DEPRESSÃO E

ANSIEDADE
Danielle Lodetti
Nutricionista pela Universidade Federal de Santa Catarina (2000)
Especialista em Fisiologia do Exercício pela Escola Paulista de Medicina (2002)
Especialista em Nutrição Estética pelo IPGS – Rio de Janeiro (2010)
Aperfeiçoamento em Bioquímica Aplicada à Patologia - Science Health- SP (2011 -2014)
Especializaçao em Nutrição Ortomolecular e Nutrigenômica – FAPES – SP (2012)
Especialização Fitoterapia Integrativa - Courses 4U – SP (2015)
Sócia Proprietária da Clínica REVIVA NUTRIÇAO – Fortaleza – CE
NEURONUTRIÇÃO
• O QUE QUE O CÉREBRO GOSTA DE ¨COMER¨?
• QUAIS NUTRIENTES ELE UTILIZA?
• O QUE ELE FABRICA?
• QUE NUTRIENTES / SUBSTÂNCIAS ATRAPALHAM
O SEU EQUILÍBRIO ?
• SERÁ QUE EU POSSO ACELERAR OU RETARDAR O
ENVELHECIMENTO DO CÉREBRO ?
• COMO EU SEI QUE MEU CÉREBRO ESTÁ
¨SAUDÁVEL¨?
• AI MEU DEUS #TENSA
 FERRAMENTAS PARA O
EQUILÍBRIO BIOQUÍMICO DO
CÉREBRO / NEUROPROTEÇÃO

NUTRIENTES E FITOQUÍMICOS PARA

O CÉREBRO
 SISTEMA NERVOSO CENTRAL

CÉLULAS CONSTITUINTES

Danielle Lodetti
 GABA
NOREPINEFRINA
ACETILCOLINA

SEROTONINA
DOPAMINA GLUTAMATO
 A BIOLOGIA DA FELICIDADE ( GENÉTICA)

Iran J Public Health. 2014 Nov; 43(11): 1468–1477.

Happiness & Health: The Biological Factors- Systematic Review Article
 Ca

The pharmacological basis of the serotonin system: Application to antidepressant response.

Encephale. 2016 Jun;42(3):255-63.
SINAPSE ¨TRIPARTIDA ¨
 ESTAMOS NA ERA DA MEDICINA /
NUTRIÇÃO DE PRECISÃO

PLoS One. 2014; 9(11): e113662.

Transcriptional Evidence for the Role of
Chronic Venlafaxine Treatment in
Neurotrophic Signaling and Neuroplasticity
Including also Glutatmatergic- and Insulin-
Mediated Neuronal Processes
 OS ¨DEFEITOS¨PODEM ESTAR NA:

• SÍNTESE DOS NEUROTRANSMISSORES

• RECEPTORES
• DENSIDADE SINÁPTICA ( COMUNICAÇÃO)
• BAIXA CAPACIDADE DE ADAPTAÇÃO /
SOBREVIVÊNCIA DOS NEURÔNIOS
• E MAIS...
Curr Neuropharmacol. 2015;13(4):505-13.
Zinc in the Glutamatergic Theory of Depression.
 AMBIENTE
GENÉTICA (Dieta, Sono, Stress, Traumas,
(programação/enzimas, etc) Medicamentos, Crenças, etc)
The pharmacological basis of the serotonin system: Application to antidepressant response.
Encephale. 2016 Jun;42(3):255-63.
 A baixa síntese se serotonina, por
exemplo, pode ocorrer devido a:

• BAIXA ATIVIDADE ENZIMÁTICA ( POLIMORFMISMO

GENÉTICO)

• BAIXA DISPONIBILIDADE DOS NUTRIENTES PRECURSORES

• BAIXA DENSIDADE SINÁPTICA

• ALGUM FATOR EXTERNO ( FORA DO CÉREBRO / DE OUTRO

ÓRGÃO) QUE ESTÁ IMPEDINDO A SÍNTESE DE ACONTECER
 Integration of incentive-based nonpharmacological interventions with
pharmacotherapies can lead to decreasing the dose of pharmaceutical drugs

Curr Clin Pharmacol. 2016 May; 11(2): 128–145.

