRQRFLWRVH
2GHVYLRjHVTXHUGDUHDFLRQDODRSURFHVVRLQIHFFLRVRRXLQÁDPDWyULRpHVFDORQDGRRXVHMDDSURSRUomR
Leucopenia GHFpOXODVPDGXUDVpPDLRUTXHDVFpOXODVMRYHQVUHÁHWLQGRDKLHUDUTXLDQRUPDOTXHRFRUUHQDSURGXomR
GRVQHXWUyÀORV1RHQWDQWRRGHVYLRjHVTXHUGDSRGHVHUFODVVLÀFDGRFRPRUHJHQHUDWLYRRXGHJHQHUDWLYR
$OHXFRSHQLDpDUHGXomRGRQ~PHURGHOHXFyFLWRVQRVDQJXHHRFRUUHIUHTXHQWHPHQWHSRUQHXWURSHQLD
RXOLQIRSHQLD$OHXFRSHQLDpXPDDOWHUDomRKHPDWROyJLFDIUHTXHQWHHLQGLFDTXHDVGHIHVDVRUJkQLFDV
HVWmRGLPLQXtGDVRXTXHDPHGXODyVVHDSRGHHVWDUFRPVXDDWLYLGDGHVXSULPLGD
$V OHXFRSHQLDV SRGHP WHU YiULDV FDXVDV GHQWUH DV TXDLV VH GHVWDFDP DV RFDVLRQDGDV SRU DJHQWHV
TXtPLFRV PHGLFDPHQWRV VXEVWkQFLDV PLHORWy[LFDV  ItVLFRV UDGLDo}HV  RX LQIHFFLRVRV 3RGH WDPEpP
UHVXOWDUHPOHXFRSHQLDDSURGXomRLQHÀFD]QDPHGXODyVVHDFDXVDGDSRUGRHQoDVLPXQRPHGLDGDV(P
GRHQoDVQHRSOiVLFDVFRPPHWiVWDVHQDPHGXODyVVHDRWHFLGRKHPDWRSRLpWLFRpVXEVWLWXtGRSRUFpOXODV
neoplásicas podendo resultar em leucopenia, anemia e trombocitopenia.
3RGHVHUREVHUYDGRQRKHPRJUDPDDOHXFRSHQLDDQHXWURSHQLDHDOLQIRSHQLDHPGRHQoDVYLUDLVFRPR
H[HPSORFLQRPRVHSDUYRYLURVHOHXFHPLDIHOLQDGHQWUHRXWUDV(PLQIHFo}HVEDFWHULDQDVVHYHUDVFRPR
nas septicemias, é frequente a ocorrência de leucopenia associada à neutropenia e outras citopenias.

1HXWURÀOLD
Figura 18 'LJUDPDGH6FKLOOLQJ'HPRQVWUDQGRR1HXWUyÀORPDGXUR VHJPHQWDGR DVFpOXODVLPDWXUDV
$QHXWURÀOLDpRDXPHQWRGHQHXWUyÀORVQRVDQJXHSHULIpULFR2FRUUHGHYLGRDRDXPHQWRGDSURGXomRRX ORFDOL]DGDVjHVTXHUGDGRGLDJUDPDHDFpOXODYHOKD KLSHUVHJPHQWDGD jGLUHLWDGRGLDJUDPD
OLEHUDomRGDPHGXODyVVHDHPGHFRUUrQFLDGHHVWUHVVH DXPHQWRGRVFRUWLFRVWHURLGHVRXDGUHQDOLQD RX
HPUHVSRVWDjLQÁDPDomRRXLQIHFomRPRGHUDGDDJUDYH
Desvio à esquerda regenerativo
6mR FDXVDV GH QHXWURÀOLD D H[FLWDomR R PHGR RV H[HUFtFLRV DV FRQYXOV}HV D JHVWDomR H R SDUWR $
HOHYDomRQDVFRQFHQWUDo}HVGHFRUWLFRVWHURLGHVHQGyJHQRVRXH[yJHQRVSRGHFDXVDUQHXWURÀOLD1HVVDV
eFDUDFWHUL]DGRSHODSUHVHQoDGHEDVWRQHWHVHRXWUDVFpOXODVMRYHQVQRVDQJXHSHULIpULFRVHPDSHUGD
VLWXDo}HVDQHXWURÀOLDpGLWDPDGXUDSRLVRFRUUHHOHYDomRGRVQHXWUyÀORVVHJPHQWDGRVQmRKDYHQGR
GDUHODomRGHSURGXomRRXVHMDRDXPHQWRGHQHXWUyÀORVYHPDFRPSDQKDGRGHHVWtPXORHOLEHUDomRGH
DXPHQWRGRQXPHURGHQHXWUyÀORVLPDWXURV QHXWUyÀORVHPEDVWmR 
FpOXODVMRYHQV2Q~PHURGHQHXWUyÀORVLPDWXURV EDVW}HV HQFRQWUDVHDEDL[RGRQ~PHURGHQHXWUyÀORV
3URFHVVRVLQÁDPDWyULRV ORFDLVRXJHQHUDOL]DGRV IUHTXHQWHPHQWHUHVXOWDPHPQHXWURÀOLD1HVVHVFDVRV PDGXURV VHJPHQWDGRV  LQGLFDQGR XPD ERD UHVSRVWD GR RUJDQLVPR DOpP GH PRVWUDU WDPEpP TXH
D QHXWURÀOLD p DFRPSDQKDGD GH HOHYDomR QR QXPHUR GH QHXWUyÀORV LPDWXURV EDVW}HV  VHQGR HVVD D PHGXOD yVVHD WHP WHPSR VXÀFLHQWH  GLDV  SDUD UHVSRQGHU j GHPDQGD H QHFHVVLGDGH WHFLGXDO
VLWXDomRGHQRPLQDGDGHVYLRGHQHXWUyÀORVjHVTXHUGD DXPHQWDGDGHQHXWUyÀORV

2XWUDVFDXVDVGHDXPHQWRQRQ~PHURGHQHXWUyÀORVVmRLQWR[LFDo}HVSRUFKXPERPHUF~ULRDGUHQDOLQDH

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Desvio à esquerda degenerativo SURPRYHQGRDPDUJLQDomRRXVHTXHVWURGHHRVLQyÀORVQRVWHFLGRVDOpPGHLQLELomRGDOLEHUDomRGHVVDV


FpOXODVSHODGDPHGXODyVVHD3RGHRFRUUHUDLQGDQDIDVHDJXGDGDLQÁDPDomRQRHVWUHVVHHPRFLRQDO
eFDUDFWHUL]DGRTXDQGRRQ~PHURGHFpOXODVMRYHQVVXSHUDRQ~PHURGHVHJPHQWDGRVRXTXDQGRRFRUUH no parto e na atividade física intensa.
SHUGDGDSURSRUomRPDWXUDWLYD PLHOyFLWRV²PHWDPLHOyFLWRV²EDVWRQHWHV²VHJPHQWDGRV LQGLFDQGR
TXH D PHGXOD yVVHD HVWi HVJRWDGD QD VXD UHVHUYD GH QHXWUyÀORV PDGXURV VHJPHQWDGRV  OLEHUDQGR Linfocitose
células imaturas.
/LQIRFLWRVHpRDXPHQWRDEVROXWRQRQ~PHURGHOLQIyFLWRVQRVDQJXH$VSULQFLSDLVFDXVDVGHOLQIRFLWRVH
1RVERYLQRVRGHVYLRjHVTXHUGDGHJHQHUDWLYRpFRPXPGXUDQWHRHVWiJLRLQLFLDOGHGRHQoDVLQIHFFLRVDV VmRGHVFULWDVFRPRÀVLROyJLFDVHPTXHVHREVHUYDXPDUHVSRVWDjHSLQHIULQDSDUWLFXODUPHQWHHPJDWRV
RXLQÁDPDWyULDVKLSHUDJXGDVDDJXGDVGHYLGRDSUHVHQWDUHPXPFRPSDUWLPHQWRGHUHVHUYDGDPHGXOD H FDYDORV H HP DQLPDLV MRYHQV UHVXOWDQGR HP XPD OLQIRFLWRVH WUDQVLWyULD 2FRUUH OLQIRFLWRVH WDPEpP
yVVHDFRPVXSULPHQWROLPLWDGRGHQHXWUyÀORVPDGXURV/RJRQmRpFRQVLGHUDGRXPSURJQyVWLFRUXLP DSyVDVYDFLQDo}HVFRPREVHUYDomRGHLPXQyFLWRVQDVGRHQoDVLQIHFFLRVDVGHQDWXUH]DFU{QLFDHP
DQmRVHUTXHHVWHWHQKDSHUVLVWLGRSRUYiULRVGLDV(PRXWUDVHVSpFLHVRSURJQyVWLFRpGHVIDYRUiYHOH FDVRVGHPHGRHDQVLHGDGHHPIHOLQRVQDIDVHFU{QLFDGDLQÁDPDomRHPSURWR]RRQRVHVHPIDVHGH
UHTXHUDWHQomRHWUDWDPHQWRULJRURVR FRQYDOHVFHQoDHPFDVRVGHOLQIRPDHOHXFHPLDOLQIRFtWLFD
Desvio à direita 2VDQLPDLVMRYHQVPHQRUHVGHVHLVPHVHVSRGHPWHUDFRQWDJHPGHOLQIyFLWRVPDLVHOHYDGDGRTXHRV
DGXOWRV(DSHVDUGHUDUDTXDOTXHUHVWLPXODomRDQWLJrQLFDSRGHUHVXOWDUHPOLQIRFLWRVHFRPRHPFDVRV
eFDUDFWHUL]DGRSHODREVHUYDomRGHQHXWUyÀORVKLSHUVHJPHQWDGRV FRPPDLVGHOyEXORV HPTXDQWLGDGH GHDJHQWHVLQIHFFLRVRVHLQÁDPDomRFU{QLFD (KUOLFKLDFDQLVH9tUXVGD/HXFHPLD%RYLQD 
DXPHQWDGDQRVDQJXHSHULIpULFR,QGLFDTXHDGLDSHGHVHGRVQHXWUyÀORVSRGHHVWDUGLPLQXtGDHHVVDV
FpOXODV HVWmR HQYHOKHFHQGR QD FRUUHQWH VDQJXtQHD 3RGH VHU REVHUYDGR XP DXPHQWR GR Q~PHUR GH Linfopenia
QHXWUyÀORVKLSHUVHJPHQWDGRVHPSDFLHQWHVPHGLFDGRVFRPFRUWLFRLGHVRXFRPVtQGURPHGH&XVKLQJ$
GHÀFLrQFLDGHYLWDPLQD%SRGHOHYDUDKLSHUVHJPHQWDomR&RPDUHVROXomRGRSURFHVVRLQÁDPDWyULR $OLQIRSHQLDpFDUDFWHUL]DGDSHODGLPLQXLomRGRQ~PHURGHOLQIyFLWRVQRVDQJXH$VSULQFLSDLVFDXVDV
RXLQIHFFLRVRDGLDSHGHVHHVWiUHGX]LGDHSRGHPVHUREVHUYDGRVHVVHVQHXWUyÀORVQRVDQJXHSHULIpULFR GH OLQIRSHQLD LQFOXHP DGPLQLVWUDomR GH FRUWLFRVWHURLGHV IDVH DJXGD GDV LQIHFo}HV YLUDLV SURFHVVRV
LQIHFFLRVRVJUDYHV HQGRWR[HPLDVHSWLFHPLDLQtFLRGHYLURVHV GURJDVLPXQRVVXSUHVVRUDVRXUDGLDomRH
Neutropenia SHUGDGHOtTXLGRVULFRVHPOLQIyFLWRV HIXVmRTXLORVD 
eFDUDFWHUL]DGDSHODGLPLQXLomRGRQ~PHURGHQHXWUyÀORVQRVDQJXH$QHXWURSHQLDSRGHVHUUHVXOWDGR 2 OHXFRJUDPD GH HVWUHVVH RFRUUH GHYLGR DRV FRUWLFRVWHURLGHV HQGyJHQRV H H[yJHQRV VHQGR D FDXVD
GHXPDJUDYHLQIHFomRHPSHTXHQRVDQLPDLV FmHVHJDWRV 6mRFDXVDVGHQHXWURSHQLDVHSWLFHPLDSRU PDLVFRPXPGHOLQIRSHQLD$LQIHFomRDJXGDSRGHVHUPHGLDGDSRUFRUWLFRVWHURLGHVRXHPFRQVHTXrQFLD
DJHQWHVEDFWHULDQRVJUDPQHJDWLYRVLQIHFo}HVSXOPRQDUHVWRUiFLFDVSHULWRQHDLVLQWHVWLQDLVHXWHULQDV D XPD LQIHFomR OHYDQGR D XPD GLPLQXLomR QD SURGXomR GH OLQIyFLWRV DXPHQWR GD PDUJLQDOL]DomR H
7RGDVHVVDVFDXVDVSRGHPOHYDUDXPDQHXWURSHQLDHDLQGDSRGHPVHUDJUDYDGDVSRUHQGRWR[HPLD PLJUDomRSDUDRVWHFLGRV$SHUGDGHOLQIyFLWRVRFRUUHGHYLGRDSHUGDGHHIXV}HVULFRVHPOLQIyFLWRVRX
$QHXWURSHQLDSRGHRFRUUHUHPFDVRVGHLQÁDPDomRSXUXOHQWDDJXGDHGRHQoDVDXWRLPXQHV3RGHP SHUGDGHOLQIDJHUDOPHQWHDSDUWLUGRWUDWRJUDVWURLQWHVWLQDO OLQIDQJHFWDVLD 
UHVXOWDUHPQHXWURSHQLDDUHDOL]DomRGHTXLPLRWHUDSLDLQWR[LFDomRSRUHVWUyJHQRKHPDWRSRLHVHFtFOLFD Monocitose
FDQLQD &ROOLHVFLQ]DV HUOLFKLRVHUDGLDomRGRHQoDVYLUDLVHPLHORSWLVH2DXPHQWRGDJUDQXORSRLHVH
LQHÀFD] HP FDVRV GH )H/9 9tUXV GD /HXFHPLD )HOLQD  PLHORSWLVH H VtQGURPHV PLHORGLVSOiVLFDV SRGH ,QGLFDRDXPHQWRGRQ~PHURGHPRQyFLWRVQRVDQJXH$VSULQFLSDLVFDXVDVLQFOXHPIDVHGHUHFXSHUDomR
resultar em neutropenia. GDVLQÁDPDo}HVHIHLWRHVWHURLGHV QRFmR GHVQXWULomRFDTXH[LDLQÁDPDo}HVFU{QLFDVLQHVSHFtÀFDV
leucemia monocítica, necrose tecidual e doenças causadas por protozoários.
(RVLQRÀOLD
$ UHVSRVWD DR HVWUHVVH SRGH FDXVDU XPD PRQRFLWRVH SDUWLFXODUPHQWH HP FmHV 1DV LQÁDPDo}HV
(RVLQRÀOLDpRDXPHQWRGRQ~PHURDEVROXWRGHHRVLQyÀORVQRVDQJXH2VWHFLGRVFRPPDLRUQ~PHURGH LQIHFFLRVDVRXQmRLQIHFFLRVDVDJXGDVRXFU{QLFDVWDPEpPVmRFRPXQV$SHVDUGHUDURpLPSRUWDQWH
HRVLQyÀORVUHTXHUHPXPDPDLRUYLJLOkQFLDSRLVDSUHVHQWDPFRQWDWRFRPRPHLRH[WHUQR SHOHSXOP}HV REVHUYDU TXH QD UHFXSHUDomR GH OHVmR DJXGD GD PHGXOD yVVHD VHFXQGiULD D H[SRVLomR D DJHQWHV
HDSDUHOKRJDVWURLQWHVWLQDO  quimioterapêuticos, a monocitose pode estar bastante aumentada e imitar uma leucemia. A resposta
paraneoplásica, em casos de linfoma pode induzir uma monocitose através de secreção de citocinas,
$ HRVLQRÀOLD SRGH RFRUUHU HP FDVRV GH SDUDVLWLVPR YHUPHV SXOPRQDUHV H JDVWULQWHVWLQDLV GLURÀOiULD porém, também é incomum.
GHPRGLFRVHHHFWRSDUDVLWLVPR KLSHUVHQVLELOLGDGH SQHXPRQLDHRVLQRItOLFDDOHUJLDDSLFDGDGHSXOJD
DWRSLD KLSHUVHQVLELOLGDGH DOLPHQWDU  JUDQXORPD HRVLQRItOLFR IHOLQR H JDVWURHQWHULWHV HRVLQRItOLFDV Monocitopenia
([LVWHPUHODWRVGHHRVLQRÀOLDHPIHOLQRVFRPLQIHFo}HVSRUHVWDÀORFRFRVHHVWUHSWRFRFRV1HRSODVLDV
OHXFHPLDHRVLQRItOLFDHDOJXQVWXPRUHVVyOLGRVSRGHPUHVXOWDUHPHRVLQRÀOLD $PRQRFLWRSHQLDpDGLPLQXLomRGHPRQyFLWRVQRVDQJXH2VLQWHUYDORVGHUHIHUrQFLDSRGHPEDL[DUj
]HURQmRDSUHVHQWDQGRVLJQLÀFDGRFOtQLFR
Eosinopenia
%DVRÀOLD
(RVLQRSHQLD p D GLPLQXLomR QD FRQWDJHP DEVROXWD GR Q~PHUR HRVLQyÀORV QR VDQJXH e GLItFLO UHODWDU
XPDHRVLQRSHQLDSRLVDOJXQVLQWHUYDORVGHUHIHUHQFLDSRGHPWHUR]HURFRPRYDORUPtQLPR3RUpPD e FDUDFWHUL]DGR SHOR DXPHQWR GR Q~PHUR DEVROXWR GH EDVyÀORV QR VDQJXH VHQGR XP DFKDGR UDUR H
HRVLQRSHQLDSRGHRFRUUHHPFRQVHTXrQFLDGHUHVSRVWDDRVJOLFRFRUWLFRLGHV OHXFRJUDPDGHHVWUHVVH  TXHRFRUUHQRUPDOPHQWHHPDVVRFLDomRFRPDHRVLQRÀOLD2VEDVyÀORVQmRDVVRFLDGRVDRVHRVLQyÀORV