Incorporating Natural Products, Pharmaceutical Drugs, Self-Care and Digital/Mobile Health Technologies into
Molecular-Behavioral Combination Therapies for Chronic Diseases
 DESEQUILÍBRIOS NA
NEUROTRANSMISSÃO
GERAM SINTOMAS /
DOENÇAS
Curr Neuropharmacol. 2015;13(4):505-13.
Zinc in the Glutamatergic Theory of Depression.
 PARA QUE OS
NEUROTRANSMISSORES EXERÇAM
SUAS FUNÇÕES, OS NEURÔNIOS
PRECISAM ¨COMUNICAREM-SE UNS
COM OS OUTROS¨
 CICLO DE KENNEDY

Serina
Etanolamina

Annu. Rev. Nutr. 2009.29:59-87

Use of Phosphatide Precursors to Promote Synaptogenesis
 SAME

Fosfatidilcolina
Neurotransmissores
DNA, RNA
Expressão genes
Membranas
celulares
Detoxificação

GLUTATIONA
 (300 mg/day )PS/ dia

Clin Interv Aging. 2013; 8: 557–563.

The effect of soybean-derived phosphatidylserine on cognitive performance in elderly
with subjective memory complaints: a pilot study
 METILAÇÃO

• P. EX: HIPOMETILAÇÃO - maior expressão de genes

responsáveis pela ação do Transportador de Serotonina

• MENOR CAPACIDADE DE ELIMINAÇÃO DE TOXINAS QUE

PODEM AGREDIR MEU ORGANISMO / CÉREBRO

• BAIXA CAPACIDADE DE SINTETIZAR

NEUROTRANSMISSORES
doi:10.1016/j.jad.2018.11.092
DEPRESSÃO
Can J Psychiatry. 2016 Sep; 61(9): 510–523.
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major
Depressive Disorder
Can J Psychiatry. 2016 Sep; 61(9): 510–523.
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder
Nat Med. 2016 Mar;22(3):238-49. Synaptic plasticity and depression: new insights from stress and
rapid-acting antidepressants.
ESTA PROGRAMAÇÃO JÁ
COMEÇA DURANTE A
GESTAÇÃO
 STRESS
Minerva Endocrinol. 2010 Jun;35(2):109-25.
Glucocorticoids, stress, and fertility.
 Má alimentação aumenta percepção de stress e altera
neurotransmissão Ser / GABA

Int J Mol Sci. 2015 Dec; 16(12): 29856–29874.

Allostatic Load and Preterm Birth
 Children with shorter telomeres exhibited significantly greater
cortisol reactivity to stress than did children with longer telomeres

Mol Psychiatry. 2015 May; 20(5): 615–620.

Telomere length and cortisol reactivity in children of depressed mothers
 Consequences of gestational diabetes to the brain and
behavior of the offspring

Memory and
mood disorders

An. Acad. Bras. Ciênc. vol.90 no.2 supl.1 Rio de Janeiro Aug. 2018
 The Interplay Between Nutrition and Stress in Pregnancy: Implications f
or Fetal Programming of Brain Development.