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

SRGHPVHUREVHUYDGRVQDGRHQoDPLHORSUROLIHUDWLYDFU{QLFD OHXFHPLDPLHORLGHFU{QLFDHWURPERFLWHPLD 6.4 Alterações morfológicas nos leucócitos


HVVHQFLDOWDPEpPFKDPDGDGHOHXFHPLDFU{QLFDGHSODTXHWDVHOHXFHPLDEDVRItOLFDTXHWDPEpPWHP
VLGRUHODWDGDHPDQLPDLV 3RGHRFRUUHEDVRÀOLDHPFDVRVGHGLURÀOiULDOLSHPLDHWXEHUFXORVH
Linfócitos reativos, linfócitos atípicos ou imunócitos
Basopenia
$SUHVHQoDGHOLQIyFLWRVUHDWLYRVQRVDQJXHJHUDOPHQWHHVWiDVVRFLDGDDXPDUHVSRVWDLPXQLWiULDGR
1mRWHPUHOHYkQFLDGHYLGRjPDLRULDGRVDQLPDLVVDXGiYHLVQmRDSUHVHQWDUHPEDVyÀORVHRLQWHUYDORGH RUJDQLVPRHSRGHVHUREVHUYDGDHPTXDOTXHUDQLPDOSULQFLSDOPHQWHHPDQLPDLVPDLVMRYHQVUHFpP
UHIHUrQFLDJHUDOPHQWHp]HUR1mRWHPVLJQLÀFDGRFOtQLFR YDFLQDGRV RX HP FRQYDOHVFrQFLD GH GRHQoDV YLUDLV 2V OLQIyFLWRV UHDWLYRV DSUHVHQWDP R WDPDQKR
YDULDGRFLWRSODVPDPDLVEDVRItOLFR D]XODGR SRGHQGRDSUHVHQWDUDOJXQVYDF~RORVQ~FOHRSOHRPyUÀFR
H DJUHJDGRV GH FURPDWLQD  $SUHVHQWDP XPD iUHD HVEUDQTXLoDGD SHULQXFOHDU TXH FRUUHVSRQGH DR
FRPSOH[RGHJROJLeLPSRUWDQWHTXHVHGLIHUHQFLHRVOLQIyFLWRVUHDWLYRVJUDQGHVGRVEODVWRVTXHHVWmR
DVVRFLDGRVjVOHXFHPLDVSRUPHLRGHH[DPHVPDLVHVSHFtÀFRVHFLWRORJLDHPFRQMXQWRFRPRKLVWyULFR
GRDQLPDODFKDGRVFOtQLFRVDOpPGDDQiOLVHFRPSOHWDGRKHPRJUDPD )LJXUD 
Linfócitos granulares
IMPORTANTE SABER
$SUHVHQWDP SHTXHQRV JUkQXORV YHUPHOKRV HP XPD iUHD GR FLWRSODVPD JHUDOPHQWH HVVHV JUkQXORV
Leucemia:eXPDQHRSODVLDTXHHQYROYHFpOXODVKHPDWRSRLpWLFDVGRVDQJXH
ÀFDPGHQWURGHXPDUHHQWUkQFLDGRQ~FOHR2VOLQIyFLWRVJUDQXODUHVVmRSURYDYHOPHQWHDVFpOXODV7
RX GD PHGXOD yVVHD FRP SUROLIHUDomR FORQDO DQRUPDO $ OHXFHPLD SRGH
FLWRWy[LFDVRXFpOXODV1.HVHHQFRQWUDPHPSHTXHQDTXDQWLGDGH DGHWRGRVRVOLQIyFLWRV QR
VHUGHTXDOTXHUOLQKDJHPGHFpOXODVKHPDWRSRLpWLFDVLQFOXLQGRTXDOTXHU
VDQJXHGHDQLPDLVVDXGiYHLV2DXPHQWRQDTXDQWLGDGHGRVOLQIyFLWRVJUDQXODUHVQRVDQJXHSRGHVHU
FpOXOD PLHOyLGH PHJDFDULyFLWRV JUDQXOyFLWRV PRQyFLWRV H HULWUyFLWRV  RX
REVHUYDGRHPFRQGLo}HVUHDWLYDVFRPRHPLQIHFomRSRUEhrlichia canisGRHQoDUHQDOFU{QLFDHPFmHV
OLQIyLGH OLQIyFLWRV  $ OHXFHPLD SRGH VHU DJXGD RX FU{QLFD 1D OHXFHPLD
RXHPFDVRVGHOHXFHPLDVSULPiULDV OHXFHPLDGRVOLQIyFLWRVJUDQXODUHV 
DJXGDRFRUUHSUHGRPLQkQFLDGHEODVWRV FpOXODVLQGLIHUHQFLDGDV QDPHGXOD
yVVHD H VDQJXH SHULIpULFR $V OHXFHPLDV DJXGDV WrP XPD SURJUHVVmR Cromatina sexual
UiSLGD VHQGR QHFHVViULD D UHDOL]DomR GH H[DPHV HVSHFtÀFRV FRPR
LPXQRFLWRTXtPLFDHDFLWRPHWULDGHÁX[RSDUDDMXGDUQDGHWHUPLQDomRGD $OJXQVQHXWUyÀORVDSUHVHQWDPDFURPDWLQDVH[XDOTXHWDPEpPSRGHVHUFKDPDGDGH&RUS~VFXORGH%DDU
OLQKDJHPFHOXODUQHRSOiVLFD1DOHXFHPLDFU{QLFDRFRUUHSUHGRPLQkQFLDGH VHQGRXPSURORQJDPHQWRFDUDFWHUtVWLFRGRQ~FOHRGHRFRUUrQFLDQRUPDOHLPSRUWDQWHQDGLIHUHQFLDomR
células bem diferenciadas (semelhantes às células normais) e apresenta entre machos e fêmeas. A cromatina sexual é o cromossomo X inativo e condensado das células que
XPDSURJUHVVmROHQWDTXHSRGHGHPRUDUDQRVVHQGRD/HXFHPLDOLQIRFtWLFD constituem as fêmeas do sistema XY de determinação do sexo existente nos seres humanos, na maioria
FU{QLFDDPDLVFRPXP GRVRXWURVPDPtIHURVDOJXQVLQVHWRV Drosophila HDOJXPDVSODQWDV *LQNJR  )LJXUD²$ 
É importante destacar que a diferenciação em relação a aparência e as
FRQGLo}HVGDOHXFHPLDOLQIRLGHHOLQIRPDpPXLWDVYH]HVGLItFLOTXDQGRRFRUUH 1HXWUyÀORVKLSHUVHJPHQWDGRVRXSROLOREyFLWRV
LQÀOWUDomRGDPHGXODyVVHD1DIDVHFU{QLFDGROLQIRPDPHGXODUDVFpOXODV
QHRSOiVLFDV TXH LQYDGHP D FRUUHQWH VDQJXtQHD SRGHP VHU FRQIXQGLGDV 2V QHXWUyÀORV VmR FRQVLGHUDGRV KLSHUVHJPHQWDGRV TXDQGR DSUHVHQWDP PDLV GH FLQFR VHJPHQWRV
FRPFpOXODVGDOHXFHPLDOLQIyLGHDVVLPFRPRDVFpOXODVOHXFrPLFDVSRGHP nucleares. São células que estão na circulação há mais tempo do que o normal, ou seja, são consideradas
LQÀOWUDUROLQIRQRGRDSDUHQWDQGRXPOLQIRPD ´FpOXODVYHOKDVµ2XWUDFDXVDGDSUHVHQoDGHQHXWUyÀORVKLSHUVHJPHQWDGRVQDFLUFXODomRVHGHYHDDomR
GHFRUWLFyLGHV HQGyJHQRVRXH[yJHQRV TXHSUHMXGLFDPDGLDSHGHVHGHVVDVFpOXODVRTXHH[SOLFDR
Reação leucemóide: $V UHDo}HV OHXFHPyLGHV SRGHP VHU FRQIXQGLGDV HQYHOKHFLPHQWRGRVPHVPRVQDFRUUHQWHVDQJXtQHD
FRP D OHXFHPLD SRUpP VmR UHDo}HV KHPDWROyJLFDV JHUDOPHQWH XPD $ SUHVHQoD GH QHXWUyÀORV KLSHUVHJPHQWDGRV TXDQGR DVVRFLDGD D OHXFRFLWRVH LQGLFD DXPHQWR QD
leucocitose reativa, que ocorrem devido à presença de determinadas SURGXomR GH FRUWLFyLGHV HQGyJHQRV H[ VtQGURPH GH &XVKLQJ RX HVWUHVVH FU{QLFR  RX DGPLQLVWUDomR
HQIHUPLGDGHV H TXH PHOKRUDP TXDQGR VmR WUDWDGDV 2FRUUH JHUDOPHQWH GH FRUWLFRLGH H[yJHQR 4XDQGR D REVHUYDomR GHVVDV FpOXODV QmR HVWi DVVRFLDGD j OHXFRFLWRVH RX VH
XPDDOWDFRQWDJHPGHOHXFyFLWRVFRPFRQWDJHPDEVROXWDGHGHWHUPLQDGR DSUHVHQWDDVVRFLDGDDXPDOHXFRSHQLDSRGHFDUDFWHUL]DUXPHVJRWDPHQWRGDPHGXODyVVHD$SUHVHQoD
OHXFyFLWRRXSUHVHQoDDFHQWXDGDGHGHVYLRDHVTXHUGDDTXDOVXJHUHXPD GH QHXWUyÀORV KLSHUVHJPHQWDGRV p WDPEpP REVHUYDGD QD DQHPLD PHJDOREOiVWLFD SRU GHÀFLrQFLD GH
OHXFHPLDJUDQXORFtWLFD3RGHPRFRUUHUWDPEpPRFDVLRQDOPHQWHFRPRXWURV 9LWDPLQD% )LJXUD²%& 
OHXFyFLWRV FRPR RV OLQIyFLWRV H RV HRVLQyÀORV 7HPVH FRPR H[HPSOR GH
doenças que causam uma reação leucêmica a piometra e a peritonite com
GHVYLRDHVTXHUGDUHJHQHUDWLYR