Biol Psychiatry. 2019 Jan 15; 85(2): 135–149. 10.1016/j.biopsych.2018.06.021

Front Neurosci. 2015; 9: 194. doi: 10.3389/fnins.2015.00194
The role of maternal obesity in the risk of neuropsychiatric disorders
Summary of human research demonstrating that maternal obesity increases the risk for menta
Child outcome
ADHD symptomology/Risk
ASD risk/Severity of symptoms Pre-pregnancy BMI
Anxiety/depression risk
Schizophrenia risk
Food addiction
Anorexia nervosa/Bulimia
nervosa risk
Risk of cognitive impairments
health disorders.
Maternal factor
Pre-pregnancy BMI
GWG
Gestational diabetes & SES
Dietary intake of omega-3 fatty acids
GWG
Diabetes, hypertension, or pre-eclampsia
Pre-pregnancy BMI
Pre-pregnancy BMI
GWG
Pre-eclampsia/hypertension and diuretic
treatment
BMI 5 months post-delivery
Intake of sweets during pregnancy
BMI 6 months post-delivery Disordered eating
Intake of sweets during pregnancy
Pre-pregnancy BMI
Science. 2016 Aug 19; 353(6301): 772–777.
Maternal immune activation: implications for neuropsychiatric disorders
Aberrations in the microbiome following MIA can lead to altered
development of peripheral immunity, which in turn leads to
alterations in brain development.
10.1126/science.aag3194
FISIOPATOLOGIA DA DEPRESSÃO E
ANSIEDADE
Curr Neuropharmacol. 2015;13(4):505-13.
Zinc in the Glutamatergic Theory of Depression.
Hood, S., Bell, C., Argyropoulos, S., & Nutt, D. (2016). Don’t panic. A guide to tryptophan
depletion with disorder-specific anxiety provocation. Journal of Psychopharmacology, 30(11),
 NEUROTROFINA

Int J Nanomedicine. 2015; 10: 3245–3267.

Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness
Neural Plast. 2017; 2017:
Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection
 Effects of physical activity on brain-derived neurotrophic factor (BDNF).

Reference Sample Treatment Assessment outcome

[233] 13 young, healthy men Moderate-intensity ↑ plasma BDNF
aerobic PA 4 d/wk for
5 wks
[234] 7 healthy, sedentary males Aerobic PA 7 d/wk for ↑ plasma BDNF
12 wks
[238] 60 older adults Aerobic PA 3 d/wk for ↑ BDNF and ↑ hippocampal volume
60 wks
[236] 47 healthy, sedentary males Aerobic PA 3 d/wk for ↑ serum BDNF following PA and ↑ memory on
5 wks face name matching

[235] 62 healthy, sedentary males Moderate-intensity ↑ serum BDNF following PA and ↑ memory on
aerobic PA for 2 wks face name matching

[247] 104 persons with partial response Add-on high Persons entering with ↑ BDNF levels exhibited
to antidepressants (16 kcal/kg/week) or ↑ rate of response to antidepressants
low (4 KKW) PA for
12 wks to standard
depression care
[248] 15 severely depressed adults Add-on aerobic PA Similar ↑ in BDNF in aerobic PA and medication-
16 kcal/kg/week for only group, but ↓ in oxidative stress markers
3 d/wk for 3 wks to seen only in PA group
standard care for
depression or
medication-only
Neural Plast. 2017; 2017: group
Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection
Curr Neuropharmacol. 2015;13(4):505-13.
Zinc in the Glutamatergic Theory of Depression.
Curr Neuropharmacol. 2015 Sep; 13(5): 558–576.
The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder:
An Opportunity for Domain Specific Treatments
INFLAMAÇÃO SISTÊMICA
HIPERPERM. INTESTINAL

ATIVAÇÃO DA GLIA
Front Cell Neurosci. 2015; 9: 392.
Breaking down the barriers: the gut microbiome, intestinal
permeability and stress-related psychiatric disorders
Front Cell Neurosci. 2015; 9: 392.
Breaking down the barriers: the gut microbiome, intestinal
permeability and stress-related psychiatric disorders
 SEROTONINA ↓

REDUÇÃO DESEMPENHO
COGNITIVO
intestinal fatty acid
binding protein

Suicide Assessment Scale

Acta Psychiatr Scand. 2019 Feb; 139(2): 185–193.
Leaky gut biomarkers in depression and suicidal behavior
: J Neuroinflammation. 2013; 10: 43.
 Feed Back -

B3

Neuropsychiatr Dis Treat. 2011; 7: 431–439.

A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase
 PSICOPROBIÓTICOS

Trends Neurosci. 2016 Nov;39(11):763-781.

Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals.
Curr Neuropharmacol. 2015;13(4):505-13.
Zinc in the Glutamatergic Theory of Depression.
Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2485-94.
Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic
mouse model of depression.
BMC Neurosci. 2009; 10: 26.
A mathematical model of aging-related and cortisol induced hippocampal dysfunction
 INDÍVIDUOS DEPRIMIDOS TÊM
PERCEPÇÃO DE STRESS AUMENTADA

Psychoneuroendocrinology. 2013 Jun;38(6):927-40. doi: Cortisol secretion in

depressed, and at-risk adults.
 Capacidade
mental

10.14336/AD.2016.1017 Aging Dis. 2017 May; 8(3): 267–276.

 TRATAMENTO
OPÇÕES NUTRICIONISTA
 COMO TRATAR O CÉREBRO?

• 1. MODULAR O CORTISOL
• 2. EQUILIBRAR NEUROTRANSMISSORES ( NUTRIENTES)
• 3. MELHORAR A ¨CONVERSA¨ENTRE OS
NEURÔNIOS -SINAPSES ( INDIVIDUALIZAR)
• 4. REDUZIR GLUTAMATO
• 5. DIETA ANTIINFLAMATÓRIA / CONTROLE DA INFLAMAÇÃO
• 6. CONTROLE DA DISBIOSE
• 7.TERAPIA ANTIOXIDANTE
• 8. CAPACIDADE DE METILAÇÃO
 Ca

SER

The pharmacological basis of the serotonin system: Application to antidepressant response.

Encephale. 2016 Jun;42(3):255-63.
PLoS One. 2014; 9(11): e113662. 10.1371/journal.pone.0113662

Mol Med Rep. 2019 Jul 12. doi: 10.3892/mmr.2019.10489.

Antidepressant effect of venlafaxine in chronic unpredictable stress: Evidence of the involvement of key
enzymes responsible for monoamine neurotransmitter synthesis and metabolism.
NUTRINDO / EQUILIBRANDO O
CÉREBRO

PASSO A PASSO
 1. IDENTIFICAR QUAL
NEUROTRANSMISSOR ESTÁ EM
DESEQUILÍBRIO
 DEFICIÊNCIA DE SEROTONINA
• TENDE A VARIAR O HUMOR NUNCA – 0
RARO – 1
• TRISTEZA /DEPRESSÃO OCASIONAL – 2
FREQUENTE – 3
• COMPULSÃO ALIMENTAR
• VONTADE DE CARBO, À TARDE SOMAR E DIVIDIR POR 9

• ALTERAÇÕES DE SONO RESULTADO > 1,6 = FALTA

• MUDANÇAS DE PERSONALIDADE
• TENDENCIAS SUICIDAS
• TAQUICARDIAS
• CRISES DE MANIA
 DEFICIÊNCIA DE GABA
NUNCA – 0
RARO – 1
• IRRITABILIDADE OCASIONAL – 2
FREQUENTE – 3
• IMPACIÊNCIA
SOMAR E DIVIDIR POR 8
• AGRESSIVIDADE
RESULTADO > 1,6 = FALTA
• INTOLERÂNCIA
• VONTADE DE COMER CARBOIDRATOS
• ALTERAÇÃO DO SONO
• COMPULSÃO ALIMENTAR GERAL
• ERUPÇÃO DÉRMICA OU NEURODERMATITE
 DEFICIÊNCIA DE DOPAMINA
NUNCA – 0
• ASTENIA E ADINAMICA RARO – 1
OCASIONAL – 2
• CANSAÇO FACIL FREQUENTE – 3

• FALTA DE DISPOSIÇAO SOMAR E DIVIDIR POR 8

• APATIA MATINAL RESULTADO > 1,6 = FALTA
• REDUÇAO DA LIBIDO
• DESEJO DE COMER AÇUCAR
• NECESSIDADE AUMENTADA DE CAFÉ
• AUMENTA TABAGISMO, CASO SEJA
• REDUÇAO DA CRIATIVIDADE
 DEFICIÊNCIA DE NOREPINEFRINA
NUNCA – 0
RARO – 1
• VIVE EM STRESS OCASIONAL – 2
FREQUENTE – 3
• VONTADE DE COMER SALGADOS
SOMAR E DIVIDIR POR 8
• CANSAÇO FACIL
• FALTA DE DISPOSIÇAO RESULTADO > 1,6 = FALTA