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

1HXWUyÀORVKLSRVHJPHQWDGRV

6mR QHXWUyÀORV TXH QmR VRIUHP D VHJPHQWDomR QXFOHDU FDUDFWHUtVWLFD GDV FpOXODV PDGXUDV 6mR
REVHUYDGRV HP XPD GRHQoD KHUHGLWiULD UDUD GHQRPLQDGD 3HOJHU+HW Mi GHVFULWD HP FmHV JDWRV
FRHOKRVHHTXLQRV$SHVDUGDDOWHUDomRPRUIROyJLFDDVFpOXODVDSUHVHQWDPVXDVIXQo}HVLQDOWHUDGDV
QmRKDYHQGRUHSHUFXVV}HVFOtQLFDVSDUDRSDFLHQWH1mRKiQHQKXPDHYLGrQFLDTXHLQGLTXHDXPHQWRGD
VXVFHSWLELOLGDGHDLQIHFo}HVRXLPXQRGHÀFLrQFLDHPSRUWDGRUHVGDDQRPDOLDGH3HOJHU+XHWW
*HUDOPHQWH R GLDJQyVWLFR p LQFLGHQWDO H LPSRUWDQWH SDUD HYLWDU VXD LQWHUSUHWDomR FRPR XP GHVYLR j
HVTXHUGD$KLSRVHJPHQWDomRWDPEpPSRGHVHUREVHUYDGDHPHRVLQyÀORVHEDVyÀORV3RGHRFRUUHSVHXGR
3HOJHU+HWVHQGRHVVDDOWHUDomRFDXVDGDSRUUHDo}HVDGURJDVHHPDOJXQVFDVRVGHPLHORGLVSODVLDV
1HXWUyÀORVWy[LFRVRXQHXWUyÀORVFRPJUDQXODo}HVWy[LFDV

$REVHUYDomRGHJUDQXODo}HVWy[LFDVpVXJHVWLYDGHDXPHQWRGDSURGXomRHDWLYDomRGRVQHXWUyÀORV1D
SURGXomRQRUPDOGHQHXWUyÀORVDVFpOXODVPDGXUDV VHJPHQWDGDV DSUHVHQWDPJUDQXODo}HVVHFXQGiULDV
TXHQmRVHFRUDP$VJUDQXODo}HVWy[LFDVLQGLFDPJUDQXORSRLHVHPXLWRDWLYDHTXHHVWmRVHQGRHQYLDGRV
SDUDFLUFXODomRQHXWUyÀORVVHJPHQWDGRVDLQGDFRPSHUVLVWrQFLDGRVJUkQXORVSULPiULRV(VVHVJUkQXORV
SULPiULRVVmRFRUDGRVFRPRVFRUDQWHVGDURWLQDKHPDWROyJLFDHÀFDPHYLGHQWHVQRFLWRSODVPD
Figura 19 /LQIyFLWRVUHDWLYRVA. B. C. D. 3UHVHQoDGHOLQIyFLWRVUHDWLYRVLGHQWLÀFDGRVSHODVÁHFKDVHP
2XWUD H[SOLFDomR SDUD HVVD DOWHUDomR PRUIROyJLFD GRV QHXWUyÀORV p TXH DV JUDQXODo}HV Wy[LFDV VmR OkPLQDVGHVDQJXHSHULIpULFRFDQLQR$XPHQWRFRPREMHWLYDGH[FRUDQWH3DQyWLFRUiSLGR
JUkQXORV DQRUPDLV UHVXOWDQWHV GD IDJRFLWRVH GH DJHQWHV Wy[LFRV FRPR EDFWpULDV RX SURWHtQDV VpULFDV
desnaturadas.
0RUIRORJLFDPHQWH HVVDV DOWHUDo}HV Wy[LFDV LQFOXHP EDVRÀOLD FLWRSODVPiWLFD DXPHQWDGD FRP
DSDUHFLPHQWRGRVJUkQXORVD]XUyÀORVRXYDFXROL]DomRQRFLWRSODVPD2FRUUHQXPDYDULHGDGHGHGRHQoDV
SULQFLSDOPHQWHHPGRHQoDVLQÁDPDWyULDVHLQIHFo}HVEDFWHULDQDVVLVWrPLFDV )LJXUD²'( 
Corpúsculo de Dohle

6mR FRQVLGHUDGDV SRU DOJXQV DXWRUHV FRPR D FRQGHQVDomR GH YiULRV JUkQXORV Wy[LFRV TXH IRUPDP
uma inclusão oval de coloração azul pálida localizada, quase sempre, na periferia do citoplasma. Outra
explicação é que os Corpúsculos de Dohle é que seriam remanescentes de ribossomas livres que
SHUVLVWHPQDVFpOXODVPDGXUDV6mRREVHUYDGRVQDVPHVPDVVLWXDo}HVTXHOHYDPDRDSDUHFLPHQWRGDV
JUDQXODo}HVWy[LFDV
Monócitos ativados

2VPRQyFLWRVDSUHVHQWDPYDF~RORVQRVHXLQWHULRUQRUPDOPHQWHDSDUHFHPHPDQLPDLVFRPRUHVSRVWD
à hemoparasitos.

Figura 20 $OWHUDo}HVUHODFLRQDGDVDRVQHXWUyÀORVLGHQWLÀFDGDVSHODVVHWDV&RUDQWH3DQyWLFRUiSLGR
A.&URPDWLQDVH[XDOHPQHXWUyÀORGHFmR REMHWLYDGH[ B. e C.1HXWUyÀORKLSHUVHJPHQWDGRGHFmR
(objetiva de 100x), D. e E.1HXWUyÀORVWy[LFRVRXQHXWUyÀORVFRPJUDQXODo}HVWy[LFDVGHFmR REMHWLYDGH
100x).

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

07 PLAQUETAS

1RVPDPtIHURVDVSODTXHWDVRXWURPEyFLWRVVmRIUDJPHQWRVFLWRSODVPiWLFRVGHULYDGRVGHXPDFpOXOD
HQFRQWUDGD QD PHGXOD yVVHD R PHJDFDULyFLWR )LJXUD  ² $  $ SULQFLSDO IXQomR GDV SODTXHWDV p D
IRUPDomR GH FRiJXORV SDUWLFLSDQGR GD KHPRVWDVLD SULPiULD LQWHUURPSHQGR PRPHQWDQHDPHQWH D
KHPRUUDJLDDQWHVGDHVWDELOL]DomRGRFRiJXOR2XWUDVIXQo}HVLPSRUWDQWHVVmRPDQWHUDLQWHJULGDGH
YDVFXODUPRGXODUDUHVSRVWDLQÁDPDWyULDHSURPRYHUDFLFDWUL]DomRGDVIHULGDVDSyVXPDOHVmRWHFLGXDO
(PUpSWHLVHDYHVRVWURPEyFLWRVVmRFpOXODVWtSLFDVSRVVXLQGRQ~FOHRHFLWRSODVPD1HVVDVHVSpFLHV
DOpPGHSDUWLFLSDUHPGRSURFHVVRKHPRVWiWLFRDVSODTXHWDVWDPEpPDSUHVHQWDPIXQomRIDJRFtWLFD

7.1 Trombocitopoese
1RVPDPtIHURVDVSODTXHWDVVmRRULJLQDGDVQDPHGXODyVVHDDSDUWLUGHXPDFpOXODWURQFR ´6WHP&HOOµ 
TXHVHGLIHUHQFLDHPXPSUHFXUVRUPLHOyLGHPXOWLSRWHQWH$FpOXODPXOWLSRWHQWHVHGLIHUHQFLDHP8QLGDGH
)RUPDGRUDGH([SORVmR0HJDFDULRFtWLFDVHJXLGDPHQWHHPPHJDFDULREODVWRLPDWXURSULPHLURSUHFXUVRU
plaquetário.
2 Q~FOHR GR PHJDFDULREODVWR VH GLYLGH VHP GLYLGLU R FLWRSODVPD IRUPDQGR R SUyPHJDFDULyFLWR TXH
DSUHVHQWDTXDWURQ~FOHRVVHJXLGDPHQWHGDIDVHGHDPDGXUHFLPHQWRHIRUPDomRGRPHJDFDULyFLWR2
FLWRSODVPDGRPHJDFDULyFLWRVHIUDJPHQWDIRUPDQGRDVSUySODTXHWDVTXHYmRGDURULJHPDVSODTXHWDV
&DGDPHJDFDULyFLWRRULJLQDHPPpGLDSODTXHWDV2VSULQFLSDLVIDWRUHVHVWLPXODQWHVGDSURGXomR
GH SODTXHWDV VmR IDWRU HVWLPXODQWH GH FRO{QLD PHJDFDULRFtWLFD IDWRU HVWLPXODQWH GD WURPERFLWRVH
WURPERSRLHWLQDHLQWHUOHXFLQD )LJXUD 

Figura 21 Trombocitopoiese. A célula tronco (“Stem Cell”) se diferencia em precursor mieloide


PXOWLSRWHQWH$FpOXODPXOWLSRWHQWHVHGLIHUHQFLDHP8QLGDGH)RUPDGRUDGH&RO{QLD 8)& 0HJDFDULRFtWLFD
HSRVWHULRUPHQWHHPPHJDFDULyFLWRLPDWXUR(PVHJXLGDIRUPDRPDJDFDULyFLWRPDGXURTXHGiRULJHP
as plaquetas.