• ALTERAÇAO NA MEMORIA
• DORES MUSCULARES MIGRATORIAS
• TPM
• TENDENCIA A DEPRESSÃO
MODULAÇÃO SEROTONINA
 B3

B6
* Polimorfismos
BH4
Oxigênio
GRIFFONIA SIMPLICIFOLIA
5HTP
Competição para atravessar a BHE
 • FONTE DE 5-HTP

• 5-HTP atravessa a barreira Hematoencefálica

e converte-se em Serotonina

• Absorção não é influenciada por aa,

podendo ser administrada nas refeições.
• Cuidado ao associar com antidepressivos

Natural Products of relevance in the prevention and supportive treatment of depression, 2015
Jacobsen, J. P. R., Krystal, A. D., Krishnan, K. R. R., & Caron, M. G. (2016). Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-
Resistant Depression: Clinical and Preclinical Rationale. Trends in Pharmacological Sciences, 37(11), 933–944.doi:10.1016/j.tips.2016.09.001
 GRUPO A 5 HTP
50 mg – 3x dia – 0-2 sem
100 mg - 3x dia – 2-4 sem
130 mg – 3x dia - 4-8 sem

GRUPO B FLUOXETINA
20 mg– 0-2 sem
30 mg– 2-4 sem
40 mg - 4-8 sem
 800 mg SAME / dia

doi:10.1176/appi.ajp.2009.09081198
 Ex: Sintomas de Deficiência de SEROTONINA +
Homocisteína acima de 8:

GRIFFONIA SIMPLICIFOLIA ------------------------------- 40 mg

Metil folato ---------------------------------------------------- 200 mcg
Metil cobalamina --------------------------------------------- 200 mcg **
Ácido Fólico ---------------------------------------------------- 100 mcg

Usar 1 dose, 2 x ao dia

 Ex: Sintomas de Deficiência de SEROTONINA +
Homocisteína abaixo de 5:

GRIFFONIA SIMPLICIFOLIA ------------------------------------ 40 mg ***

Metil folato ----------------------------------------------------- 200 mcg
Metil cobalamina ---------------------------------------------- 200 mcg **
Ácido Fólico ---------------------------------------------------- 100 mcg
Metionina -------------------------------------------------------- 200 mg

Usar 1 dose, 2 x ao dia

Longe das refeições

*** REVER DOSES CASO O PACIENTE USE UM IRS

 SAME

Fosfatidilcolina
Neurotransmissores
DNA, RNA
Expressão genes
Membranas
celulares
Detoxificação

GLUTATIONA
CREATINA
Fifty-two women with major depressive
disorder were enrolled in an 8-week double-
blind placebo-controlled clinical trial and
randomly assigned to receive escitalopram in
addition to either creatine (5 g/day, N=25)
or placebo (N=27).
 INIBIDOR DA RECAPTAÇÃO SELETIVA DE
SEROTONINA
+

100 mg 5HTP – 2X DIA

5g de CREATINA

(2017). An Open-Label Pilot Study of Combined Augmentation With Creatine Monohydrate and 5-Hydroxytryptophan for
Selective Serotonin Reuptake Inhibitor– or Serotonin-Norepinephrine Reuptake Inhibitor–Resistant Depression in Adult
Women. Journal of Clinical Psychopharmacology, 37(5), 578–583.
(2015). Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study.
Journal of Dual Diagnosis, 11(3-4), 189–202.doi:10.1080/15504263.2015.1100471
• Indivíduos com Depressão apresentam bioenergética /
síntese de ATP reduzidos no Cérebro / DOENÇA
MITOCONDRIAL

• Fosfocreatina aumenta a disponibilidade de ATP

intraneuronal

• Neuromoduladora

• Eventualmente funciona como um Neurotransmissor

• Antiinflamatória, Antioxidante, anti –excitotóxica e anti-

apoptótica
Allen et al., 2015;Andres et al., 2008; Bender and Klopstock, 2016; Gualano et al.,
2016; Schulze, 2013).

J Neural Transm (Vienna). 2018 Feb;125(2):247-257.

Amino Acids. 2016; 48: 1941–1954.