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

7.2 Alterações numéricas das plaquetas 1R SODTXHWRJUDPD DOpP GDV LQIRUPDo}HV TXDQWLWDWLYDV GDV SODTXHWDV VmR GHVFULWDV DOWHUDo}HV
PRUIROyJLFDV WDLV FRPR SUHVHQoD GH SODTXHWDV JLJDQWHV RX DJUHJDGRV SODTXHWiULRV $ SUHVHQoD GH
SODTXHWDV JLJDQWHV p LQGLFDWLYD GH TXH D WURPERFLWRSRLHVH HVWi DWLYD )LJXUD  ² '  2V DJUHJDGRV
2 SODTXHWRJUDPD p D SDUWH GR KHPRJUDPD TXH TXDQWLÀFD H DYDOLD PRUIRORJLFDPHQWH DV SODTXHWDV
SODTXHWiULRVVmRTXDVHVHPSUHGHFRUUHQWHVGHHUURVSUpDQDOtWLFRVGXUDQWHDFROHWDGHVDQJXH )LJXUD
A FRQWDJHP WRWDO GH SODTXHWDV p H[SUHVVD HP Q~PHUR GH SODTXHWDV SRU OLWUR RX PLOLOLWUR GH VDQJXH
²%& 
A redução no número de plaquetas é tecnicamente denominada trombocitopenia (plaquetopenia),
enquanto o aumento é dito trombocitose (plaquetose).
$V WURPERFLWRSHQLDV VmR DOWHUDo}HV KHPDWROyJLFDV PXLWR FRPXQV QD YHWHULQiULD H SRGHP RFRUUHU SRU
redução na produção de plaquetas (trombocitopoiese), aumento da destruição ou consumo e por
sequestro ou perda de plaquetas.
2FRUUH UHGXomR QD WURPERFLWRSRLHVH HP VLWXDo}HV FRPR PLHORSWLVH LQÀOWUDomR GD PHGXOD yVVHD SRU
FpOXODVWXPRUDLV UDGLDo}HVHGHVWUXLomRLPXQRPHGLDGDGRVPHJDFDULyFLWRV1DLQVXÀFLrQFLDUHQDOSRGH
RFRUUHUWURERFLWRSHQLDSRLVWURPERSRLHWLQDpSURGX]LGDQRWHFLGRUHQDO$OJXPDVGURJDVSRGHPFDXVDU
UHGXomRQDSURGXomRGHSODTXHWDVFRPRH[HPSORIHQLOEXWD]RQDHVWUyJHQRVLQWpWLFRTXLPLRUHWiSLFRV
DQWLELyWLFRV
Doenças infecciosas também podem resultar em trombocitopenia por aumento do consumo ou destruição
das plaquetas. São exemplos de doenças que resultam em trombocitopenia erlichiose, babesiose,
peritonite infecciosa felina (PIV), panleucopenia felina, leptospirose, salmonelose etc. As plaquetas
também podem ser destruídas em doenças autoimunes como na anemia hemolítica autoimune.
2FRUUHDXPHQWRQRFRQVXPRGHSODTXHWDVHFRQVHTXHQWHWURPERFLWRSHQLDQDFRDJXODomRLQWUDYDVFXODU
disseminada (CID).
1DHVSOHQRPHJDOLD DXPHQWRGRWDPDQKRGREDoR SRGHRFRUUHUWRPERFLWRSHQLD2EDoRpXPyUJmR
LPSRUWDQWHQRDUPD]HQDPHQWRHGHVWUXLomRGHFpOXODVVDQJXtQHDV'HVVDIRUPDRDXPHQWRQRYROXPH
Figura 22 Plaquetas. A. 3UHVHQoD GH SODTXHWDV LGHQWLÀFDGDV SHODV VHWDV HP VDQJXH SHULIpULFR
RX IXQomR HVSOrQLFD SRGH UHVXOWDU HP FLWRSHQLDV UHGXomR QR Q~PHUR GH FpOXODV VDQJXtQHDV  FRPR
canino (aumento com objetiva de 100x), B. 3UHVHQoD GH DJUHJDGR SODTXHWiULR HP VDQJXH SHULIpULFR
trombocitopenias, anemia e leucopenias.
FDQLQR DXPHQWRFRPREMHWLYDGH[ LGHQWLÀFDGRSHODVHWDC. 3UHVHQoDGHDJUHJDGRVSODTXHWiULRV
3RGH RFRUUHU XPD IDOVD WURPERFLWRSHQLD HP VLWXDo}HV HP TXH RFRUUH JUDQGH Q~PHUR GH DJUHJDGRV HPVDQJXHSHULIpULFRFDQLQR DXPHQWRFRPREMHWLYDGH[ LGHQWLÀFDGRSHODVVHWDVD. Presença de
SODTXHWiULRVGLÀFXOWDQGRDFRQWDJHPJOREDOGHSODTXHWDV1HVVDVVLWXDo}HVRQ~PHURGHSODTXHWDVHVWi PDFURSODTXHWDVHPVDQJXHSHULIpULFRFDQLQRLGHQWLÀFDGDVSHODVVHWDVeREVHUYDGDWDPEpPKHPiFLDV
UHGX]LGRSRUpPEHPSUy[LPRGRLQWHUYDORGHUHIHUrQFLDLQIHULRU )LJXUD²%&  com hipocromia (aumento com objetiva de 100x).

$WURPERFLWRVHWDPEpPGHQRPLQDGDSODTXHWRVHpXPDDOWHUDomRKHPDWROyJLFDPHQRVIUHTXHQWHQD
YHWHULQiULD3RGHVHUFODVVLÀFDGDFRPRSULPiULDRXVHFXQGiULD UHDWLYD $WURPERFLWRVHSULPiULDFRQVLVWH
HPXPDGRHQoDKHPDWROyJLFDUDUDQDTXDORFRUUHSUROLIHUDomRQHRSOiVLFDGRVSUHFXUVRUHVSODTXHWiULRV
resultando em aumento no número de plaquetas.
$ WURPERFLWRVH VHFXQGiULD RX UHDWLYD RFRUUH SRU HVWLPXODomR GD PHGXOD yVVHD RX SRU UHGXomR GR IMPORTANTE SABER
´FOHDUDQFHµHVSOrQLFR1DVGRHQoDVLQÁDPDWyULDVJHUDOPHQWHRFRUUHDXPHQWRGRQ~PHURGHSODTXHWDV
SRLVDWURPERSRLHWLQDSRGHHVWDUHOHYDGDQHVWHVHVWDGRVFOtQLFRVFRPRSDUWHGDUHDomRGHIDVHDJXGD $ &RDJXODomR ,QWUDYDVFXODU 'LVVHPLQDGD &,'  p XP TXDGUR FOtQLFR TXH RFRUUH
1DV DQHPLDV UHJHQHUDWLYDV SRGH VHU REVHUYDGD WURPERFLWRVH SRU HVWtPXORV LQHVSHFtÀFRV VREUH RV VHFXQGiULRDGRHQoDVJUDYHVFRPRH[HPSORVHSWLFHPLDOHXFHPLDVOHSWRVSLURVH
precusores de plaquetas. EDEHVLRVH1HVVDVLWXDomRRFRUUHDWLYDomRFRQMXQWDGRPHFDQLVPRGDFRDJXODomRH
GDÀEULQyOLVHUHVXOWDQGRHPGLPLQXLomRGRQ~PHURGHSODTXHWDV WURPERFLWRSHQLD 
$OpP GDV DOWHUDo}HV QXPpULFDV SRGHP RFRUUHU DOWHUDo}HV IXQFLRQDLV GDV SODTXHWDV VHQGR HVWDV HIDWRUHVGDFRDJXODomR2FRUUHDXPHQWRGRVSURGXWRVGHULYDGRVGDÀEULQD 3')V 
GHQRPLQDGDV WURPERFLWRSDWLDV $V WURPERFLWRSDWLDV SRGHP VHU GHFRUUHQWHV GH DOWHUDo}HV IXQFLRQDLV
FRQJrQLWDV UDUDVQDYHWHULQiULD GHDomRGHDJHQWHVLQIHFFLRVRV HUOLFKLRVH RXGHYLGRDXWLOL]DomRGH
DOJXPDVGURJDVFRPRH[HPSORDVSLULQDLEXSURIHQRDFHWRPLQRIHQDQWLELyWLFRVEORTXHDGRUHVGRFDQDO
GHFiOFLRHWF$FLGHQWHVRItGLFRVXUHPLDGRHQoDKHSiWLFDQHRSODVLDVHDOJXPDVGRHQoDVLQIHFFLRVDV
(erlichia) também podem alterar a função plaquetária.

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Relacionadas à amostra
8WLOL]DURDQWLFRDJXODQWHFRUUHWRSDUDHVSpFLHDQLPDO )LJXUD 
8WLOL]DURDQWLFRDJXODQWHFRUUHWRSDUDRH[DPHDVHUUHDOL]DGR
5HVSHLWDUDFRUUHWDUHODomRDQWLFRDJXODQWHVDQJXH
(YLWDUJDUURWHSURORQJDGR
08 TÉCNICAS HEMATOLÓGICAS / AULAS PRÁTICAS
(YLWDUFDXVDVGHKHPyOLVHHOHXFyOLVH
,GHQWLÀFDUDDPRVWUDFRUUHWDPHQWH
5HPHWHURPDLVUiSLGRSRVVtYHOSDUDRODERUDWyULR
8.1 Roteiro de aula prática de coleta de amostras

Tema: Coleta de amostras de sangue

As etapas de coleta, armazenamento e remessa de amostras clínicas para exames laboratoriais são
GHJUDQGHLPSRUWkQFLDSDUDDVVHJXUDUTXHRVUHVXOWDGRVREWLGRVVHMDPGHPi[LPDFRQÀDELOLGDGHSDUD
SURSyVLWRVGLDJQyVWLFRV(PKHPDWRORJLDFRQVLGHUDVHTXHRKHPRJUDPDVHLQLFLDFRPDHWDSDGDFROHWD
HTXDOTXHUDOWHUDomRQHVVDIDVHSRGHLQÁXHQFLDUQHJDWLYDPHQWHRVUHVXOWDGRVGHVWHH[DPHUHVXOWDQGR
HPHUURVSUpDQDOtWLFRV3RUWDQWRRSURFHGLPHQWRGHFROHWDGHVDQJXHGHYHVHUUHDOL]DGRREHGHFHQGR
WRGDVDVUHFRPHQGDo}HVWpFQLFDVGHFXLGDGRVFRPRSDFLHQWHHFRPDDPRVWUD

Objetivos
5HDOL]DUFROHWDGHVDQJXHHPYiULDVHVSpFLHVDQLPDLV
,GHQWLÀFDomRHUHPHVVDGDDPRVWUD
&RQKHFHURVGLIHUHQWHVVLVWHPDVGHFROHWDGHVDQJXH
&RQKHFHURVGLIHUHQWHVWLSRVGHDQWLFRDJXODQWHVHVXDVLQGLFDo}HVGHXVR
Diferenciar plasma e soro.

Recomendações técnicas para coleta de sangue Figura 23 7XERVYDFXQWDLQHUVFRPGLIHUHQWHVVXEVWkQFLDVDQWLFRDJXODQWHVLGHQWLÀFDGDVSRUFRUHVGH


tampas padronizadas. Os tubos de tampa vermelha e amarela são utilizados para obtenção de soro e,
Relacionadas ao animal GHVVDIRUPDQmRDSUHVHQWDPVXEVWkQFLDDQWLFRDJXODQWH2VWXERVFRPWDPSDDPDUHODFRQWHPXPJHO
-HMXPGHKRUDV PRQRJiVWULFRV  VHSDUDGRUGHFRiJXOR
&ROHWDUVDQJXHGHDQLPDLVUHSRXVDGRVHWUDQTXLORV
'HSUHIHUrQFLDQmRXWLOL]DUWUDQTLOL]DQWHVVHGDWLYRVRXDQHVWpVLFRVJHUDLV HPDOJXPDVHVSp- Procedimentos de coleta
FLHVVLOYHVWUHVDVHGDomRpQHFHVViULD 
5HDOL]DUXPDFROHWDUiSLGDHSUHFLVD &RQWHURDQLPDOGHIRUPDDGHTXDGDHTXHIDFLOLWHRSURFHGLPHQWRGHFROHWD
Realizar a coleta no local adequado para cada espécie (Tabela 3). 5HDOL]DUDQWLVHSVLD iOFRROiOFRROLRGDGRRXLRGRSRYLGLQH 
4XDQGRQHFHVViULRUHDOL]DUWULFRWRPLD
Tabela 3 /RFDOLQGLFDGRSDUDFROHWDGHVDQJXHHPGLIHUHQWHVHVSpFLHVGHDQLPDLVGRPpVWLFRV )D]HURJDUURWHSUy[LPRDRORFDOGHLQWURGXomRGDDJXOKD
,QWURGX]LUDDJXOKD
Espécie Animal Local de coleta 'HVID]HURJDUURWHHFROKHURVDQJXHOHQWDPHQWH
Bovina 9HLDMXJXODUFDXGDORXPDPiULD 5HWLUDUDDJXOKDDSyVFRPSOHWDURYROXPHGHVHMDGR
Ovina e caprina 9HLDMXJXODU )D]HUDKHPRVWDVLD
(TLQD 9HLDMXJXODU 6HHVWLYHUXWLOL]DQGRVHULQJD5(7,5$5$$*8/+$DQWHVGHWUDQVIHULURVDQJXHSDUDRWXER
Canina e Felina 9HLDMXJXODUFHIiOLFDRXVDIHQD 7UDQVIHULUOHQWDPHQWHRVDQJXHSHODVSDUHGHVGRWXER
)HFKDURWXERHKRPRJHQHL]DUOHQWDPHQWHSRULQYHUVmR
Suína Veia cava anterior, seio venoso oftálmico
4XDQGRDDPRVWUDIRUFROHWDGDSDUDREWHQomRGHVRURVDQJXtQHRRSURFHGLPHQWRGHKRPRJH-
Aves Veia ulnar neização não deve ser realizado.