RHODIOLA ROSEA
 Rhodiola rosea INIBE MAO A E MAO B.

Ethnopharmacological communication
Monoamine oxidase inhibition by Rhodiola rosea L. roots
 31 29 29

340 mg/dia
680 mg/dia

Biomed Res Int. 2017;2017:6596241. Therapeutic Effects of Phytochemicals and Medicinal Herbs on Depression.
 These findings suggest that R. rosea, although less effective than sertraline, may possess a
more favorable risk to benefit ratio for individuals with mild to moderate depression.

Phytomedicine. 2015 Mar 15;22(3):394-9.

Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.
 Rhodiola Rosea - 576 mg extract/day
28 dias

Planta Med. 2009 Feb;75(2):105-12. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of
the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue
CURCUMA LONGA
N = 50
500 MG CURCUMINA (88%
CURCUMINÓIDES) - 2 X DIA
 250mg CURCUMINA + 15mg SAFFRON

Lopresti, A. L., & Drummond, P. D. (2017). Efficacy of curcumin, and a

saffron/curcumin combination for the treatment of major depression: A
randomised, double-blind, placebo-controlled study. Journal of
Affective Disorders, 207, 188–196.doi:10.1016/j.jad.2016.09.047
• Curcumin --------------------- 500 mg
• Piperina ------------------------ 5 mg
• Usar 1 dose, 1 a 2x / dia

OU

• Cureit --------------------------- 500 mg

• Usar 1 dose, 1 a 2x / dia

OU

• CURCUMA ( MTC – VITAFOR) ------------------- 1000 mg CURCUMA +

TCM + LECITINA DE SOJA
CROCUS SATIVUS ( SAFFRON)
Crocin , crocetina,
Kampferol, Safranal

Inibição da MAO
Aumento da Dopamina
Antagonista NMDA r
Antiinflamatórios
Antioxidantes

Iran J Basic Med Sci. 2015 Dec; 18(12): 1153–1166.

Razi’s Al-Hawi and saffron (Crocus sativus): a review
 154 mg Rhodiola Rosea + 15 mg Saffron – 2 x dia

Neuropsychiatr Dis Treat. 2018; 14: 1821–1829.PMCID: PMC6049049

A preliminary assessment of a combination of rhodiola and saffron in
the management of mild–moderate depression
Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a
double-blind, randomized and placebo-controlled trial,” Phytomedicine,vol. 13, no. 9-10,
pp. 607–611, 2006.
 DEPRESSÃO PÓS PARTO
30 MG / DIA

(2017). A double-blind, randomized, placebo-controlled trial of saffron stigma ( Crocus sativus L . ) in mothers suffering
from mild-to-moderate postpartum depression. Phytomedicine, 36, 145–152.
 ✓ Extrato com elevado teor de componentes
ativos: 3,5% de Lepticrosalides® (safranal e
crocins).

AFFRON ®

(2017). affron ® a novel saffron extract ( Crocus sativus L .) improves mood in healthy adults over 4 weeks in a
double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine, 33, 58–
64.doi:10.1016/j.ctim.2017.06.001
• Saffron ® / Saffrin ®----------------- 80 mg
Usar 1 dose, 2 x dia

OU

• Affron ® ------------------------------- 15 mg
Usar 1 dose, 2 x dia

OU

Affron ® ------------------------------- 15 mg
Griffonia Simplicifolia --------------- 30 mg
Usar 1 dose, 2 x dia
+

Metilfolato ---------------------------- 200 mcg

Piridoxina ------------------------------ 10 mg
Metilcobalamina ---------------------- 300 mcg***
Usar 1 dose, 2 x dia

Obs – adicionar a Metionina caso Homocisteína esteja baixa

OMEGA 3
 CICLO DE KENNEDY

Serina
Etanolamina

Annu. Rev. Nutr. 2009.29:59-87

Use of Phosphatide Precursors to Promote Synaptogenesis
J Clin Psychiatry. 2011 Dec;72(12):1577-84.
Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression.
J Clin Psychiatry. 2011 Dec;72(12):1577-84.
Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression.
 MECANISMOS DE AÇÃO DO W3
• FLUIDEZ DE MEMBRANA ( MELHORA A
EFICIÊNCIA DOS RECEPTORES DE SEROTONINA E
DOPAMINA)

• DENSIDADE SINÁPTICA

• REGULAM TRANSDUÇÃO DE SINAIS NA

MEMBRANA NEURONAL

• ANTIIFLAMATÓRIO
Biochem J. 1994 Jun 1; 300(Pt 2): 509–518.
Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity.
• EQUILÍBRIO W3/W6/GORDURA SATURADA

CONTROLE DA INFLAMAÇÃO

INSULTO QUE GERE

LESÕES NA ESTRUTURA
DA MEMBRANA CELULAR

ATIVAÇÃO DE ENZIMAS
QUE ¨CORTAM¨OS ÁCIDOS
GRAXOS DAS
MEMBRANAS
GORDURA SATURADA / TRANS / ÓLEOS VEGETAIS
Adv Nutr. 2011 Jul; 2(4): 304–316.
Published online 2011 Jun 28. doi: 10.3945/an.111.000505
Eur J Pharmacol. 2016 Aug 15;785:144-155. doi: 10.1016/j.ejphar.2015.11.001. Epub 2015 Nov 3.
DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation.
 DHA DA DIETA / SUPLEMENTOS !!
Prog Lipid Res. 2014 Oct; 0: 1–18.
Phosphatidylserine in the Brain: Metabolism and Function
Curr Neuropharmacol. 2015;13(4):505-13.
Zinc in the Glutamatergic Theory of Depression.
DEFICIÊNCIA DE GABA
E AUMENTO DE
CORTISOL
 SUPLEMENTAÇÃO COM GABA
molecules need to enter via active uptake by specialized
transporter molecules or diffusion into the cells of the BBB

Front Psychol. 2015; 6: 1520.

Neurotransmitters as food supplements: the effects of GABA on brain
and behavior
 LAVANDULA ANGUSTIFOLIA

Gelfuso, E., Rosa, D., Fachin, A., Mortari, M., Cunha, A., & Beleboni, R. (2014). Anxiety: A Systematic Review of Neurobiology, Traditional Pharmaceuticals
and Novel Alternatives from Medicinal Plants. CNS & Neurological Disorders - Drug Targets, 13(1), 150–165.
Silexan contains a quality-selected, well-defined preparation from Lavandula angustifolia in
an immediate release capsule. Silexan acts via the GABAA receptors

80mg LAVANDULA

PACIENTES COM TRANSTORNO DE ANSIEDADE GENERALIZADA

A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for
generalized anxiety disorder. Phytomedicine, 17(2), 94–99.
 20 mg Citalopran 20 mg citalopran + 5g de Lavanda Chá

The Effects of Lavandula Angustifolia Mill Infusion on Depression in Patients Using Citalopram: A comparison Study

Copyright: Copyright © 2013, Iranian Red Crescent Medical Journal. .

TÃO EFICAZ QUANTO BENZODIAZEPÍNICOS
(EM DOSES INICIAIS) NO TRAMANTO DA ANSIEDADE

TAMBÉM EFICAZ EM SINTOMAS DE ANSIEDADE -

DISTÚRBIOS DO SONO, COMPLICAÇÕES SOMÁTICAS E PERDA
DE QUALIDADE DE VIDA

BAIXA INTERAÇÃO COM MEDICAMENTOS

POUCOS EFEITOS COLATERAIS

doi:10.1186/1472-6882-14-503
 LAVANDULA ANGUSTIFOLIA

Flores ( Alfazema)
1 col chá das flores + 150 ml de água – abafar e deixar em infusão por 10 minutos

Distúrbios de comportamento, Agitação, insônia, Ansiedade generalizada e

transtornos de humor

Óleo Essencial
3 gotas – esfregar na palma das mãos ( infusão a seco)

Difusor de óleos essenciais / travesseiro / pijama

CITRUS SINENSIS
• Óleo Essencial de Citrus Sinensis ( Laranja
doce) – efeitos ansiolíticos ( adultos e
crianças)
 SERENZO ® ( D-Limoneno)