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

8.2 Roteiro de aula prática de esfregaço sanguíneo 3LQJDUXPDJRWDGHVDQJXHQDH[WUHPLGDGHGHXPDOkPLQDOLPSDFRPDDMXGDGHXPWXERFDS-


LODU )LJXUD 
Tema: Prática de esfregaço sanguíneo &RORFDUXPDOkPLQDH[WHQVRUDRXODPtQXODVREUHDOkPLQDDQWHVGDJRWDGHVDQJXHIRUPDQGR
2 HVIUHJDoR VDQJXtQHR RX H[WHQVmR VDQJXtQHD p REWLGR D SDUWLU GH XPD JRWD GH VDQJXH GLVWHQGLGD XPkQJXORGHž )LJXUD 
VREUH XPD OkPLQD GH PLFURVFRSLD 'HSRLV GH FRQIHFFLRQDGR R HVIUHJDoR p FRUDGR H SHUPLWH TXH RV 5HWRUQDUFXLGDGRVDPHQWHDH[WHQVRUDDWpWRFDUDJRWDGHVDQJXH$JRWDLUiVHHVSDOKDUSRU
GLIHUHQWHV WLSRV FHOXODUHV GR VDQJXH VHMDP REVHUYDGRV DR PLFURVFySLR 2V HVIUHJDoRV VmR XWLOL]DGRV WRGDDERUGDGDOkPLQDH[WHQVRUD )LJXUD 
QDLQYHVWLJDomRGHDOWHUDo}HVKHPDWROyJLFDVHGHWHFomRGHKHPRSDUDVLWDV1RKHPRJUDPDFRPSOHWRR 'HPDQHLUDSUHFLVDVHJXUDHFRQVWDQWHPRYHUDOkPLQDH[WHQVRUDDWpDH[WUHPLGDGHRSRVWDGD
HVIUHJDoRVDQJXtQHRpXWLOL]DGRSDUDID]HUDDYDOLDomRPRUIROyJLFDGDVFpOXODVVDQJXtQHDVHUHDOL]DUD RXWUDOkPLQD2HVIUHJDoRVDQJXtQHRGHYHFREULUWUrVTXDUWRVGDOkPLQD )LJXUD 
FRQWDJHPGLIHUHQFLDOGHOHXFyFLWRV 6HFDUDRDUOLYUH
&RUDUXWLOL]DQGRR.LWSDQyWLFRUiSLGR6HJXLUDVRULHQWDo}HVGRIDEULFDQWH
2HVIUHJDoRVDQJXtQHRpIRUPDGRSRUWUrViUHDV FRUSRPRQRFDPDGDHFDXGD $iUHDPDLVHVSHVVD
FKDPDGDGH´FDEHoDµQmRpXWLOL]DGDSDUDSHVTXLVDHDYDOLDomR$iUHDSDUDOHLWXUDGRHVIUHJDoRpDTXH
DVFpOXODVVHGLVWULEXHPHPPRQRFDPDGDeLPSRUWDQWHTXHVHFRQIHFFLRQHXPHVIUHJDoRGHTXDOLGDGH
SDUDUHDOL]DUXPDERDOHLWXUDHDYDOLDomRGRVDQJXHREWHQGRXPUHVXOWDGRFRQÀiYHO )LJXUD 

Figura 24 4XDOLGDGHGRHVIUHJDoRVDQJXtQHRHFDPDGDVSDUDDDYDOLDomRPRUIROyJLFDGDVFpOXODV2
HVIUHJDoRVDQJXtQHRpIRUPDGRSRUWUrViUHDV FRUSRPRQRFDPDGDHFDXGD $iUHDSDUDOHLWXUDpDTXH
as células se distribuem em monocamada.

Objetivos Figura 25 (WDSDVGDFRQIHFomRGRHVIUHJDoRVDQJXtQHR

&RQIHFFLRQDUHFRUDUHVIUHJDoRVVDQJXtQHRV

Procedimentos
&ROHWDURVDQJXH (WDSDUHDOL]DGDSHORJUXSRTXHGHYHOHYDUSDUDDXODSUiWLFDXPDDPRVWUD
VDQJXtQHDUHFpPFROHWDGD 
+RPRJHQHL]DURWXERFRPRVDQJXH

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

8.3 Roteiro de aula prática de Hemograma completo

Tema: Técnicas hematológicas - Hemograma completo


2KHPRJUDPDFRPSOHWRpXPH[DPHODERUDWRULDOTXHIRUQHFHLPSRUWDQWHVLQIRUPDo}HVVREUHRHVWDGR
ÀVLROyJLFRGRDQLPDOQRPRPHQWRGDFROHWDGHVDQJXH(VVHH[DPHLQFOXLGDGRVTXDQWLWDWLYRVHTXDOLWDWLYRV
HpGLYLGLGRHPWUrVSDUWHVHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD(QWUHRVGDGRVTXDQWLWDWLYRVHVWmR
DVFRQWDJHQVJOREDLVGHFpOXODV KHPiFLDVOHXFyFLWRVHSODTXHWDV DGHWHUPLQDomRGRKHPDWyFULWR +W 
)LJXUDH DGRVDJHPGHKHPRJORELQD +E DFRQWDJHPGLIHUHQFLDOGHOHXFyFLWRVHRFiOFXORGRV
tQGLFHVKHPDWLPpWULFRV 9*0&+*0H+*0 2VGDGRVTXDOLWDWLYRVVmRUHIHUHQWHVjPRUIRORJLDFHOXODUH
REWLGRVGXUDQWHRH[DPHGRHVIUHJDoRVDQJXtQHR
1DV ~OWLPDV GpFDGDV RFRUUHX XPD JUDQGH HYROXomR WHFQROyJLFD QD UHDOL]DomR GR KHPRJUDPD H DV
WpFQLFDV PDQXDLV WrP VLGR VXEVWLWXtGDV SRU HTXLSDPHQWRV DXWRPDWL]DGRV JDUDQWLQGR PDLRU SUHFLVmR
QRV UHVXOWDGRV HP XP PHQRU LQWHUYDOR GH WHPSR 1D YHWHULQiULD DV PHWRGRORJLDV PDQXDLV DLQGD VmR
EDVWDQWHXWLOL]DGDVSULQFLSDOPHQWHSDUDUHDOL]DUKHPRJUDPDVGHHVSpFLHVVLOYHVWUHVHGHDQLPDLVFRP
hemácias e plaquetas nucleadas (aves, répteis, anfíbios e peixes).
Objetivos
([HFXWDURVSURFHGLPHQWRVQHFHVViULRVSDUDUHDOL]DomRGRKHPRJUDPD
&RQKHFHURVPpWRGRVPDQXDLV KHPRFLW{PHWURGH1HXEDXHU HVHPLDXWRPDWL]DGRV &HOP 
HDXWRPDWL]DGRV %&9HW 
&DOFXODURVtQGLFHVKHPDWLPpWULFRV 9*0H&+*0 
5HDOL]DUDIyUPXODOHXFRFLWiULD
Tabular e interpretar os resultados.

Procedimentos Figura 26 (WDSDV SDUD D UHDOL]DomR GR KHPDWyFULWR &ROHWD GH PDWHULDO VDQJXH HP WXER FDSLODU
FHQWULIXJDomR 'HPRQVWUDomR GD OHLWXUD GR KHPDWyFULWR DSyV D FHQWULIXJDomR VHSDUDomR HP SODVPD
&ROHWDURVDQJXH HWDSDUHDOL]DGDSHORJUXSRTXHGHYHOHYDUSDUDDXODSUiWLFDXPDDPRVWUD
OHXFyFLWRVSODTXHWDVHHULWUyFLWRV 
VDQJXtQHDUHFpPFROHWDGD 
&RQIHFFLRQDUHFRUDURHVIUHJDoRVDQJXtQHR
5HDOL]DURKHPDWyFULWR +W  )LJXUDH 
5HDOL]DUDFRQWDJHPJOREDOGHKHPiFLDVPDQXDOHDXWRPDWL]DGD &*+ 
'RVDUDKHPRJORELQD +E 
&DOFXODURVtQGLFHVKHPDWLPpWULFRV &+*0H9*0 
5HDOL]DUDFRQWDJHPJOREDOGHOHXFyFLWRVPDQXDOHDXWRPDWL]DGD &*/ 
5HDOL]DUDFRQWDJHPGLIHUHQFLDOGHOHXFyFLWRV &'/ 

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

LEUCOGRAMA
CONTAGEM GLOBAL DE LEUCÓCITOS (CGL)

Leucograma Valor obtido Valor de Interpretação


(BC 2800 Vet) referência
&*/ [—/

CONTAGEM DIFERENCIAL DE LEUCÓCITOS (CDL)

Valores obtidos Valor de referência Interpretação


Absoluto Absoluto
Leucograma Relativo Relativo
(x 103/ ( x 103/
 
—/ —/
1HXWUyÀORV
1HXWUyÀORV

Figura 27 $PRVWUD GH VDQJXH HP WXER FDSLODU SDUD UHDOL]DomR GR KHPDWyFULWR 7XER FDSLODU FRP VHJPHQWDGRV
DPRVWUDGHVDQJXHWRWDODQWHVGDFHQWULIXJDomRHWXGRFDSLODUDSyVDFHQWULIXJDomRFRPVHSDUDomRGH 1HXWUyÀORV
SODVPDOHXFyFLWRVSODTXHWDVHHULWUyFLWRV2SODVPDSRGHHVWDUFRPDFRUQRUPDOLQFRORU FmHVHJDWRV 
e amarela nos casos dos herbívoros devido à presença de caroteno, ou cor anormal amarela (icterícia EDVW}HV
HPFmHVHJDWRV FRUEUDQFDHPFDVRGHOLSHPLDSyVSUDQGLDO ÀVLROyJLFR RXHPFDVRVGHGLDEHWHVH (RVLQyÀORV
KLSRWLUHRLGLVPR SDWROyJLFR 
/LQIyFLWRV
0RQyFLWRV
Tabulação e Interpretação dos resultados do hemograma %DVyÀORV
(Usar dados obtidos pelo equipamento BC2800Vet)
ERITROGRAMA OBS:___________________________________________________________________
1. Calcule os valores leucocitários absolutos
Valor obtido Valor de
Eritrograma Interpretação ,QWHUSUHWHRVOHXFRJUDPDHPDVVRFLDomRFRPDKLVWyULDHRVVLQDLVFOtQLFRV
(BC2800 Vet) referência 3. Utilize os termos técnicos indicados para cada alteração observada
+W 
PLAQUETOGRAMA
&*+ [—/
+E JG/ Valor obtido
Plaquetograma Valor de referência Interpretação
VGM fL (BC 2800 Vet)
&+*0  Plaq. (x 103—/
OBS.___________________________________________________________________
&DOFXOHR9*0H&+*0HFODVVLÀTXHDVDQHPLDVVHKRXYHU OBS:___________________________________________________________________

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

METODOLOGIA MANUAL PARA CONTAGEM GLOBAL DE LEUCÓCITOS

Componentes (Diluição do sangue 1:20)


P/GH785.
P/ —/ GH6DQJXH

Protocolo
'LOXLURVDQJXH
$JLWDUIRUWHPHQWHRWXER
(QFKHURUHWLFXORGDFkPDUD Figura 28 (VTXHPDGHPRQVWUDQGRRUHWtFXORGH1HXEDXHUHRVORFDLVSDUDFRQWDJHPGHOHXFyFLWRVH
5HSRXVDUSRUPLQXWRV KHPiFLDV/RFDOGHFRQWDJHPGHOHXFyFLWRVUHSUHVHQWDGRSHODOHWUD/HORFDOGHFRQWDJHPGHKHPiFLDV
&RQWDURVFDPSRVGHVWLQDGRVjTXDQWLÀFDomRGHOHXFyFLWRV )LJXUD  representado pelos cinco quadrados vermelhos.
Resultado x 50.