Redução dos efeitos da

Inflamação / Stress no SNC

Redução da irritabilidade,
Percepção do Stress,

Serenzo ® - ----- 250 mg, 2 x dia

TPM, MENOPAUSA, STRESS, INFLAMAÇÃO

SISTÊMICA
RELORA ( Magnolia Officinalis +
Phelodendron Amurense)
Talbott, S. M., Talbott, J. A., & Pugh, M. (2013). Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and
psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 10(1), 37.
The product is standardized to “not less than 1.5% honokiol and
0.1% berberine.”

breakfast (250 mg) and dinner (250 mg)

 BERBERINA

Fan, J., Zhang, K., Jin, Y., Li, B., Gao, S., Zhu, J., & Cui, R. (2018). Pharmacological effects of
berberine on mood disorders. Journal of Cellular and Molecular Medicine.doi:10.1111/jcmm.13930
• Phelodendron ® ( 97% Berberina)

• 500 mg, 2 x / dia, no almoço e jantar - efeito Insulina Like

doi:10.1111/jcmm.13930
 Extracts of Magnolia officinalis and Phellodendron amurense (Relora®) on
anxiety, stress and sleep in healthy premenopausal women. 250 mg / 3x dia

Kalman, D. S., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D. R., & Garrison, R. (2008). Effect of a
proprietary Magnolia and Phellodendronextract on stress levels in healthy women: a pilot, double-blind, placebo-
controlled clinical trial. Nutrition Journal, 7(1). doi:10.1186/1475-2891-7-11
European J Med Plants. 2016 May; 15(1): 14802.
doi: 10.9734/EJMP/2016/26453
 tyrosine
hydroxylase
Dopamine
B6 β-hydroxylase

DOPA
Bh4 descarboxilase
Ferro
Vesículas
O2 B
Sinápticas
FENILALANINA

Sexually Dimorphic Effects of Catechol-O-Methyltransferase (COMT) Inhibition on Dopamine Metabolism in Multiple Brain Regions
PLoS One. 2013;8(4):e61839.
MELISSA OFFICINALIS
 Melissa Officinalis

Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med 66:607–613
:

Cyracos ( Extrato de Melissa Officinallis)contains rosmarinic acid and the pentacyclic

triterpenoids, ursolic and oleanolic acids , which inhibit gamma-aminobutyric acid
(GABA) catabolism ( GABA-T)

Mediterranean Journal of Nutrition and Metabolism, 4(3), 211–218. doi:10.1007/s12349-010-0045-4

 330 a 500 mg / 1 a 2 x dia

Gelfuso, E., Rosa, D., Fachin, A., Mortari, M., Cunha, A., & Beleboni, R. (2014). Anxiety: A Systematic Review of
Neurobiology, Traditional Pharmaceuticals and Novel Alternatives from Medicinal Plants. CNS & Neurological Disorders -
Drug Targets, 13(1), 150–165.
TAURINA
GABAÉRGICO – 2000 a 3000 mg
1 A 2 x dia
 Taurine supplementation might help forestall the age-
related decline in cognitive functions through interaction
with the GABAergic system.
L-TAURINA ------------------- 200 mg
Piridoxina --------------------- 10 mg
Usar 1 dose, 2 x ao dia, 30 minutos antes das refeições,
pelo menos
 500mg of Erythrina mulungu
1 hora antes da Cirurgia

Med Oral Patol Oral Cir Bucal. 2014 Sep 1;19(5):e518-24.

Effect of Erythrina mulungu on anxiety during extraction of third molars.
• Erytrina Mulungu ----------------- 300 mg
• Usar 1 dose ao deitar-se

OU

• Usar 1 dose no meio da manhã e 1 dose no final da

tarde ( longe das refeições)
doi: 10.1080/14656566.2018.1491966
Pharmacotherapy for Generalized Anxiety Disorder in Adults and Pediatric Patients: An Evidence-Based Treatment Review. 2018
@ danylodetti
@revivanutricao

www.revivanutricao.com.br