Em caso de leucocitose, a diluição será:


0,76 mL x 100 1,52 mL x 200
1,14 mL x 150 1,90 mL x 250

METODOLOGIA MANUAL PARA CONTAGEM GLOBAL DE HEMÁCIAS

Componentes (Diluição do sangue 1:200)


P/GH*2:(5+$<(0RXVRURÀVLROyJLFR
P/ —/ GH6DQJXH

Protocolo
$JLWDUOHYHPHQWHRWXER
(QFKHURUHWLFXORGDFkPDUD
5HSRXVDUSRUPLQXWRV
&RQWDUFDPSRVGHVWLQDGRVjTXDQWLÀFDomRGHKHPiFLDV )LJXUD 
Resultado x 10.000.

OBS: 3DUDFRQWDJHPGHKHPiFLDVGHRYLQRVHFDSULQRVXWLOL]DVHDVHJXLQWHGLOXLomR Figura 29 +HPRFLWRPHWULDeRPpWRGRSDUDFRQWDJHPJOREDOGDVFpOXODVVDQJXtQHDVTXHFRQVLVWHHP


GLOXLURVDQJXH /HXFyFLWRV²POGH785.PO —/ GHVDQJXH+HPiFLDV²POGH*2:(5
P/GH*2:(5+$<(0RXVRURÀVLROyJLFR RXVRURÀVLROyJLFRPO —/ GHVDQJXH SHUPLWLQGRDFRQVHUYDomRGDVFpOXODV$SyVDSUHSDUDomR
P/ —/ GH6DQJXH da diluição de acordo com o protocolo, preencher o retículo da câmara de Neubauer com a utilização da
Lembrar no cálculo de multiplicar o resultado por 20.000. pipeta, evitando o excesso de líquido e bolhas de ar sob a lamínula. Realizar a leitura nos locais indicados
OHXFyFLWRVHKHPiFLDV VLVWHPDWL]DQGRDFRQWDJHPGHDFRUGRFRPDVHWDD]XOGDÀJXUD

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

DESCREVENDO AS CÉLULAS SANGUÍNEAS PESQUISE E RESPONDA

'HVHQKHRVGLIHUHQWHVWLSRVGHFpOXODVVDQJXtQHDVLGHQWLÀTXHFDGDXPGHOHVHGHVFUHYDVXDVSULQFLSDLV 1. 1RV~OWLPRVDQRVRFRUUHXXPDJUDQGHHYROXomRWHFQROyJLFDQDUHDOL]DomRGRKHPRJUDPDID]HQGR
IXQo}HV)DoDWRGRVRVGHVHQKRVFRORULGRVSDUDH[HPSOLÀFDUDVFDUDFWHUtVWLFDVPRUIROyJLFDVHWLQWRULDLV FRPTXHDVWpFQLFDVPDQXDLVVHMDPVXEVWLWXtGDVSRUVLVWHPDVDXWRPDWL]DGRV(VVDWHFQRORJLDWDPEpP
de cada tipo celular. FKHJRXDRVODERUDWyULRVGHDQiOLVHVFOtQLFDVYHWHULQiULDVJHUDQGRUHVXOWDGRVPDLVSUHFLVRVHPXPPHQRU
LQWHUYDORGHWHPSR$OpPGLVVRFRPDDXWRPDomRDOJXPDVLQRYDo}HVVmRREVHUYDGDVQRKHPRJUDPD
FRPRQRYRVtQGLFHVKHPDWLPpWULFRV9HMDDEDL[RDOJXQVtQGLFHVJHUDGRVSHODDXWRPDomRHSHVTXLVHVHXV
VLJQLÀFDGRVHXWLOLGDGHVGLDJQyVWLFDV
D 5': UHGFHOOGLVWULEXWLRQZLGWK  &RHÀFLHQWHGHYDULDomRGRYROXPHJOREXODUPpGLR

b) VPM (volume plaquetário médio)

F 3': SODWHOHWGLVWULEXWLRQZLGW &RHÀFLHQWHGHYDULDomRGRYROXPHSODTXHWiULR

2. 4XDORSULQFLSDODYDQoRWHFQROyJLFRREVHUYDGRQDVpULHOHXFRFLWiULD"

3. 7UDGLFLRQDOPHQWHDGHWHUPLQDomRGHSURWHtQDVQmRID]SDUWHGRKHPRJUDPD(QWUHWDQWRQDYHWHULQiULD
HVVHSDUkPHWURpLQFOXtGRQRUHVXOWDGRGRKHPRJUDPDFRPSOHWRSRLVIRUQHFHLQIRUPDo}HVLPSRUWDQWHV
DRFOtQLFRVROLFLWDQWH'LDQWHGRH[SRVWRUHVSRQGDDVTXHVW}HVDEDL[R
D 4XDORYDORUREWLGRSDUDSURWHtQDVWRWDLVGRVDQJXHXWLOL]DGRQDDXODSUiWLFD"

E 4XDODPHWRGRORJLDXWLOL]DGDQDDXODSDUDGHWHUPLQDUDVSURWHtQDV"

F 4XDLVDVLQIRUPDo}HVLPSRUWDQWHVTXHHVVHSDUkPHWURIRUQHFHDRFOtQLFR"

G 4XDLV RV WHUPRV WpFQLFRV XWLOL]DGRV SDUD GHVLJQDU R DXPHQWR H D GLPLQXLomR GDV SURWHtQDV
SODVPiWLFDV"

H 4XDLVVmRDVSULQFLSDLVSURWHtQDVGRVDQJXH"

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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Hemograma 2. &DQLQR 0HJ  PHVHV IrPHD 0XFRVDV SiOLGDV DQLPDO SURVWDGR QmR VH DOLPHQWD H
desidratado.

Parâmetros Resultados Valores de Referência**


+HPiFLDV PLOK}HVPP3) 1,15 5,0 a 8,5
09 INTERPRETAÇÃO DE HEMOGRAMAS
+HPRJORELQD JG/ 2,9 12 a 18
+HPDWyFULWR  8 37 a 55
Hemograma 1. Canino Rex, 4 anos, macho. Animal com mucosas pálidas, não se alimenta, fraqueza, 9&0 Á 73 60 a 77
RIHJDQWHGHVLGUDWDGRDSUHVHQWDQGRPXLWRVFDUUDSDWRV
+&0 SJ 25,2 19 a 23
Parâmetros Resultados Valores de Referência** &+&0 JG/ 36,3 32 a 36
+HPiFLDV PLOK}HVPP3) 1,08 5,0 a 8,5 /HXFyFLWRV PP3) 23.500 6.000 a 17.000
+HPRJORELQD JG/ 2,4 12 a 18 %DVyÀORV PP3) 0 Raros
+HPDWyFULWR  7 37 a 55 (RVLQyÀORV PP3) 0 150 a 1.250
9&0 Á 64,8 60 a 77 1HXWUyÀORVVHJPHQWDGRV PP3) 17.500 3.000 a 11.500
+&0 SJ 22,2 19 a 23 1HXWUyÀORVEDVW}HV PP3) 300 0 a 300
&+&0 JG/ 34,3 32 a 36 /LQIyFLWRV PP3) 4.500 1.000 a 4.800
/HXFyFLWRV PP3) 33.500 6.000 a 17.000 0RQyFLWRV PP3) 1.200 150 a 1.350
%DVyÀORV PP3) 0 Raros Plaquetas (mm3) 80.000 200.000 a 500.000
(RVLQyÀORV PP3) 330 150 a 1.250 6FKDOP·V9HWHULQDU\+HPDWRORJ\ 
1HXWUyÀORVVHJPHQWDGRV PP3) 27.500 3.000 a 11.500
2%63ODVPDOHYHPHQWHKHPROLVDGR$QLVRFLWRVH  3ROLFURPDVLD  +LSRFURPLD  
1HXWUyÀORVEDVW}HV PP3) 2.664 0 a 300
/LQIyFLWRV PP3) 1.665 1.000 a 4.800
INTERPRETAÇÃO DO HEMOGRAMA:)DoDDLQWHUSUHWDomRGRHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD
0RQyFLWRV PP3) 333 150 a 1.350
Plaquetas (mm )3
153.000 200.000 a 500.000

6FKDOP·V9HWHULQDU\+HPDWRORJ\ 

2%6 3ODVPD OtPSLGR $QLVRFLWRVH   3ROLFURPDVLD   +LSRFURPLD    GH PHWDUUXEUtFLWRV


/HXFyFLWRVPRUIRORJLFDPHQWHQRUPDLV

INTERPRETAÇÃO DO HEMOGRAMA:)DoDDLQWHUSUHWDomRGRHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD

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84 85
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Hemograma 3. )HOLQD3DQGRUDDQRIrPHD$QLPDOFRPVHFUHomRSXUXOHQWDYDJLQDOIHEUHGHž&H Hemograma 4. )HOLQD-DGLWHDQRVIrPHD$QLPDODSUHVHQWDDXPHQWRGRDEG{PHQIHEUHGHž&QmR


com anorexia. Animal não é castrado. VHDOLPHQWD3URSULHWiULRUHODWRXTXHDQLPDOQmRpFDVWUDGRHWHPDFHVVRDUXD6XVSHLWRXVHGHJUDYLGH]

Parâmetros Resultados Valores de Referência** Parâmetros Resultados Valores de Referência**


+HPiFLDV PLOK}HVPP3) 5,06 5.0 a 10.0 +HPiFLDV PLOK}HVPP 9,62 5.0 a 10.0
+HPRJORELQD JG/ 9,7 8 a 15 +HPRJORELQD JG/ 13,3 8 a 15
+HPDWyFULWR  31 24 a 45 +HPDWyFULWR  46 24 a 45
9&0 Á 60,5 39 a 55 9&0 Á 47,8 39 a 55
+&0 SJ 19,2 19 a 23 +&0 SJ 13,8 19 a 23
&+&0 JG/ 31,3 31 a 35 &+&0 JG/ 28,9 31 a 35
/HXFyFLWRV PP3) 61.100 5.500 a 19.500 /HXFyFLWRV PP3) 33.700 5.500 a 19.500
%DVyÀORV PP3) 0 Raros %DVyÀORV PP3) 0 Raros
(RVLQyÀORV PP ) 3
1.220 0 a 1.500 (RVLQyÀORV PP3) 3.707 0 a 1.500
1HXWUyÀORVVHJPHQWDGRV PP3) 35.438 2.500 a 12.500 1HXWUyÀORVVHJPHQWDGRV PP3) 23.253 2.500 a 12.500
1HXWUyÀORVEDVW}HV PP3) 5.500 0 a 300 1HXWUyÀORVEDVW}HV PP3) 0 0 a 300
/LQIyFLWRV PP3) 15.886 1.500 a 7.000 /LQIyFLWRV PP3) 5.392 1.500 a 7.000
0RQyFLWRV PP3) 3.055 0 a 850 0RQyFLWRV PP3) 1.348 0 a 850
Plaquetas (mm3) 282.000 300.000 a 800.000 Plaquetas (mm3) 213.000 300.000 a 800.000

6FKDOP·V9HWHULQDU\+HPDWRORJ\  6FKDOP·V9HWHULQDU\+HPDWRORJ\ 

OBS: Anisocitose (+), Macroplaquetas (+). INTERPRETAÇÃO DO HEMOGRAMA:)DoDDLQWHUSUHWDomRGRHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD

INTERPRETAÇÃO DO HEMOGRAMA:)DoDDLQWHUSUHWDomRGRHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
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HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Hemograma 5. Canina Cacau, 6 anos, fêmea. Animal apático, fezes normais, urinando normal, não tem Hemograma 6. Peixe-boi (Trichechus manatus manatus) Osmar, 6 meses, macho. Proteínas Totais: 9,8
bom apetite. Apresenta petéquias pelo corpo e vive deitada, quieta, não quer andar. Animal vacinado JGO DJGO 
corretamente.
Parâmetros Resultados Valores de Referência**
Parâmetros Resultados Valores de Referência**
+HPiFLDV PLOK}HVPP 3,46 2,17 a 3,39
+HPiFLDV PLOK}HVPP3) 5.14 5.0 a 8.5
+HPRJORELQD JG/ 9,9 9,4 a 13,5
+HPRJORELQD JG/ 13 12 a 18
+HPDWyFULWR  33 28,9 a 43,5
+HPDWyFULWR  38 37 a 55
9&0 Á 95,3 114 a 140
9&0 Á 74.3 60 a 77
&+&0 JG/ 30 28 a 35,4
+&0 SJ 25.3 19 a 23
/HXFyFLWRV PP 5.050 2.770 a 13.500
&+&0 JG/ 34.2 32 a 36
%DVyÀORV PP 0 0 a 270
/HXFyFLWRV PP3) 3.200 6.000 a 17.000
(RVLQyÀORV PP 50 0 a 1.230
%DVyÀORV PP3) 0 Raros
+HWHUyÀORV PP 2.778 770 a 6.530
(RVLQyÀORV PP3) 0 150 a 1.250
%DVW}HV PP 0 0 a 220
1HXWUyÀORVVHJPHQWDGRV PP3) 2.800 3.000 a 11.500
/LQIyFLWRV PP 2.070 1.010 a 7.200
1HXWUyÀORVEDVW}HV PP3) 0 0 a 300
0RQyFLWRV PP 152 800 a 1.700
/LQIyFLWRV PP3) 280 1.000 a 4.800
Plaquetas (mm3) -------- 111.000 a 424.000
0RQyFLWRV PP3) 100 150 a 1.350
Plaquetas (mm3) 42.000 200.000 a 500.000
Plaquetas (mm3) 42.000 200.000 a 500.000
+DUYH\HWDO+HPDWRORJ\RIKHDOWK\)ORULGDPDQDWHHV 7ULFKHFKXVPDQDWXV 9HW&OLQ3DWKROS0pWRGR
6FKDOP·V9HWHULQDU\+HPDWRORJ\  0HWRGRORJLDPDQXDOHP+HPRFLW{PHWURGH1HXEDXHUWpFQLFDGHPLFURKHPDWyFULWRHGDFLDQRPHWDKHPRJORELQD

2%63UHVHQoDGHLQFOXV}HVHPKHPiFLDVVXJHVWLYDVGHBabesia sp. 2%6 3ODVPD KHPROLVDGR  GH PHWDUUXEUyFLWR 3UHVHQoD GH PXLWRV DJUHJDGRV SODTXHWiULRV
LQYLDELOL]DQGRDGHWHUPLQDomRGHSODTXHWDV/HXFyFLWRVPRUIRORJLFDPHQWHQRUPDLV
INTERPRETAÇÃO DO HEMOGRAMA:)DoDDLQWHUSUHWDomRGRHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD
INTERPRETAÇÃO DO HEMOGRAMA:)DoDDLQWHUSUHWDomRGRHULWURJUDPDOHXFRJUDPDHSODTXHWRJUDPD

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
88 89
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Observações nas plaquetas (Plaquetograma)


‡6HDGHWHUPLQDomRIRUSRUHVWLPDWLYDHPHVIUHJDoRFRORFDVHDVHJXLQWHREVHUYDomR'HWHUPL-
QDomRGHSODTXHWDVREWLGDVSRUHVWLPDWLYDHPHVIUHJDoRVDQJXtQHR
‡3UHVHQoDGHSODTXHWDVJLJDQWHV
‡3UHVHQoDGHDJUHJDGRVSODTXHWiULRV
10 INFORMAÇÕES QUALITATIVAS QUE PODEM VIR EXPRESSAS
NOS RESULTADOS DO HEMOGRAMA
1R FDVR GH WURPERFLWRSHQLD VHYHUD    ID]VH D FRQÀUPDomR QR HVIUHJDoR H FRORFD QDV
REVHUYDo}HVGDVSODTXHWDV7URPERFLWRSHQLDFRQÀUPDGDSRUDYDOLDomRGRHVIUHJDoRVDQJXtQHR

Observações da série vermelha (eritrograma)


Observações para pesquisa de hemoparasitas
• Característica do plasma: límpido, hemolisado (levemente, discretamente, moderadamente),
ictérico (levemente, discretamente, moderadamente), lipêmico (discretamente, levemente). No Descrever no laudo os hemoparasitas observados. A Babesia e Erlichia são os hemoparasitas mais
SODVPDGHUXPLQDQWHVHHTXLQRVVyLQIRUPDULFWHUtFLDVHIRUEHPPDUFDQWH/HPEUDUTXHRSODV- REVHUYDGRVQDURWLQDGRODERUDWyULR
PDRXVRURGHVVDVHVSpFLHVVmRÀVLRORJLFDPHQWHPDLVDPDUHODGRV
Atenção para a observação e a correta descrição de outros hemoparasitas (Ex: Anaplasma spp.,
‡$QLVRFLWRVHGLIHUHQoDGHWDPDQKRGDVKHPiFLDV
Trypanossoma spp., Mycoplasma spp., etc.). Nesses casos falar com o responsável técnico para
‡3ROLFURPDWRÀOLDDXPHQWRGHQ~PHURGHSROLFURPDWyÀORV FRQÀUPDomRGRGLDJQyVWLFRHFRUUHWDGHVFULomRQRODXGRGRH[DPH
• Rouleuax eritrocitário ou hemácias em rouleuax
6HQmRIRUHPREVHUYDGRVKHPRSDUDVLWDVSRGHVHREVHUYDUDVHJXLQWHREVHUYDomR
‡3UHVHQoDGHKHPRSDUDVLWDV
Ex: Presença de merozoítas de Babesia spp. $ DXVrQFLD GH KHPRSDUDVLWDV QD DPRVWUD H[DPLQDGD QmR p VXÀFLHQWH SDUD H[FOXLU D SRVVLELOLGDGH GH
‡3UHVHQoDGHLQFOXV}HVYLUDLV LQIHFomR SRLV D SUHVHQoD GH SDUDVLWDV QR VDQJXH YDULD FRP D IDVH H R JUDX GH LQIHFomR 3RUWDQWR R
resultado deste exame deverá sempre ser avaliado em conjunto com os dados obtidos no exame clínico
 ([)RUDPREVHUYDGDVLQFOXV}HVGH/HQW]QRLQWHULRUGRVHULWUyFLWRV OHPEUDUTXHHVVDVLQFOXV}HV
e os resultados de outros exames laboratoriais.
WDPEpPSRGHPVHUREVHUYDGDVQRVOHXFyFLWRV 
‡3HUFHQWXDOGHPHWDUUXEUyFLWRV PHWHUUXEUtFLWRVRXKHPiFLDVQXFOHDGDV FRQWDGRVQDFRQWDJHP
GLIHUHQFLDOGHOHXFyFLWRV6HRSHUFHQWXDOGHPHWDUUXEUyFLWRVIRUVXSHULRUDDOHXFRPHWULD
JOREDOGHYHVHUFRUULJLGD YHUIyUPXODGHFRUUHomR HQDREVHUYDomRDEDL[RGROHXFRJUDPDGHYH
VHULQGLFDGDDFRUUHomRFRPDVHJXLQWHREVHUYDomROHXFRPHWULDJOREDOFRUULJLGD

Observação na série branca (leucograma)


‡/HXFyFLWRV PRUIRORJLFDPHQWH QRUPDLV RX 1HXWUyÀORV VHP DOWHUDo}HV PRUIROyJLFDV OLQIyFLWRV
VHPDWLSLDV
‡3UHVHQoDGHOLQIyFLWRVDWtSLFRVRXOLQIyFLWRVUHDWLYRV
‡3UHVHQoDGHPRQyFLWRVDWLYDGRV
‡3UHVHQoDGHQHXWUyÀORVWy[LFRVRXSUHVHQoDGHQHXWUyÀORVFRPJUDQXODo}HVWy[LFDV
‡1HXWUyÀORVKLSHUVHJPHQWDGRV
‡/HXFRPHWULDJOREDOFRUULJLGD YLGHREVHUYDomRSDUDPHWDUUXEUyFLWRV 
‡(PFDVRVGHVHYHUDOHXFRSHQLDTXDQGRDFRQWDJHPGLIHUHQFLDOQmRSRGHVHUUHDOL]DGDFROR-
FDVHDVHJXLQWHREVHUYDomR'HYLGRjVHYHUDOHXFRSHQLDDFRQWDJHPGLIHUHQFLDOGHOHXFyFLWRV
IRLLQYLDELOL]DGD
‡3UHVHQoD GH PyUXOD GH (UOLFKLD VSS QR LQWHULRU GH QHXWUyÀOR VHJPHQWDGR RX RXWUR WLSR GH
OHXFyFLWRRQGHIRLREVHUYDGDDPyUXOD 

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
90 91
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

 8)&*²&203529 $UHVSRVWDOHXFRFLWiULDGHERYLQRVGLIHUHGDGHFmHVRXVHMDHPFmHVDV


HQIHUPLGDGHVLQÁDPDWyULDVFU{QLFDVGHFDYLGDGHIHFKDGDSRGHPLQGX]LUQHXWURÀOLDWmRHOHYDGDTXDQWR
FpOXODVƫ/HQTXDQWRQRVERYLQRVXPDGRHQoDVHPHOKDQWHUHVXOWDHPFRQWDJHPPi[LPDHP
WRUQRGHFpOXODVƫ/,VVRRFRUUHSRUTXr"
D 2VERYLQRVQmRQHFHVVLWDPGHQHXWUyÀORVSDUDHVVHWLSRGHUHVSRVWD
11 QUESTÕES DE PROVA / CONCURSOS
b) Os bovinos não apresentam pool de reserva.
c) Os cães apresentam maior pool de reserva do que os bovinos.
d) Os bovinos são resistentes a esse tipo de infecção.
 8)&* ²   &203529  6H R VDQJXH IRL FROHWDGR FRP ('7$   H PDQWLGR QD WHPSHUDWXUD e) Os cães apresentam capacidade de proliferação da medula desprezível.
DPELHQWHXPKHPRJUDPDGHYHUiVHUUHDOL]DGRQRPi[LPRDWp
D GXDVKRUDVDSyVDFROHWD  38&35²5HVLGrQFLDHP3DWRORJLD&OtQLFD9HWHULQiULD $SUHVHQoDGHSODTXHWDVJUDQGHVHP
E WUrVKRUDVDSyVDFROHWD HVIUHJDoRVDQJXtQHRGHXPSDFLHQWHWURPERFLWRSrQLFRVXJHUH
F GR]HKRUDVDSyVDFROHWD
G YLQWHHTXDWURKRUDVDSyVDFROHWD a) Aplasia medular.
H TXDUHQWDHRLWRKRUDVDSyVDFROHWD b) Presença de disfunção plaquetária.
F 3URGXomRDWLYDGDQDPHGXODyVVHD
d) Não há alteração com relação às plaquetas.
 8)&*²&203529 $OHXFRSHQLDpXPDUHGXomRQRQ~PHURGRVOHXFyFLWRVDEDL[RGRVYDORUHV H 8PGLDJQyVWLFRGHPLHORVHPHJDFDULRFtWLFD
GHUHIHUrQFLD/HXFRSHQLDSRUGHSOHomRVLJQLÀFD
D 'HÀFLrQFLD GD DWLYLGDGH PHGXODU UHÁHWLQGRVH QR DSDUHFLPHQWR GH JUDQGH Q~PHUR GH  38&35²5HVLGrQFLDHP3DWRORJLD&OtQLFD9HWHULQiULD 2YROXPHJOREXODUPpGLR 9*0 DXPHQWD
QHXWUyÀORVLPDWXURV HPWRGRVRVFDVRVDVHJXLU EXCETO:
E 3HUGHGDFDSDFLGDGHGDPHGXODSURGX]LUQHXWUyÀORVHPFRQVHTXrQFLDjUDGLDomRLRQL]DQWH
F  'HPDQGD GH OHXFyFLWRV DQRUPDOPHQWH JUDQGH QHFHVVLGDGH LQWHQVD GH QHXWUyÀORV H a) Reticulocitose.
DSDUHFLPHQWRGHDOJXPDVSRXFDVFpOXODVMRYHQV b) Infecção pelo vírus da leucemia felina.
d) Destruição medular, manifestando-se por uma diminuição de todos os tipos de células formadas c) Em cães da raça Poodle miniatura.
QDPHGXODyVVHD G $QHPLDSRUGHÀFLrQFLDGHIHUUR
H ,QDELOLGDGHGDPHGXODHPSURGX]LUQHXWUyÀORVDXVrQFLDGHFpOXODVLPDWXUDV e) Anemia hemolítica imunomediada.

 8)&*²&203529 $KHPyOLVHLQWUDYDVFXODUH[FHVVLYDSRGHRFRUUHUQDVDQHPLDVKHPROtWLFDV  38&35 ²   5HVLGrQFLD HP 3DWRORJLD &OtQLFD 9HWHULQiULD  3DUD DYDOLDU GH IRUPD FRUUHWD XP
SRGHQGRJHUDURDSDUHFLPHQWRGH PLHORJUDPDGHYHVHUHDOL]DUDRPHVPRWHPSR

D +HPRJORELQ~ULD D 3HUÀOELRTXtPLFR
E 0LRJORELQ~ULD E +HPRJUDPDFRPSOHWR
F +HPDW~ULD F &RDJXORJUDPD
G +LSHUPLRJORELQHPLD d) Urinálise.
H 'LPLQXLomRGDKHPRJORELQDOLYUHQRSODVPD e) Biopsia de baço.

 8)&*²&203529 3DUDRSUHSDURGHFRQWDJHPGHHULWUyFLWRVQDFkPDUDGH1HXEDXHUXWLOL]D  8)0*²5HVLGrQFLDHP3DWRORJLD&OtQLFD9HWHULQiULD (PUHODomRjVDQHPLDVHP0HGLFLQD


se: 9HWHULQiULDPDUTXH9SDUDDVDÀUPDWLYDVYHUGDGHLUDVH)SDUDDVIDOVDV

D P/GHVROXomRGH+D\HQHƫ/GHVDQJXHWRWDO  $QHPLDpFDUDFWHUL]DGDSHODGLPLQXLomRGDFRQFHQWUDomRGHHULWUyFLWRVGHKHPRJORELQDHRX


E P/GHVROXomRGH+D\HQHƫ/GHVDQJXHWRWDO GRKHPDWyFULWRVDQJXtQHR
F P/GHVROXomRGH+D\HQHƫ/GHVDQJXHWRWDO  (P UHODomR j UHVSRVWD PHGXODU D DQHPLD VHUi FRQVLGHUDGD DUUHJHQHUDWLYD VH KRXYHU
G P/GHVROXomRGH+D\HQHƫ/GHVDQJXHWRWDO reticulocitose concomitante.
H P/GHVROXomRGH+D\HQHƫ/GHVDQJXHWRWDO  (TXLQRVUDUDPHQWHOLEHUDPHULWUyFLWRVSROLFURPDWRItOLFRVGDPHGXODSDUDRVDQJXH
 $DQHPLDUHVSRQVLYDRFRUUHSULPDULDPHQWHHPUHVSRVWDjSHUGDVDQJXtQHDRXKHPyOLVH

MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO MALENA NORO SILVA orientadora: MARIA VIVINA B. MONTEIRO
92 93
HEMATOLOGIA VETERINÁRIA produção de material didático HEMATOLOGIA VETERINÁRIA produção de material didático

Assinale a sequência correta.  38&35²5HVLGrQFLDHP3DWRORJLD&OtQLFD9HWHULQiULD &RPUHODomRDRVQHXWUyÀORVWy[LFRV


DVVLQDOHDDOWHUQDWLYDTXHGHVFUHYHFDUDFWHUtVWLFDVGHQRPLQDGDV´DOWHUDo}HVWy[LFDVµ
a) V, F, V, V.
b) V, V, F, V. D 'HVYLRQXFOHDUGHQHXWUyÀORVjHVTXHUGDHPDWXUDomRQXFOHDUDVVtQFURQD
c) F, F, V, F. E &LWRSODVPDHVSXPRVRHGHVYLRQXFOHDUGHQHXWUyÀORVjGLUHLWD
d) F, V, F, F. F 1HXWUyÀORVKLSHUVHJPHQWDGRVHEDVRÀOLDFLWRSODVPiWLFD
G $XPHQWRQRQ~PHURGHEDVWRQHWHVHQHXWUyÀORVKLSHUVHJPDQWDGRV
H %DVRÀOLDFLWRSODVPiWLFDHFRUS~VFXORGH'|KOH
 8)0*²5HVLGrQFLDHP3DWRORJLD&OtQLFD9HWHULQiULD &RQVLGHUDQGRTXHFDGDWLSRGHOHXFyFLWR
p~QLFRIUHTXHQWHPHQWHDVDOWHUDo}HVQDVFRQFHQWUDo}HVRFRUUHPHPSDGU}HVSUHYLVtYHLVHPWRGRVRV
PDPtIHURVGRPpVWLFRVSRUpPFRPGLIHUHQoDVVLJQLÀFDWLYDVQDVHVSpFLHV$UHVSHLWRGDLQWHUSUHWDomRGR  38&35 ²   5HVLGrQFLD HP 3DWRORJLD &OtQLFD 9HWHULQiULD  $ HULWURFLWRVH p YHULÀFDGD TXDQGR
OHXFRJUDPDQDVHVSpFLHVDQDOLVHDVDÀUPDWLYDV VH REWrP UHVXOWDGRV GH YROXPH JOREXODU DXPHQWDGR Q~PHUR GH HULWUyFLWRV WRWDLV DXPHQWDGRV H
FRQFHQWUDomRGHKHPRJORELQDDXPHQWDGD
,2SDGUmRFOiVVLFRGHOHXFRJUDPDGHHVWUHVVHHPFmHVFRQVLVWHHPOHXFRFLWRVHSRUQHXWURÀOLD
eosinopenia, linfopenia e monocitose. &RPUHODomRjSDWRJHQLDGDVHULWURFLWRVHVDVVLQDOHDUHVSRVWDCORRETA.
,,  2V HTXLQRV IUHTXHQWHPHQWH WrP OHXFRFLWRVH SRU QHXWURÀOLD FRP GHVYLR j HVTXHUGD GXUDQWH
HVWDGRVLQÁDPDWyULRV D $OLEHUDomRGHHSLQHIULQDHPVLWXDo}HVGH´OXWDµRX´IXJDµOHYDjFRQWUDomRGDPXVFXODWXUD
,,,2VERYLQRVDGXOWRVHPHVWDGRVLQÁDPDWyULRVDJXGRVWrPQHXWURSHQLDSRUWHUXPFRPSDUWLPHQWR OLVD KHSiWLFD H GHVVD PDQHLUD j OLEHUDomR GH VDQJXH KHSiWLFR SDUD RV YDVRV VDQJXtQHRV
GHUHVHUYDGHQHXWUyÀORVUHODWLYDPHQWHSHTXHQRQDPHGXOD periféricos provocando a eritrocitose.
,9$PDJQLWXGHGDQHXWURÀOLDHPJDWRVSRGHVHUGHDWpYH]HVROLPLWHVXSHULRUGHUHIHUrQFLDSRU b) A produção aumentada de eritropoetina estimula a eritropoese e causa eritrocitose. Essa
HVVDHVSpFLHWHUXPFRPSDUWLPHQWRPDUJLQDOGHQHXWUyÀORVPDLRU SURGXomR SRGH VHU DSURSULDGD VH HVWLPXODGD SRU KLSy[LD WHFLGXDO  RX LQDSURSULDGD VH QmR
HVWLPXODGDSRUKLSy[LDWHFLGXDO (VWHTXDGURpGHQRPLQDGRHULWURFLWRVHSULPiULD
c) A eritrocitose secundária pode ser neoplásica ou não neoplásica.
(VWiFRUUHWRRTXHVHDÀUPDHP G $GHVLGUDWDomRUHVXOWDHPGLPLQXLomRGRÁXLGRH[WUDFHOXODUHSRUWDQWRHPYROXPHSODVPiWLFR
GLPLQXtGR(VWDVDOWHUDo}HVSRGHPOHYDUjHULWURFLWRVHGHKHPRFRQFHQWUDomR
a) I, II e IV. e) Uma leucemia neutrofílica tem como causa secundária a eritrocitose secundária.
b) I, III e IV.
c) II, III e IV.
d) II e III, apenas.  38&35²5HVLGrQFLDHP3DWRORJLD&OtQLFD9HWHULQiULD 2HVIUHJDoRGHDPRVWUDGHVDQJXHp
XPDSDUWHGDUHDOL]DomRGRKHPRJUDPDPXLWRLPSRUWDQWHSRUTXHGHOHGHSHQGHDDYDOLDomRTXDQWLWDWLYD
PDVSULQFLSDOPHQWHTXDOLWDWLYDGRVHOHPHQWRVÀJXUDGRVGRVDQJXH
 8)0*²5HVLGrQFLD8QLSURÀVVLRQDOHP0HGLFLQD9HWHULQiULD (PUHODomRjVFRQFHQWUDo}HV
DQRUPDLVGHOHXFyFLWRVQRVDQJXHGRVDQLPDLVPDUTXH9SDUDDVDÀUPDWLYDVYHUGDGHLUDVH)SDUDDV $VVLQDOHDDOWHUQDWLYDTXHGHVFUHYHRVFXLGDGRVSDUDSUHSDUDUXPHVIUHJDoRGHERDTXDOLGDGH
falsas.
D /kPLQDOLPSDHVHFDVDQJXHKRPRJHQHL]DGRFRUDQWHGRWLSR5RPDQRZVNL
 8PGHVYLRjHVTXHUGDVHFDUDFWHUL]DSHORDXPHQWRGHQHXWUyÀORVMRYHQVQRVDQJXH E /kPLQDPDQWLGDHPIRUPRO´FDSDOHXFRFLWiULDµFRUDQWHD]XOFUHVLOEULOKDQWH
 /HXFRJUDPD GH HVWUHVVH HP FmHV FRQVLVWH HP OHXFRSHQLD SRU QHXWURSHQLD OLQIRFLWRVH F /kPLQDOLPSDHVHFD´FDSDOHXFRFLWiULDµFRUDQWHGRWLSR5RPDQRZVNL
monocitose e eosinopenia. G /kPLQDOLPSDHVHFDVDQJXHKRPRJHQHL]DGRFRUDQWHD]XOGHWROXLGLQD
    $ OLQIRFLWRVH RFRUUH SRU OLQIRSRHVH DXPHQWDGD GHYLGR D HVWtPXOR FU{QLFR SRU DQWtJHQRV RX H /kPLQDOLPSDHVHFDVDQJXHKRPRJHQHL]DGRFRUDQWH6XGDQ%ODFN
citocinas.
 $HRVLQRÀOLDpXPDFKDGRFRPXPQDVGRHQoDVDOpUJLFDV
 38&35 ²   5HVLGrQFLD HP 3DWRORJLD &OtQLFD 9HWHULQiULD  6REUH D DQHPLD KHPROtWLFD
LPXQRPHGLDGDDQDOLVHRVLWHQVDVHJXLU
Assinale a sequência correta.
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)iUPDFRVH$QWLWURPEyWLFRVRevista Química Nova, v. 33. n. 1.p. 172-180, 2010.
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REFERÊNCIAS BIBLIOGRÁFICAS
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$QLPDOV6DXQGHQ&RPSDQ\3HQQV\OYDQLD
RAMOS, J.J. et al. A novel educational approach:8VLQJVKHHSDVDPRGHOLQWHDFKLQJYHWHULQDU\
+2.$0$1HZWRQ.0$&+$'23DXOR(GXDUGR$,QWHUSUHWDomR&OtQLFDGR+HPRJUDPDQDV
SDWKRORJ\'HSDUWDPHQWRGH3DWRORJtD$QLPDO)DFXOWDGGH9HWHULQDULD=DUDJR]D6SDLQ
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JAIN, N. C. Essentials of veterinary hematology3KLODGHOSKLD/HD )HELJHU
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REOLON, Mariana. et al. ,QVXÀFLrQFLDUHQDOFU{QLFDHPFmR²5HODWRGHFDVR. XVI Seminário
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LAURINO, Felipe. Alterações hematológicas em cães e gatos sob estresse. Trabalho de
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Conclusão de Curso em Medicina Veterinária. Universidade Júlio de Mesquita Filho. Botucatu,
SP. 2009.
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Oriental. Revista Acta AmazônicaYQS²
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LOPES, Sonia T. dos A. BIONDO, Alexander W. SANTOS, Andrea P. Manual de Patologia Clínica Ciência Animal Brasileira, V. 15. n. 1. p. 87-92. Goiânia, jan/mar 2014.
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6,1.&$)(/'0$1%)Urinálise e Hematologia Laboratorial para o Clínico de Pequenos
0(<(5'-&2/(6(+5,&+/-Medicina de Laboratório Veterinária: Interpretação e Animais. São Paulo: Roca, 2006.
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025$**+Exames Laboratoriais em Medicina Veterinária. 2. ed. São Paulo: Roca, 2003. Ensaios e Ciência: Ciências Biológicas, Agrárias e da Saúde, v. 16, n. 4, p. 87-100. Universidade
$QKDQJXHUD &DPSR *UDQGH 06  'LVSRQtYHO HP 'LVSRQtYHO HP KWWSZZZUHGDO\F
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ZZZVRYHUJVFRPEU!$FHVVRHPGHDJRVWRGH SOUZA, Anderson. Oliveira. SALVATTI, José. Reinaldo Jr. PICCININ, Adriana. Anemia infecciosa
equina. 5HYLVWD&LHQWtÀFD(OHWU{QLFDGH0HGLFLQD9HWHULQiULD$QR9,²Q²-DQHLURGH
1$9$552&(.*Manual de Hematologia Veterinária. 2. ed. São Paulo: Varela, 2005. 'LVSRQtYHOHPKWWSIDHIUHYLVWDLQIEU!$FHVVRHPGHDJRVWRGH

OLIVEIRA, Vânia Maria. AROEIRA, Luiz Januário. M. SILVA, Márcio Roberto. Como prevenir a 628=$+XJR&9Hemoterapia em Cães:DLPSRUWkQFLDGDWUDQVIXVmRVDQJXtQHDQDFOtQLFD
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cnptia.embrapa.br/>. Acesso em: 24 de fevereiro de 2016. dezembro, 2013.

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